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Oncogenic BRAF can result from mutations in the BRAF gene, which may cause the protein to become overactive. The most common alteration in the BRAF gene leads to the BRAFV600E mutation. Mutations in...
Aranca discusses the considerable advances that have occured in the last few years in gene therapy. Considerable research has been conducted in genomics in the past two decades. Extensive research in ...
A disorder caused by a mutation in a single gene, Duchenne muscular dystrophy is an attractive candidate for gene therapy; however, the mutated gene happens to be one of the largest in the human...
What is gene therapy? [Gene therapy] is a way to fix a gene defect in a person’s cells. One way is with a retrovirus. When these viruses infect cells, they are able to transcribe genetic information...
Gene reporters enable valuable insight into gene expression. The GUS gene reporter system is one of the popular and common plant reporter systems. GUS, is short for glucuronidase, an enzyme in the b...
Intrexon aims to enhance its gene transfer capabilities by acquiring AdenoVerse gene delivery platform developer GenVec in a -More-
Gene editing, led by the discovery of CRISPR-Cas, promises widesprea
To investigate the association of several single nucleotide polymorphisms (SNPs) within vascular endothelial growth factor (VEGF) and vitamin D receptor (VDR) gene polymorphisms and additional gene- g...
The aim was to investigate the impact of PPARG and APOE gene single nucleotide polymorphisms (SNPs) and additional gene- gene interaction on late-onset Alzheimer's disease (LOAD) risk based on Chinese...
Non-viral polymer-based gene transfer represents an adaptable system for tumor-targeted gene therapy, as various design strategies of shuttle systems together with the mechanistic concept of active tu...
One of the major challenges limiting development of gene therapy is absence of efficient and safe gene carriers. Among the non-viral gene delivery methods, lipofection is considered as one of the most...