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08:50 EST 9th February 2016 | BioPortfolio

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Intravenously Administered Recombinant Human Type VII Collagen Derived from Chinese Hamster Ovary Cells Reverses the Disease Phenotype in Recessive Dystrophic Epidermolysis Bullosa Mice

Increase CHO Antibody Production Rapidly And Efficiently

Chinese Hamster Ovary (CHO) cells are used extensively to produce recombinant proteins. One of the most challenging aspects of culturing recombinant CHO cell clones is providing the diverse nutritiona...

Cover Picture: Biotechnology Journal 9/2015

The cover of this regular issue of BTJ is inspired by several articles in which Chinese hamster ovary (CHO) cells were used. These articles include metabolite profiling in CHO cells, the one‐step ge...

Horizon seals first-of-its-kind hamster cell deal

Horizon Discover (LON:HZD) has inked an agreement with a leading contract research firm to licence out a cell line that has been adapted for manufacturing conditions. The deal – the first of its k...

Study shows a way to tell if your hamster is happy

(Phys.org)—A pair of researchers at Liverpool John Moores University in the U.K. believe they have found a way to measure happiness in hamsters. In their paper published in Royal Society Open Scien...

A novel regulatory element (E77) isolated from CHO‐K1 genomic DNA enhances stable gene expression in Chinese hamster ovary cells

Vectors flanked by regulatory DNA elements have been used to generate stable cell lines with high productivity and transgene stability; however, regulatory elements in Chinese hamster ovary (CHO) cell...

Mechanisms underlying epigenetic and transcriptional heterogeneity in Chinese hamster ovary (CHO) cell lines

Recombinant cell lines developed for therapeutic antibody production often suffer instability or lose recombinant protein expression during long-term culture. Heterogeneous gene expression among cell ...

Optimizing production of Fc-amidated peptides by Chinese hamster ovary cells

Background: Amidation of the carboxyl terminal of many peptides is essential for full biological potency, often increasing receptor binding and stability. The single enzyme responsible for this reacti...

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Photoperiod regulates the differential expression of KiSS-1 and GPR54 in various tissues and sexes of striped hamster.

In order to investigate how photoperiod affects the expression of KiSS-1/G-protein-coupled receptor 54 (GPR54), the hypothalamus, the ovaries and testicles of the striped hamster were studied followin...

Development of novel DNA markers for genetic analysis of grey hamsters by cross-species amplification of microsatellites.

The grey hamster has been used in biomedical research for decades. However, effective molecular methods for evaluating the genetic structure of this species are lacking, which hinders its wider usage....

A Hamster Model of Diet-Induced Obesity for Preclinical Evaluation of Anti-Obesity, Anti-Diabetic and Lipid Modulating Agents.

Unlike rats and mice, hamsters develop hypercholesterolemia, and hypertriglyceridemia when fed a cholesterol-rich diet. Because hyperlipidemia is a hallmark of human obesity, we aimed to develop and c...

Expression and activity levels of chymase in mast cells of burn wound tissues increase during the healing process in a hamster model.

The present study aimed to investigate the changes in the expression levels and activity of mast cell chymase in the process of burn wound healing in a hamster model of deep second-degree burn. The ha...

Hamster weight patterns predict the intensity and course of Schistosoma haematobium infection.

Although Syrian golden hamsters are a widely used host for experimental infection by Schistosoma haematobium, surprisingly little is known about the course of infection and associated intensity (as de...

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