Table 2 : Cell cycle kinases as therapeutic targets for cancer ...
Cell cycle kinases as therapeutic targets for cancer. Silvia Lapenna & Antonio Giordano. Nature Reviews Drug Discovery 8, 547-566 (July 2009) ...
http://www.nature.com/nrd/journal/v8/n7/fig_tab/nrd2907_T2.h...
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Myc activation of cyclin E/Cdk2 kinase involves induction of ...
As a consequence phosphorylation of CycE-bound Cdk2 by cyclin activating kinase (CAK) is accelerated. We propose a model in which the active newly ...
http://www.ncbi.nlm.nih.gov/pubmed/9188852...
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Polo kinase controls cell-cycle-dependent transcription by ...
Polo kinases have crucial conserved functions in controlling the eukaryotic cell cycle through orchestrating several events during mitosis. ...
http://www.nature.com/nature/journal/v444/n7118/abs/nature05...
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G1 cyclin-dependent kinases are insufficient to reverse dE2F2 ...
Alleles; Animals; Blotting, Northern; Blotting, Western; CDC2-CDC28 Kinases*; Cell Cycle; Cells, Cultured; Chromatin/metabolism; Cyclin E/metabolism ...
http://www.ncbi.nlm.nih.gov/pubmed/12651890...
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Oncogene - Abstract of article: The cell cycle checkpoint kinase ...
The cell cycle checkpoint kinase CHK2 mediates DNA damage-induced stabilization of TTK/hMps1. Y-H Yeh1,3, Y-F Huang1,2, T-Y Lin1 and S-Y Shieh1 ...
http://www.nature.com/onc/journal/v28/n10/abs/onc2008477a.ht...
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Cell cycle kinases in cancer.
Cell division in mammalian cells is driven by protein kinases that regulate progression through the various phases of the cell cycle. ...
http://www.ncbi.nlm.nih.gov/pubmed/17208431...
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cdc2-cyclin B regulates eEF2 kinase activity in a cell cycle- and ...
Kinase activity against Ser359 in eEF2K also peaks at this stage of the cell cycle and eEF2 phosphorylation is low in mitotic cells. ...
http://www.nature.com/emboj/journal/v27/n7/abs/emboj200839a....
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The cell cycle checkpoint kinase Chk2 is a negative regulator of ...
In conclusion, a conflict in cell cycle progression or DNA damage can lead to mitotic catastrophe, provided that the checkpoint kinase Chk2 is inhibited. ...
http://www.ncbi.nlm.nih.gov/pubmed/15048074...
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A cell cycle-regulated inhibitor of cyclin-dependent kinases.
Cyclin-dependent kinases (Cdks) previously have been shown to drive the major cell cycle transitions in eukaryotic organisms ranging from yeast to humans. ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=43...
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The cell-cycle checkpoint kinase Chk1 is required for mammalian ...
The essential checkpoint kinase Chk1 is required for cell-cycle delays after DNA damage or blocked DNA replication. However, it is unclear whether Chk1 is ...
http://www.ncbi.nlm.nih.gov/pubmed/15665856...
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