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CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker. This receptor is expressed by activated, but not by resting, T and B cells. It ...
Polo-like kinase (Plk) is an important cell cycle regulatory kinase that has been implicated in a multitude of cell cycle events. Plks form a family of four different proteins that regulates many as...
Sphingosine-1-phospate (S1P) is a phospholipid released by platelets, mast and other cells. It is now known that S1P stimulates at least five different G-protein coupled receptors (GPCRs): S1P1, S1P2,...
LMX1A/LMX1B-knockout mice could be useful for screening therapies to treat PD.
Mice with knockout of the
GLIS3-knockout mice transgenically expressing chicken
PTCHD1-knockout mice could be useful for screening therapies to help treat ADHD.
(Chinese Academy of Sciences Headquarters) By using a systemic mtEF4 gene knockout mouse model, researchers from the Institute of Biophysics of the Chinese Academy of Sciences found that mtEF4 knockou...
Two mouse models with knockout of interferon-related genes could be useful for screening therapies to treat Zika infection.
Researchers have identified a mutation in a commonly used commercial mouse strain that could impact experimental results.
Major urinary proteins (MUPs) are the most abundant protein species in mouse urine, accounting for more than 90% of total protein content. Twenty-one Mup genes and 21 pseudogenes are clustered in a re...
To investigate the underlying molecular mechanism for connexin 26 (Cx26) knockout-induced apoptosis, we performed TUNEL assays to detect apoptosis in the cochlear sensory epithelium in Cx26 knockout m...
Leucine is known to increase mTOR-mediated phosphorylation of 4EBP. In this study, leucine was administered to skeletal muscle-PGC-1α knockout mice. We observed attenuated 4EBP phosphorylation in the...
This study investigated the molecular mechanisms underlying the inhibition of MMP-9 expression by probucol, which is widely used for atherosclerotic prevention, in cultured human umbilical vein endoth...
Aspergillus fumigatus is an opportunistic fungal pathogen that causes severe invasive infections in immunocompromised patients. Innate immunity plays a major role in protection against A. fumigatus. T...