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22:52 EDT 26th March 2017 | BioPortfolio

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Pirfenidone inhibits post-traumatic proliferative vitreoretinopathy

Pirfenidone inhibits post-traumatic proliferative vitreoretinopathy Eye advance online publication, March 17 2017. doi:10.1038/eye.2017.21 Authors: B N M K Khanum, R Guha, V P Sur, S Nandi,...

ProMetic's PBI-4050 Demonstrates Early Evidence of Efficacy in its Idiopathic Pulmonary Fibrosis ("IPF") Phase 2 Clinical Trial

Early evidence of efficacy of PBI-4050 alone and also in combination with one of the commercially available IPF drugs PBI-4050 shown to be very well tolerated whether used alone or in combi...

Global Idiopathic Pulmonary Fibrosis 20162020 Prices from USD $2500

About Idiopathic Pulmonary FibrosisIdiopathic pulmonary fibrosis belongs to a group of lung diseases known as interstitial lung diseases. It affects people in the age group 5070 years. Diagnosis is ef...

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An Open-label, Phase II Study of the Safety and Tolerability of Pirfenidone in Patients with Scleroderma-associated Interstitial Lung Disease: the LOTUSS Trial.

Systemic sclerosis-associated interstitial lung disease (SSc-ILD) shares a number of clinical features and pathogenic mechanisms with idiopathic pulmonary fibrosis (IPF). This study was designed to ev...

Pirfenidone inhibits post-traumatic proliferative vitreoretinopathy.

PurposeThe purpose of the study was to evaluate the efficacy and safety of intravitreal pirfenidone for inhibition of proliferative vitreoretinopathy (PVR) in a model of penetrating ocular injury.Pati...

A Novel Antifibrotic Mechanism of Nintedanib and Pirfenidone: Inhibition of Collagen Fibril Assembly.

Idiopathic pulmonary fibrosis (IPF) is characterized by excessive deposition of extracellular matrix, in particular collagens. Two IPF therapeutics, nintedanib and pirfenidone, decelerate lung functio...

Pirfenidone-induced photoallergic reaction in a patient with idiopathic pulmonary fibrosis.

Idiopathic pulmonary fibrosis (IPF) is a progressive, fibrotic, fatal lung disease associated with inevitable loss of lung function. The prognosis is poor, with a median survival of 2.5-3.5 years afte...

Suppression of TGF-β pathway by pirfenidone decreases extracellular matrix deposition in ocular fibroblasts in vitro.

In glaucoma surgery, fibrotic processes occur, leading to impairment of liquid outflow. Activated fibroblasts are responsible for postoperative scarring. The transforming growth factor-β (TGF-β) pat...

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