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18:23 EDT 28th May 2017 | BioPortfolio

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Harms of Nighttime Light Exposure Passed to Offspring

Hamster study finds evidence of immune, endocrine problems

The Austrian Center of Industrial Biotechnology collaborates with GE Healthcare

Biospectrum The goal of the three-year partnership is to explore and identify new tools and methods to modify and optim...

Synpromics to develop synthetic promotors for GE’s CHO platform

GE Healthcare hopes to increase the yield of biopharmaceuticals made using its Chinese Hamster Ovary (CHO) expression system through a partnership with synthetic biology firm Synpromics.

Synpromics and GE Healthcare to extend the biologics production toolbox

Synpromics will develop a complex barcoded library of synthetic promoters, using its proprietary PromPT platform, for extensive screening in GE Healthcare s Chinese Hamster Ovary (CHO)-based expressio...

CHO stopper? Biogen looks to alternative cell lines for future of bioproduction

The Chinese hamster ovary (CHO) cell line is not the future for biomanufacturing says Biogen, which will publish results from a study of alternative hosts later this year.

Stable high-level expression of factor VIII in Chinese hamster ovary cells in improved elongation factor-1 alpha-based system

Recombinant factor VIII (FVIII), used for haemophilia A therapy, is one of the most challenging among the therapeutic proteins produced in heterologous expression systems. Deletion variant of FVIII, i...

Researchers develop new tools to optimize CHO cell lines for making biologic drugs

Chinese hamster ovary (CHO) cells are the most commonly used cells to produce biologics—protein-based drugs for treating cancers, autoimmune diseases and much more. CHO cells are the workhorses behi...

Harms of nighttime light exposure passed to offspring: Hamster study finds evidence of immune, endocrine problems

Animals can pass the damaging effects of nighttime light exposure to their offspring, a new study has found, adding to a growing body of evidence that there's a health cost to our increasingly illumin...

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Imaging visceral leishmaniasis in real time with golden hamster model: Monitoring the parasite burden and hamster transcripts to further characterize the immunological responses of the host.

Characterizing the clinical, immunological and parasitological features associated with visceral leishmaniasis is complex. It involves recording in real time and integrating quantitative multi-paramet...

A synthetic biology standard for Chinese Hamster Ovary cell genome monitoring and contaminant detection by polymerase chain reaction.

Chinese Hamster Ovary (CHO) cells are the current industry standard for production of therapeutic monoclonal antibodies at commercial scales. Production optimisation in CHO cells hinges on analytical ...

Adverse and beneficial effects in Chinese hamster lung fibroblast cells following radiofrequency exposure.

In this study, the effect of radiofrequency (RF) exposure to 1950 MHz, Universal Mobile Telecommunication System signal, was investigated in Chinese hamster lung fibroblast cell line (V79). Genotoxi...

Seasonal differential expression of KiSS-1/GPR54 in the striped hamsters (Cricetulus barabensis) among different tissues.

Kisspeptins and G protein coupled receptor (GPR54) play significant roles in regulating reproductive activity among seasonal reproductive animals; however, the mechanisms of KiSS-1 and GPR54 gene affe...

Comprehensive Transcriptome Analyses of the Fructose-Fed Syrian Golden Hamster Liver Provides Novel Insights into Lipid Metabolism.

Dyslipidemia has been widely proven to contribute to cardiovascular diseases and other metabolic disorders, especially in insulin resistance and type 2 diabetes. The overproduction of VLDL is a signif...

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