Alzumab (Itolizumab) Research

17:49 EDT 14th August 2018 | BioPortfolio

Psoriasis dermatitis: an overlap condition of psoriasis and atopic dermatitis in children.

Some children present with a so-called overlap condition with clinical features of both psoriasis and atopic dermatitis (AD), previously described as 'psoriasis dermatitis'(PD). Though its existence is not questioned in literature, only one study demonstrated clinical characteristics of children with coexisting psoriasis and AD, and its course over time has not been described so far. We conducted ...

Understanding the prospective of nano-formulations towards the treatment of psoriasis.

Psoriasis is a consistently recurring, inflammatory, autoimmune disorder of the skin, affecting about 2-5% of the world population. Abundant therapeutic agents are accessible for the treatment of psoriasis. Nevertheless, none of them are entirely secure and effective to treat the disease without compromising patient compliance. Furthermore, already existing drugs are supposed to restrain the ailme...

Role of Galectin-3 in subclinical myocardial impairment in psoriasis.

Psoriasis has been shown to increase cardiovascular risk, and a contributor to this might be enhanced myocardial fibrosis promoted by the disease-associated proinflammatory milieu.

COMMENTS ON "Short-term reasons for withdrawal and adverse events associated with apremilast therapy for psoriasis in real-world practice compared with in clinical trials: A multicenter retrospective study".

Serum concentrations of interleukin 18 and 25-hydroxyvitamin D3 correlate with depression severity in men with psoriasis.

Psoriasis and depression may have common mechanisms, such as systemic inflammation, dysfunction of the hypothalamic-pituitary-adrenal axis, and vitamin D3 deficiency. Among men with psoriasis, this study examined whether depression severity was associated with serum concentrations of different metabolic and inflammatory markers.

Psoriasis is not associated with cognition, brain imaging markers and risk of dementia: the Rotterdam Study.

Based on increased cardio-metabolic comorbidities, inflammation and an overlap in genetics with Alzheimer's disease, psoriasis patients may be at risk for cognitive dysfunction and dementia.

The Evolution of Topical Formulations in Psoriasis.

Most people with mild-to-moderate psoriasis manage their disease with topical therapies. However, adherence to topical treatment remains a challenge, as the daily application creates a significant treatment burden. New topical therapeutic options need to offer higher efficacy and better patient acceptability, including easier application, to reduce treatment burden and enhance patient adherence. T...

Synergistic antiproliferative and differentiating effect of 2,4-monofurfurylidene-tetra-O-methylsorbitol and 4,6-dimethyl-2-(3,4,5-trimethoxyphenylamino)pyrimidine on primary and immortalized keratinocytes.

Psoriasis is one of the most common chronic autoinflammatory skin disease, associated with hyperproliferation and abnormal differentiation of keratinocytes, inflammation, and angiogenesis. The available treatments for psoriasis are not curative and may have numerous side effects, and topical administration is preferred over systemic therapy due to the reduced systemic burden of the drug. Thus, nov...

Bariatric Surgery in Obese Patients With Psoriasis and COPD: Killing Three Birds With One Stone?

Polycystin-1 downregulation induces ERK-dependent mTOR pathway activation in a cellular model of psoriasis.

Psoriatic plaques tend to localize to the knees and elbows, areas that are particularly subject to mechanical stress resulting from bending and friction. Moreover, plaques often develop at sites of mechanical trauma or injury (Koebner phenomenon). Nevertheless, mechanotransduction has never been linked to psoriasis. Polycystins (polycystin-1, PC1; polycystin-2, PC2) are mechanosensitive molecules ...

Plaque psoriasis following Kawasaki disease and varicella.

We describe the case of a 15-month-old boy with Kawasaki disease who developed varicella 7 days after the beginning of the disease and diffuse plaque psoriasis after 43 days. Associations between Kawasaki disease and psoriasis, between Kawasaki disease and varicella and between varicella and psoriasis have all been reported in the literature. The triple association of Kawasaki disease, varicella...

New insights into psychodermatology in psoriasis.

Treating a Multidrug-Resistant Psoriatic HLA-C*18:01 Allele Carrier with Combination Ustekinumab Apremilast Therapy.

Nowadays, even though several biologic therapies are available to treat psoriasis, multidrug-resistant disease continues to be a therapeutic challenge. Combination therapy has therefore become increasingly important. In this context, apremilast, according to its safety profile, could easily be combined with biologics in patients with comorbidities and/or recalcitrant multidrug-resistant psoriasis.

Candidate long-range regulatory sites acting on the IL17-pathway genes TRAF3IP2 and IL17RA are associated with psoriasis.

Drug-mediated disruption of IL17A, IL17F, and IL17RA proteins is effective in psoriasis. However, disruption of the IL17 pathway by functional mutations has so far only been shown to affect risk in IL23R and TRAF3IP2. It is unclear if this is due to rarity of disruptive mutations.

Serum homocysteine, folate, and vitamin B levels in patients with psoriasis: A systematic review and meta-analysis.

Patients with psoriasis are at increased risk for cardiovascular (CV) comorbidities. Previous studies examined the possible contribution of serum homocysteine, folate and vitamin B to CV risks in psoriasis patients but had conflicting conclusions.

Infliximab is associated with an increased risk of serious infection in patients with psoriasis in the United Kingdom and Republic of Ireland: results from the British Association of Dermatologists Biologic Interventions Register (BADBIR).

Patients with psoriasis and clinicians are concerned that infliximab may be associated with a risk of serious infections.


Systematic review of the real-world evidence of adalimumab safety in psoriasis registries.

Long-term safety of adalimumab in psoriasis clinical studies has been established. The objective of this research was to review real-world evidence of adalimumab safety from registries of adult patients with psoriasis treated in clinical practise. Databases (BIOSIS Previews, Current Contents Search, Derwent Drug File, Embase, Embase Alert, EMCare, MEDLINE, SciSearch) were searched for psoriasis re...

Indirubin ameliorates imiquimod-induced psoriasis-like skin lesions in mice by inhibiting inflammatory responses mediated by IL-17A-producing γδ T cells.

Indirubin (IR) is a bisindole compound extracted from the leaves of Chinese herb Indigo Naturalis. Indigo Naturalis has been widely used in traditional Chinese medicine to treat inflammatory and autoimmune diseases. Psoriasis is a chronic immune-mediated inflammatory skin disease in which γδ T cells play an important role. This study aims to determine the immunoregulatory effects and the underly...

Why Shouldn't We Forget About the Role of Clinical Psychologists in the Treatment of Patients with Psoriasis?

Depictions of acne and psoriasis influence interpersonal aversion.

The presence of a dermatological condition may deter contact with the affected person because it falsely signals the threat of infection. The current study investigated interpersonal aversion towards individuals with the appearance of acne and psoriasis. Participants (N = 196) either viewed a female face with the appearance of acne, psoriasis, or no visible dermatological condition. Participants...

Increased risk of keratopathy after psoriasis: A nationwide population-based study.

To evaluate whether the presence of psoriasis increases the risk of keratopathy incidence by using Taiwan's National Health Insurance Research Database (NHIRD).

Clinical and genetic differences between pustular psoriasis subtypes.

The term pustular psoriasis indicates a group of severe skin disorders characterised by eruptions of neutrophil-filled pustules. The disease, which often manifests with concurrent psoriasis vulgaris (PV), can have an acute systemic (generalised pustular psoriasis, GPP) or chronic localised presentation (palmoplantar pustulosis, PPP; acrodermatitis continua of Hallopeau, ACH). While mutations have ...

Serum calprotectin correlates with risk and disease severity in psoriasis patients and the decrease of calprotectin predicts better response to tumor necrosis factor inhibitors.

This study aimed to investigate the correlation of serum calprotectin expression with risk and severity of psoriasis, as well as its predictive value for clinical response to tumor necrosis factor inhibitors (TNFi) treatment in psoriasis patients.

Compounded Low-dose Naltrexone for the Treatment of Guttate Psoriasis: A Case Report.

The ancient autoimmune skin condition psoriasis is still ubiquitous worldwide, produces the same, often-intolerable effects noted in its earliest recorded descriptions, and remains without cure. Management options designed to resolve the itchy, scaly, weeping, erythematous, and often widespread lesions of that disorder are now available, but they vary in efficacy, most are associated with the deve...

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