Xofigo (radium-223 dichloride)

New treatment for castration-resistant prostate cancer (CRPC) patients with bone metastases. Xofigo shown in a pivotal phase III trial to significantly improve overall survival. Xofigo® with...

Antisense

Antisense therapy is a form of treatment for genetic disorders or infections. When the genetic sequence of a particular gene is known to be causative of a particular disease, it is possible to synth...

Anti Infective Peptides

Anti-viral peptides are used to treat infections such as HIV and AIDS, influenza incl. H5N1 strains, hepatitis C virus infections (HCV). Anti-bacterial peptides are used to treat infectiou...

Anti-Inhibitor Coagulant Baxter

Anti-Inhibitor Coagulant Nabi

Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing

Biotinylated tags bind double-strand breaks in genomic DNA; after enrichment and sequencing, this allows precise, genome-wide mapping of the breaks.

Tbf1 and Vid22 promote resection and non-homologous end joining of DNA double-strand break ends

Tbf1 and Vid22 promote resection and non-homologous end joining of DNA double-strand break endsThe yeast Myb domain protein Tbf1, previously implicated in telomeric processes and transcriptional activ...

DNA template strand sequencing of single-cells maps genomic rearrangements at high resolution

The Strand-seq method independently sequences each parental strand of template DNA from single proliferating cells. It can be used to detect sister chromatid exchange and other chromosomal abnormaliti...

The SOSS1 single-stranded DNA binding complex promotes DNA end resection in concert with Exo1

Distinct functional properties of the two mammalian single-strand DNA-binding activities, RPA and the hSSB1-containing SOSS1 complex, underlie their preferential involvement in replication and in DNA...

Damage control reporters

Damage to the genomic DNA may endanger the whole organism. A new study shows that in the fruit fly Drosophila melanogaster RNA transcripts derived from DNA sequences that have been disrupted by double...

RNF4 is required for DNA double-strand break repair in vivo

Genetics: Accumulation of DNA double-strand breaks underlies the ageing of oocytes in mice and humans

Human Stn1 protects telomere integrity by promoting efficient lagging-strand synthesis at telomeres and mediating C-strand fill-in

Collaboration and competition between DNA double-strand break repair pathways.

DNA double-strand breaks resulting from normal cellular processes including replication and exogenous sources such as ionizing radiation pose a serious risk to genome stability, and cells have evolved...

Double-strand breaks and the concept of short- and long-term epigenetic memory.

Double-strand breaks represent an extremely cytolethal form of DNA damage and thus pose a serious threat to the preservation of genetic and epigenetic information. Though it is well-known that double-...

53BP1-mediated DNA double strand break repair: Insert bad pun here.

53BP1 is an established player in the cellular response to DNA damage and is a canonical component of ionizing-radiation induced foci - that cadre of proteins which assemble at DNA double strand break...

Repair of DNA Double-Strand Breaks Following UV Damage in Three Sulfolobus solfataricus Strains.

DNA damage repair mechanisms have been most thoroughly explored in the eubacterial and eukaryotic branches of life. The methods by which members of the archaeal branch repair DNA is significantly less...

The HTLV-1 Tax oncoprotein represses Ku80 gene expression.

The HTLV-I oncoprotein Tax interferes with DNA double strand break repair. Since non-homologous end joining (NHEJ) is a major pathway used to repair DNA double strand breaks we examined the effect of...