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The interaction of complement C5a and its receptor for the treatment of inflammatory diseases include rheumatoid arthritis, systemic lupus erythematosus, asthma, wet age-related macular degeneration...
InWeb_InBioMap (InWeb_IM for short) is a scored, integrated human protein–protein interaction network resource aggregated from public, experimentally determined protein–protein interactions. The r...
Nature Methods published (online) a comparative study of leading Protein-Protein Interaction (PPI) Networks.
(Massachusetts General Hospital) An international research team has developed the largest database of protein-to-protein interaction networks, a resource that can illuminate how numerous disease-assoc...
A Japanese research group has determined the crystal structure of the JUNO protein, an egg surface protein essential for fertilization. These structure-based mutational analyses elucidated a mechanism...
(Osaka University) A Japanese research group has determined the crystal structure of the JUNO protein, an egg surface protein essential for fertilization. These structure-based mutational analyses elu...
Perinuclear localization of CED-3 zymogen in C. elegans germ cells and interaction with nuclear-pore protein NPP-14 inhibit autocatalytic activation of CED-3, a central event in apoptosis.
A linearized programming method of memristor-based neural weights is proposed. Memristor is known as an ideal element to implement a neural synapse due to its embedded functions of analog memory and a...
Protein-protein interaction and signaling crosstalk contribute to the regulation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) and broaden their cellular function.
Wilms' tumor (WT), or nephroblastoma, is the most common malignant renal cancer that affects the pediatric population. Great progress has been achieved in the treatment of WT, but it cannot be cured a...
A small-molecule inhibitor with a 1,4-dibenzoylpiperazine scaffold was designed to match the critical binding elements in the β-catenin/B-cell lymphoma 9 (BCL9) protein-protein interaction interface....
p-Coumalic acid (PCA), caffeic acid (CA), gallic acid (GA) and chlorogenic acid (CGA) are the major phenolic acids that co-exist with soy protein components in foodstuffs. Surprisingly, there are only...