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Oncogenic BRAF can result from mutations in the BRAF gene, which may cause the protein to become overactive. The most common alteration in the BRAF gene leads to the BRAFV600E mutation. Mutations in...
Aranca discusses the considerable advances that have occured in the last few years in gene therapy. Considerable research has been conducted in genomics in the past two decades. Extensive research in ...
A "gene drive" occurs when a specific gene is spread at an enhanced rate through an animal or plant population.
Researchers are beginning to gain a clearer understanding of how the immune system responds, in both a reactive and tolerant way, to gene therapy delivered using what has become the preferred gene del...
A disorder caused by a mutation in a single gene, Duchenne muscular dystrophy is an attractive candidate for gene therapy; however, the mutated gene happens to be one of the largest in the human...
Gene reporters enable valuable insight into gene expression. The GUS gene reporter system is one of the popular and common plant reporter systems. GUS, is short for glucuronidase, an enzyme in the b...
Intrexon aims to enhance its gene transfer capabilities by acquiring AdenoVerse gene delivery platform developer GenVec in a -More-
The aim of this study was to investigate the impact of CYP4A11 single-nucleotide polymorphisms (SNP), additional gene-gene and gene-environment interactions on essential hypertension (EH) risk.
To investigate the association of several single nucleotide polymorphisms (SNPs) within vascular endothelial growth factor (VEGF) and vitamin D receptor (VDR) gene polymorphisms and additional gene- g...
The aim was to investigate the impact of PPARG and APOE gene single nucleotide polymorphisms (SNPs) and additional gene- gene interaction on late-onset Alzheimer's disease (LOAD) risk based on Chinese...
Non-viral polymer-based gene transfer represents an adaptable system for tumor-targeted gene therapy, as various design strategies of shuttle systems together with the mechanistic concept of active tu...
One of the major challenges limiting development of gene therapy is absence of efficient and safe gene carriers. Among the non-viral gene delivery methods, lipofection is considered as one of the most...