Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and ...
We have screened a chemical library and identified a small molecule named RITA ( reactivation of p53 and induction of tumor cell apoptosis), which bound to ...
http://www.ncbi.nlm.nih.gov/pubmed/15558054...
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Reply to 'NMR indicates that the small molecule RITA does not ...
Small molecule RITA binds to p53, blocks p53?HDM-2 interaction and activates p53 function in tumors. Nature Medicine Article (01 Dec 2004) ...
http://www.nature.com/nm/journal/v11/n11/abs/nm1105-1136.htm...
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Targeting MDM2 by the small molecule RITA: towards the development ...
In all cases, these molecules bind to MDM2 and block the p53-MDM2 interaction. In contrast, Issaeva et al. reported the small molecule RITA (reactivation of
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1243243/...
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Cancer Cell - Ablation of Key Oncogenic Pathways by RITA ...
5 May 2009 ... We report a potent inhibition of crucial oncogenes by p53 upon reactivation by small-molecule RITA in vitro and in vivo. ...
http://www.cell.com/cancer-cell/abstract/S1535-6108(09)00110...
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Targeting MDM2 by the small molecule RITA: towards the development ...
20 Sep 2005 ... Targeting MDM2 by the small molecule RITA: towards the development of new multi- target drugs against cancer. Espinoza-Fonseca LM. ...
http://www.ncbi.nlm.nih.gov/pubmed/16174299...
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Patented small molecule inhibitors in the ubiquitin proteasome system
Issaeva N., Bozko P., Enge M., Protopopova M., Verhoef L.G., Masucci M., Pramanik A., Selivanova G. Small molecule RITA binds to p53, blocks p53-HDM-2
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http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=pm...
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NMR indicates that the small molecule RITA does not block p53-MDM2 ...
NMR indicates that the small molecule RITA does not block p53-MDM2 binding in vitro. Krajewski M, Ozdowy P, D'Silva L, Rothweiler U, Holak TA. ...
http://www.ncbi.nlm.nih.gov/pubmed/16270059...
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Cancer Cell - MDM2-Dependent Downregulation of p21 and hnRNP K ...
We report a potent inhibition of crucial oncogenes by p53 upon reactivation by small-molecule RITA in vitro and in vivo. RITA-activated p53 unleashes the ...
http://www.cell.com/cancer-cell/abstract/S1535-6108(09)00028...
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Small-molecule activation of p53 blocks hypoxia-inducible factor ...
Here, we show that induction of p53 by the small-molecule RITA (reactivation of p53 and induction of tumor cell apoptosis) [2 ...
http://www.ncbi.nlm.nih.gov/pubmed/19223463...
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Geron Announces Presentation Of Data Supporting The Utility Of ...
The new data, presented by Rita Effros, Ph.D., Elizabeth and Thomas Plott ... " We were extremely pleased to discover that our small molecule compounds, ...
http://www.geron.com/media/pressview.aspx?id=996...
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