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Linking Cytotoxic Agents To Monoclonal Antibodies Service Contracts Pages on BioPortfolio:

BioPortfolio - ImmunoGen
Conjugates of antibodies with cytotoxic agents offer a targeted. ... linking cytotoxic agents to monoclonal antibodies service contracts | immunogen email
...
http://www.bioportfolio.com/biocorporate/5298-ImmunoGen.html...

BioPortfolio - MedImmune research
Monoclonal antibodies are traditionally used to block the function of a. ... MedImmune,, Arthritis Rheum. 2009 Jun;60(6):1785-96. DOI Direct Link ... models
as a single agent and in combination with trastuzumab or lapatinib. ... cell-
mediated cytotoxicity effector-enhanced EphA2 agonist monoclonal antibody ...
http://www.bioportfolio.com/biocorporate/6860-MedImmune/rese...

BioPortfolio - Neuroectodermal Tumors Primitive Peripheral
Pediatr Blood Cancer. 2009 Oct;53(4):678-9. DOI Direct Link ... 2 Study with LHRH-Receptor Targeted Cytotoxic Conjugate AEZS-108 in Ovarian Cancer ...
Reportlinker Adds Ion Channel Modulator Pipelines: Targets and Agents in
Development ... Reportlinker Adds Monoclonal Antibodies: Pipeline Analysis and
Competitive ...
http://www.bioportfolio.com/indepth/Neuroectodermal_Tumors_P...

BioPortfolio - Drug Compounding
[Improvement of quality of practices for the preparation of cytotoxic drugs: ... Despite the publication of guidelines for handling antineoplastic agents,. ...
monoclonal antibodies and monoclonal antibody fragments for in vivo use ...
Soderlund Village Drug is a full service Minnesota compounding pharmacy with a
...
http://www.bioportfolio.com/indepth/Drug_Compounding.html...

BioPortfolio - CCL2 - chemokine (C-C motif) ligand 2
17917677, preliminary evidence linking genetic variation in CCR2 to ... Leprosy, whose etiologic agent is Mycobacterium leprae, is an illness of. ... and
protects prostate cancer cells from docetaxel-induced cytotoxicity. ...
Monoclonal Antibody against CCL2 for use in ELISA, Inhibition Assays, Western
Blot. ...
http://www.bioportfolio.com/gene/6347-CCL2.html...

BioPortfolio - Lupus Nephritis
Lupus. 2009 Oct 27. DOI Direct Link ... A focus on "engineered" antibodies Monoclonal Antibodies: Pipeline Analysis and Competitive Assessment reviews the
... 7534431, Methods and compositions for administering therapeutic and
diagnostic agents ... 7544487, Fusion proteins containing recombinant cytotoxic
RNAses ...
http://www.bioportfolio.com/indepth/Lupus_Nephritis.html...

BioPortfolio - CD55 - CD55 molecule, decay accelerating factor for ...
... expression of CD52 on clonal cytotoxic T cells in CD8+ large granular lymphocyte leukemia. ... 2009 Sep;46(15):2885-91. Epub 2009 Aug 5. DOI Direct
Link ... 7462460, Methods for identifying agents that increase the p44 function
of microtubule ... CD55 antibody [BRIC 216]. Flow Cyt, IP. Mouse monoclonal .
...
http://www.bioportfolio.com/gene/1604-CD55.html...

BioPortfolio - Pharmexa
Coordinated interactions between helper and cytotoxic T-lymphocytes (HTL. ... A focus on "engineered" antibodies Monoclonal Antibodies: Pipeline Analysis and
Competitive ... 7097837, Synthetic vaccine agents. →View more Pharmexa patents.
... This page has been viewed 431 times since April 2007, the link to the ...
http://www.bioportfolio.com/biocorporate/26141-Pharmexa.html...

BioPortfolio - AVI BioPharma - Profile
on intracellular delivery and cytotoxicity. ... Antimicrob Agents Chemother. 2006. Aug;50(8):2789-96. (DOI Direct Link) ... antibodies Monoclonal Antibodies:
Pipeline Analysis and Competitive ... AVI BioPharma gets $11.5M military
contract ... will also improve your exposure on BioPortfolio's related service
...
http://www.bioportfolio.com/biocorporate/1121-AVI+BioPharma....

BioPortfolio - Cathepsin B
2009 Oct;5(10):e1000628. Epub 2009 Oct 16. DOI Direct Link ... in an increased cytotoxic potential for trifluorothymidine compared to 5-fluorouracil ... VisEn
Launches New Cat-K FAST(TM) Fluorescence Molecular Imaging Agent, 7th July, 2009
... 7553953, Chimeric, human and humanized anti-CSAp monoclonal antibodies ...
http://www.bioportfolio.com/indepth/Cathepsin_B.html...

Results from other life science and pharmaceutical sites:

Cytotoxic agents directed to peptide hormone receptors: Defining ...
... such as the development of neutralizing antibodies (3), have limited the ..... Linking Ell directly to 7G via a urea linker (Ell-CO-7G), resulted in an
agent that ... respect to the level of CCKBR expression, although they are
monoclonal. ... Human Services, under contract with Advanced BioScience
Laboratories. ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=21...

Site-Specific Linking of Biomolecules via Glycan Residues Using ...
Monoclonal antibodies (mAb) have one conserved N-linked oligosaccharide chain at the Asn297 ... they provide a means to target cytotoxic drugs, toxins,
radionuclides, .... can next be coupled with the orthogonal reactive coupling
agents. .... Cancer Institute, National Institutes of Health, under contract No.
...
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2435414/...

Applications of Glycosyltransferases in the Site-specific ...
General Utility of the Technique of Linking via Glycan Residue ... Keywords: Bioconjugation via glycan residues, MRI agents, cytotoxic agents, .... The
monoclonal antibodies whose N-linked glycan moieties have been modified with the
... National Cancer Institute, National Institutes of Health, under contract No.
...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=22...

Novel Human IGF-I-Specific And IGF-I, IGF-II Cross-Reactive ...
16 Apr 2009 ... Monoclonal antibody-based therapies have taken a lead among the new ... Agents that inhibit IGF1R expression or function can potentially block ... Fully human
antibodies reduce the probability for immune responses and cytotoxic side
effects ... TTC maintains an e-mail service to notify you of new ...
http://ttc.nci.nih.gov/opportunities/opportunity.php?opp_id=...

Autophagy Facilitates the Development of Breast Cancer Resistance ...
In contrast to either agent alone, Tzb and autophagy LC3 gene-siRNA .... Mouse anti-SQSTM1/p62 monoclonal antibody was purchased from Abcam plc. .... is the
recipient of a “Sara Borrell” post-doctoral contract (CD08/00283, ..... Role of
autophagy in temozolomide-induced cytotoxicity for malignant glioma cells. ...
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708925/...

Human Monoclonal Antibody Against Mesothelin - Technology Transfer ...
28 Apr 2008 ... Additionally, the antibody may be used as a research agent for the detection of ... TTC maintains an e-mail service to notify you of new ...
http://ttc.nci.nih.gov/opportunities/opportunity.php?opp_id=...

Roche Annual Report 2008 - Pharmaceuticals
23 Jan 2009 ... by the National Health Service. ... market, characterised by heavily discounted contract ..... R3502) is a novel antibody–drug conjugate linking trastuzumab (
the active ingredient of Herceptin) and the cytotoxic agent DM1. By targeting
the HER2 ... monoclonal antibody being developed by Roche, ...
http://www.roche.com/gb08e04.pdf...

Therapeutics - Technology Transfer Center
26 Aug 2009 ... Imaging Agents to Monitor the Distribution of Therapies Delivered to the Brain ... Human and Improved Murine Monoclonal Antibodies Against CD22 .... TTC
maintains an e-mail service to notify you of new Collaborative Opportunities.
... of Health and Human Services] · [Link to the First Gov web site]
http://ttc.nci.nih.gov/opportunities/opportunities.php?cat_i...

Induction of Tumor-specific T Cell Immunity by Anti-DR5 Antibody ...
Induction of perforin- and FasL-mediated T cell cytotoxicity that can ... cross- linking of DR5 by MD5-1 was sufficient to cause caspase-dependent tumor cell
death in vitro. .... National Institutes of Health, under contract number N01-C0
-12400. .... IgG2a monoclonal antibodies inhibit human tumor growth through ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=22...

Selenocysteine Enables a New Platform for Immunoconjugates ...
An application of interest is therapeutic agents for hematologic malignancies, ... An economic advantage compared to conventional monoclonal antibodies is the
... to whole antibodies and antibody fragments for the conjugation of cytotoxic
... [Link to the web site of the Department of Health and Human Services] ...
http://ttc.nci.nih.gov/opportunities/opportunity.php?opp_id=...

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