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Search Results for "Chemerine Knockout Mice"

12:42 EDT 27th July 2017 | BioPortfolio

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CD30 Antibodies

CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker. This receptor is expressed by activated, but not by resting, T and B cells. It ...

Polo like kinase Plk 1

Polo-like kinase (Plk) is an important cell cycle regulatory kinase that has been implicated in a multitude of cell cycle events. Plks form a family of four different proteins that regulates many as...

Sphingosine 1 Phosphate S1P

Sphingosine-1-phospate (S1P) is a phospholipid released by platelets, mast and other cells. It is now known that S1P stimulates at least five different G-protein coupled receptors (GPCRs): S1P1, S1P2,...

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Knockout Mice Model MarketBy TypeConstitutive, Conditional, Safe Other Knockouts Technology Homologous Recombination, Flex, Others Service Custom Mouse, Rat, Cell Other Models ApplicationHumanization Of Target Genes, Monitoring Biomarker Expression, Oth

A knockout mouse refers to a laboratory mouse in which researchers have either inactivated or knocked out an already existing gene by replacing it or disrupting it by an artificial piece of DNA. The l...

Role of Atg5-dependent cell death in the embryonic development of Bax/Bak double-knockout mice

Optogenetic activation of dorsal raphe neurons rescues the autistic-like social deficits in Shank3 knockout mice

Gene knockout of Zmym3 in mice arrests spermatogenesis at meiotic metaphase with defects in spindle assembly checkpoint

One-step generation of complete gene knockout mice and monkeys by CRISPR/Cas9-mediated gene editing with multiple sgRNAs

M3 Muscarinic Receptor Knockout Mice (Chrm3 tm1Jwe) for the Study of Obesity and Other Metabolic Disorders

The five Muscarinic Acetylcholine (ACh) receptors are G-protein coupled receptors (M1R-M5R). M3 muscarinic ACh receptors are present in the central nervous system and the periphery.M3R knockout mice a...

Low levels of off-target effects in gene-editing of animal zygotes using CRISPR method

A follow up to the previous posts, with further confirmation that off-target changes in gene-editing can be minimised Off-target effect in complete knockout animals by C-CRISPRFinally, we examine...

Western Diet Linked to Microbiome Changes and Chronic Liver Inflammation

The typical western diet, which is high in fat and sugar, has long been suspected to have a negative impact on human health. Now, a team of investigators at UC Davis have just released new findings wh...

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Insulin resistance in vitamin D-deficient mice is alleviated by n-acetylcysteine.

Vitamin D deficiency will lead to insulin resistance. In the current study, vitamin D3 1α-Hydroxylase ["1α(OH)ase"] knockout mice were generated to mimic vitamin D deficiency in vivo. As compared to...

Accelerated kindling epileptogenesis in Tg4510 tau transgenic mice, but not in tau knockout mice.

The biologic processes underlying epileptogenesis following a brain insult are not fully understood, but several lines of evidence suggest that hyperphosphorylation of tau may be an important factor i...

UCP-2 is involved in angiotensin-II-induced abdominal aortic aneurysm in apolipoprotein E-knockout mice.

UCP-2 shows an important role in modulating of mitochondrial membrane potential and cell apoptosis. Whether or not UCP-2 could been a critical factor in preventing AAA formation is not known. We repor...

Exploring the Behavioral and Metabolic Phenotype Generated by Re-Introduction of the Ghrelin Receptor in the Ventral Tegmental Area.

Ghrelin receptor (Ghr-R) signaling in neurons of the ventral tegmental area (VTA) can modulate dopaminergic function and the reward-related effects of both palatable foods and drugs of abuse. In this ...

Characterization of Smad3 knockout mouse derived skin cells.

TGF-β plays an important role in skin wound healing process, in which Smad3 acts as a signaling molecule. Smad3 knockout mice exhibit enhanced wound healing and less inflammatory process, but the int...

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