Fibrosis

Fibrosis and Cirrhosis

Idiopathic Pulmonary Fibrosis

Pleural Fibrosis and Calcification

Cystic Fibrosis

Affecting over 8,500 people in the UK, Cystic Fibrosis (CF) is one of the UK's most common life-threatening inherited diseases. Around half of the CF population can expect to live over 38 year...

Endoplasmic reticulum–mitochondria contacts: function of the junction

The characterization of dynamic contacts that form between the endoplasmic reticulum and mitochondria have highlighted the different ways in which the functions of these organelles can be coordinated....

Close encounter: mitochondria, endoplasmic reticulum and Alzheimer’s disease

Alzheimer’s disease (AD) pathogenesis is linked to loss of presenilins, components of γ-secretase. Presenilins are located at MAM, a membrane domain at the interface of mitochondria and endoplasmic...

Altered sarcoplasmic reticulum calcium cycling—targets for heart failure therapy

Ca2+ cycling defects in cardiac myocytes are a hallmark of heart failure. Roger Hajjar and colleagues discuss the association between abnormalities in sarcoplasmic reticulum Ca2+ handling proteins and...

BiP-mediated closing of the Sec61 channel limits Ca2+ leakage from the ER

Sec61, the protein-conducting channel of the endoplasmic reticulum, also mediates calcium efflux. The chaperone BiP binds to a luminal loop of Sec61 to inhibit calcium leakage and to link channel gati...

A pseudoatomic model of the COPII cage obtained from cryo-electron microscopy and mass spectrometry

The COPII cage, formed by Sec13 and Sec31, organizes other proteins into a lattice on the endoplasmic-reticulum membrane and is involved in transporting cargo from the endoplasmic reticulum to the Gol...

PARP16 is a tail-anchored endoplasmic reticulum protein required for the PERK- and IRE1α-mediated unfolded protein response

Chang and colleagues reveal that the poly(ADP-ribose) polymerase PARP16 participates in the endoplasmic reticulum (ER) stress response. They report that PARP16 is a transmembrane ER protein that PARsy...

[UCB] teams up with [Five Prime] to discover inflammatory disease/CNS disorder treatments

[Five Prime Therapeutics Inc.] (drug discovery platforms) will use its drug discovery platforms on up to five of [UCB]’s programs to identify targets and mechanisms in the areas of fibrosis-related...

Leading Organizations Announce New Research Grant for Pulmonary Fibrosis Research

Culver City, California - March 18, 2013 - The Coalition for Pulmonary Fibrosis (CPF), the Pulmonary Fibrosis Foundation (PFF), and the American Thoracic Society (ATS) announce that the CPF and the PF...

Mechanistic connection between inflammation and fibrosis.

Fibrosis of the kidney is caused by the prolonged injury and deregulation of normal wound healing and repair processes, and by an excess deposition of extracellular matrices. Despite intensive researc...

Role of endoplasmic reticulum stress in cystic fibrosis-related airway inflammatory responses.

Chronic airway infection and inflammation are hallmarks of cystic fibrosis (CF) pulmonary disease. The altered airway environment resulting from infection and inflammation can affect the innate defens...

Azithromycin fails to reduce inflammation in cystic fibrosis airway epithelial cells.

Cystic fibrosis is a hereditary disease caused by a mutation in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) gene that encodes a chloride (Cl(-)) channel. Cystic fibrosis pulmonary p...

Proteasome Inhibition Prevents Development of Experimental Dermal Fibrosis.

Scleroderma is a chronic fibrotic disorder. Bortezomib, a proteasome inhibitor, is reported to attenuate experimentally induced renal and cardiac fibrosis. This study aimed to evaluate the preventive...

TNF-α transiently induces endoplasmic reticulum stress and an incomplete unfolded protein response in the hypothalamus.

In diet-induced obesity, hypothalamic inflammation is triggered as an outcome of prolonged exposure to dietary fats. Toll-like receptor 4 (TLR4) activation plays a central role in this process, induci...