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- LeadDiscovery Case Study 1 - Pharmaceutical approaches to COPD
- LeadDiscovery - Therapeutic Advances
- LeadDiscovery - Therapeutic Advances - Target of the Month
- Role of the intestinal tight junction modulator zonulin in the pathogenesis of type I diabetes in BB diabetic-prone rats.
- Targeting beta-catenin by celecoxib (Celebrex) as an anti-cancer mechanism of action and as a lead for the identification of improved oncology agents
- MPEP a prototypical glutamate (mGlu5) receptor antagonist with similar anxiolytic efficacy compared to diazepam but with reduced cognitive adverse effects.
- Eisai's retinoic acid (RAR)-alpha receptor agonist as a candidate therapy for the treatment of lupus nephritis
- SOCS1 silencing dramatically increases the anti-cancer efficacy of dendritic cell vaccines
- Novel 3-oxa lipoxin A4 analogues with enhanced chemical and metabolic stability have anti-inflammatory activity in vivo.
- Exploiting the peptide uptake transporters PEPT1 and PEPT2 to improve drug absorption and targeting
- Insulin Use in Type 2 Diabetes - From Last Resort to Early Intervention
- MBD2 inhibition identified as a selective strategy for reducing tumor growth
- The effects of insulin on airway function: repercussions for intra-tracheal insulin delivery and for asthma therapeutics
- Janus tyrosine kinase 3 inhibition for the prevention of transplant rejection
- NVP-LAQ824 a novel histone deacetylase inhibitor
- Cx43 as a target for improved wound healing
- Development of GSK-3 inhibitors by GlaxoSmithKline and by Johnson & Johnson
- HDAC7: A novel target for autoimmune disorders
- Ki-67 as a target for anticancer strategies
- Successful gene therapy of pulmonary hypertension
- MAPK/ERK-kinase inhibitors as a promising strategy for the treatment of neuropathic pain
- Retinoids as candidate targets for alzheimer’s disease treatment
- PI3K inhibitors: Targeting multiple tumor progression pathways
- Gap junctions: The future of cancer therapy and prevention?
- Advances in Kv1.3 channel research
- Sigma(1) agonists offer hope to Alzheimer’s disease patients
- BMS-191095, a K(ATP) channel opener with improved cardioprotective properties
- Survivin as a target for cancer therapy
- GSK-3: A target for Alzheimer's disease
- Melatonin: An emerging target for multiple conditions
- Stat5: A target for immunological and neoplastic disease
- Protein kinase D: A signalling molecule with multiple therapeutic implications
- Leptin: a target for a growing list of conditions
- The interleukin-10 family of cytokines
- Serotonin 5-HT7 receptor antagonists as candidate migraine therapies
- PLA2, an unexploited target for inflammation and infectious diseases
- Hemostasis modulators: The next generation of anticancer molecules?
- GSK-3 inhibitors for diabetes, Alzheimer's disease, stroke and manic depression
- The broad based therapeutic potential of PARP-1 inhibitors
- Casomorphins as possible anti-tumor/analgesic candidates for cancer treatment
- Preventing neural cell death and improving memory in Alzheimer's disease
- Endostatin as a lead anti-angiogenic treatment
- Histone deacetylase inhibitors: An emerging class of anti-cancer drugs
- LeadDiscovery - Therapeutic Advances - Focus on Airway diseases
- Histone deacetylase 2 (HDAC2): Modulation of HDAC2 and its implication for chronic obstructive airway diseases (COPD) and cancer.
- Improved assay technology for the evaluation of airway therapeutic activity or toxicology
- Inspire’s Denufosol tetrasodium (INS37217), a selective P2Y(2) agonist showing promise for the treatment of cystic fibrosis.
- ISIS 101757: ISIS Pharmaceuticals' p38 MAPK antisense - a candidate treatment of asthma
- Estrogen receptors regulate pulmonary alveolus formation and estrogen is required for alveolar architectural stability, and induces alveolar regeneration in mice.
- The development of a dual 5-LO inhibitor/H1 receptor antagonist for the treatment of asthma
- Key Trends in the Asthma and COPD Market - Uncertain times for novel inhalation devices
- Selectin - its role as a target for airway disorders
- Blocking the CXCL10:CXCR3 axis for the treatment of COPD
- Effects of Phosphodiesterase 4 (PDE4) inhibition on host defense
- PDE4D: A target for the treatment of airway hyper-responsiveness in asthma
- IDEC-152 as a candidate treatment of asthma
- AWD 12-281, a PDE4 inhibitor with low emetic potential
- Syk tyrosine kinase as a target for asthma
- Suplatast tosilate: Anti-asthma properties
- Targeting NKT cells for the treatment of asthma
- The role of VEGF in emphysema
- Improved PDE4 inhibitors
- Potential benefits of retinoid treatment to COPD sufferers
- A small molecule inhibitor of VLA-4 for the treatment of allergic airway disease
- Treating corticosteroid resistant airway disease
- Steroid treatment of COPD: relationship to MMP-9
- Targeting phosphodiesterases for the treatment of pulmonary hypertension
- Targeting phosphodiesterases for the treatment of pulmonary hypertension
- Novel approaches to cystic fibrosis
- Breakthroughs in cystic fibrosis?
- LXA4 mimics as asthma therapies
- Histone acetylation: A target for asthma
- ADAM33: A novel target for asthma
- STAT6: A key pathological target for localized treatment of asthma
- MMP-9 as a target for COPD
- Increased expression of the human Ca2+-activated Cl- channel 1 (CaCC1) gene in the asthmatic airway.
- CD44 mimics as candidates for the treatment of asthma
- Novel inhibitors of cell adhesion for the treatment of asthma
- NVP-ABE171, a selective PDE4D inhibitor for the treatment of airway inflammatory disease
- CCR3 antagonists for the treatment of allergy
- Galectin 14, a novel galectin with potential as an asthma target
- IL-18 antagonists as potential treatments of acute airway
- IL-13 blockade as a therapeutic intervention for asthma
- Experimental models of COPD: A critical review
- Ecalectin: a novel eosinophil-activating factor
- LeadDiscovery - Therapeutic Advances - Focus on Oncology
- Potential barriers to the development of HSP-90 inhibitors as treatments for cancer.
- CKBM as a candidate anticancer therapeutic: p53 induction, G2/M arrest and apoptosis as mechanisms of action
- Dual Methionine aminopeptidase MetAP-1 and MetAP-2 inhibition as a candidate approach to tumor and endothelial cell cytostasis
- Strategies for improving the selectivity of VEGFR-2 targeted angiogenesis inhibitors
- Actin Inhibition: The identification of PTX-2 as a novel anti-mitotic agent that selectively induces apoptosis in p53 deficient cancer cells
- Novel non-hydroxamic histone deactylase (HDAC) inhibitors in development from Miikana
- MGI Pharma's 5HT3 antagonist, Aloxi (palonosetron), is effective against delayed emesis following the administration of highly emetic chemotherapy
- Proof of concept for targeting hepatocellular carcinoma with inhibitors of EGFR1 (HER1) such as Iressa and Tarceva
- Potent antitumor activity of interleukin-27
- Cytokine targeting of dendritic cells to tumors produces dramatic anti-cancer activity
- NicOx's NO-ASA, NCX 4040, reduces the developement of intestinal tumors
- Broad based inhibition of multidrug resistance proteins for improved cancer treatment
- Targeting oncolytic viruses to colorectal tumors
- Increasing the anticancer efficacy of docetaxel by ERK inhibitors
- Advances in the development of histone deacetylase inhibitors
- siRNA blocking CXCR4 expression limits metastasis
- Development of an oncolytic virus targeted to the hypoxic tumor milieu
- Leptin and its role in tumor progression
- Cpd 5, a novel Cdc25A inhibitor with anticancer activity
- Aurora2 inhibitors for the treatment of cancer
- Oncolytic viruses as a means of improving radiation therapy
- ATN-161, and integrin antagonists that reduces angiogenesis and tumor progression
- Reintroducing retinoid sensitivity to breast cancer cells
- A-161906 a TGF-beta-like agonist that acts via histone deacetylase inhibition
- Advances in anticancer retinoids
- Combined use of histone deacetylase and methylation inhibitors for improved tumor control
- Combined use of histone deacetylase and methylation inhibitors for improved tumor control
- EphA2 ligands as specific inhibitors of tumor angiogenesis
- Cathepsin-D: A novel approach to breast cancer
- Unleashing the therapeutic potential of maspin
- Chromatin methylation: An approach to gene silencing
- Targeting Critical Regions of Genomic DNA with DNA-Damaging Agents
- Novel histone deacetylase inhibitors
- Stat1 negatively regulates angiogenesis, tumorigenicity and metastasis of tumor cells.
- Preventing the attachment of metastatic cells to distant vasculature
- Novel Sulindac derivatives as candidate anti-cancer drugs
- Bisphosphonates prevent tumor progression as well as metastatic bone destruction
- Targeting platelets in the treatment of cancer
- An anti-metastatic non-toxic tetracycline derivative
- LeadDiscovery/0415.htm
- IL-6 induces multidrug resistance in breast cancer
- Reversing resistance to chemotherapy
- CLN3 boosts ceramide production with dramatic anti-cancer activity
- LeadDiscovery - Therapeutic Advances - Focus on Cardiovascular Disease
- LOXIN, an isoform of the oxidized low-density lipoprotein receptor LOX-1, protects against macrophage apoptosis and may confer plaques stabilizing activity as well as protection against myocardial infarction
- The combined use of angiotensin receptor blockers and long-acting calcium channel blockers as an effective approach to hypertension
- Renalase as a new target for the treatment of cardiovascular disease particularly amongst patient with end-stage renal disease
- Long term beta adrenergic receptor blockade following myocardial infarction promotes myocardial angiogenesis
- Efficacy and safety of Guidant's everolimus eluting stent system.
- Increased Expression of Transforming Growth Factor-{beta}1 as a Stabilizing Factor in Human Atherosclerotic Plaques.
- Sitaxentan as an effective treatment of pulmonary arterial hypertension
- MIF as a target for atherogenesis
- Tamoxifen as a dual chemopreventative and anti-atherosclerosis treatment
- PDE5 inhibition as a treatment of pulmonary hypertension
- The involvement of PDE4D in stroke
- Targeting PDE5 for the treatment of pulmonary hypertension
- Targeted delivery of thrombolytics to newly formed thrombi
- Lithium as a treatment for stroke
- A stable preparation of PGI2 as an effective treatment of stroke
- Recombinant VEGF improves angina
- HO-1 as a target for ischemic disease
- SSR69071: A highly potent elastase inhibitor
- Further benefits of targeting angiotensin for the prevention of stroke
- RWJ-58259 a PAR-1 antagonist with antithrombotic activity
- FGF-4 gene transfer as a treatment of limb ischemia
- Fractalkine:CX3CR1 binding as a target for coronary artery disease
- Fractalkine:CX3CR1 binding as a target for coronary artery disease
- DPC423, a selective inhibitor of factor Xa for the treatment of thrombotic diseases
- Microplasmin as an improved treatment of stroke
- PAR-2: A therapeutic target for limb ischemia
- The role of angiotensin in ischemic stroke
- Angiotensin II receptor antagonists prevent atherosclerosis
- YM358: An AT1 receptor antagonist for the prevention and treatment of myocardial infarction
- Treatment of peripheral vascular disease with rFGF-2
- Fractalkine receptor antagonists: Novel approaches to stroke
- NCX4016 (NO-aspirin) reduces infarct size and suppresses arrhythmias following myocardial ischaemia/reperfusion in pigs.
- Neuroserpin as a candidate neuroprotective in the treatment of stroke
- Prourokinase variants as improved thrombolytics
- The therapeutic opportunities of targeting MCP-1
- P2 receptors: new potential players in atherosclerosis
- FR183998 inhibits Na+/H+ exchange and IL-8 accumulation following cardiac ischemia
- CB1 antagonists reduce survival rates following experimental myocardial infarction
- Ezetimibe prevents the development of artherosclerosis
- Identification of relaxin receptors
- Expanding the possible indication of erythropoietin from anemia to CNS disease
- LeadDiscovery/0513.htm
- LeadDiscovery - Therapeutic Advances - Focus on Metabolic Disease
- FGF-21 as a candidate for the treatment of diabetes
- Vanilloid receptor desensitization as a strategy for improving glucose tolerance as well as reducing diabetic neuropathic pain
- Developing gene therapy approaches to target GLP-1 independently of dipeptidyl peptidase IV (DPP IV): New approaches to the treatment of diabetes
- The potential benefit of statins in the treatment of lupus
- Clinical data further demonstrates the efficacy of Pfizer's pregabalin (Lyrica) in the treatment of diabetic neuropathic pain
- Kv1.3 potassium channel blockade as an approach to insulin resistance
- COX-2 inhibitors limit cachexia as well as tumor progression
- LG100268 (LG268) as an appetite suppressor and insulin sensitizing agent
- Alpha(v)beta(3) integrin antagonism as a treatment of osteoporosis
- 11beta-hydroxysteroid dehydrogenase inhibition reduces insulin resistance
- Stimulating Munc1-13 as a means of increasing insulin release
- Stearoyl-CoA desaturase (SCD) as a target for diabetes
- Bone hypoxia: A contributor to bone fracture
- Kv1.3 potassium channels as targets for the treatment of obesity
- Treatments for pulmonary hypertension
- A novel target for osteoporosis
- NO and NMDA in the control of osteoclast function
- Mitofusin 2: a regulator of energy expenditure that contributes to the development of obesity
- Targeting RXR receptors for the treatment of diabetes and obesity
- Matrix metalloproteinases, an emerging target for obesity
- Neuropeptide Y involvement in insulin resistance
- JNK1 as a promising target for obesity, diabetes and insulin resistance
- JNK1 as a promising target for obesity, diabetes and insulin resistance
- GSK-3 inhibition as a strategy for improving glucose handling in diabetes
- Modulating insulin receptor phosphorylation as a treatment for diabetes
- PMT13, a novel PPARgamma agonist for the treatment of diabetes and obesity
- Endothelin as a factor underlying insulin resistance
- The link between diabetes and erectile dysfunction
- SREBP-1: A target for insulin resistance
- LeadDiscovery/0454.htm
- Advances in the development of insulin analogues
- Failure of eating to trigger ghrelin reduction in obesity
- Acute effect of L-796568, a novel beta 3-adrenergic receptor agonist, on energy expenditure in obese men.
- Advances in artificial insulin secreting cells
- DGAT1, a target for obesity and diabetes
- Exploiting the anorectic and insulin sensitizing activity of endogenous leptin
- Improved targets for diabetic retinopathy
- Adenosine A1 receptor agonists as therapeutic candidates for diabetes
- Targeting the link between aging and obesity
- Leptin uptake by the brain
- LeadDiscovery - Therapeutic Advances - Focus on Immunology and Inflammatory Disease
- Optimizing gene transfection strategies for the targeted treatment of rheumatoid arthritis
- Viramidine (Valeant Pharmaceuticals), a ribavirin prodrug for the improved treatment of hepatitis C (HCV) infection: reduced anemia with similar efficacy compared to ribavirin
- Valeant Pharmaceuticals' remofovir mesylate, an improved adefovir prodrug for targeted and tolerable treatment of hepatitis B (HBV) infection
- Advances in Introgen's oncolytic virus INGN 241 drive forward the field of anti-cancer viral therapies
- Efficacy and safety of ABI793, a novel human anti-human CD154 monoclonal antibody, in cynomolgus monkey renal allotransplantation.
- Drug delivery technology predicted to allow safer and more effective use of steroids in the treatment of rheumatoid arthritis
- Stakeholder Insight: Rheumatoid Arthritis DMARDs Gain Ground as Biologics Competition Intensifies
- Dual MMP and TACE inhibition as a treatment of rheumatoid arthritis
- HDAC inhibitors for the treatment of rheumatoid arthritis
- FR167653, a candidate p38 MAPK inhibitor for the treatment of rheumatoid arthritis
- VEGFR-1 as a target for rheumatoid arthritis therapies
- Blocking Tie-2 as a treatment of rheumatoid arthritis
- Ribozyme technology as an effective approach to HBV infection
- Kv1.3 potassium channel blockade as an immunomodulatory strategy
- FTY720 as a treatment for multiple sclerosis
- A pilot trial of SCH55700, a humanized monoclonal antibody to IL-5
- The role of p-glycoprotein in intestinal damage
- IL-2 antibodies as an effective treatment of ulcerative colitis
- Clinical potential of retinoid RAR antagonists in arthritis
- SangStat’s RDP58 as a novel anti-inflammatory
- TNF anti-sense oligonucleotides for the treatment of chronic inflammation
- T-614 induces bone formation offering improved treatment of rheumatoid arthritis
- Peripheral benzodiazapine receptors as a target for rheumatoid arthritis
- CD200Fc, a treatment for autoimmune disease
- Rho inhibitors for the blockade of IL-8 release during inflammatory disease?
- MCC-478: a promising new anti-HBV agent
- Endomorphins: Improved analgesia and anti-inflammatory molecules
- Capsiates: Anti-inflammatory activity without VR1 binding
- PDE4 inhibitors for the treatment of atopic dermatitis
- Effective therapy of Crohn's disease
- A novel peptide derivative exhibits anti inflammatory and antioxidant activity in adjuvant induced arthritis in rats.
- Treatment of IBD through selective prostaglandin receptor agonists?
- A novel CsA receptor (cyclophilin) ligand with exciting anti-inflammatory activity
- Angiogenesis inhibitors for the treatment of arthritis
- Misoprostol enhances the analgesic activity of NSAIDs
- Improved anti-inflammatory PDE IV inhibitors
- HS 378, a novel immunomodulatory candidate
- MAPK inhibitors as novel treatments for Crohn's disease
- NSAIDs vs COX-2 inhibitors for osteoarthritis
- Novel roles of p-glycoprotein
- LeadDiscovery - Therapeutic Advances - Focus on Pain
- Advances in the development of Cav2.2 (N-type) calcium channel blockers as analgesics.
- A-425619: A TRPV1 receptor antagonist with potential for the treatment of inflammatory, postoperative and arthritic pain
- CB2 cannabinoid receptor agonists offer analgesia against neuropathic and other types of pain despite their lack of binding within the CNS
- Corticotropin-releasing hormone (CRH) produces analgesia in a thermal injury model independent of its effect on systemic beta-endorphin and corticosterone.
- New data reveals that the anti-epileptic drug ethosuximide is an effective treatment for chemotherapy-evoked pain
- HIV Related Neuropathic Pain - Useful Niche for Peripheral Companies
- Diabetic Neuropathic Pain - Market Success is Not Limited to Pregabalin
- Neuropathic Pain - Comparative Overview of Treatment Preferences Across the Seven Major Markets
- Novartis' COX-2 inhibitor, Lumiracoxib reduces cancer pain
- JTC-801 an orally active ORL1 antagonist for the treatment of neuropathic pain
- 5-HT3 receptor antagonists as analgesics
- T-type Ca2+ channel involvement in visceral pain
- Cannabinoid receptor ligands in the treament of pain
- HSV transfer of Glial cell-derived neurotrophic factor (GDNF) as a treatment of pain
- F 13640, a novel candidate analgesic
- A potent VR1 receptor antagonist blocks inflammatory and neuropathic pain
- F 13640, an exciting candidate analgesic
- H3 agonists as prophylactic treatments of migraine
- Newron’s NW-1029, a candidate for inflammatory and neuropathic pain
- Postsynaptic density protein-95 (PSD-95) as a target for neuropathic pain
- NaV1.8, a sodium channel target for the treatment of chronic pain
- Nociceptin:ORL-1 as a target for analgesia
- The involvement of 5-HT1B/1D receptors in trigeminal pain pathways
- BDNF receptor antagonists as anti-nociceptives
- Orexin as a target for pain
- Modulators of VR1: A novel approach to analgesia
- HSP90 modulated VR1 function
- LeadDiscovery - Therapeutic Advances - Focus on CNS Disease
- Blockers of the low voltage activated calcium channel (also know as the T-type calcium channel) as a neuroprotective approach to stroke
- Simvastatin as a disease modifying immunoregulatory candidate treatment of Parkinson's disease
- Taishi's 20-HETE synthesis inhibitor, TS-011 as a candidate acute treatment for hemorrhagic and ishemic stroke
- Efficacy and improved tolerability of Hypericum perforatum extract, WS 5570, compared to paroxetine in patients with moderate to severe depression
- Abbott's H3 histamine receptor antagonist, ABT-239, a candidate treatment of cognitive disorders, ADHD, Alzheimer's and schizophrenia
- Relapse prevention in bipolar I disorder: 18-month comparison of olanzapine plus mood stabiliser v. mood stabiliser alone.
- Growing evidence for a link between type 2 diabetes and Alzheimer's disease
- Potential for Cross-Risk Factor Combinations: Targeting Hypertension, Dyslipidemia and Diabetes
- Aricept versus Reminyl in the treatment of Alzheimer’s disease
- Regulation of GSK 3b by beta amyloid and ApoE4
- Novel corticotropin-releasing factor (CRF) receptor antagonists as effective anxiolytics
- Efficacy of the mixed 5-HT2 antagonist/SSRI, nefadozone in Parkinson’s disease
- RS-1259, a dual inhibitor of AChE and SERT for treating Alzheimers disease
- CB2 receptor agonists with anagesic activity
- Development of highly potent inhibitors of the cannabinoid transporter
- Muscarinic receptor activation reduces Abeta1-42 in Alzheimer’s disease
- Induction of NGF as a treatment of Alzheimer’s disease
- Astrocytes as a target for Alzheimers disease therapeutics
- GSK-3 in the etiology of schizophrenia
- Increasing central leptin levels reduces obesity
- Effects of ghrelin on memory and behavior
- Targeting the Inhibitor of Apoptosis family for the treatment of neurodegenerative disorders
- Further evidence linking GSK-3 to Alzheimer’s disease
- Advances in Alzheimer’s disease vaccine therapy
- Novel apomorphine analogues as candidate treatments of Alzheimer's disease
- Leptin receptor activation plays a role in memory function
- Clusterin as a target for Alzheimer’s disease
- Identifying new targets for the treatment of cognitive dysfunction
- Further insights into antidepressant activity of NK-1 antagonists
- Novel dual 5-HT1A antagonists/SSRI activity
- Selective and effective target for novel analgesics
- Treating spinal cord injury
- Eliminating membrane depolarization caused by the Alzheimer peptide A(1-42, aggr.)
- Neuroprotection through the blockade of proteolytic activation of t-PA
- The renin-angiotensin system as a target for Alzheimer's and affective disorders
- Novel beta sheet breakers as candidates for Alzheimer's disease
- Improving spatial memory deficit following stroke
- Novel VR1 antagonists
- Specific inhibitors of Aß42 accumulation
- Proteomic analysis of Alzheimer's disease
- Human kallikrein 6 as a target for multiple CNS diseases
- LeadDiscovery - Therapeutic Advances - Focus on Angiogenesis
- Dual VEGF- and Erb-receptor inhibition as an improved strategy for treating cancer
- Combining Avastin and Tarceva as a synergistic approach to cancer?
- Promising development of BAY 43-9006, a novel Raf Kinase and Vascular Endothelial Growth Factor Receptor Inhibitor, for the treatment of renal and other advanced Refractory Solid Tumors.
- Advances in the development of AstraZeneca's anti-cancer angiogenesis inhibitor, ZD6474: Experimental evidence supports the importance of schedule dependent combination with radiotherapy.
- Antiangiogenic potency of FK866/K22.175, a new inhibitor of intracellular NAD biosynthesis, in murine renal cell carcinoma.
- Novartis/Schering’s VEGF receptor tyrosine kinase inhibitor, PTK787/ZK222584 as a candidate treatment of rheumatoid arthritis.
- Optimizing the anti-cancer activity of thalidomide
- The development of a VEGF-receptor antagonist, VGA115
- Bisphosphonates as inhibitors of tumor angiogenesis
- Mutual regulation of angiogenesis and adipogenesis
- Combined radiation/SU11248 therapy for the treatment of cancer
- Arteriogenesis as a treatment of stroke
- Angiostatin gene transfer as an approach to the treatment of metastatic liver cancer
- An alpha(1)beta(1) integrin antagonist with anticancer activity
- RNAi technology for the development of improved VEGF therapeutics
- Small molecule antagonists of FGF tyrosine kinase receptor binding
- CD146, a target for the inhibition of angiogenesis
- Phenylacetate-bisphosphonate as a new anticancer candidate
- Dual inhibition of Rho kinase and matrix metalloproteinases offers effective approach to cancer
- Cannabinoid agonists as anticancer agents
- Stem cell treatment of myocardial infarction
- Endorepellin, a novel anticancer target
- Novel approaches to cardiovascular disease
- ZD6474, a VEGF-2 receptor antagonist for the treatment of cancer
- Bisphosphonates are inhibitors of angiogenesis
- GSK-3 inhibitors as stimulators of angiogenesis
- New approaches to VEGF blockade
- ANO-2: A novel inhibitor of angiogenesis
- Mu opioid receptors may increase tumor progression
- New anti-angiogenic shark cartilage derivatives
- Angiogenic factors in endometriosis.
- HIF-1 and tumor progression: pathophysiology and therapeutics
- Targeting chemotherapeutics to tumor vasculature
- Targeted thrombosis as an effective treatment of cancer
- Targeting hematasis in the treatment of cancer
- Lmo2 as a novel anti-angiogenic target
- Screening for angiogenesis inhibitors
- Breakthrough in the search for treatments of cancer and spinal cord injury
- Oltipraz, a candidate antiangiogenesis molecule
- LeadDiscovery - Therapeutic Advances - Focus on Cell Death
- Pancratistatin: A tumor selective apoptosis stimulator
- Inhibitors of AP-1 and NF-kappa B activity: Dual neuroprotective and anti-inflammatory agents in development by Bayer Healthcare for the treatment of traumatic head injury, stroke, Parkinson's disease and Alzheimer' s disease.
- Oncolytic viruses offer hope in the treatment of metastatic brain cancer
- Possible anti-cancer activity of proton pump inhibitors - new indications may lead to market advantage within a highly competitive therapeutic class
- Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma.
- The development of novel small molecule XIAP inhibitors with anti-cancer activity
- The MLK inhibitor, CEP11004: A candidate for the treatment of Parkinson’s disease
- ABPD: An optimized retinoid with RAR-dependent and independent activity
- Mechanisms of apoptosis in Alzheimers disease
- Protein kinase C delta (PKC delta) inhibitors as a target for pro-apoptotic treatment of cancer
- CD271, a retinoid with potential for the treatment of colon cancer
- High throughput screening for stimulators of apoptosis
- ARMER, a novel regulator of apoptosis
- Ketotifen widens the therapeutic window of doxorubicin
- Retinoids as inhibitors of I-kappaB kinase (IKK)
- Pro-apoptotic effects of retinoid like molecules
- XIAP inhibitors as treatments for hormone resistant prostate cancer
- KRN5500 induces apoptosis in leukemia cells
- Histone deacetylase involvement in neuroprotection
- Histone deacetylase regulates survivin expression and apoptosis
- Lipoxygenase inhibitors as treatments of pancreatic cancer
- Reintroducing apoptosis into cancer cells by inhibiting specific tyrosine kinase activity
- Death-associated protein kinase (DAP-kinase) as a target for stroke
- GSK-3 mediates the neurotoxic effects of beta-amyloid
- Targeting apoptosis as a treatment of stroke
- The impact of P-glycoprotein and MRP expression on SCLC response
- MMP-9 nitrosylation: A role in neurodegenerative diseases and stroke
- STATs: Key components of the apoptosis cascade
- Apoptosis in the treatment of rheumatoid arthritis
- Reversing tumor drug resistance
- Identification of inhibitor-of-differentiation 2 (Id2) as a modulator of neuronal apoptosis.
- Histone deacetylase inhibitors as pro-apoptotic candidates
- Predicting p-glycoprotein inhibitors
- A Novel activator of apoptosis
- Apoptosis targets for pancreatic cancer
- Apicidin stimulates the production of Fas/Fas ligand
- Prostate cancer specific derivatives of thapsigargin
- Sigma 2 receptor agonists as novel anticancer treatments
- LeadDiscovery/0527.htm
- LeadDiscovery - Therapeutic Advances - 2003 Archive
- LeadDiscovery - Therapeutic Advances - Lifestyle
- The effect of PDE5 inhibition on patients with stable angina
- BAY 41-2272: A novel guanylate cyclase activator for the treatment of erectile dysfunction
- Expanding the therapeutic benefit of sildenafil to the treatment of premature ejaculation
- Oxytocin as a treatment of erectile dysfunction
- Stimulation of angiogenesis as an approach to erectile dysfunction
- The effect of PDE5 inhibition on patients with stable angina
- LeadDiscovery - Therapeutic Advances - Focus on Infectious Disease
- Advances in the treatment of HSV-1 infection
- Mechanisms underlying the respiratory symptomology of RSV infection
- P-glycoprotein inhibitors as adjuvants to antimicrobials
- Optimizing ribozyme therapeutics
- E5564: An emerging treatment of sepsis
- CS-758, an antifungal with activity in fluconazole-resistant candidiasis
- Advances in infectious disease
- Gene silencing as an approach to HIV infection
- LeadDiscovery - Therapeutic Advances - Focus on Licensing opportunities
- ED-71: a vitamin D analogue with bone selective activity
- ONT-093: A P-glycoprotein inhibitor for use in patients with cancer, chronic pain, epilepsy and HIV infection
- LeadDiscovery - Therapeutic Advances - Focus on Industrial Development
- Strategies for improving high throughput screening
- Axokine: Phase II and III studies demonstrating anti-obesity efficacy
- Tryptase TC30, a novel target for influenza therapeutics
- Non-peptidic protein tyrosine phosphatase inhibitors
- Biochemical and pharmacological characterization of SSR69071, a novel orally active elastase inhibitor.
- Key advances in the development of glycogen synthase kinase-3 (GSK-3) inhibitors
- Targeting growth factors to prevent ischemic cell death following stroke
- Novel inhibitors of VEGFR-2 and VEGFR-3 kinase
- CXCR2 antagonism as an approach to rheumatoid arthritis
- Small molecule inhibition of caspase 3/7 as a treatment of cardiovascular disease
- LeadDiscovery - Therapeutic Advances - 2002 Archive
- CD40: A novel target for the prevention of bone loss
- LXA4 mimics as asthma therapies
- Female arousal disorder
- YM358: An AT1 receptor antagonist for the prevention and treatment of myocardial infarction
- The growing world of sexual dysfunction: From erectile dysfunction to premature ejaculation?
- LeadDiscovery - Therapeutic Advances - Focus on targeted Cancer Therapy
- Metastatic control by histone deacetylase inhibitors
- Cathepsin-D: A novel approach to breast cancer
- ET(A) receptor antagonists as anti-cancer agents
- Radioligand therapy: Targeting tumors with labeled lanreotide
- Vascular targeting agents enhance chemotherapeutic agent activities in solid tumor therapy.
- Survivin a candidate for cancer-specific apoptotic- and immuno-therapies
- Camel antibody fragments for improved cancer immunotherapy
- Trastuzumab as a treatment for lung cancer?
- A prodrug of CC1065 as a candidate targeted anticancer therapy
- Immunotherapeutic targeting of P-glycoprotein
- Preventing neural cell death and improving memory in Alzheimer's disease
- Improvement to immunotherapy made possible through modified ricin toxin
- LeadDiscovery - Therapeutic Advances - Focus on Functional Genomics
- CRMP-1 as an excellent target for lung cancer
- Improved technology for identifying SNPs
- Anti-viral activity of the HIV-1 candidate, L-870812
- Emerging indications for histone deacetylase inhibitors: fungal infection
- Benzodiazapines as anti-malarials
- Therapeutic approaches to respiratory tract viruses
- Reducing HIV infectivity
- Antiviral activty of cyclin dependent kinase inhibitors
- Role of lipoteichoic acid in infection and inflammation.
- Targeting host cellular machinery to prevent HIV-1 infection
- Antiretrovirals target host proteosomes
- Kappa opioid ligands as underexploited treatments of HIV-1 infection
- Anti-viral protease inhibitors offer hope for the treatment of cancer
- Novel therapies for the treatment of malaria
- New antiviral for the treatment of hepatitis B virus infection
- RWJ-270201, a once daily treatment of influenza
- LeadDiscovery - Therapeutic Advances - Focus on Assay Technology
- Screening for molecules altering human epithelial transport
- HTS assays for cytotoxic molecules
- HTS assays of apoptosis
- LeadDiscovery - Therapeutic Advances - Focus on Metastasis
- ZD6474, a VEGF-2 receptor antagonist for the treatment of cancer
- Hypoxia increases uPAR expression and invasiveness of breast cancer cells
- COX-2 inhibitors: Growing interest in anti-cancer activity
- SHPS1: A promising target for the prevention of metastasis
- Lymphangiogenesis: A key player in metastasis?
- Laminin gamma 1 chain peptide, C-16 (KAFDITYVRLKF), promotes migration, MMP-9 secretion, and pulmonary metastasis of B16-F10 mouse melanoma cells.
- Osteopontin: The target of choice for prevention of metastasis?
- Ornithine decarboxylase as an underexploited anticancer target
- Anti-cancer effects of FTY720
- Anti-angiogenic activity of SR 25989
- S100A4, a target for metastatic cancer
- Therapeutic candidates for the treatment of cancer
- Neovastat as a treatment of metastatic breast cancer
- Osteopontin as a target for cancer metastases
- Hypoxia increases uPAR expression and invasiveness of breast cancer cells
- Identifying new targets for the treatment of cognitive dysfunction
- Therapeutic activity of high density lipoproteins
- PPAR ligands prevent and limit the damage caused by myocardial infarction
- PlGF a key target for the modulation of angiogenesis
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- cgi-bin/acatalog/Pages from 1492511.pdf
- OEM Contract Manufacturing in Medical Devices, World Market, Vol III: Finished Clinical Products and Systems
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- Cell-Based Diagnostics: Technology, Applications, and Markets, 2nd Edition
- cgi-bin/acatalog/Pages from 1393079.pdf
- Analytical Chip Technology: U.S. Markets for Lab on a Chip, DNA/Gene, Protein, and other Microarrays, 3rd. Edition
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- World Market for Prescription Cardiovascular Drugs, 2nd Edition, The
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- Healthcare Opportunities for Food Ingredient Manufacturers
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- OEM Contract Manufacturing in Medical Devices Vol II - Electronics and Advanced Systems
- Retail Clinics - The Emerging Market for Convenience and In-Store Healthcare
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- Prescribing Pharmacists - A Decision Maker Emerges
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- BioPortfolio Limited Wound Care 3rd Edition Vol II Burns
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- BioPortfolio Limited OEM Contract Manufacturing in Medical Devices Vol I Materials Processing
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- RFID Opportunities in Healthcare in the U.S.
- Asian Medical Device Markets
- U.S. Market for Home Care Products 5th Edition
- Physician Office Laboratory (POL) Testing Markets Worldwide Status Quo and Future Trends
- Medical Imaging Markets Volume V Molecular Imaging
- Anti-Infectives World Markets 2nd Edition Vol. I-III Complete Series
- Anti-Infectives World Market 2nd Edition Vol III Antivirals
- Monoclonal Antibodies Vaccines and Other Immunologic Cancer Treatments World Market
- Drug Delivery Markets Vol IV Transdermal
- Anti-Infectives World Market 2nd Edition Vol I Antifungals
- Drug Delivery Series I-IV
- Refractive Vision Correction A Market Analysis
- Smoking Cessation and Addiction Treatments A World Market Analysis
- Diabetes and Diabetic Complications Major World Markets 3rd Edition
- Medical Imaging Markets Volume IV Contrast Agents
- Drug Delivery Markets Vol III Pulmonary Delivery Systems
- Molecular Diagnostics Major World Markets
- Cancer Therapeutics The Worldwide Market 2nd Edition
- Drug Delivery Markets Vol II Implantable Injectable
- US Market for EMR Technologies Electronic Medical Records
- Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies)
- Lateral Flow Technology and the Future of Point of Care Diagnostics
- Molecular Diagnostics - Major World Markets
- Clinical Diagnostics in India - Market Sector Analyses and Participant Directory
- The Worldwide Market for Dialysis Equipment Supplies and Services 2nd Edition
- Vaccines - The World Market
- The World Market for Psychotherapeutic Drugs
- Drug Delivery Markets Vol I - Oral Delivery
- The World Market for Pain Management Drugs and Devices, 2nd Edition
- Cell Culture - The World Market for Media, Sera, and Reagents
- Biomarkers - A Market Briefing
- Biophotonics - A Strategic Assessment of Photonics Technologies for Biomedical Applications
- Worldwide Point of Care (POC) - Are Decentralized Clinical Diagnostics a Cost Drain or Revenue Driver?
- Mass Spectrometry in Protein Biomarker Applications - Software, Services, and Instrument Markets
- The Emerging Cancer Vaccine Market, 2nd Edition
- Obesity - The Worldwide Market for Pharmaceutical and Surgical Treatment
- Cardiac Markers
- Medical Imaging Markets, Volume III - Ultrasound
- The World Market for Prescription Orthopedic Drugs
- The World Market for Prescription Respiratory Drugs
- Psoriasis and Psoriatic Arthritis - A Strategic Analysis of the Market in the United States
- Pharmaceutical Outsourcing Opportunities Post-Launch - Contract Manufacturing and Contract Sales and Marketing, 2nd Edition
- Blood: The Worldwide Market for Blood Products, Blood Testing, Blood Equipment, and Synthetic Blood Products
- Medical Imaging Markets, Volume II: Magnetic Resonance
- Women's Health: Worldwide Prescription Drug Markets, 4th Edition
- The World Market for Prescription Gastrointestinal Drugs
- Advances in Ophthalmology: Markets in the Treatment of Eye Disorders and Corrective Vision
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- Contract Manufacturing Strategies - Market developments, technology transfer and key success factors
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- Innovations in The Management of Diabetes - Next generation treatments and market dynamics
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- Innovations in Bioinformatics Emerging tools for drug discovery and development
- The Cardiovascular Disorders Market Outlook to 2012
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- Drug Development Opportunities in China - Regulation, key players and initiatives for domestic and international markets
- Translational Medicine in Biopharmaceutical R and D - Enabling R and D optimization and early detection of potential failures
- Biomanufacturing Strategies - Market drivers, build-vs-buy decisions and opportunities in contract relationship management
- Outlook for RNAi, 2007 - siRNA and miRNA in biology, diagnostics and therapeutics
- Pharmaceutical Pricing and Reimbursement Strategies for market access across the US, Europe, Japan and other key geographies
- cgi-bin/acatalog/rbhc0192t.pdf
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- Drug Repositioning Strategies Innovative strategies to boost pipeline productivity
- Innovative and Targeted Cancer Therapies Key technologies new applications and leading players
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- The Indian Pharmaceutical Market to 2011 Competitive dynamics and major players
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- The Global Anti-Infectives Market Outlook to 2011
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- The Women’s Health Market Outlook to 2011
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- cgi-bin/acatalog/rbhc0179t.pdf
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- The Dermatology Market Outlook to 2011
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- cgi-bin/acatalog/rbhc0177t.pdf
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- cgi-bin/acatalog/rbhc0174t.pdf
- The Cardiovascular Market Outlook to 2011
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- Innovations in Cancer Novel therapeutics new diagnostics and future R&D strategies
- cgi-bin/acatalog/rbhc0175t.pdf
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- cgi-bin/acatalog/Specialty_Pharma_Market_Outlook.pdf
- Pharmaceutical Strategic Alliances - Maximizing returns from collaborative development and commercialization
- cgi-bin/acatalog/Pharmaceutical_Strategic_Alliances.pdf
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- cgi-bin/acatalog/Innovations_in_Diagnostics.pdf
- Pharmaceutical Growth Opportunities in Brazil, Russia, India and China - Healthcare reform, market dynamics and key players
- cgi-bin/acatalog/Pharmaceutical_Growth_Opportunities_Brazil_Russia_India_China.pdf
- The Future of Monoclonal Antibody Therapeutics - Innovation in antibody engineering, key growth strategies and forecasts to 2011
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- Forecast Insight: Antihypertensives Key patent expiries prevent market growth
- Pipeline Insight: Cancer Overview - Lung, Brain, Head and Neck, Thyroid
- Commercial Insight: Targeted Therapy Cancer Brands - High growth market will see eight new blockbusters by 2017
- Commercial Insight: Cytotoxic Therapy Cancer Brands - Looming patent expiries limit market growth
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- Pipeline Insight: Insulin antidiabetics - Return to injections alternative delivery methods fall by the wayside
- Stakeholder Opinions: Diagnostics in Neurology - Predictive biomarkers expand drug revenues
- cgi-bin/acatalog/Stakeholder_Opinions__Novel_Therapeutic_Approaches_in_Cardiovascular_Medicine_-_Lack_of_market_prospects_for_biologics_expose_an_opportunity_for_cell_and_gene_therapies.html
- Commercial and Pipeline Insight: Fibromyalgia - Approvals legitimize condition and expose underserved patient population
- Commercial and Pipeline Insight: Vaccines for Adults and the Elderly - New blockbuster opportunities ahead
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- Pipeline and Commercial Insight: Neuropathic Pain - UCB's Vimpat set to compete with major players
- Stakeholder Opinions: Non-hormonal Treatments for Menopausal Symptoms - Market open to takers as tepid pipeline fails to meet demand
- Rx-to-OTC Strategies: Maximizing the Commercial Potential of an Rx-to-OTC Switch
- Drug Repositioning Strategies - Serendipity by design
- Forecast Insight: Osteoarthritis - The COX-2 pipeline collapses
- Pipeline Insight: Acute Stroke: Commercial risk offsets high unmet need
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- Stakeholder Opinions: Percutaneous Coronary Intervention - Adverse events with drug-eluting stents demand a new safety standard
- Commercial Insight: CNS Market Overview - Commercial dynamics and outlook of the neurology, pain and psychiatry market sectors
- Commercial and Pipeline Insight: HRT for Menopausal Symptoms – A new class restores an old market
- Pipeline Insight: Nosocomial Vaccines - Minefield or Goldmine?
- Pipeline Insight: Non-Small Cell Lung Cancer - Pipeline set to offer only modest improvements
- Stakeholder Opinions: Heart Failure - When drugs do not work
- Pipeline Insight: Breast Cancer - Recent approvals increase pressure on pipeline candidates
- Commercial and Pipeline Insight: ADHD - Immature adult market continues to offer greatest commercial potential
- Stakeholder Opinions: Portable Inhaler Devices - Key tools to differentiate brands and survive generic pressure
- Stakeholder Opinions: Sepsis - The Critical Care Community Gains Critical Mass
- Commercial and Pipeline Insight: Opioids - Short acting and anti-abuse technologies set to fragment and grow the market
- Pipeline and Commercial Insight: Alzheimer's Disease - Scenario forecasts reveal vast market potential
- Stakeholder Opinions: Biologics in Infectious Diseases Well defined target populations are key to commercial success
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- Stakeholder Opinions: Systemic Lupus Erythematosus - Market set to enter era of biologic therapies
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- Bone Metastases - Impending patent expiries may help make or break newer agents
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- OTC Pharmaceuticals: Global Industry Guide
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- Non-Hodgkin's Lymphoma - Is there room to emulate Rituxan's success?
- Prostate Cancer - Hormone-refractory patients still waiting for treatment breakthroughs
- Bausch and Lomb's Contact Lens Solution Withdrawal - ReNu MultiPlus likely to struggle in attempt to regain market share
- eHealthInsight Series Reaching Doctors and Patients Through New Digital Media
- Emerging markets series Benchmarking key countries Brazil, Russia, India, China and Turkey
- Commercial Insight Infectious Diseases Overview
- Acute Coronary Syndromes Fresh look at ACS in Europe, what is the real picture?
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- Urinary Incontinence Lifecycle management strategies retain midterm market growth
- Commercial Insight Autoimmune Overview Market continues to prosper
- Generics Series Key trends and events in the 7 major markets
- AntiCounterfeiting Strategies Combating Fake Pharmaceuticals
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- Stakeholder Opinions Myelodysplastic Syndromes First approvals spur some interest in a niche market
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- Stakeholder Opinions Multiple Myeloma Exploring new targets for multiple drug therapy
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- Stakeholder Insight Parkinson's Disease Evidence of neuroprotection essential to progress treatment dynamics
- Stakeholder Insight Inflammatory Bowel Disease Debate over early aggressive treatment continues
- Stakeholder Insight Prostate Cancer Hormonerefractory patients still waiting for treatment breakthroughs
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- Pipeline Insight - Substance Dependence - Part I - Nicotine
- Commercial and Pipeline Insight - Hepatitis B
- Cardiovascular market overview - Raft of patent expires threaten blockbusters
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- Analysis of the Pharmaceutical Market to 2012 - Segmented by Drug Target Family
- Acute Stroke - TPA spurs infrastructure changes for the better
- Renal Cancer - Targeted therapies rapidly take hold of market
- Antithrombotics - Market expands as disease management focuses on prevention
- Infertility - Optimizing a market bounded by social opinion and physician preference
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- Biosimilars Series Strategic issues - Potential remains uncertain
- Cancer Overview - Increasing diversity offers both high risk and reward
- Parkinson's Disease - Market to grow as first round of lifecycle management strategies succeed
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- BioPortfolio Limited Primary Brain Cancer
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- BioPortfolio Limited Insomnia Strong brand identity critical to differentiation in an increasingly crowded market
- BioPortfolio Limited Multiple Sclerosis Continued growth makes the MS market a highly attractive investment
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- Fibromyalgia Potentially lucrative market soon to become reality
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- Antithrombotics Reaching the untreated prophylaxis market
- Dyslipidemia - Pipeline agents unlikely to rejuvenate the market
- Influenza Vaccines - Pandemic threat revitalizes the sector
- Hematological Malignancies Pursuit for the next blockbuster intensifies
- Multiple Sclerosis The oral revolution
- Pricing and Reimbursement Series Medicare Part D's progress so far
- Asthma Phenotypes A changing paradigm
- Depression Novel drugs to grow third-line market
- Nosocomial Infections The need for new gram-negative drugs
- ePrescribing Infrastructure and Impact on the Healthcare Markets in the US and EU
- Atopic Dermatitis A high level of unmet need creates market opportunities
- Small Cell Lung Cancer and Malignant Mesothelioma Limited R&D activity provides opportunity for early-phase pipeline drugs
- Esophageal Cancer Treatment paradigms need revolution not evolution
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- Psoriasis Anti-TNF's lead another indication
- Osteoarthritis Market sees steady growth
- Atherosclerosis HDL ApoA-I Carotid MRI and 64-slice CT offer opportunities for future treatment
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- Alzheimer's Disease Prescribing trends indicate that neurologists are not adhering to guidelines
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- Inflammatory Bowel Disease Competition Increases for the Biologics
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- Emerging eHealth Technologies Key trends impacting the physician-patient relationship
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- Osteoarthritis The Wait for a DMOAD Continues
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- Regulator Perceptions in Cancer Evolving opinions about the oncology drug approval process
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- Epilepsy Pipeline drugs struggle to outshine their marketed predecessors
- Colorectal Cancer Shaping the future dynamics of colorectal cancer management
- Molecular Targeted Cancer Therapies More drugs on the market more targets in the pipeline
- Stakeholder Insight Atrial Fibrillation Limited efficacy and poor safety lead to bleak outlook
- Stakeholder Insight Supportive Care in Cancer Treatment Some first-generation products proving difficult to dislodge
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- Reformulation Strategies - Comparisons of Past and Future Reformulation Strategies
- Advanced Life Sciences Cethromycin - Phase III success should allow 'me-too' market entry and above-consensus growth
- Antihypertensives - New challenges for a maturing market
- Insulins - Inhalable insulins unlikely to become blockbusters
- HIV - Extending treatment options
- Rheumatoid Arthritis - Biologics battle up the treatment algorithm
- Palatin Technologies Bremelanotide - Competition and regulatory risk cloud potential
- Sirona Dental Systems - Likely struggle for impressive annual growth despite strong reputation and technology
- Spectrum Pharmaceuticals Oral Satraplatin - Oral therapy to take share in second-line hormone-refractory prostate cancer market
- Bipolar Disorder - New treatments for bipolar depression set to drive near-term growth
- ASCO Review Part I - A summary of highlights presented at the ASCO 2006 Annual Meeting
- ASCO Review Part II - A summary of highlights presented at the ASCO 2006 Annual Meeting
- Endo Pharmaceuticals Lidoderm - Physician survey indicates increased use likely to fuel above-consensus sales growth
- Indevus Pharmaceuticals Sanctura XR - Last-to-market entrant unlikely to make an impact in crowded OAB market
- Renovis NXY-059 - Safety profile and unmet need could drive approval
- Santarus Zegerid - Fast-acting formulation gaining momentum in GERD
- Antidiabetics - Patent expiries and cost containment initiatives balanced by pipeline products
- Pharmaceutical Outsourcing Part 2 - An Introduction to Drug Discovery Strategies
- Patients as Consumers - Understanding the Increasing Consumer Level of Influence in Healthcare
- Orthopedics - Global Industry Guide
- Asthma - COPD - ICS - LABA combinations continue to dominate
- Antidyslipidemics - Branded statins beware, generics are amongst you
- Neuropathic Pain - A Plethora of Patient Segmentation and Product Differentiation Opportunities
- eCME-Leveraging Online Continuing Medical Education as a Channel of Influence
- Breast Cancer - A diverse and increasingly crowded pipeline
- Cancer Overview Emerging Therapeutic and Commercial Opportunities
- Schizophrenia
- Parkinson's Disease - Review of Key Commercial Opportunities in the Symptomatic Treatment Market
- From blockbuster to nichebuster - Niche therapies drive future drugs growth and incentivize R&D investment over sales spending
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- Ovarian Cancer - Growing importance as secondary indication for targeted therapies
- Commercial Insight Top 20 Cancer Therapeutics
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- BioPortfolio Limited The Global Antibacterials Market R&D Pipelines Market Analysis and Competitive Landscape
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- A Global Analytical Guide and Comparative Analysis of International Destinations with Location Attractiveness Index
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- The Prescribing Data Restriction Program - Critical Assessment and Best Practices
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