Cocaine

Alkermes Sees Chance to Reinvent Vivitrol For Fighting Drug Addiction, Not Just Alcoholism

If you were to poll Wall Street a few months ago for impressions of Alkermes’ naltrexone injection (Vivitrol), you’d hear a number of things. Most aren’t good. It’s a bust. The...

Making crime pay: Alkermes aims to treat prison overcrowding

Alkermes' CEO Richard Pops says he feels a "certain inevitability" over the success of its addiction drug Vivitrol (naltrexone extended-release), despite the fact that sales have been slow. In the US,...

Treating cocaine dependence: A promising new pharmacotherapy

(Elsevier) Medication development efforts for cocaine dependence have yet to result in an FDA approved treatment. The powerful rewarding effects of cocaine, the profound disruptive impact of cocaine d...

Combination of mixed amphetamine salts and topiramate shows promise for cocaine dependence

Medication development efforts for cocaine dependence have yet to result in an FDA approved treatment. The powerful rewarding effects of cocaine, the profound disruptive impact of cocaine dependence o...

A Promising New Pharmacotherapy For Treating Cocaine Dependence

Medication development efforts for cocaine dependence have yet to result in an FDA approved treatment. The powerful rewarding effects of cocaine, the profound disruptive impact of cocaine dependence o...

Conditioned Contribution of Peripheral Cocaine Actions to Cocaine Reward and Cocaine-Seeking

Cocaine Addiction Treatment and Cocaine Rehab Announced by Recovery Associates Treatment Center

(PRWEB) May 09, 2013 Cocaine abuse remains problematic for adults and children alike across the United States, leaving them in precarious health situations. Research provided by the National Ins...

Therapies For Cocaine Abuse Likely Following The Modeling Of New Enzymes

Researchers from the University of Kentucky have designed and discovered a series of highly efficient enzymes that effectively metabolize cocaine. These high-activity cocaine-metabolizing enzymes coul...

The selective dopamine uptake inhibitor, D-84, suppresses cocaine self-administration, but does not occasion cocaine-like levels of generalization.

A successful replacement pharmacotherapy for treating cocaine dependency would likely reduce cocaine's abuse, support a low abuse liability, overlap cocaine's subjective effects, and have a long durat...

Cocaine must enter the brain to evoke unconditioned dopamine release within the nucleus accumbens shell.

In addition to blocking dopamine (DA) uptake, cocaine also causes an unconditioned increase in DA release. In drug naive rats, this effect is most robust within the nucleus accumbens (NAc) shell. Rece...

Facile and Enantiospecific Syntheses of (6S,7R)-6-Chloro-7-benzyloxy-, (7S)-Halo-, and (7S)-Hydroxy-cocaine and Natural (-)-Cocaine from d-(-)-Ribose.

First syntheses of C6,7 and C7 enantiopure cocaine analogues were achieved from d-(-)-ribose via a trans-acetonide controlled endo-selective intramolecular nitrone-alkene cycloaddition (INAC) as the k...

HCV infection among cocaine users in the state of Pará, Brazilian Amazon.

In this study, the prevalence, genotype frequency, and risk factors for HCV infection in 384 cocaine users were determined. One hundred twenty-four (32.3 %) cocaine users had anti-HCV antibodies and...

Adenovirus Capsid-based Anti-cocaine Vaccine Prevents Cocaine from Binding to the Nonhuman Primate CNS Dopamine Transporter.

Cocaine addiction is a major problem for which there is no approved pharmacotherapy. We have developed a vaccine to cocaine (dAd5GNE), based on the cocaine analog GNE linked to the capsid proteins of...