Human Epidermal Growth Factor receptor EGF R

The human epidermal growth factor receptor (HER) family members include EGFR (erbB1), HER2/neu (erbB2), HER3 (erbB3), and HER4 (erbB4) that are structurally related, and all except HER3 contain intr...

CaptureSelect

BAC’s CaptureSelect products are affinity ligands and affinity resins created by a proprietary technology based on Camelid-derived single domain antibody fragments for the purification of biop...

Obinutuzumab

A glycoengineered, fully humanized IgG1 monoclonal antibody with potential antineoplastic activity. Obinutuzumab, a third generation type II anti-CD20 antibody, selectivity binds to the extracellula...

Complementary and Alternative Medicine

Alternative medicine are whole medical systems that did not fit with conventional medicine as they have completely different philosophies and ideas on the causes of disease, methods of diagnosis and...

Serine Threonine protein kinase C PKC

The serine/threonine protein kinase C (PKC) family consists of at least 11 mammalian isozymes belonging to a larger subclass of protein kinases termed the adenine-guanine-cytosine (AGC) kinases. PK...

The ATPase domain of ISWI is an autonomous nucleosome remodeling machine

Previous work has implied that the ATPase domain of ISWI chromatin remodelers cooperates with a DNA-binding accessory domain to achieve remodeling. Quantitative biochemical analyses now reveal that th...

Domain, Beijing Elite partner to bring products to China

VC firm Domain Associates and Chinese consulting firm Beijing Elite Management Consulting Ltd. partnered to form Domain Elite Holdings Ltd., which will form newcos and JVs to conduct Chinese developme...

Domain Therapeutics enters into collaboration agreement with Ono in the field of GPCR-based drug discovery

Domain Therapeutics S.A. announced that Domain Therapeutics and Ono Pharmaceutical Co., Ltd. (Osaka, Japan) signed a collaboration agreement focused on discovering small molecules targeting G-Protein...

Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F

Human JAK2 tyrosine kinase mediates signaling through numerous cytokine receptors. The JAK2 JH2 pseudokinase domain negatively regulates the activity of the JH1 kinase domain. The structures of wild-t...

Domain-Rusnano Partnership Invests $93 Million in Three Biotechs

Last March, life sciences venture firm Domain Associates and Russia’s state-owned Rusnano announced that they will jointly invest as much as $760 million in biotech. Today the partnership announced...

LIM-domain-only proteins in cancer

LIM-domain-only (LMO) proteins are a subset of the LIM-domain protein family and function primarily as transcriptional regulators. They are associated with various cancers, including T cell acute lymp...

Newly Devised Compound Promotes Cancer Cell Destruction

Scientists have developed a compound modeled from the proapoptotic, the death domain of BCL-2, the BIM BH3 domain.

Domain and Elite Team Up to Bring Life Science Products to China

Domain Associates, a US venture capital firm focused on life science, has set up a partnership with Elite Consulting, a consultant service for China's drug and medical device industry. They will estab...

Disruption of the Interface between the Pleckstrin Homology (PH) and Kinase Domains of Akt Protein Is Sufficient for Hydrophobic Motif Site Phosphorylation in the Absence of mTORC2.

The pro-survival kinase Akt requires phosphorylation at two conserved residues, the activation loop site (Thr-308) and the hydrophobic motif site (Ser-473), for maximal activation. Previous reports in...

The mTOR (Mammalian Target of Rapamycin) Kinase Maintains Integrity of mTOR Complex 2.

In higher eukaryotes, growth factors promote anabolic processes and stimulate cell growth, proliferation, and survival by activation of the phosphoinositide 3-kinase (PI3K)/Akt pathway. Deregulation o...

Sin1-mTORC2 Suppresses rag and il7r Gene Expression through Akt2 in B Cells.

Mammalian target of rapamycin (mTOR) is an important mediator of phosphoinositol-3-kinase (PI3K) signaling. PI3K signaling regulates B cell development, homeostasis, and immune responses. However, the...

Integrity of mTORC2 is dependent on the rictor Gly-934 site.

Growth factor signaling coupled to activation of the phosphatidylinositol-3-OH kinase (PI3K)/Akt pathway plays a crucial role in the regulation of cell proliferation and survival. The key regulatory k...

PPIP5K1 Modulates Ligand Competition Between Diphosphoinositol Polyphosphates and PtdIns(3,4,5)P3 for Polyphosphoinositide-Binding Domains.

We describe new signalling consequences for PPIP5K1-mediated phosphorylation of InsP6 and 5-InsP7 to 1-InsP7 and InsP8. In NIH-3T3 cells, either hyperosmotic stress or receptor-activation by PDGF prom...