Search Results for "Chemerine Knockout Mice"

01:06 EST 22nd February 2017 | BioPortfolio

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CD30 Antibodies

CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker. This receptor is expressed by activated, but not by resting, T and B cells. It ...

Polo like kinase Plk 1

Polo-like kinase (Plk) is an important cell cycle regulatory kinase that has been implicated in a multitude of cell cycle events. Plks form a family of four different proteins that regulates many as...

Sphingosine 1 Phosphate S1P

Sphingosine-1-phospate (S1P) is a phospholipid released by platelets, mast and other cells. It is now known that S1P stimulates at least five different G-protein coupled receptors (GPCRs): S1P1, S1P2,...

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Mice with midbrain neuron-specific knockout of LIM homeobox transcription factor 1 α (LMX1A; LMX1) and LMX1B as a model of Parkinson's disease (PD)

LMX1A/LMX1B-knockout mice could be useful for screening therapies to treat PD.

MMTV-cre;Ccn6 knockout mice develop tumors recapitulating human metaplastic breast carcinomas

Knockout of microRNA-21 reduces biliary hyperplasia and liver fibrosis in cholestatic bile duct ligated mice

Oliver Smithies, Technologist Behind Knockout Mice, Dies

The Nobel laureate and Lasker awardee developed tools that facilitated decades of genetics research, including starch gel electrophoresis and gene targeting.

Eye Study Advances Ability to Improve Clinical Measurement of Retinal Degeneration

University of Alabama at Birmingham researchers studying rod cell proteins GARP1 and GARP2 to learn how they function in normal phototransduction in the eye have found that GARP2 accelerates retinal d...

Amyloid precursor protein maintains constitutive and adaptive plasticity of dendritic spines in adult brain by regulating D-serine homeostasis

Dynamic synapses facilitate activity-dependent remodeling of neural circuits, thereby providing the structural substrate for adaptive behaviors. However, the mechanisms governing dynamic synapses in a...

Blood from Old Mice Makes Young Mice Decrepit

Joining the circulation of two mice weakened the younger one, but didn’t do much for the old one.

Murine Matchmaking: Starting a Breeding Colony of Mice

Mice are an extremely powerful research tool, but they do take extra time and effort. While you can purchase mice from vendors like Jackson Labs or outsource your genetic engineering to a number of co...

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Characterization of Smad3 knockout mouse derived skin cells.

TGF-β plays an important role in skin wound healing process, in which Smad3 acts as a signaling molecule. Smad3 knockout mice exhibit enhanced wound healing and less inflammatory process, but the int...

Ficolins Promote Fungal Clearance in vivo and Modulate the Inflammatory Cytokine Response in Host Defense against Aspergillus fumigatus.

Aspergillus fumigatus is an opportunistic fungal pathogen that causes severe invasive infections in immunocompromised patients. Innate immunity plays a major role in protection against A. fumigatus. T...

Loss of PINK1 inhibits apoptosis by upregulating α-synuclein in inflammation-sensitized hypoxic-ischemic injury in the immature brains.

The incidence of preterm birth is rising worldwide. Among preterm infants, many face a lifetime of neurologic impairments. Recent studies have revealed that systemic inflammation can sensitize the imm...

Gα12 is required for renal cystogenesis induced by Pkd1 inactivation.

Mutation of PKD1 is the main cause of autosomal dominant polycystic kidney disease (ADPKD). The signaling pathways of PC1 in ADPKD are still not fully understood. Here, we provide genetic evidence for...

Nicotinic acetylcholine receptors regulate vestibular afferent gain and activation timing.

Little is known about the function of the cholinergic efferents innervating peripheral vestibular hair cells. We measured vestibular sensory evoked potentials (VsEPs) in α9 knockout mice, α10 knocko...

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