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Oncogenic BRAF can result from mutations in the BRAF gene, which may cause the protein to become overactive. The most common alteration in the BRAF gene leads to the BRAFV600E mutation. Mutations in...
Gene therapy is due for a second draft. As we have known it, gene therapy amounts to gene augmentation, a fairly random procedure whereby a gene is plunked down pretty much anywhere—so lo...
(The Conversation) – Gene doping is simply gene therapy in people who don’t need it. The aim of gene therapy is to permanently cure sick individuals of their conditions by altering their genet...
What is gene therapy? [Gene therapy] is a way to fix a gene defect in a person’s cells. One way is with a retrovirus. When these viruses infect cells, they are able to transcribe genetic information...
The CRISPR gene-editing tool has been modified so that it can add or remove methyl groups at specific positions on DNA, allowing researchers to test how such changes affect gene expression.DNA methyla...
Gene editing, led by the discovery of CRISPR-Cas, promises widesprea
Researchers have found a way to repair the faulty gene that causes sickle
A team of Israeli molecular geneticists has combined two powerful genomics tools to study single cell gene expression.
Just because a gene is cut and disabled doesn’t mean the cell’s DNA repair mechanisms are ready to throw in the towel. No, they stay in the gene’s corner, patching the gene’s...
Over the last few years, huge progress has been made with regards to the understanding of molecular mechanisms underlying the pathogenesis of neurodegenerative diseases of the eye. Such knowledge has ...
One of the major challenges limiting development of gene therapy is absence of efficient and safe gene carriers. Among the non-viral gene delivery methods, lipofection is considered as one of the most...
Essential genes of pathogens are potential therapeutic targets, but are difficult to verify. Here, gene essentiality was determined by targeted knockout following engineered gene duplication. Null mut...
Effective delivery of therapeutic genes to target cells has been a fundamental goal in cancer gene therapy because of its advantages in the aspects of both safety and transfection efficiency. Here we ...