Tasidotin HCl Genzyme Kanwaldeep Kaur Rasila & Claire Verschraegen*
tasidotin HCl for the treatment of solid tumors [585593]. Studies on the mechanism of action of tasidotin HCl are in. their early stages, but evidence
thus ...
http://www.biomedcentral.com/content/pdf/cd-604640.pdf...
|
INTRACELLULAR ACTIVATION AND DEACTIVATION OF TASIDOTIN,AN ANALOGUE ...
Tasidotin, an oncolytic drug in Phase II clinical trials, is a peptide analogue of the antimitotic depsipeptide dolastatin 15. In tasidotin, the carboxyl ...
http://www.ncbi.nlm.nih.gov/pubmed/18927208...
|
American Society of Clinical Oncology - 41st Annual Meeting Drug ...
Tasidotin HCl (Genzyme Corp; Figure 3) is a synthetic ... provided data from a phase II clinical trial of tasidotin HCl. in patients with inoperable locally
...
http://www.biomedcentral.com/content/pdf/cd-608568.pdf...
|
Phase I and pharmacokinetic study of tasidotin hydrochloride ...
Phase I and pharmacokinetic study of tasidotin hydrochloride (ILX651), a third- generation dolastatin-15 analogue, administered weekly for 3 weeks every 28 ...
http://www.ncbi.nlm.nih.gov/sites/entrez?db=PubMed&cmd=retri...
|
American Association for Cancer Research - 96th Annual Meeting ...
activity of tasidotin HCl was evaluated against a range of ... Tasidotin HCl was moderately effective against Caki-1 renal ...
http://www.biomedcentral.com/content/pdf/cd-602488.pdf...
|
Mechanism of action of the microtubule-targeted antimitotic ...
Tasidotin inhibited proliferation of MCF7/GFP breast cancer cells with an IC(50) of 63 ... Tasidotin inhibited the polymerization of purified tubulin into ...
http://www.ncbi.nlm.nih.gov/pubmed/17440090...
|
Progress Across Medical Areas
The most advanced is tasidotin, a synthetic analog of the natural substance ... We are currently conducting phase 2 clinical trials of tasidotin in three ...
http://www.genzyme.com/corp/2004_AR/progress_across_medical_...
|
A phase I study of the dolastatin-15 analogue tasidotin (ILX651 ...
One patient with melanoma metastatic to liver and bone treated at 15.4 mg/m(2)/d experienced a complete response and received 20 courses of tasidotin. ...
http://www.ncbi.nlm.nih.gov/sites/entrez?db=PubMed&cmd=retri...
|
Paper alert
antimitotic depsipeptide tasidotin (formerly ILX651) and ... version of the depsipeptide dolastatin-15, called tasidotin. (N,N-dimethyl- ...
http://www.biomedcentral.com/content/pdf/cd-802923.pdf...
|
Phase I and pharmacokinetic study of the dolastatin-15 analogue ...
PATIENTS AND METHODS: Thirty-two patients were treated with 92 courses of tasidotin through seven dose levels determined by a modified Fibonacci scheme
...
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&uid=16278...
|
