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16:50 EDT 29th March 2017 | BioPortfolio

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Bioengineering resistance to Minute Mouse Virus (MVM) in Chinese Hamster Ovary (CHO) cells

MVM contamination is one of the biggest threats to CHO cells in the biopharmaceutical manufacturing industry. The post Bioengineering resistance to Minute Mouse Virus (MVM) in Chinese Hamster Ovary (...

The Austrian Center of Industrial Biotechnology collaborates with GE Healthcare

Biospectrum The goal of the three-year partnership is to explore and identify new tools and methods to modify and optim...

Synpromics to develop synthetic promotors for GE’s CHO platform

GE Healthcare hopes to increase the yield of biopharmaceuticals made using its Chinese Hamster Ovary (CHO) expression system through a partnership with synthetic biology firm Synpromics.

Synpromics and GE Healthcare to extend the biologics production toolbox

Synpromics will develop a complex barcoded library of synthetic promoters, using its proprietary PromPT platform, for extensive screening in GE Healthcare s Chinese Hamster Ovary (CHO)-based expressio...

Stable high-level expression of factor VIII in Chinese hamster ovary cells in improved elongation factor-1 alpha-based system

Recombinant factor VIII (FVIII), used for haemophilia A therapy, is one of the most challenging among the therapeutic proteins produced in heterologous expression systems. Deletion variant of FVIII, i...

#news #biotech New computational model provides a tool for improving the production of valuable drugs

// An extensive study involving partners from five continents has resulted in a model describing the metabolism of Chinese hamster ovary cells (CHO). This model can be used to improve and accelerate t...

Austrian Research Center and GE Healthcare Seek to Boost CHO Cell Line Engineering

The Austrian Centre of Industrial Biotechnology (acib) and GE Healthcare agreed to collaborate on a cell line engineering program to bring increased productivity to biomanufacturers. The goal of the t...

Integrated Genome and Protein Editing Swaps α‐2,6 Sialylation for α‐2,3 Sialic Acid on Recombinant Antibodies from CHO

Immunoglobin G with α‐2,6 sialylation has been reported to have an impact on antibody‐depend cellular cytotoxicity and anti‐inflammatory efficacy. However, production of antibodies with α‐2,...

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Chemopreventive effect of Toona sinensis leaf extract on 7,12-dimethylbenzaanthracene-induced hamster buccal pouch squamous cell carcinogenesis.

Toona sinensis leaf extract (TSL) has been shown to have anti-tumor effects on cancer cell lines. This study aimed to investigate the chemopreventive potential and the underlying mechanism of TSL duri...

Imaging visceral leishmaniasis in real time with golden hamster model: Monitoring the parasite burden and hamster transcripts to further characterize the immunological responses of the host.

Characterizing the clinical, immunological and parasitological features associated with visceral leishmaniasis is complex. It involves recording in real time and integrating quantitative multi-paramet...

A synthetic biology standard for Chinese Hamster Ovary cell genome monitoring and contaminant detection by polymerase chain reaction.

Chinese Hamster Ovary (CHO) cells are the current industry standard for production of therapeutic monoclonal antibodies at commercial scales. Production optimisation in CHO cells hinges on analytical ...

Adverse and beneficial effects in Chinese hamster lung fibroblast cells following radiofrequency exposure.

In this study, the effect of radiofrequency (RF) exposure to 1950 MHz, Universal Mobile Telecommunication System signal, was investigated in Chinese hamster lung fibroblast cell line (V79). Genotoxi...

Antibacterial and Solubility Optimization of Thiomuracin A.

Synthetic studies of the antimicrobial secondary metabolite thiomuracin A (1) provided access to analogs in the Northern region (C2-C10). Selective hydrolysis of the C10 amide of lead compound 2 and s...

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