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Original Source: Part II: Treatment with a CRH-R1 Antagonist Prevents Stress-Induced Suppression of the Central Neural Drive to the Reproductive Axis in Female Macaques.
In response to everyday life stress, some individuals readily develop reproductive dysfunction (i.e., are stress-sensitive), while others are more stress-resilient. When exposed to mild combined psychosocial + metabolic stress (change in social environment + reduced diet), female cynomolgus monkeys can be categorized as stress-sensitive ("SS"; rapidly become anovulatory in response to stress), medium stress-resilient ("MSR"; slowly become anovulatory in response to prolonged stress), or highly stress-resili...
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Acute stress has been shown to modify hypothalamus-pituitary-gonadal (HPG) axis activity. Corticotropin-releasing hormone (CRH), the principal regulator of the hypothalamus-pituitary-adrenal (HPA) axi...
This study compared the ability of CRF and UCN1 to induce a thermoregulatory response when centrally injected into rats. The effects of antipyretic drugs and CRF receptor antagonists (CRF(1) and CRF(2...
Family B of G-protein-coupled receptors (GPCRs) is comprised of receptors that bind peptides, such as secretin, glucagon, parathyroid hormone, and corticotropin releasing factor (CRF), which play crit...
RATIONALE: The endogenous opioid and corticotropin-releasing hormone (CRH) systems, present in the central amygdala (CeA), are implicated in alcohol consumption. OBJECTIVES: The purpose of this study...
Contextual fear is followed by significant reductions in rapid eye movement sleep (REM) that are regulated by the central nucleus of the amygdala (CNA). Corticotropin-releasing factor (CRF) plays a ma...
