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ROS play a critical role in the differentiation of alternatively activated macrophages and the occurrence of tumor-associated macrophages

Macrophages: Bloody regulators

CD169-expressing macrophages support erythropoiesis.

Macrophage biology in development, homeostasis and disease

Macrophages, the most plastic cells of the haematopoietic system, are found in all tissues and show great functional diversity. They have roles in development, homeostasis, tissue repair and immunity....

Macrophage accumulation of triglycerides yields insights into atherosclerosis

(Federation of American Societies for Experimental Biology) A research report appearing in the Journal of Leukocyte Biology (http://www.jleukbio.org) helps explain how specific immune cells, called ma...

Harmful Cells May Have A Role To Play In Liver Repair, Study Suggests

Liver damage could be repaired by the same cells that harm the organ in the first place, a study suggests. The cells - called macrophages - cause tissue to become scarred, which can lead to cirrhosis...

HIV Helped To Escape Destruction By Kinesin 'Chauffeur'

A study in The Journal of Cell Biology identifies a motor protein that ferries HIV to the plasma membrane, helping the virus escape from macrophages. HIV reproduces inside disease-fighting T cells, ki...

The nuclear receptor LXRα controls the functional specialization of splenic macrophages

Liver X receptors (LXRs) are transcription factors that respond to sterols. Castrillo and colleagues identify a unique requirement for LXRα in the development of splenic marginal zone macrophages and...

Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages

Macrophages consist of at least two subgroups, M1 and M2 (refs 1, 2, 3). Whereas M1 macrophages are proinflammatory and have a central role in host defence against bacterial and viral infections, M2 m...

The release of cytokines by macrophages is not affected by myelin ingestion.

Macrophages play an important role in demyelination in multiple sclerosis (MS). Activated macrophages ingest myelin particles, thereby acquiring a foamy appearance. Foamy macrophages in MS lesions wer...

IL-10 suppresses bactericidal response of macrophages against Salmonella Typhimurium.

We report, herein, an attempt to determine whether an IL-10-induced immunological state affects the response of macrophages against Salmonella Typhimurium (ST). Pretreatment with mrIL-10 induced the i...

Leishmania-induced repression of selected non-coding RNA genes containing B-box element at their promoters in alternatively polarized M2 macrophages.

Leishmania is a group of parasitic protozoa that infect blood and tissue phagocytes including macrophages. We hypothesize that Leishmania is capable of establishing infection inside the macrophages be...

In vitro differentiation of human macrophages with enhanced antimycobacterial activity.

Mycobacterium tuberculosis causes widespread, persistent infection, often residing in macrophages that neither sterilize the bacilli nor allow them to cause disease. How macrophages restrict growth of...

Microglia activation by SIV-infected macrophages: alterations in morphology and cytokine secretion.

HIV infection in the brain and the resultant encephalitis affect approximately one third of individuals infected with HIV, regardless of treatment with antiretroviral drugs. Microglia are the resident...