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04:37 EDT 28th July 2017 | BioPortfolio

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Harms of Nighttime Light Exposure Passed to Offspring

Hamster study finds evidence of immune, endocrine problems

CHO stopper? Biogen looks to alternative cell lines for future of bioproduction

The Chinese hamster ovary (CHO) cell line is not the future for biomanufacturing says Biogen, which will publish results from a study of alternative hosts later this year.

Stable high-level expression of factor VIII in Chinese hamster ovary cells in improved elongation factor-1 alpha-based system

Recombinant factor VIII (FVIII), used for haemophilia A therapy, is one of the most challenging among the therapeutic proteins produced in heterologous expression systems. Deletion variant of FVIII, i...

Researchers develop new tools to optimize CHO cell lines for making biologic drugs

Chinese hamster ovary (CHO) cells are the most commonly used cells to produce biologics—protein-based drugs for treating cancers, autoimmune diseases and much more. CHO cells are the workhorses behi...

Harms of nighttime light exposure passed to offspring: Hamster study finds evidence of immune, endocrine problems

Animals can pass the damaging effects of nighttime light exposure to their offspring, a new study has found, adding to a growing body of evidence that there's a health cost to our increasingly illumin...

Transfection Toolkit

Engineering a mutation or overexpressing a recombinant protein to study and characterize its function in mammalian cells is no easy task. Luckily, Chinese hamster ovary (CHO) cells, which have been a ...

The body relies on thousands of sugar–protein complexes to stay healthy

Over two weeks in 2004, Song Zhiwei witnessed the slow death of a colony of cells. Song, a bioengineer at the A*STAR Bioprocessing Technology Institute (BTI), had bathed a plate of Chinese hamster ova...

ATUM, Horizon Discovery Cross-License Cell-Line Development Technologies

ATUM (formerly DNA2.0) will license Horizon Discovery’s Chinese Hamster Ovary (CHO) SOURCE platform under a cross-license agreement in which Horizon will gain rights to incorporate into the biomanuf...

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HAdV-C6 Is a More Relevant Challenge Virus than HAdV-C5 for Testing Antiviral Drugs with the Immunosuppressed Syrian Hamster Model.

Adenovirus infections of immunocompromised patients can cause a severe multi-organ disease that often results in the patients' death. Presently, there are no drugs specifically approved to treat adeno...

Imaging visceral leishmaniasis in real time with golden hamster model: Monitoring the parasite burden and hamster transcripts to further characterize the immunological responses of the host.

Characterizing the clinical, immunological and parasitological features associated with visceral leishmaniasis is complex. It involves recording in real time and integrating quantitative multi-paramet...

Adverse and beneficial effects in Chinese hamster lung fibroblast cells following radiofrequency exposure.

In this study, the effect of radiofrequency (RF) exposure to 1950 MHz, Universal Mobile Telecommunication System signal, was investigated in Chinese hamster lung fibroblast cell line (V79). Genotoxi...

Karyotype Evolution and Phylogenetic Relationships of Cricetulus sokolovi Orlov et Malygin 1988 (Cricetidae, Rodentia) Inferred from Chromosomal Painting and Molecular Data.

Sokolov's dwarf hamster (Cricetulus sokolovi) is the least studied representative of the striped hamsters (Cricetulus barabensis species group), the taxonomy of which remains controversial. The specie...

Ultra-deep next generation mitochondrial genome sequencing reveals widespread heteroplasmy in Chinese hamster ovary cells.

Recent sequencing of the Chinese hamster ovary (CHO) cell and Chinese hamster genomes has dramatically advanced our ability to understand the biology of these mammalian cell factories. In this study, ...

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