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Watchman Attains Efficacy Superiority Over Warfarin in AF

The Watchman left-atrial appendage occluder had previously been found noninferior to warfarin in patients with nonvalvular atrial fibrillation; now, with an average of 45 months of follow-up, it's not...

NEXT: Biolimus-Eluting Stent Noninferior to Xience/Promus

A biolimus-eluting coronary stent lined with a biodegradable polymer was statistically noninferior to an everolimus-eluting stent with regard to the primary end point of target lesion revascularizatio...

Immunogenicity of 2 Doses of HPV Vaccine in Younger Adolescents vs 3 Doses in Young Women A Randomized Clinical Trial Immunogenicity of HPV Vaccine in Girls vs Women

ImportanceGlobal use of human papillomavirus (HPV) vaccines to prevent cervical cancer is impeded by cost. A 2-dose schedule for girls may be possible.ObjectiveTo determine whether mean antibody level...

Device therapy: New centrifugal pump noninferior

Surgery: Robotic nephrectomy outcomes noninferior to laparoscopy

Oritavancin noninferior to vancomycin for gram-positive skin infections

BRIGHT Not So Clear on Lymphoma Choice

The BRIGHT study presented at ASH 2012 showed R-bendamustine to be noninferior to R-CHOP, but what role each regimen plays in lymphoma management is still unclear, says Dr. Bruce Cheson. Medscape On...

Linagliptin noninferior to glimepiride in type 2 diabetes

(HealthDay) -- A new drug for type 2 diabetes causes significantly less weight gain and may carry lower risks for hypoglycemia (low blood sugar), heart attack and stroke than standard medications, a n...

Biosynthesis and stereoselective analysis of (-)- and (+)-zaltoprofen glucuronide in rat hepatic microsomes and its application to the kinetic analysis.

Zaltoprofen, available commercially as a racemic mixture, is a propionic acid derivative of non-steroidal anti-inflammatory drugs (NSAIDs). Firstly, (+)- and (-)-zaltoprofen glucuronide was biosynthes...

Zaltoprofen, a noninferior alternative to diclofenac for the treatment of primary knee osteoarthritis - a comparative evaluation of efficacy and safety in a 4-week, multicentric, randomized, double-blind, double-dummy trial.

Objective: To demonstrate the clinical noninferiority of the analgesic effect of zaltoprofen (80 mg t.i.d.) compared with diclofenac (50 mg t.i.d.) in active knee osteoarthritis patients. Method: In t...

Antipyretic and Analgesic Effects of Zaltoprofen for the Treatment of Acute Upper Respiratory Tract Infection: Verification of a Noninferiority Hypothesis Using Loxoprofen Sodium.

A multicenter, placebo-controlled, double-dummy, randomized, parallel-group, double-blind study was conducted to verify the hypothesis of noninferiority for single-dose administration of zaltoprofen 1...

Reduction in Platelet Reactivity With Prasugrel 5 mg in Low-Body-Weight Patients Is Noninferior to Prasugrel 10 mg in Higher-Body-Weight Patients: Results From the FEATHER Trial.

The aim of this study was to confirm prior modeling data suggesting that prasugrel 5 mg in low-body-weight (LBW) patients would be noninferior to prasugrel 10 mg in higher-body-weight (HBW) patients a...

Device therapy: New centrifugal pump noninferior.