Search Results for "Chemerine Knockout Mice"

02:30 EDT 21st April 2015 | BioPortfolio

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CD30 Antibodies

CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker. This receptor is expressed by activated, but not by resting, T and B cells. It ...

Testicular Cancer

Testicular cancer represents only 1 per cent of all cancers in men, but it is the single biggest cause of cancer-related deaths in men aged 15-35 years in the UK. The causes of testicular cancer and...

Polo like kinase Plk 1

Polo-like kinase (Plk) is an important cell cycle regulatory kinase that has been implicated in a multitude of cell cycle events. Plks form a family of four different proteins that regulates many as...

Sphingosine 1 Phosphate S1P

Sphingosine-1-phospate (S1P) is a phospholipid released by platelets, mast and other cells. It is now known that S1P stimulates at least five different G-protein coupled receptors (GPCRs): S1P1, S1P2,...

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Pharmaceutical Research: Evaluation of the Usefulness of Breast Cancer Resistance Protein (BCRP) Knockout Mice and BCRP Inhibitor-Treated Monkeys to Estimate the Clinical Impact of BCRP Modulation on the Pharmacokinetics of BCRP Substrates

Type: Original PaperPurposeTo evaluate whether the impact of functional modulation of the breast cancer resistance protein (BCRP, ABCG2 421C>A) on human pharmacokinetics after oral administration i...

Bax deficiency extends the survival of Ku70 knockout mice that develop lung and heart diseases

Germ cell-specific Atg7 knockout results in primary ovarian insufficiency in female mice

The E3 ligase synoviolin controls body weight and mitochondrial biogenesis through negative regulation of PGC-1{beta}

Obesity is a major global public health problem, and understanding its pathogenesis is critical for identifying a cure. In this study, a gene knockout strategy was used in post-neonatal mice to delete...

Nutrient-sensing nuclear receptors coordinate autophagy

Autophagy is an evolutionarily conserved catabolic process that recycles nutrients upon starvation and maintains cellular energy homeostasis. Its acute regulation by nutrient-sensing signalling pathwa...

Pharmaceutical Research: Phospho-NSAIDs Have Enhanced Efficacy in Mice Lacking Plasma Carboxylesterase: Implications for their Clinical Pharmacology

Type: Original PaperPurposeThe purpose of the study was to evaluate the metabolism, pharmacokinetics and efficacy of phospho-NSAIDs in Ces1c-knockout mice.MethodsHydrolysis of phospho-NSAIDs by Ces1c ...

Immune cells from stressed mice found to lessen depression when injected into other mice

(Medical Xpress)—A team of researchers working at the NIH–DHHS facility in Bethesda Maryland has found that injecting immune cells from mice that were stressed, caused lessened depression symptoms...

Neuroscience: How to form a fake memory in mice

Unrelated memories can be artificially linked by activating distinct groups of neurons at the same time.Kaoru Inokuchi at the University of Toyama, Japan, and his colleagues let mice explore a cylindr...

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Rab11a is required for apical protein localisation in the intestine.

The small GTPase Rab11 plays an important role in the recycling of proteins to the plasma membrane as well as in polarised transport in epithelial cells and neurons. We generated conditional knockout ...

Aberrant production of IL-13 by T cells promotes exocrinopathy in Id3 knockout mice.

Elevated levels of the cytokine IL-13 has been found to be associated with autoimmune diseases, including Sjögren's Syndrome. However, whether IL-13 plays a causative role in disease development is n...

The Roles of P2Y2 Purinergic Receptors in Osteoblasts and Mechanotransduction.

We previously demonstrated, using osteoblastic MC3T3-E1 cells, that P2Y2 purinergic receptors are involved in osteoblast mechanotransduction. In this study, our objective was to further investigate, u...

Significant deterioration of anti-atherogenic efficacy of nebivolol in a double (apolipoprotein E and endothelial nitric oxide synthase) knockout mouse model of atherosclerosis in comparison to single (apolipoprotein E) knockout model.

Anti-atherogenic action of nebivolol in apolipoprotein E (apoE)-single knockout mouse model can be explained by its beneficial effect on endothelium, especially on endothelial nitric oxide synthase (e...

PTPRT Regulates High-Fat Diet-Induced Obesity and Insulin Resistance.

Obesity is a risk factor for many human diseases. However, the underlying molecular causes of obesity are not well understood. Here, we report that protein tyrosine phosphatase receptor T (PTPRT) knoc...

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