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Transgenic ZP2 Mouse Model Produces Eggs That Bind to Human Sperm Protein

Fertilizing sperm bind to an extracellular coat surrounding mammalian eggs called zona pellucida. Depending on the species, the zona pellucida is composed of ZP1, ZP2, ZP3, and/or ZP4 proteins. Recen...

TECTA mutations in Japanese with mid-frequency hearing loss affected by zona pellucida domain protein secretion

A commentary on ‘TECTA mutations in Japanese with mid-frequency hearing loss affected by Zona Pellucida domain protein secretion’

Low-dose flutamide doesn't eliminate hepatotoxicity risk

NEW YORK (Reuters Health) - Low or ultralow doses of flutamide don't entirely eliminate the drug's potential for injuring the liver, researchers saw in a study of women with polycystic ovary syndr...

Premature Hardening Of The Zona Pellucida Can Be A Cause Of Infertility

Scientists in Mainz and Aachen have discovered a new mechanism that controls egg cell fertility and that might have future therapeutic potential. It was revealed by Professor Dr. Walter Stocker of the...

Provost Umphrey Law Firm: $65 Million Judgment Against First National Bank Edinburg

HOUSTON, Nov. 30, 2012 /PRNewswire/ -- On Wednesday, November 28, 2012, 281st State District Court Judge Sylvia Matthews entered a judgment in the amount of $65,884,838.70 against First Nationa...

Precision Engineered Products Expands Medical Manufacturing Capability with New Dominican Republic Facility

Precision Engineered Products LLC (PEP), a global manufacturer of surgical and medical instruments, devices, and components, is increasing its global manufacturing base wit...

PCF Funding Contributed to the Development and Approval of Xtandi

Xtandi, formerly known as MDV3100, today received approval from the U.S. Food and Drug Administration (FDA). This drug is a new-generation anti-androgen treatment that can prolong...

ZP2 and ZP3 cytoplasmic tails prevent premature interactions and ensure incorporation into the zona pellucida.

The zona pellucida contains three proteins (ZP1, ZP2, ZP3), the precursors of which possess signal peptides, 'zona' domains and short (9-15 residue) cytoplasmic tails downstream of a transmembrane dom...

Correlation of oocyte morphometry parameters with woman's age.

PURPOSE: Aim of this study was to evaluate morphometric parameters of metaphase II oocytes, including cytoplasm diameter (CD), zona pellucida thickness (ZPT) and width of the perivitelline space (PS),...

Zona pellucida-induced acrosome reaction in human spermatozoa is potentiated by glycodelin-A via down-regulation of extracellular signal-regulated kinases and up-regulation of zona pellucida-induced calcium influx.

BACKGROUND Glycodelin-A interacts with spermatozoa before fertilization, but its role in modulating sperm functions is not known. Zona pellucida-induced acrosome reaction is crucial to fertilization a...

Possible mechanism of polyspermy block in human oocytes observed by time-lapse cinematography.

PURPOSE: To analyze the fertilization process related to polyspermy block in human oocytes using an in vitro culturing system for time-lapse cinematography. METHODS: We had 122 oocytes donated for thi...

Galectins as tools for glycan mapping in histology: comparison of their binding profiles to the bovine zona pellucida by confocal laser scanning microscopy.

Gene divergence has given rise to the galectin family of mammalian lectins. Since selective binding to distinct β-galactosides underlies the known bioactivities of galectins, they could find applicat...