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21:26 EST 22nd January 2017 | BioPortfolio

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Evaluating the use of a CpG free promoter for long-term recombinant protein expression stability in Chinese hamster ovary cells

Methylated CpG dinucleotides in promoters are associated with the loss of gene expression in recombinant Chinese hamster ovary (CHO) cells during large-scale commercial manufacturing. We evaluated a p...

Bioengineering resistance to Minute Mouse Virus (MVM) in Chinese Hamster Ovary (CHO) cells

MVM contamination is one of the biggest threats to CHO cells in the biopharmaceutical manufacturing industry. The post Bioengineering resistance to Minute Mouse Virus (MVM) in Chinese Hamster Ovary (...

Synpromics to develop synthetic promotors for GE’s CHO platform

GE Healthcare hopes to increase the yield of biopharmaceuticals made using its Chinese Hamster Ovary (CHO) expression system through a partnership with synthetic biology firm Synpromics.

Synpromics and GE Healthcare to extend the biologics production toolbox

Synpromics will develop a complex barcoded library of synthetic promoters, using its proprietary PromPT platform, for extensive screening in GE Healthcare s Chinese Hamster Ovary (CHO)-based expressio...

#news #biotech New computational model provides a tool for improving the production of valuable drugs

// An extensive study involving partners from five continents has resulted in a model describing the metabolism of Chinese hamster ovary cells (CHO). This model can be used to improve and accelerate t...

Optimizing Protein Expression

Like a train that consists of a particular sequence of cars, from locomotive to caboose, proteins can only “leave the station” after each of its segments, amino acids, are hooked togethe...

Novel Genetically Engineered CHO Cells

Chinese hamster ovary (CHO)-based animal component-free (ACF) systems are currently responsible for producing more than $50 billion of therapeutic products a year. The introduction of animal origin-...

Biogen, Gates seek new antibody manufacturing techniques

Biogen Inc. (NASDAQ:BIIB) said it will co-fund a project with the Bill & Melinda Gates Foundation to improve production and manufacturing techniques for antibody-based therapies. Biogen said the initi...

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Chemopreventive effect of Toona sinensis leaf extract on 7,12-dimethylbenzaanthracene-induced hamster buccal pouch squamous cell carcinogenesis.

Toona sinensis leaf extract (TSL) has been shown to have anti-tumor effects on cancer cell lines. This study aimed to investigate the chemopreventive potential and the underlying mechanism of TSL duri...

Imaging visceral leishmaniasis in real time with golden hamster model: Monitoring the parasite burden and hamster transcripts to further characterize the immunological responses of the host.

Characterizing the clinical, immunological and parasitological features associated with visceral leishmaniasis is complex. It involves recording in real time and integrating quantitative multi-paramet...

A synthetic biology standard for Chinese Hamster Ovary cell genome monitoring and contaminant detection by polymerase chain reaction.

Chinese Hamster Ovary (CHO) cells are the current industry standard for production of therapeutic monoclonal antibodies at commercial scales. Production optimisation in CHO cells hinges on analytical ...

Adverse and beneficial effects in Chinese hamster lung fibroblast cells following radiofrequency exposure.

In this study, the effect of radiofrequency (RF) exposure to 1950 MHz, Universal Mobile Telecommunication System signal, was investigated in Chinese hamster lung fibroblast cell line (V79). Genotoxi...

Antibacterial and Solubility Optimization of Thiomuracin A.

Synthetic studies of the antimicrobial secondary metabolite thiomuracin A (1) provided access to analogs in the Northern region (C2-C10). Selective hydrolysis of the C10 amide of lead compound 2 and s...

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