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13:08 EST 8th December 2016 | BioPortfolio

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Acceptable tolerability found with pirfenidone for SSc-associated interstitial lung disease

Researchers found pirfenidone had an acceptable tolerability profile for the treatment of patients with systemic sclerosis-associated interstitial lung disease and suggested tolerability may improve w...

Human medicines European public assessment report (EPAR): Esbriet, pirfenidone, Revision: 16, Authorised

NICE rejects expanded treatment indication for Roche's Esbriet

NICE has published a final appraisal rejecting the expanded use of Roche’s Esbriet (pirfenidone) for the treatment of early idiopathic pulmonary fibrosis (IPF) in the UK. Roche said the decision lea...

ProMetic's PBI-4050 Demonstrates Early Evidence of Efficacy in its Idiopathic Pulmonary Fibrosis ("IPF") Phase 2 Clinical Trial

Early evidence of efficacy of PBI-4050 alone and also in combination with one of the commercially available IPF drugs PBI-4050 shown to be very well tolerated whether used alone or in combi...

Global Idiopathic Pulmonary Fibrosis 20162020 Prices from USD $2500

About Idiopathic Pulmonary FibrosisIdiopathic pulmonary fibrosis belongs to a group of lung diseases known as interstitial lung diseases. It affects people in the age group 5070 years. Diagnosis is ef...

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An Open-label, Phase II Study of the Safety and Tolerability of Pirfenidone in Patients with Scleroderma-associated Interstitial Lung Disease: the LOTUSS Trial.

Systemic sclerosis-associated interstitial lung disease (SSc-ILD) shares a number of clinical features and pathogenic mechanisms with idiopathic pulmonary fibrosis (IPF). This study was designed to ev...

A safety evaluation of pirfenidone for the treatment of idiopathic pulmonary fibrosis.

Pirfenidone is a novel oral anti-fibrotic agent approved for the treatment of idiopathic pulmonary fibrosis (IPF). Since IPF is a chronic and progressive disease most commonly encountered in an older ...

Characterization and use of HapT1-derived homologous tumors as a preclinical model to evaluate therapeutic efficacy of drugs against pancreatic tumor desmoplasia.

Desmoplasia in human pancreatic cancer (PC) promotes cancer progression and hinders effective drug delivery. The objectives of this study were to characterize a homologous orthotopic model of PC in Sy...

Drug Therapy for Treatment of Idiopathic Pulmonary Fibrosis: Systematic Review and Network Meta-Analysis.

Idiopathic pulmonary fibrosis (IPF) is a form of chronic progressive fibrosing interstitial lung disease of unknown origin. Recently, nintedanib and pirfenidone demonstrated efficacy in slowing diseas...

Recent Advances and Future Needs in Interstitial Lung Diseases.

Interstitial lung diseases (ILDs) are a diverse range of conditions affecting the lung interstitium. The prototypic ILD, idiopathic pulmonary fibrosis (IPF), is a chronic progressive fibrotic lung dis...

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