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Highly Potent and Selective Deubiquitinating Enzyme Inhibitor

Available for licensing are inhibitors that target the USP1/ UAF1 deubiquitinating enzyme (DUB) complex. The FDA approval and commercial success of Velcade?, a small molecule proteasome inhibitor, has...

USP1 regulates AKT phosphorylation by modulating the stability of PHLPP1 in lung cancer cells.

BACKGROUND: Hyperactivation of phosphatidylinositol 3-kinase/Akt signaling is commonly associated with human tumors including lung cancers. PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1)...

Mechanisms of disease: USP1 keeps ID proteins stable.

Tumorigenesis: USP1 keeps ID proteins stable.

Dysregulation of DNA polymerase κ recruitment to replication forks results in genomic instability.

Translesion synthesis polymerases (TLS Pols) are required to tolerate DNA lesions that would otherwise cause replication arrest and cell death. Aberrant expression of these specialized Pols may be res...

Regulation of the activation of the Fanconi anemia pathway by the p21 cyclin-dependent kinase inhibitor.

Fanconi anemia (FA) is a rare disease characterized by congenital defects, progressive bone marrow failure and heightened cancer susceptibility. The FA proteins, BRCA1 and FANCD1/BRCA2 function cooper...