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Search Results for "Chemerine Knockout Mice"

18:24 EDT 28th May 2017 | BioPortfolio

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CD30 Antibodies

CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker. This receptor is expressed by activated, but not by resting, T and B cells. It ...

Polo like kinase Plk 1

Polo-like kinase (Plk) is an important cell cycle regulatory kinase that has been implicated in a multitude of cell cycle events. Plks form a family of four different proteins that regulates many as...

Sphingosine 1 Phosphate S1P

Sphingosine-1-phospate (S1P) is a phospholipid released by platelets, mast and other cells. It is now known that S1P stimulates at least five different G-protein coupled receptors (GPCRs): S1P1, S1P2,...

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Optogenetic activation of dorsal raphe neurons rescues the autistic-like social deficits in Shank3 knockout mice

Oliver Smithies, Technologist Behind Knockout Mice, Dies

The Nobel laureate and Lasker awardee developed tools that facilitated decades of genetics research, including starch gel electrophoresis and gene targeting.

Eye Study Advances Ability to Improve Clinical Measurement of Retinal Degeneration

University of Alabama at Birmingham researchers studying rod cell proteins GARP1 and GARP2 to learn how they function in normal phototransduction in the eye have found that GARP2 accelerates retinal d...

Promising mouse model for a devastating genetic deficiency

(RIKEN) Researchers from the Global Research Cluster in Japan have developed a potential mouse model for the genetic disorder known as an NGLY1 deficiency. Published in the journal PLOS Genetics, the ...

Envigo launches R2G2 double knockout mouse model

Unique mixed background mouse enables researchers to examine effects of a wider range of radiation dosages. The post Envigo launches R2G2 double knockout mouse model appeared first on PharmaAsia.

Gene therapy restores hearing in deaf mice… down to a whisper – Medical Xpress

Medical XpressGene therapy restores hearing in deaf mice... down to a whisperMedical XpressUnaffected mice, at left, have sensory hair bundles organized in 'V' formations with three rows of cilia (bot...

α-Synuclein promotes dilation of the exocytotic fusion pore

The authors used knockout mice to demonstrate the normal function of the protein α-synuclein, which has a central role in Parkinson's and other neurodegenerative diseases. The presynaptic protein pro...

Genetically engineered killer zombie mice? Not quite

Neuroscientists at Yale University published a paper  [On Jan. 12, 2017,] in the journal Cell showing how they could trigger a mouse’s predatory instincts with a clever genetic trick. Key word: i...

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Exploring the Behavioral and Metabolic Phenotype Generated by Re-Introduction of the Ghrelin Receptor in the Ventral Tegmental Area.

Ghrelin receptor (Ghr-R) signaling in neurons of the ventral tegmental area (VTA) can modulate dopaminergic function and the reward-related effects of both palatable foods and drugs of abuse. In this ...

Characterization of Smad3 knockout mouse derived skin cells.

TGF-β plays an important role in skin wound healing process, in which Smad3 acts as a signaling molecule. Smad3 knockout mice exhibit enhanced wound healing and less inflammatory process, but the int...

Deletion of Efemp1 Is Protective Against the Development of Sub-RPE Deposits in Mouse Eyes.

EFEMP1 (fibulin-3) is mutated in Malattia Leventinese/Doyne's honeycomb retinal dystrophy (ML/DHRD), an inherited macular dystrophy similar to AMD. Both ML/DHRD and AMD are characterized by the presen...

General anesthetic actions on GABAA receptors in vivo are reduced in phospholipase C-related catalytically inactive protein knockout mice.

The aim of this study was to investigate the action of general anesthetics in phospholipase C-related catalytically inactive protein (PRIP)-knockout (KO) mice that alter GABA receptor signaling.

Loss of PINK1 inhibits apoptosis by upregulating α-synuclein in inflammation-sensitized hypoxic-ischemic injury in the immature brains.

The incidence of preterm birth is rising worldwide. Among preterm infants, many face a lifetime of neurologic impairments. Recent studies have revealed that systemic inflammation can sensitize the imm...

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