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03:20 EDT 25th September 2016 | BioPortfolio

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Augmenting Chinese hamster genome assembly by identifying regions of high confidence

Chinese hamster Ovary (CHO) cell lines are the dominant industrial workhorses for therapeutic recombinant protein production. The availability of genome sequence of Chinese hamster and CHO cells will ...

CHO and E. coli Residual DNA Quantification Kit

Product ReleaseBio-Rad’s new ddPCR CHO Residual DNA Quantification Kit and PCR E. coli Residual DNA Quantification Kit allow for direct quantification of host-cell DNA impurities in biopharmace...

Survival of the oldest

The oldest surviving species of vertebrates, such as the cane toad and the California sea lion, which have endured past extreme environmental events, will be more likely to adapt to future climate cha...

Lonza Launches PowerCHO Advance™ Media for Improved Protein-Production Yields

Lonza has launched PowerCHO Advance™ Media, the latest addition to the company’s range of specialized, chemically defined, serum-free media for culturing Chinese Hamster Ovary (CHO) cells....

Novel Genetically Engineered CHO Cells

Chinese hamster ovary (CHO)-based animal component-free (ACF) systems are currently responsible for producing more than $50 billion of therapeutic products a year. The introduction of animal origin-...

Biogen, Gates seek new antibody manufacturing techniques

Biogen Inc. (NASDAQ:BIIB) said it will co-fund a project with the Bill & Melinda Gates Foundation to improve production and manufacturing techniques for antibody-based therapies. Biogen said the initi...

Pharmaceutical Research: Targeted Delivery of Epirubicin to Cancer Cells by Polyvalent Aptamer System in vitro and in vivo

Type: Original PaperPurposeThe clinical use of Epirubicin (Epi), as an anthracycline drug, is limited because of its cardiotoxicity. Here, an Epirubicin (Epi)-modified polyvalent aptamer system (MPAS)...

Bio-Rad ddPCR CHO and E. coli Residual DNA Quantification Kits

Bio-Rad Laboratories has announced the launch of two residual DNA quantification (RDQ) kits to simplify the quantification of host-cell DNA (HCD) in process development, quality control and biomanufac...

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Chemopreventive effect of Toona sinensis leaf extract on 7,12-dimethylbenzaanthracene-induced hamster buccal pouch squamous cell carcinogenesis.

Toona sinensis leaf extract (TSL) has been shown to have anti-tumor effects on cancer cell lines. This study aimed to investigate the chemopreventive potential and the underlying mechanism of TSL duri...

A synthetic biology standard for Chinese Hamster Ovary cell genome monitoring and contaminant detection by polymerase chain reaction.

Chinese Hamster Ovary (CHO) cells are the current industry standard for production of therapeutic monoclonal antibodies at commercial scales. Production optimisation in CHO cells hinges on analytical ...

Antibacterial and Solubility Optimization of Thiomuracin A.

Synthetic studies of the antimicrobial secondary metabolite thiomuracin A (1) provided access to analogs in the Northern region (C2-C10). Selective hydrolysis of the C10 amide of lead compound 2 and s...

Seasonal differential expression of KiSS-1/GPR54 in the striped hamsters (Cricetulus barabensis) among different tissues.

Kisspeptins and G protein coupled receptor (GPR54) play significant roles in regulating reproductive activity among seasonal reproductive animals; however, the mechanisms of KiSS-1 and GPR54 gene affe...

Comprehensive Transcriptome Analyses of the Fructose-Fed Syrian Golden Hamster Liver Provides Novel Insights into Lipid Metabolism.

Dyslipidemia has been widely proven to contribute to cardiovascular diseases and other metabolic disorders, especially in insulin resistance and type 2 diabetes. The overproduction of VLDL is a signif...

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