Adempas (riociguat) Research

20:40 EST 11th December 2018 | BioPortfolio

Beneficial effects of combined therapy with lacidipine and candesartan in obese hypertensive patients.

Obesity is becoming one of the leading risk factors of coronary heart disease, hypertension, cerebrovascular disease. Despite the presence of a large number of antihypertensive agents and scientific substantiation of antihypertensive treatment principles it would be wrong to assume that the problem is completely solved. Development of endothelial dysfunction is one of the key pathogenic mechanisms...

Growth achieved and correlation with blood pressure levels in schoolchildren.

The prevalence of systemic arterial hypertension in childhood has increased progressively.

The waiting room: potential for people with arterial hypertension to learn.

To analyze the meanings assigned by people with systemic arterial hypertension to health education actions in the waiting room.

Prevalence of arterial hypertension according to different diagnostic criteria, National Health Survey.

To determine the population prevalence of arterial hypertension in adults according to different diagnostic criteria.

Association of Periodontal Disease and Edentulism With Hypertension Risk in Postmenopausal Women.

Multiple cross-sectional epidemiologic studies have suggested an association between periodontal disease and tooth loss and hypertension, but the temporality of these associations remains unclear. The objective of our study was to evaluate the association of baseline self-reported periodontal disease and edentulism with incident hypertension.

Comparing pulmonary hypertension severity between rat strains suggests right ventricle NK cells are protective.

Somatic Growth and the Risks of Bronchopulmonary Dysplasia and Pulmonary Hypertension: Connecting Epidemiology and Physiology.

In the premature infant, poor growth in utero (fetal growth restriction) and in the first weeks of life (postnatal growth restriction) are associated with increased risk for bronchopulmonary dysplasia and pulmonary hypertension. In this review, we summarize the epidemiologic data supporting these associations, present a novel rodent model of postnatal growth restriction and review five promising m...

Prevalence and characteristics of apparent treatment-resistant hypertension in older people in China: a cross-sectional study.

The prevalence and associated risk factors of apparent treatment-resistant hypertension (aTRH) in older people in China is unknown. The aim of this study is to investigate the prevalence of aTRH in older people and describe the characteristics of older patients with aTRH. Using two-stage random clustering sampling, 3774 patients with hypertension aged ≥60-75 years were recruited between July 20...

Effects of Gut Bacteria Depletion and High-Na and Low-K Intake on Circulating Levels of Biogenic Amines.

High-sodium and low-potassium (HNaLK) content in Western diets increases the risk of hypertension and cardiovascular disease (CVD). We investigated if the dietary minerals interact with gut bacteria to modulate circulating levels of biogenic amines, which are implicated in various pathologies, including hypertension and CVD.

Primary Aldosteronism and Cerebrovascular Diseases.

As diagnostic techniques have advanced, primary aldosteronism (PA) has emerged as the most common cause of secondary hypertension. The excess of aldosterone caused by PA resulted in not only cardiovascular complications, including coronary artery disease, myocardial infarction, arrhythmia, and heart failure, but also cerebrovascular complications, such as stroke and transient ischemic attack. More...

Kidneys are key in secondary hypertension: a case of fibromuscular dysplasia.

Magnetic resonance direct thrombus imaging for pre-operative assessment of acute thrombosis in chronic thromboembolic pulmonary hypertension.

Therapeutic effect of pirfenidone in the sugen/hypoxia rat model of severe pulmonary hypertension.

Heightened pulmonary artery smooth muscle cell (PA-SMC) proliferation and migration and dynamic remodeling of the extracellular matrix are hallmark pathogenic features of pulmonary arterial hypertension (PAH). Pirfenidone (PFD) is an orally bioavailable pyridone derivative with antifibrotic, antiinflammatory, and antioxidative properties currently used in the treatment of idiopathic pulmonary fibr...

Active-site directed peptide L-Phe-D-His-L-Leu inhibits angiotensin converting enzyme activity and dexamethasone-induced hypertension in rats.

Hypertension is the fundamental cause of cardiovascular and cerebrovascular disorders. Several natural and synthetic peptides are being used as anti-hypertensive agents, which target angiotensin converting enzyme (ACE), the master regulator of angiotensin (Ang) II production. In this study, we have evaluated ACE-inhibitory potential of the tripeptide L-Phenylalanyl-D-Histidyl-L-Leucine (L-Phe-D-Hi...

Relationship between Aortic Arch Calcification, Detected by Chest X-Ray, and Renal Resistive Index in Patients with Hypertension


Aortic arch calcification is a surrogate marker for arterial stiffness and hypertension-related vascular damage. Renal Resistive Index, a renal Doppler ultrasound parameter, is used to assess renal hemodynamics. In this study, the authors aimed to evaluate the relationship between Renal Resistive Index and aortic arch calcification in patients with hypertension.

Long-term blood pressure monitoring by office and 24-h ambulatory blood pressure in renal transplant patients: a longitudinal study.

Renal transplant patients have a high prevalence of nocturnal hypertension, and hypertension misclassification by office blood pressure (BP) is quite common in these patients. The potential impact of hypertension misclassification by office BP on hypertension management in this population has never been analysed.

Interactions of CDH13 gene polymorphisms and ambient PM air pollution exposure with blood pressure and hypertension in Korean men.

Associations between air pollution and blood pressure (BP) traits can be modified by several candidate genes, which might explain differences in individual genetic susceptibility. Based on recent evidence hypothesized to link air pollution and BP traits, we examined whether the polymorphisms of CDH13-a candidate gene-would modify the relationship between them in adult Korean men. A total of 1816 s...

A Review of Plants Used in South African Traditional Medicine for the Management and Treatment of Hypertension.

South Africa contains 9% of the world's higher plants, and despite its rich biodiversity, it has one of the highest prevalence of hypertension in Africa. This review provides information on medicinal plants embraced in South Africa for hypertension management, with the aim of reporting pharmacological information on the indigenous use of these plants as antihypertensives. This review not only focu...

Energetically wasteful wave reflections due to impedance mismatching in hypertension and their reversal with vasodilator: Time and frequency domain evaluations.

Increased pulse wave reflections in hypertension arise due to impedance mismatching and the effective energy transmission to the vasculature is compromised. Their quantification in the time and the frequency domains are compared and the beneficial effect of vasodilator is evaluated in the study.

Association between medication adherence and quality of life of patients with diabetes and hypertension attending primary care clinics: a cross-sectional survey.

To evaluate the association between medication adherence and quality of life (QoL) of patients with diabetes and/or hypertension attending primary care clinics.

Is it Possible to Significantly Modify Blood Pressure with a Combined Nutraceutical on Top of a Healthy Diet? The Results of a Pilot Clinical Trial.

Beyond the well-known effects on blood pressure (BP) of the dietary approaches to stop hypertension (DASH) and the Mediterranean diets associated to a correct lifestyle, often a lifestyle change is not simple and can show only long-time results: in this sense, a possible support might be derived from the use of some anti-hypertensive supplements or nutraceuticals, which may provide a significant r...

Assessment of the Impact of an Endpoint Committee in the Ocular Hypertension Treatment Study.

To assess the impact of a masked Endpoint Committee on estimates of the incidence of primary open angle glaucoma (POAG), treatment efficacy and statistical power of the Ocular Hypertension Treatment Study-Phase 1, 1994-2002 (OHTS-1).

Accuracy of algorithms to identify pulmonary arterial hypertension in administrative data: a systematic review.

The diagnosis of pulmonary arterial hypertension (PAH) is challenging, and there is significant overlap with the more heterogenous diagnosis of pulmonary hypertension (PH). Clinical and research efforts that rely on administrative data are limited by current coding systems that do not adequately reflect the clinical classification scheme. The aim of this systematic review is to investigate current...

Estimated glomerular filtration rate predicts incident stroke among Ghanaians with diabetes and hypertension.

Sub-Saharan Africa is currently experiencing a high burden of both chronic kidney disease (CKD) and stroke as a result of a rapid rise in shared common vascular risk factors such as hypertension and diabetes mellitus. However, no previous study has prospectively explored independent associations between CKD and incident stroke occurrence among indigenous Africans. This study sought to fill this kn...

Effects of miR-155 on hypertensive rats via regulating vascular mesangial hyperplasia.

Vascular smooth muscle cell (VSMC) excessive proliferation is related to hypertension. The cell cycle inhibitory factor (p27) can arrest cell cycle, while its down-regulation is associated with hypertension. It is found that microRNA-155 (miR-155) plays a regulatory role in VSMC proliferation, while its relationship with hypertension is still unclear. Bioinformatics analysis reveals the targeted r...

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