Saturday November 21 2009 | Biotechnology feed | All feeds
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Biovideo: Single-Molecule, Real-Time (SMRT) DNA sequencing technologyKeywords:Single-Molecule, Real-Time (SMRT) DNA sequencing technologySource: http://www.pacificbiosciences.com/index.php?q=technology-introduction This video has been viewed 1325 times on Bioportfolio. Recent Search Terms used to find this page: Technology used DNA observation | t | SMRT Practitioner | SMRT DNA | Real-Time DNA Sequencing from Single Polymerase Molecules vdo | smrt sequencing | single dna sequencing | smrt dna sequencing video | smrt dna sequencing video | Smrt sequencing | . Description:Pacific Biosciences was funded in 2004 with the goal of developing Single-Molecule, Real-Time (SMRT) DNA sequencing technology. This technology enables, for the first time, the observation of natural DNA synthesis by a DNA polymerase as it occurs. Our approach is based on eavesdropping on a single DNA polymerase molecule working in a continuous, processive manner. Distinguished by its long reads, short run times, and high quality sequence data with less effort and cost, SMRT DNA sequencing promises to be a transformative technology that will enable a new paradigm in genomic analysis. PacBio's SMRT technology is built upon two key innovations that overcome major challenges facing the field of DNA sequencing: The SMRT chip, which enables observation of individual fluorophores against a dense background of labeled nucleotides by maintaining a high signal-to-noise ratio, and Phospholinked nucleotides, which produce a completely natural DNA strand through fast, accurate, and processive DNA synthesis MiscellaneousRelated Videos:
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