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03:36 EDT 26th September 2017 | BioPortfolio

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Transfection Toolkit

Engineering a mutation or overexpressing a recombinant protein to study and characterize its function in mammalian cells is no easy task. Luckily, Chinese hamster ovary (CHO) cells, which have been a ...

The body relies on thousands of sugar–protein complexes to stay healthy

Over two weeks in 2004, Song Zhiwei witnessed the slow death of a colony of cells. Song, a bioengineer at the A*STAR Bioprocessing Technology Institute (BTI), had bathed a plate of Chinese hamster ova...

ATUM, Horizon Discovery Cross-License Cell-Line Development Technologies

ATUM (formerly DNA2.0) will license Horizon Discovery’s Chinese Hamster Ovary (CHO) SOURCE platform under a cross-license agreement in which Horizon will gain rights to incorporate into the biomanuf...

ChromaTan Wins $2.5M FDA Contract to Develop CCTC Continuous Purification Platform

ChromaTan has won a $2.5 million FDA contract to develop an integrated, continuous downstream purification platform for production of monoclonal antibodies (mAbs). The two-year project will entail...

ChromaTan Wins $2.5M FDA Contract to Develop Integrated Continuous Purification Platform

ChromaTan has won a $2.5 million FDA contract to develop an integrated, continuous downstream purification platform for production of monoclonal antibodies (mAbs). The two-year project will entail...

Growth rate changes in CHO host cells are associated with karyotypic heterogeneity

Chinese hamster ovary (CHO) cell line instability and clonality issues can affect cell culture phenotypes such as cell growth, productivity, or product quality and remain challenges for biopharmaceuti...

Sean Spicer needs you to understand that he wasn't hiding in the bushes. He was 'among' them.

In the immediate aftermath of FBI Director James Comey's firing on May 9, the press looked to the White House press secretary for answers. The only problem? Press Secretary Sean Spicer was evadin...

Polysome Profiling of mAb Producing CHO Cell Lines Links Translational Control of Cell Proliferation and Recombinant mRNA Loading onto Ribosomes with Global and Recombinant Protein Synthesis

mRNA translation is a key process determining growth, proliferation and duration of a Chinese hamster ovary (CHO) cell culture and influences recombinant protein synthesis rate. During bioprocessing, ...

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Genetic characterization of the Turkish gray hamster (Cricetulus migratorius) based on mitochondrial cytochrome b and 12S rRNA sequences.

Although genetic diversity and phylogenetic status of the gray hamster (Cricetulus migratorius) have been investigated from different regions in previous studies, genetic data on this species from Tur...

HAdV-C6 Is a More Relevant Challenge Virus than HAdV-C5 for Testing Antiviral Drugs with the Immunosuppressed Syrian Hamster Model.

Adenovirus infections of immunocompromised patients can cause a severe multi-organ disease that often results in the patients' death. Presently, there are no drugs specifically approved to treat adeno...

Ameloblastoma of the Jaw in Three Species of Rodent: a Domestic Brown Rat (Rattus norvegicus), Syrian Hamster (Mesocricetus auratus) and Amargosa Vole (Microtus californicus scirpensis).

Ameloblastoma is a locally aggressive tumour derived from the odontogenic epithelium of the developing tooth germ. This uncommon odontogenic tumour is generally considered benign, but rarely, both dis...

Lessons from the hamster: Cricetulus griseus tissue and CHO cell line proteome comparison.

Chinese hamster ovary cells represent the dominant host for therapeutic recombinant protein production. However, few large-scale datasets have been generated to characterize this host organism and der...

Karyotype Evolution and Phylogenetic Relationships of Cricetulus sokolovi Orlov et Malygin 1988 (Cricetidae, Rodentia) Inferred from Chromosomal Painting and Molecular Data.

Sokolov's dwarf hamster (Cricetulus sokolovi) is the least studied representative of the striped hamsters (Cricetulus barabensis species group), the taxonomy of which remains controversial. The specie...

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