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04:34 EDT 24th August 2016 | BioPortfolio

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Vitamin K

Vitamin K is a group of 2-methilo-naphthoquinone derivatives. There are three notable forms of vitamin K; K1 which can be synthesized by plants, K2 which can be formed by natural bacteria in the int...

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Warfarin Can Be Safe, Effective for People With Irregular Heartbeat

WEDNESDAY, April 20, 2016 -- Millions of American heart patients take warfarin -- for decades a cheap, but often tricky-to-manage mainstay blood thinner. Now, new research shows that when it is well-m...

Well-managed warfarin therapy may lower complication rates

If patients assigned warfarin had adequate time in therapeutic range, the drug was associated with a low rate of complications, according to the results of a registry study.Researchers conducted a ret...

VIDEO: Bleeding rates ‘higher than expected’ with warfarin in veterans with AF

ORLANDO, Fla. — John Dodson, MD, MPH, cardiologist and assistant professor of medicine and population health at NYU Langone Medical Center, offers investigator insight at the annual AHA Scientific S...

Warfarin and Dabigatran, Similarities and Differences

Warfarin and Dabigatran, Similarities and Differences Author: Danut Dragoi, PhD Warfarin (NB-which goes by the brand name Coumadin, see link in here) reduces the risk of stroke in patients with atrial...

Warfarin vs. Apixaban in Atrial Fibrillation Patients Who Receive Multiple Drugs

Apixaban was superior to warfarin in the setting of polypharmacy.

Long-Term Warfarin Use for AF Linked to Dementia Risk

Patients with the heart rhythm disorder atrial fibrillation (AF) who were treated long term with the blood thinner, warfarin, may have higher rates of dementia, according to a recent study of more tha...

Warfarin INR Instability Common, Supports Shift to NOACs: Study

At least a third of patients on warfarin had INR values that were off, not "just slightly out of range" but "significantly out of range," an author says. Heartwire from Medscape

Stability of International Normalized Ratios With Long-term Warfarin Therapy

This cohort study uses data from an atrial fibrillation registry to describe the proportion of patients on warfarin who had stable INR values over an 18-month period.

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Warfarin-induced skin necrosis following heparin-induced thrombocytopenia.

Anticoagulants, such as heparin and warfarin, are commonly used in the treatment and prevention of thromboembolic events. The risk of developing warfarin-induced skin necrosis (WISN) with warfarin is ...

Warfarin improves neuropathy in monoclonal gammopathy of undetermined significance.

We report a case of a 60-year-old man who was referred to a palliative care clinic with monoclonal gammopathy of undetermined significance (MGUS)-associated neuropathy, responding to a therapeutic tri...

Warfarin resistance associated with genetic polymorphism of VKORC1: linking clinical response to molecular mechanism using computational modeling.

The variable response to warfarin treatment often has a genetic basis. A protein homology model of human vitamin K epoxide reductase, subunit 1 (VKORC1), was generated to elucidate the mechanism of wa...

Warfarin and Vascular Calcification.

The vitamin K antagonist, warfarin, is the most commonly prescribed oral anticoagulant. Use of warfarin appears to be associated with an increase in systemic calcification, including the coronary and ...

In silico evaluation of warfarin-bucolome therapy.

Some reports have suggested that bucolome, an inhibitor of cytochrome P450 2C9, is useful for decreasing inter-patient variation in warfarin clearance. The purpose of the present study was to evaluate...

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