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00:25 EDT 30th May 2015 | BioPortfolio

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Safety and antitumor effect of oncolytic and helper-dependent adenoviruses expressing interleukin-12 variants in a hamster pancreatic cancer model

Horizon Discovery enters crowded CHO cell line market

Horizon Discovery Group announced Monday that its bioproduction division has shipped its first commercially available engineered CHO (Chinese Hamster Ovary) cell line for use in manufacturing of antib...

Production of human polyclonal neutralizing antibodies in cattle

In vitro and hamster studies suggest polyclonal neutralizing antibodies produced by vaccination of genetically modified cattle - transchromosomal bovines (TcBs) - could be used to treat viral infectio...

Horizon Discovery lands a share of £1.67m Biotech research grant

The CEO of AIM listed Biotech research group Horizon Discovery (LON:HZD) tells Proactiveinvestors about their latest joint venture Genomics project. Darrin Disley is confident that their research...

CHOgenome.org 2.0: Genome resources and website updates

Chinese hamster ovary (CHO) cells are a major host cell line for the production of therapeutic proteins, and CHO cell and Chinese hamster (CH) genomes have recently been sequenced using next‐generat...

Horizon Discovery consortium lands £6.2mln govt funding

Horizon Discovery (LON:HZD) is part of a group of firms has won £6.2mln of government funding designed to improve the global competitiveness of UK businesses. The consortium is led by the Centre...

Medvet licenses cell line for cancer antibody

South Australia’s Medvet Science has licensed a cell line from ACYTE Biotech to produce its monoclonal cancer antibody APOMAB.Medvet has arranged to use ACYTE’s XL-99 Chinese hamster ovary cell li...

Direct analysis of mAb aggregates in mammalian cell culture supernatant

Background: Protein aggregation during monoclonal antibody (mAb) production can occur in upstream and downstream processing (DSP). Current methods to determine aggregate formation during cell culture ...

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Sequencing, Annotation and Analysis of the Syrian Hamster (Mesocricetus auratus) Transcriptome.

The Syrian hamster (golden hamster, Mesocricetus auratus) is gaining importance as a new experimental animal model for multiple pathogens, including emerging zoonotic diseases such as Ebola. Neverthel...

Effective cryopreservation of golden Syrian hamster embryos by open pulled straw vitrification.

Golden Syrian hamster embryos are difficult to cryopreserve due to their high sensitivity to cryoprotectants and in vitro handling. The objective of this study is to develop a robust open pulled stra...

Annotation of additional evolutionary conserved microRNAs in CHO cells from updated genomic data.

MicroRNAs are small non-coding RNAs that play a critical role in post-transcriptional control of gene expression. Recent publications of genomic sequencing data from the Chinese Hamster (CGR) and Chin...

The promoting effect of carbamide peroxide teeth bleaching gel in a preclinical model of head and neck cancer in hamster buccal pouch.

The aim of this study was to verify the promoting effect of carbamide peroxide on dimethylbenzanthracene (DMBA)-induced carcinogenesis in the hamster buccal pouch, in order to reduce the period of lat...

Efficient Gene Targeting in Golden Syrian Hamsters by the CRISPR/Cas9 System.

The golden Syrian hamster is the model of choice or the only rodent model for studying many human diseases. However, the lack of gene targeting tools in hamsters severely limits their use in biomedica...

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