Selective Estrogen Receptor Modulators SERMs

Selective estrogen receptor modulators (SERMs) act as estrogen receptor (ER) agonists or antagonist depending on the targeted tissue and the specific configuration of the used SERM. Effects on bone, e...

Luteinizing Hormone LH

Luteinizing hormone (LH), a gonadotropin, stimulates the gonads - in males, the testes, and in females, the ovaries. It is essential for reproduction, and secreted from cells in the anterior pituita...

Foresee, ScinoPharm to form joint venture for new oncological Leuprolide injectable drug

ScinoPharm and Foresee Pharmaceuticals, Inc. jointly announced today that an investment agreement to form a joint venture has been signed. This venture looks to develop a series of peptide injectable...

10 Years of Tamoxifen Better Than Five: Are You Kidding Me?

FIRST PERSON | Results from a recent study called ATLAS (adjuvant tamoxifen longer against shorter) show that 10 years of tamoxifen therapy is better than the current treatment of five years. The find...

Tamoxifen And Coffee Consumption May Help Prevent Return Of Breast Cancer

Drinking coffee could decrease the risk of breast cancer recurring in patients taking the widely used drug Tamoxifen, a study at Lund University in Sweden has found. Patients who took the pill, along...

Draft NICE guideline recommends tamoxifen as chemoprevention

Tamoxifen should be offered to women who have not had breast cancer but are at high risk of developing the disease...

Predicting Tamoxifen Resistance In Breast Cancer Treatment

Scientists have identified a molecular 'flag' in women with breast cancer who do not respond or have become resistant to the hormone drug tamoxifen. Tamoxifen - used alongside traditional chemotherapy...

Tamoxifen helps muscular dystrophy symptoms in mice

A new study has found that tamoxifen, a well-known breast cancer drug, can counteract some pathologic features in a mouse [...]

Pronounced Reduction In Breast Density During Tamoxifen Treatment Reduces Risk Of Dying From Breast Cancer

Researchers at Karolinska Institutet have developed a method for assessing the effect of tamoxifen, a common drug to prevent the relapse of breast cancer. The key lies in monitoring changes in the pro...

Biomarker Of Tamoxifen Resistance In Breast Cancer Identified

New research led by the University of Manchester in the UK has found a biomarker or molecular "flag" in women with breast cancer who do not repond, or who have become resistant, to treatment with the...

Goserelin versus leuprolide in the chemical castration of patients with prostate cancer.

PURPOSE: To evaluate the relative efficiency of leuprolide 3.75 mg, leuprolide 7.5 mg, and goserelin 3.6 mg in relation to the reduction in serum testosterone, regarding the l...

Development and in vivo evaluation of a new oral nanoparticulate dosage form for leuprolide based on polyacrylic acid.

It was the aim of this study to develop a nanoparticulate oral drug delivery system for leuprolide based on polyacrylic acid (PAA). In order to achieve formation of nanoparticles in a mild, aqueous en...

Ulipristal acetate versus leuprolide acetate for uterine fibroids.

The efficacy and side-effect profile of ulipristal acetate as compared with those of leuprolide acetate for the treatment of symptomatic uterine fibroids before surgery are unclear.

Preparation and evaluation of carborane analogues of tamoxifen.

A stereoselective synthesis of closo carborane analogues of tamoxifen was developed where the products represent a new approach to developing metabolically robust SERMs. The A-ring found in the backbo...

Tamoxifen and its New Derivatives in Cancer Research.

A major challenge in cancer research is to discover drugs with high selectivity and minor side-effects. Tamoxifen has been widely used for more than 30 years in breast cancer treatment and prevention....