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The interaction of complement C5a and its receptor for the treatment of inflammatory diseases include rheumatoid arthritis, systemic lupus erythematosus, asthma, wet age-related macular degeneration...
Mitochondrial cytochrome c oxidase (CcO) transfers electrons from cytochrome c (Cyt.c) to O2 to generate H2O, a process coupled to proton pumping. To elucidate the mechanism of electron transfer, we d...
InWeb_InBioMap (InWeb_IM for short) is a scored, integrated human protein–protein interaction network resource aggregated from public, experimentally determined protein–protein interactions. The r...
Nature Methods published (online) a comparative study of leading Protein-Protein Interaction (PPI) Networks.
(Massachusetts General Hospital) An international research team has developed the largest database of protein-to-protein interaction networks, a resource that can illuminate how numerous disease-assoc...
Transient protein interactions are paramount to life where fast and efficient transfer of information and cargo are often integral to pathways and networks. However, complexes formed by transient prot...
Perinuclear localization of CED-3 zymogen in C. elegans germ cells and interaction with nuclear-pore protein NPP-14 inhibit autocatalytic activation of CED-3, a central event in apoptosis.
A linearized programming method of memristor-based neural weights is proposed. Memristor is known as an ideal element to implement a neural synapse due to its embedded functions of analog memory and a...
The identification of Protein-Protein Interaction (PPI) sites is an important step towards the characterization of protein functional integration in the cell complexity. Experimental methods are costl...
Protein-protein interaction and signaling crosstalk contribute to the regulation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) and broaden their cellular function.
Wilms' tumor (WT), or nephroblastoma, is the most common malignant renal cancer that affects the pediatric population. Great progress has been achieved in the treatment of WT, but it cannot be cured a...
Recently a novel neuronal activity sensor exploiting the intrinsic thresholded integrator capabilities of memristor devices has been proposed. Extracellular potentials captured by a standard bio-signa...