Search Results for "Chemerine Knockout Mice"

00:02 EDT 26th October 2016 | BioPortfolio

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CD30 Antibodies

CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker. This receptor is expressed by activated, but not by resting, T and B cells. It ...

Polo like kinase Plk 1

Polo-like kinase (Plk) is an important cell cycle regulatory kinase that has been implicated in a multitude of cell cycle events. Plks form a family of four different proteins that regulates many as...

Sphingosine 1 Phosphate S1P

Sphingosine-1-phospate (S1P) is a phospholipid released by platelets, mast and other cells. It is now known that S1P stimulates at least five different G-protein coupled receptors (GPCRs): S1P1, S1P2,...

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Mice with midbrain neuron-specific knockout of LIM homeobox transcription factor 1 α (LMX1A; LMX1) and LMX1B as a model of Parkinson's disease (PD)

LMX1A/LMX1B-knockout mice could be useful for screening therapies to treat PD.

Generation of knockout mice by Cpf1-mediated gene targeting

Mice with knockout of interferon-related genes as models of Zika infection

Two mouse models with knockout of interferon-related genes could be useful for screening therapies to treat Zika infection.

Knockout of microRNA-21 reduces biliary hyperplasia and liver fibrosis in cholestatic bile duct ligated mice

Immune Defect Detected in Knockout Mice

Researchers have identified a mutation in a commonly used commercial mouse strain that could impact experimental results.

JAX Wins $28.3M in NIH Funding for Knockout Mouse Project

The Jackson Laboratory (JAX) said today it has won $28.3 million over 5 years from the NIH to fund the second phase of its Knockout Mouse Production and Phenotyping Project (KOMP2). JAX said the f...

Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss

FUS is an RNA-binding protein involved in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Cytoplasmic FUS-containing aggregates are often associated with concomitant loss of nuc...

Faster, more efficient CRISPR editing in mice

(University of California - Berkeley) Creating transgenic mice, while critical to biomedical research, is laborious and expensive, despite improvements since the advent of CRISPR-Cas9 gene editing. No...

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Mup-knockout mice generated through CRISPR/Cas9-mediated deletion for use in urinary protein analysis.

Major urinary proteins (MUPs) are the most abundant protein species in mouse urine, accounting for more than 90% of total protein content. Twenty-one Mup genes and 21 pseudogenes are clustered in a re...

Phosphorylation of 4EBP by oral leucine administration was suppressed in the skeletal muscle of PGC-1α knockout mice.

Leucine is known to increase mTOR-mediated phosphorylation of 4EBP. In this study, leucine was administered to skeletal muscle-PGC-1α knockout mice. We observed attenuated 4EBP phosphorylation in the...

Probucol inhibits MMP-9 expression through regulating miR-497 in HUVECs and apoE knockout mice.

This study investigated the molecular mechanisms underlying the inhibition of MMP-9 expression by probucol, which is widely used for atherosclerotic prevention, in cultured human umbilical vein endoth...

Ficolins Promote Fungal Clearance in vivo and Modulate the Inflammatory Cytokine Response in Host Defense against Aspergillus fumigatus.

Aspergillus fumigatus is an opportunistic fungal pathogen that causes severe invasive infections in immunocompromised patients. Innate immunity plays a major role in protection against A. fumigatus. T...

Effects of dopamine D1-like and D2-like antagonists on cocaine discrimination in muscarinic receptor knockout mice.

Muscarinic and dopamine brain systems interact intimately, and muscarinic receptor ligands, like dopamine ligands, can modulate the reinforcing and discriminative stimulus (S(D)) effects of cocaine. T...

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