Search Results for "Zolmitriptan Determination"
Original Source: Identification, preparation and UHPLC determination of process-related impurity in zolmitriptan.
A new impurity was detected and determined using gradient ion-pair UHPLC method with UV detection in zolmitriptan (ZOL). Using MS, NMR and IR study the impurity was identified as (4S,4'S)-4,4'-(2,2'-(4-(dimethylamino)butane-1,1-diyl)bis(3-(2-(dimethylamino) ethyl)-1H-indole-5,2-diyl))bis(methylene)di(oxazolidin-2-one) (ZOL-dimer). The standard of ZOL-dimer was consequently prepared via organic synthesis followed by semipreparative HPLC purification. The UHPLC method was optimized in order to selectively det...
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Determination of a specific causative disorder
Myc is the protein encoded by the MYC gene that activates the cell cycle
Myc is the protein encoded by the MYC gene that activates the cell cycle. It promotes cell replication through genetic coding for p14, inhibiting MDM2 and preventing the degradation of the pro-apopt...
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FDA approves Mylan Zolmitriptan ANDA
The US FDA has approved Mylan Pharmaceuticals' abbreviated new drug application (ANDA) for Zolmitriptan tablets, 2.5mg and 5mg.
Dual Color CISH for Determination of HER2 Status
Chromogenic in situ hybridization is becoming a well established technique for determination of HER2 gene status in breast cancer. How reliable is it compared to the more commonly used FISH? BMC Cli...
A new source of Omega3 oils, not involving fish stock depletion in the ocean, is now available:We are advising the public of our determination that a soybean line developed by the Monsanto Co., design...
Mylan Launches Generic Zomig® Tablets
PITTSBURGH, May 15, 2013 /PRNewswire/ -- Mylan Inc. (Nasdaq: MYL) today announced that its subsidiary Mylan Pharmaceuticals Inc. has received final approval from the U.S. Food and Drug Ad...
Determination of RSV Prefusion Glycoprotein Crystal Structure Expected to Boost Vaccine Development
Determination of the respiratory syncytial virus fusion glycoprotein's prefusion shape is expected to boost efforts to develop a neutralizing...
First-ever determination of protein structure with X-ray laser
Read more about First-ever determination of protein structure with X-ray laserComments
Impax introduces authorized generic of Zomig in US
Impax Laboratories has introduced authorized generic of Zomig (zolmitriptan) tablets and orally disintegrating tablets, 2.5mg and 5mg, in the US.
Soluble Therapeutics to introduce high-throughput second viral coefficient determination system
Birmingham-based Soluble Therapeutics, Inc, today announced the official launch of its high-throughput second viral coefficient determination system, HSC Technology, at the IBC BioProcess Internationa...
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Influence of formulation variables in transdermal drug delivery system containing zolmitriptan.
The effects of different formulation variables including pressure sensitive adhesive (PSA), thickness of the matrix, solvent system, inclusion of crystallization inhibitor, loading amount of drug and...
A fast HPLC-ESI-MS/MS method has been developed and validated for the quantification of the potent and selective antimigraine zolmitriptan in rat blood and cerebrospinal fluid (CSF). The assay has bee...
Identification, preparation and UHPLC determination of process-related impurity in zolmitriptan.
A new impurity was detected and determined using gradient ion-pair UHPLC method with UV detection in zolmitriptan (ZOL). Using MS, NMR and IR study the impurity was identified as (4S,4'S)-4,4'-(2,2'-(...
Submicron emulsion was prepared for rapid and effective nasal absorption of zolmitriptan (ZT). The different charge inducers and pH values of the formulations were evaluated to optimize the formulatio...
Surface Thermodynamics of Mucoadhesive Dry Powder Formulation of Zolmitriptan.
Microparticle powders for nasal delivery were formulated to contain the model drug, zolmitriptan, and varying proportions of different polymers. The objective of the study was to investigate the effec...
