Adempas (riociguat) Research

10:16 EDT 19th October 2018 | BioPortfolio

Left main coronary artery compression in a patient with portopulmonary hypertension.

Pharmacological Potentiation of the Efferent Vagus Nerve Attenuates Blood Pressure and Renal Injury in a Murine Model of Systemic Lupus Erythematosus.

Recent evidence suggests hypertension may be secondary to chronic inflammation that results from hypoactive neuro-immune regulatory mechanisms. To further understand this association, we used systemic lupus erythematosus (SLE) as a model of inflammation-induced hypertension. In addition to prevalent inflammatory kidney disease and hypertension, SLE patients suffer from dysautonomia in the form of ...

Salt-Responsive Metabolite, β-Hydroxybutyrate, Attenuates Hypertension.

Dietary salt reduction and exercise are lifestyle modifications for salt-sensitive hypertensives. While exercise has prominent metabolic effects, salt has an adverse effect on metabolic syndrome, of which hypertension is a hallmark. We hypothesized that dietary salt impacts metabolism in a salt-sensitive model of hypertension. An untargeted metabolomic approach demonstrates lower circulating level...

Annals Consult Guys - Should Your Patient's Surgery Be Stopped for Hypertension? The Pressure Is On.

Vascular angiotensin AT1 receptor neuromodulation in fetal programming of hypertension.

Fetal stress increases the susceptibility to cardiovascular diseases in adult age, including hypertension, a process known as fetal programming of hypertension (FPH). This study intends to investigate the interplay between vascular sympathetic nervous system (SNS) and RAS, namely the neuromodulatory role exerted by Angiotensin II (Ang II) receptor AT1 in FPH, and respective contribution for hypert...

Diabetes, but Not Hypertension and Obesity, Is Associated with Postoperative Cognitive Dysfunction.

Older people undergoing surgery are at risk of developing postoperative cognitive dysfunction (POCD), but little is known of risk factors predisposing patients to POCD. Our objective was to estimate the risk of POCD associated with exposure to preoperative diabetes, hypertension, and obesity.

AJH Peer Review 2017.

Association between lifestyle risk factors and incident hypertension among middle-aged and older Australians.

This study aimed to examine the association between individual and combined lifestyle risk factors and the incidence of hypertension 1) in middle-aged and older Australians, and 2) to compare findings in men and women. A sample of 32,393 adults aged ≥45 years from New South Wales completed baseline (2006-2008) and follow-up (2010) questionnaires. Self-reported incident hypertension was defined...

Prevalence of auto-antibodies associated to pulmonary arterial hypertension in scleroderma - A review.

The prevalence of auto-antibodies associated to pulmonary arterial hypertension in scleroderma patients was reviewed, based on reports cited in two major scientific databases. Data was collected on the following types of antibodies: antinuclear, anti-double-stranded DNA, anticentromere, anti-CENP-A, anti-CENP-B, anti-bicaudal D2, anti-nucleolar, anti-Scl-70 (anti-topoisomerase I), anti-topoisomera...

Effect of gastrectomy on blood pressure in early gastric cancer survivors with hypertension.

We investigated the effect of gastrectomy on blood pressure (BP) in early gastric cancer survivors with hypertension and whether well-controlled BP was due solely to surgery-induced weight loss.

Prediabetes with Hypertension and Dyslipidemia: Are They Triad of Future Cardiovascular Risk?

Effect of premorbid hypertension control on outcome of patients with aneurysmal subarachnoid hemorrhage.

Hypertension is common in patients with aneurysmal subarachnoid hemorrhage (SAH). However, it is still unclear whether premorbid antihypertensive therapy can help to reduce the risk of severe aneurysmal bleeding. Therefore, this study aims to assess the effect of premorbid hypertension control on outcome of patients with aneurysmal SAH.

Right atrial to left atrial volume index ratio is associated with increased mortality in patients with pulmonary hypertension.

Pulmonary hypertension (PH) is characterized by increased pulmonary vascular resistance leading to right heart failure. Elevated right atrial (RA) pressure reflects right ventricular (RV) pressure overload and is an established risk factor for mortality in PH. We hypothesized that PH patients with an increased ratio of RA to LA volume index (RAVI/LAVI), would have increased mortality.

Survival after diagnosis of hypertension in cats attending primary care practice in the United Kingdom.

Hypertension is common in older cats. There is limited evidence for predictors of survival after diagnosis.

Persistent pulmonary hypertension of the newborn after fetomaternal hemorrhage.

Newborns with anemia are at increased risk of persistent pulmonary hypertension of the newborn (PPHN), yet reports on the association between fetomaternal hemorrhage (FMH) and PPHN are rare. To optimize care for pregnancies complicated by FMH, clinicians should be aware of the risks of FMH and the possible diagnostic and therapeutic options. To increase the current knowledge, the incidence of PPHN...

General obesity, abdominal adiposity, and the risk of incident hypertension-From anthropometry to modern imaging techniques.

Association between abdominal obesity and increased risk for the development of hypertension regardless of physical activity: A nationwide population-based study.

The presence of abdominal obesity and lack of physical activity are both risk factors for the development of hypertension. The aim of this study was to analyze the risk of developing hypertension according to baseline waist circumference (WC). In total, 16 312 476 non-hypertensive participants who were covered by the National Health Insurance Service (NHIS) from 2009 to 2012 in Korea were includ...

Bone Morphogenetic Protein 9 is a Mechanistic Biomarker of Portopulmonary Hypertension.

Bone Morphogenetic Protein 9 (BMP9) is a circulating endothelial quiescence factor with protective effects in pulmonary arterial hypertension (PAH). Loss-of-function mutations in BMP9, its receptors and downstream effectors have been reported in heritable PAH.

Potential mechanisms linking gut microbiota and portal hypertension.

Gut microbiota is the largest collection of commensal microorganisms in the human body, engaged in reciprocal cellular and molecular interactions with the liver. This mutually beneficial relationship may break down and result in dysbiosis, associated with disease phenotypes. Altered composition and function of gut microbiota has been implicated in the pathobiology of nonalcoholic fatty liver disea...

Falling risk factors in patients with arterial hypertension 55+ years old.

Arterial hypertension (AH) is the most prevalent cardiac risk factor in old patients. Falls-related complications includes increased disability and mortality, decreased activity levels, quality of life, and overall health status. So falls are an important health problem. The aim of our study was to study falls in patients with AH 56+ years old finding fall risk factors in this population.

Epigenetic Soluble Epoxide Hydrolase Regulation Causes Endothelial Dysfunction.

A novel epigenetic regulator, Jarid1b (KDM5B), that contributes to increasing vascular soluble epoxide hydrolase (sEH) protein expression and impairing endothelial function was identified by Vasconez et al. in this edition of Acta Physiologica. Elevated angiotensin II levels contribute to several cardiovascular diseases and endothelial dysfunction in hypertension. Endothelial dysfunction in angio...

Serum concentration of renin-angiotensin system components in association with ACE I/D polymorphism among hypertensive subjects in response to ACE inhibitor therapy.

Renin-angiotensin system (RAS) is a complex network of enzymes and peptides with the essential role in blood pressure control. The relationships between RAS components, RAS-related genetic polymorphisms and therapy response in essential hypertension (EH) were widely explored but the results were inconclusive.

Type 2 diabetes with hypertensive patients results in changes to features of adipocytokines: Leptin, Irisin, LGR4, and Sfrp5.

The incidence of hypertension and diabetes is increasing, it is reported that adipocytokines might be involved in the pathogenesis of diabetes and hypertension. We aimed to investigate the features of adipocytokines, included of Leptin, Irisin, LGR4, and Sfrp5 in type 2 diabetes mellitus (T2DM) patients with hypertension, simultaneously analyzed the connection of the alteration of adipocytokines w...

Pulmonary hypertension-targeted therapies in heart failure: A systematic review and meta-analysis.

Pulmonary hypertension (PH) due to left heart failure (HF) is the most common form of PH. However, treatment is unclear because there are conflicting results about safety and efficacy of PH-targeted therapies.


To report the incidence and course of ocular hypertension after intravitreal injection of 2-mg triamcinolone acetonide (IVT).

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