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Search Results for "Chemerine Knockout Mice"

11:07 EST 20th January 2017 | BioPortfolio

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CD30 Antibodies

CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker. This receptor is expressed by activated, but not by resting, T and B cells. It ...

Polo like kinase Plk 1

Polo-like kinase (Plk) is an important cell cycle regulatory kinase that has been implicated in a multitude of cell cycle events. Plks form a family of four different proteins that regulates many as...

Sphingosine 1 Phosphate S1P

Sphingosine-1-phospate (S1P) is a phospholipid released by platelets, mast and other cells. It is now known that S1P stimulates at least five different G-protein coupled receptors (GPCRs): S1P1, S1P2,...

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Mice with midbrain neuron-specific knockout of LIM homeobox transcription factor 1 α (LMX1A; LMX1) and LMX1B as a model of Parkinson's disease (PD)

LMX1A/LMX1B-knockout mice could be useful for screening therapies to treat PD.

MMTV-cre;Ccn6 knockout mice develop tumors recapitulating human metaplastic breast carcinomas

Knockout of microRNA-21 reduces biliary hyperplasia and liver fibrosis in cholestatic bile duct ligated mice

JAX Wins $28.3M in NIH Funding for Knockout Mouse Project

The Jackson Laboratory (JAX) said today it has won $28.3 million over 5 years from the NIH to fund the second phase of its Knockout Mouse Production and Phenotyping Project (KOMP2). JAX said the f...

Oliver Smithies, Technologist Behind Knockout Mice, Dies

The Nobel laureate and Lasker awardee developed tools that facilitated decades of genetics research, including starch gel electrophoresis and gene targeting.

Maine lab awarded grant for mice genome mapping project

The National Institutes of Health has awarded a grant to a Maine laboratory that will help fund the second phase of a project mapping the genome of lab mice. The Portland Press Herald reports the Jack...

Amyloid precursor protein maintains constitutive and adaptive plasticity of dendritic spines in adult brain by regulating D-serine homeostasis

Dynamic synapses facilitate activity-dependent remodeling of neural circuits, thereby providing the structural substrate for adaptive behaviors. However, the mechanisms governing dynamic synapses in a...

Blood from Old Mice Makes Young Mice Decrepit

Joining the circulation of two mice weakened the younger one, but didn’t do much for the old one.

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Ficolins Promote Fungal Clearance in vivo and Modulate the Inflammatory Cytokine Response in Host Defense against Aspergillus fumigatus.

Aspergillus fumigatus is an opportunistic fungal pathogen that causes severe invasive infections in immunocompromised patients. Innate immunity plays a major role in protection against A. fumigatus. T...

Loss of PINK1 inhibits apoptosis by upregulating α-synuclein in inflammation-sensitized hypoxic-ischemic injury in the immature brains.

The incidence of preterm birth is rising worldwide. Among preterm infants, many face a lifetime of neurologic impairments. Recent studies have revealed that systemic inflammation can sensitize the imm...

Gα12 is required for renal cystogenesis induced by Pkd1 inactivation.

Mutation of PKD1 is the main cause of autosomal dominant polycystic kidney disease (ADPKD). The signaling pathways of PC1 in ADPKD are still not fully understood. Here, we provide genetic evidence for...

Nicotinic acetylcholine receptors regulate vestibular afferent gain and activation timing.

Little is known about the function of the cholinergic efferents innervating peripheral vestibular hair cells. We measured vestibular sensory evoked potentials (VsEPs) in α9 knockout mice, α10 knocko...

Effects of D1 receptor knockout on fear and reward learning.

Dopamine signaling is involved in a variety of neurobiological processes that contribute to learning and memory. D1-like dopamine receptors (including D1 and D5 receptors) are thought to be involved i...

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