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Vitamin K is a group of 2-methilo-naphthoquinone derivatives. There are three notable forms of vitamin K; K1 which can be synthesized by plants, K2 which can be formed by natural bacteria in the int...
Although NOAC drugs compare favorably with warfarin in patients with AF, questions remain about the differences when warfarin is well managed. Dr Mandrola reports on a provocative observational study ...
The binding sites for the anticoagulant drug warfarin and for vitamin K on the human VKOR are determined through biochemistry and computational approaches. The results indicate a competitive mechanism...
Not having set guidelines for managing patients on warfarin is costing hospitals and physicians a fortune. Researchers from Boston University School of Medicine (BUSM) have developed new performance m...
Warfarin alone or with antiplatelet therapy may protect against thrombosis after transcatheter aortic-valve replacement, but not everyone agrees there is enough support for anticoagulants yet. Heart...
The meta-analysis included four phase III clinical trials comparing novel anticoagulants to warfarin in patients with atrial fibrillation.
At least a third of patients on warfarin had INR values that were off, not "just slightly out of range" but "significantly out of range," an author says. Heartwire from Medscape
This cohort study uses data from an atrial fibrillation registry to describe the proportion of patients on warfarin who had stable INR values over an 18-month period.
New performance measures have been developed for patients on warfarin that may save lives and money, report investigators.
Roof rats (Rattus rattus) live mainly in human habitats. Heavy use of rodenticides, such as warfarin, has led to the development of drug resistance, making pest control difficult. There have been many...
We report a case of a 60-year-old man who was referred to a palliative care clinic with monoclonal gammopathy of undetermined significance (MGUS)-associated neuropathy, responding to a therapeutic tri...
Some reports have suggested that bucolome, an inhibitor of cytochrome P450 2C9, is useful for decreasing inter-patient variation in warfarin clearance. The purpose of the present study was to evaluate...
Warfarin is the most commonly used oral anticoagulant for the treatment and prevention of thromboembolic disorders. Pharmacogenomics studies have shown that variants in CYP2C9 and VKORC1 genes are str...
We describe a 70-year-old Haitian man who had been taking warfarin for 5 years for atrial fibrillation and pulmonary hypertension. This patient had his international normalized ratio (INR) checked in ...