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05:01 EDT 30th April 2016 | BioPortfolio

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Increase CHO Antibody Production Rapidly And Efficiently

Chinese Hamster Ovary (CHO) cells are used extensively to produce recombinant proteins. One of the most challenging aspects of culturing recombinant CHO cell clones is providing the diverse nutritiona...

A novel regulatory element (E77) isolated from CHO‐K1 genomic DNA enhances stable gene expression in Chinese hamster ovary cells

Vectors flanked by regulatory DNA elements have been used to generate stable cell lines with high productivity and transgene stability; however, regulatory elements in Chinese hamster ovary (CHO) cell...

Mechanisms underlying epigenetic and transcriptional heterogeneity in Chinese hamster ovary (CHO) cell lines

Recombinant cell lines developed for therapeutic antibody production often suffer instability or lose recombinant protein expression during long-term culture. Heterogeneous gene expression among cell ...

Lonza Launches PowerCHO Advance™ Media for Improved Protein-Production Yields

Lonza has launched PowerCHO Advance™ Media, the latest addition to the company’s range of specialized, chemically defined, serum-free media for culturing Chinese Hamster Ovary (CHO) cells....

Lonza PowerCHO Advance Media

Lonza has launched PowerCHO Advance Media, the latest addition to the company’s range of specialised, chemically defined, serum-free media for culturing Chinese hamster ovary (CHO) cells. The media...

Transcriptome study and identification of potential marker genes related to the stable expression of recombinant proteins in CHO clones

Background: Chinese hamster ovary (CHO) cells have become the host of choice for the production of recombinant proteins, due to their capacity for correct protein folding, assembly, and posttranslatio...

Trends in mammalian cell cultures

LONDON, Feb. 3, 2016 /PRNewswire/ -- With the growing need for better therapeutics, and the current patent cliff that is underway, therapies such as monoclonal antibodies, recombinant protein the...

Baxalta Gains EU Marketing Authorization to Provide OBIZUR to Adult Patients with Acquired Haemophilia A

OBIZUR is the only approved treatment in Europe for acquired haemophilia A that enables physicians to monitor treatment response by measuring FVIII activity levels, h...

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Photoperiod regulates the differential expression of KiSS-1 and GPR54 in various tissues and sexes of striped hamster.

In order to investigate how photoperiod affects the expression of KiSS-1/G-protein-coupled receptor 54 (GPR54), the hypothalamus, the ovaries and testicles of the striped hamster were studied followin...

Development of novel DNA markers for genetic analysis of grey hamsters by cross-species amplification of microsatellites.

The grey hamster has been used in biomedical research for decades. However, effective molecular methods for evaluating the genetic structure of this species are lacking, which hinders its wider usage....

A Hamster Model of Diet-Induced Obesity for Preclinical Evaluation of Anti-Obesity, Anti-Diabetic and Lipid Modulating Agents.

Unlike rats and mice, hamsters develop hypercholesterolemia, and hypertriglyceridemia when fed a cholesterol-rich diet. Because hyperlipidemia is a hallmark of human obesity, we aimed to develop and c...

Expression and activity levels of chymase in mast cells of burn wound tissues increase during the healing process in a hamster model.

The present study aimed to investigate the changes in the expression levels and activity of mast cell chymase in the process of burn wound healing in a hamster model of deep second-degree burn. The ha...

Hamster weight patterns predict the intensity and course of Schistosoma haematobium infection.

Although Syrian golden hamsters are a widely used host for experimental infection by Schistosoma haematobium, surprisingly little is known about the course of infection and associated intensity (as de...

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