aspartimide Pages on BioPortfolio:

BioPortfolio - Bachem AG - Profile
The aspartimide problem in Fmoc-based SPPS. Part II. The sequence dependence of base-catalysed aspartmide formation during...30th March, 2004 ...
http://www.bioportfolio.com/biocorporate/1174-Bachem%2BAG.pd...

Results from other life science and pharmaceutical sites:

The aspartimide problem in Fmoc-based SPPS. Part I.
The extent of formation of aspartimide and aspartimide-related by-products was determined by RP-HPLC. This study included three new Fmoc-Asp-OH derivatives:
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http://www.ncbi.nlm.nih.gov/pubmed/12587881...

Characterization of a Side Reaction Using Stepwise Detection in ...
fragment, the side reaction due to aspartimide formation was detected and. eventually defined. Peptide ladder mass spectrometric analysis was used for a
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http://www.rockefeller.edu/labheads/chait/pdf/95/95_yang_tec...

The aspartimide problem in Fmoc-based SPPS. Part III.
When synthesizing the hexapeptide incorporating Gly, Arg(Pbf), Asn(Mtt), Asp( OtBu) or Cys(Acm) for Xaa, considerable amounts of aspartimide-related ...
http://www.ncbi.nlm.nih.gov/pubmed/15849777...

Market Growing for Custom-Made Peptides
CEM has also focused on minimizing aspartimide formation and by substituting piperizine for piperidine for aspartic acid activation for standard Fmoc ...
http://www.genengnews.com/articles/chitem_print.aspx?aid=181...

The aspartimide problem in Fmoc-based SPPS. Part II.
The extent of formation of aspartimide and related by-products was determined by RP-HPLC. Considerable amounts of by-products were formed in the case of Xaa ...
http://www.ncbi.nlm.nih.gov/pubmed/12952393...

The importance of residues 195-206 of human blood clotting factor ...
A structurally rearranged form of peptide 195-206 containing an aspartimide residue inhibited these reactions half-maximally at concentrations of 250-300
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http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=54...

Synthesis of peptide sequences related to thrombospondin: factors ...
Aspartimide formation is one of the most common secondary reactions on solid phase peptide synthesis. In the present work, we describe the optimization of
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http://www.ncbi.nlm.nih.gov/pubmed/14632926...

ABRF ESRG 2005 Study: Identification of Seven Modified Amino Acids ...
This modification occurs via an aspartimide intermediate as a result of spontaneous asparagine deamidation in proteins, and can also occur during ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=22...

Solid-phase peptide synthesis: from standard procedures to the ...
Figure 5: Base-catalyzed aspartimide formation on an OtBu-protected aspartic ... The mass of the aspartimide peptide corresponds to the mass of the target ...
http://www.nature.com/nprot/journal/v2/n12/full/nprot.2007.4...

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