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18:40 EDT 26th September 2016 | BioPortfolio

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Effect of Continued Treatment With Pirfenidone in IPF

Do idiopathic pulmonary fibrosis patients benefit from continued treatment with pirfenidone -- particularly those who experienced meaningful disease progression during treatment? Thorax

Acceptable tolerability found with pirfenidone for SSc-associated interstitial lung disease

Researchers found pirfenidone had an acceptable tolerability profile for the treatment of patients with systemic sclerosis-associated interstitial lung disease and suggested tolerability may improve w...

Human medicines European public assessment report (EPAR): Esbriet, pirfenidone, Revision: 16, Authorised

NICE rejects expanded treatment indication for Roche's Esbriet

NICE has published a final appraisal rejecting the expanded use of Roche’s Esbriet (pirfenidone) for the treatment of early idiopathic pulmonary fibrosis (IPF) in the UK. Roche said the decision lea...

Kadmon Initiates Phase 2 Clinical Trial Evaluating KD025 in Idiopathic Pulmonary Fibrosis

NEW YORK, NY -- (Marketwired) -- 06/03/16 -- Kadmon Corporation, LLC today announced that the first patient has been dosed in a Phase 2 clinical trial of KD025, the Company's rho-associated coiled-co...

Synairgen PLC and why the market is not the best arbiter of value

If the market worked as perfectly as its more rabid advocates insist, we wouldn’t have attractive anomalies such as Synairgen plc (LON:SNG). Its shares are trading at a fraction of what would be c...

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An Open-label, Phase II Study of the Safety and Tolerability of Pirfenidone in Patients with Scleroderma-associated Interstitial Lung Disease: the LOTUSS Trial.

Systemic sclerosis-associated interstitial lung disease (SSc-ILD) shares a number of clinical features and pathogenic mechanisms with idiopathic pulmonary fibrosis (IPF). This study was designed to ev...

A safety evaluation of pirfenidone for the treatment of idiopathic pulmonary fibrosis.

Pirfenidone is a novel oral anti-fibrotic agent approved for the treatment of idiopathic pulmonary fibrosis (IPF). Since IPF is a chronic and progressive disease most commonly encountered in an older ...

Characterization and use of HapT1-derived homologous tumors as a preclinical model to evaluate therapeutic efficacy of drugs against pancreatic tumor desmoplasia.

Desmoplasia in human pancreatic cancer (PC) promotes cancer progression and hinders effective drug delivery. The objectives of this study were to characterize a homologous orthotopic model of PC in Sy...

Effect of pirfenidone delivered using layer-by-layer thin film on excisional wound healing.

The aim of this study was to evaluate the effect of a new anti-fibrotic agent, pirfenidone (PFD), delivered using polyelectrolyte multilayer films on excisional wound healing. Polyelectrolyte multilay...

Drug Therapy for Treatment of Idiopathic Pulmonary Fibrosis: Systematic Review and Network Meta-Analysis.

Idiopathic pulmonary fibrosis (IPF) is a form of chronic progressive fibrosing interstitial lung disease of unknown origin. Recently, nintedanib and pirfenidone demonstrated efficacy in slowing diseas...

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