Search Results for "Chemerine Knockout Mice"

11:13 EST 12th February 2016 | BioPortfolio

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CD30 Antibodies

CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker. This receptor is expressed by activated, but not by resting, T and B cells. It ...

Polo like kinase Plk 1

Polo-like kinase (Plk) is an important cell cycle regulatory kinase that has been implicated in a multitude of cell cycle events. Plks form a family of four different proteins that regulates many as...

Sphingosine 1 Phosphate S1P

Sphingosine-1-phospate (S1P) is a phospholipid released by platelets, mast and other cells. It is now known that S1P stimulates at least five different G-protein coupled receptors (GPCRs): S1P1, S1P2,...

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Upregulation of GSK3β Contributes to Brain Disorders in Elderly REGγ-knockout Mice

Knockout of silent information regulator 2 (SIRT2) preserves neurological function after experimental stroke in mice

M5 Muscarinic Receptor Knockout (Chrm5tm1Jwe) Mouse Model for Neurological Studies

M5 muscarinic receptor knockout: Deficiency of M5Rs reduces drug-seeking behavior. The five Muscarinic Acetylcholine (ACh) receptors are G-protein coupled receptors (M1R-M5R). M1R, M3R and M5R selecti...

TRPC Knockout (KO) Mice and Mice with a Floxed Allele of TRPC Ion Channel Genes

TRPCs (Canonical Transient Receptor Potential Channels) are a group of non-selective cation channels that allow sodium and calcium into cells. There are seven different genes in mice that code TRPCs. ...

WNT1-Induced Secreted Protein-1 Knockout Mouse Model

WNT1-induced secreted protein-1 (WISP1) is expressed at high levels in osteoblasts and their precursors. WIPS1 plays an important role in various aspects of bone formation. Scientists at the NIH gen...

Nutrient-sensing nuclear receptors coordinate autophagy

Autophagy is an evolutionarily conserved catabolic process that recycles nutrients upon starvation and maintains cellular energy homeostasis. Its acute regulation by nutrient-sensing signalling pathwa...

Distinct regulatory mechanisms governing embryonic versus adult adipocyte maturation

By analysing inducible knockout mice, Scherer and colleagues report that the adipogenic transcription factor C/EBPα is dispensable for white adipogenesis in mouse embryos, but not in adults.

An ataxia telangiectasia mutated (ATM)-knockout mouse model of pancreatic ductal adenocarcinoma (PDAC)

ATM-knockout mouse models of PDAC could be used to screen for new therapies.

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Mup-knockout mice generated through CRISPR/Cas9-mediated deletion for use in urinary protein analysis.

Major urinary proteins (MUPs) are the most abundant protein species in mouse urine, accounting for more than 90% of total protein content. Twenty-one Mup genes and 21 pseudogenes are clustered in a re...

IgG Suppresses Antibody Responses in Mice Lacking C1q, C3, Complement Receptors 1 and 2, or IgG Fc-Receptors.

Antigen-specific IgG antibodies, passively administered to mice or humans together with large particulate antigens like erythrocytes, can completely suppress the antibody response against the antigen....

Mir-27a promotes apoptosis of cochlear sensory epithelium in Cx26 knockout mice.

To investigate the underlying molecular mechanism for connexin 26 (Cx26) knockout-induced apoptosis, we performed TUNEL assays to detect apoptosis in the cochlear sensory epithelium in Cx26 knockout m...

Erythropoiesis and Blood Pressure Are Regulated via AT1 Receptor by Distinctive Pathways.

The renin-angiotensin system (RAS) plays a central role in blood pressure regulation. Although clinical and experimental studies have suggested that inhibition of RAS is associated with progression of...

The protective role of tacrine and donepezil in the retina of acetylcholinesterase knockout mice.

To determine the effect of different concentrations of the acetylcholinesterase (AChE) inhibitors tacrine and donepezil on retinal protection in AChE(+/-) mice (AChE knockout mice) of various ages.

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