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Novartis has backup for false protection against Voltaren counterfeits

Supplies of Novartis' Voltaren (diclofenac sodium) are safe despite reports that the company may have purchased anti-counterfeiting technology that is not as secure as promised for the injectable for...

New Zealand's Medsafe Decides To Leave Voltaren NSAID Drug On Market

New Zealand's Medsafe has decided to leave the Novartis painkiller Voltaren (diclofenac) on the local market despite moves by other countries, such as Canada and the U.K., to order recalls.

Pharmaceutical Research: Use of Partial AUC (PAUC) to Evaluate Bioequivalence—A Case Study with Complex Absorption: Methylphenidate

Type: Original PaperPurposeMethylphenidate modified-release products produce early and late peak concentrations critical for treatment of morning and afternoon symptoms of attention deficit hyperactiv...

The AAPS Journal: Metrics for the Evaluation of Bioequivalence of Modified-Release Formulations

Type: Original PaperMetrics are discussed which are used for the evaluation of bioequivalence of modified-release formulations. In order to ensure the therapeutic equivalence of the compared drug prod...

AAPS PharmSciTech: Preparation and Evaluation of Orally Disintegrating Tablets Containing Taste-Masked Microcapsules of Berberine Hydrochloride

Type: Original PaperThe purpose of this study was to prepare and evaluate a taste-masked berberine hydrochloride orally disintegrating tablet for enhanced patient compliance. Taste masking was perform...

Pharmaceutical Research: Use of In Vitro–In Vivo Correlation to Predict the Pharmacokinetics of Several Products Containing a BCS Class 1 Drug in Extended Release Matrices

Type: Original PaperPurposeTo determine if an IVIVC model can predict PK profiles of varying formulations of a BCS Class 1 drug that is a salt of a weak base.MethodAn IVIVC model (Level A) was created...

Pharmaceutical Research: Preclinical Studies of YK-4-272, an Inhibitor of Class II Histone Deacetylases by Disruption of Nucleocytoplasmic Shuttling

Type: Original PaperPurposeThe HDAC shuttling inhibitor, YK-4-272 functions by restricting nuclear shuttling of Class II HDACs. Pre-clinical investigations of YK-4-272 bioavailability, pharmacokinetic...

EMA releases updated guidelines for biosimilar insulin products

EMA's CHMP released draft guidelines that update 2006 guidelines on the non-clinical and clinical requirements for biosimilar insulin products. The updated guidelines state that clinical studies shoul...

Distribution of olive oil phenolic compounds in rat tissues after administration of a phenolic extract from olive cake.

Scope: The distribution and accumulation of olive oil phenolic compounds in the body are topics lacked of information. The aim of this study was to evaluate the bioavailability, metabolism and distrib...

Impact of four loci on serum tamsulosin hydrochloride concentration.

Tamsulosin hydrochloride is one of the most potent drugs for treatment of benign prostatic hyperplasia (BPH), however, the efficacy of tamsulosin hydrochloride varies among individuals. In this study,...

Age effect on whole blood cyclosporine concentrations following oral administration in children with nephrotic syndrome.

The aim of this study was to investigate age-related pharmacokinetic differences of cyclosporine (CyA) in children with nephrotic syndrome. Whole blood concentrations of CyA were monitored for a total...

Pharmacokinetics of single and multiple oral doses of arbidol in healthy Chinese volunteers.

Background: Arbidol is licensed in Russia and China for prophylaxis and treatment of influenza A and B. This study was to assess the pharmacokinetics of single and multiple doses of arbidol in healthy...

Effects of route of administration and feeding schedule on pharmacokinetics of robenacoxib in cats.

Objective-To establish pharmacokinetics of robenacoxib after administration to cats via the IV, SC, and oral routes. Animals-24 cats. Procedures-In a crossover design, robenacoxib was administered IV,...