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Oncogenic BRAF can result from mutations in the BRAF gene, which may cause the protein to become overactive. The most common alteration in the BRAF gene leads to the BRAFV600E mutation. Mutations in...
Gene therapy is due for a second draft. As we have known it, gene therapy amounts to gene augmentation, a fairly random procedure whereby a gene is plunked down pretty much anywhere—so lo...
What is gene therapy? [Gene therapy] is a way to fix a gene defect in a person’s cells. One way is with a retrovirus. When these viruses infect cells, they are able to transcribe genetic information...
Intrexon aims to enhance its gene transfer capabilities by acquiring AdenoVerse gene delivery platform developer GenVec in a -More-
The CRISPR gene-editing tool has been modified so that it can add or remove methyl groups at specific positions on DNA, allowing researchers to test how such changes affect gene expression.DNA methyla...
Gene editing, led by the discovery of CRISPR-Cas, promises widesprea
Researchers have found a way to repair the faulty gene that causes sickle
A team of Israeli molecular geneticists has combined two powerful genomics tools to study single cell gene expression.
Using CRISPR gene-editing technology and genetically engineered mice, scientists have discovered that a “collateral vessels” gene, Rabep2, protects against stroke...
One of the major challenges limiting development of gene therapy is absence of efficient and safe gene carriers. Among the non-viral gene delivery methods, lipofection is considered as one of the most...
Essential genes of pathogens are potential therapeutic targets, but are difficult to verify. Here, gene essentiality was determined by targeted knockout following engineered gene duplication. Null mut...
Meiotic recombination involves a combination of gene conversion and crossover events that, along with mutations, produce germline genetic diversity. Here we report the discovery of 3,176 SNP and 61 in...
Microarray and next generation sequencing has led to the exploration of correlated gene patterns and their shared functions. Gene modulators are proteins that alter the activity of transcription facto...