AntigenPresenting Cells

Murine Endemic Typhus

Prior neonate with a genetic or congenital disorder

Cytotoxic lymphocyte associated molecule 4 CTLA 4 CD152

Cytotoxic lymphocyte-associated molecule-4 (CTLA-4, CD152) is a member of the CD28 receptor family which is expressed on the surface of Helper T cells. CTLA-4 is similar to the T-cell costimulatory pr...

Serine Threonine protein kinase C PKC

The serine/threonine protein kinase C (PKC) family consists of at least 11 mammalian isozymes belonging to a larger subclass of protein kinases termed the adenine-guanine-cytosine (AGC) kinases. PK...

Mouse-Derived T Cell Receptor for Use in Immunotherapy that Recognizes NY-ESO-1, a Cancer Testis Antigen Expressed by Many Human Cancers

Scientists at the National Institutes of Health have developed a T cell receptor (TCR) derived from mouse T cells (i.e. murine TCR) that can be expressed in human T cells to recognize the cancer testi...

T cells key in atherosclerosis-linked inflammation

(HealthDay) -- In a mouse model of atherosclerosis, CD4+ T cells interact with antigen-presenting cells (APCs) in the presence of cognate antigen, leading to cell activation and proliferation and the...

Mouse-Derived NY-ESO-1 T Cell Receptor for Use in Immunotherapy

Scientists at the National Institutes of Health have developed a T cell receptor (TCR) derived from mouse T cells (i.e. murine TCR) that can be expressed in human T cells to recognize the cancer testi...

Cytomegalovirus and tumor stress surveillance by binding of a human γδ T cell antigen receptor to endothelial protein C receptor

How γδ T cells 'see' antigen is poorly defined. Déchanet-Merville and colleagues demonstrate that a subset of γδ T cells functionally recognize the stress-associated self molecule EPCR on both vi...

Pharmaceutical Research: Nanocarriers Targeting Dendritic Cells for Pulmonary Vaccine Delivery

Type: Review PaperPulmonary vaccine delivery has gained significant attention as an alternate route for vaccination without the use of needles. Immunization through the pulmonary route induces both mu...

TAP-deficient human iPS cell-derived myeloid cell lines as unlimited cell source for dendritic cell-like antigen-presenting cells

Integration of the movement of signaling microclusters with cellular motility in immunological synapses

TCR microcluster signaling occurs in cognate T cells after they encounter antigen-presenting cells. Krummel and colleagues show that immune synapses are motile as microclusters coalesce after the acti...

Immunology: Vitamins prime immunity

The finding that derivatives of vitamin B can bind to an antigen-presenting protein that stimulates specialized immune cells suggests a novel mechanism by which the immune system detects microbial inf...

Neonate Antigen Presenting Cells within Murine Intestinal Muscular Layer.

The intestinal mucosa is exposed to a vast antigenic contact. Several antigen presenting cell (APCs) have been described within the gut associated lymphoid tissue (GALT) (Peyer's patches, lamina propr...

The role of antigen presenting cells in multiple sclerosis.

Multiple Sclerosis (MS) is a debilitating T cell-mediated autoimmune disease of the central nervous system (CNS). Animal models of MS, such as experimental autoimmune encephalomyelitis (EAE) and Theil...

The roles of antigen-specificity, responsiveness to transforming growth factor-beta and antigen-presenting cell subsets in tumour-induced expansion of regulatory T cells.

Summary In this study we investigated the impact of several factors on the expansion of natural regulatory T (nTreg) cells by tumours, including antigen specificity, transforming growth factor-beta (T...

Dendritic cells in oral tolerance in the gut.

Oral tolerance is a process that allows generation of systemic unresponsiveness to food antigens. Hence if the same antigen is introduced systemically even under immunogenic conditions it does not ind...

Antigen amount dictates CD8(+) T-cell exhaustion during chronic viral infection irrespective of the type of antigen presenting cell.

Chronic viral infections lead to CD8(+) T-cell exhaustion, characterized by impaired cytokine secretion and loss of proliferative capacity. While viral load and T-cell dysfunction correlate, it is cur...