Anesthesiology Research

01:37 EDT 21st October 2018 | BioPortfolio

A Better Way to Evaluate Postoperative Pain?

On the relevance of an in vitro reconstructed human epidermis model for drug screening in atopic dermatitis.

Recent advances in the development of human-based in vitro models offer new tools for drug screening and mechanistic investigations of new therapeutic agents. However, there is a lack of evidence that disease models respond favorably to potential drug candidates. Atopic dermatitis (AD) is a very common disease associated with an altered skin barrier and chronic inflammation. Here, we demonstrate t...

Beating tumour drug resistance: "Lamarckian" induction in the spotlight.

Drug resistance is a major problem in cancer treatment. In cutaneous melanoma, a large fraction of tumours carry BRAF or BRAF mutations (hereinafter referred to as BRAF ), which result in activation of the mitogen-activated protein kinase (MAPK) pathway, sustaining cancer cell proliferation and survival. In 2011, a landmark phase III study demonstrated that vemurafenib, a drug specifically targeti...

In Memoriam: L. Donald Bridenbaugh, MD, 1923-2018.

Perioperative Esmolol and Opioids: Is More Really Less?

Anesthesia During Awake Breast Surgery: Additional Questions.

Reply to Dr Woodham et al.

Is a Thoracic Fascial Plane Block the Answer to Upper Abdominal Wall Analgesia?

Reply to Drs Hamilton and Manickam.

An Afterthought on "Standard of Care".

Reply to Dr Orebaugh.

Maximum Recommended Dosage of Ropivacaine and Bupivacaine for Pediatric Regional Anesthesia.

Comprehensive Complication Index Validates Improved Outcomes Over Time Despite Increased Complexity in 3707 Consecutive Hepatectomies.

The aim of this study was to evaluate trends over time in perioperative outcomes for patients undergoing hepatectomy.

Hepatitis C is an Independent Risk Factor for Perioperative Complications and Nonroutine Discharge in Patients Treated Surgically for Hip Fractures.

To evaluate the relationship between noncirrhotic hepatitis C virus (HCV) infection, perioperative complications, and discharge status in patients undergoing surgical procedures for hip fractures.

Regional Vastus Medialis and Lateralis Activation in Females with Patellofemoral Pain.

To investigate whether regional activation patterns in the vasti muscles differ between females with and without patellofemoral pain (PFP), and whether muscle activation patterns correlate with knee extension strength.

A fixed moderate-dose combination of tiletamine+zolazepam outperforms midazolam in induction of short-term immobilization of ball pythons (Python regius).

Laboratory animals are commonly anesthetized to prevent pain and distress and to provide safe handling. Anesthesia procedures are well-developed for common laboratory mammals, but not as well established in reptiles. We assessed the performance of intramuscularly injected tiletamine (dissociative anesthetic) and zolazepam (benzodiazepine sedative) in fixed combination (2 mg/kg and 3 mg/kg) in comp...

Binding residence time through scaled molecular dynamics: a prospective application to hDAAO inhibitors.

Traditionally, a drug potency is expressed in terms of thermodynamic quantities, mostly Kd, and empirical IC50 values. While binding affinity as an estimate of drug activity remains relevant, it is increasingly clear that it is also important to include (un)binding kinetic parameters in the characterization of potential drug-like molecules. Herein, we used standard in silico screening to identify ...

Perioperative pain and postoperative nausea and vomiting (PONV) management after day-case surgery: The SFAR-OPERA national study.

Since pain and postoperative nausea and vomiting (PONV) are the main reasons for failed discharge after day-case surgery, assessing pain and PONV is important. The aim was to describe the perioperative pain and PONV management within selected day-case surgical procedures in France.

Imagining My Painful Hand Is Not Mine: Self-distancing Relieves Experimental Acute Pain Induced by a Cold Pressor Task.

Self-distancing has been shown to alleviate emotional pain and also to have potential efficacy for treating chronic pain and imagined acute pain, relative to self-immersing. This study examined the efficacy of self-distancing in relieving acute physical pain caused by a cold pressor task (CPT) in healthy adults. Sixty-five undergraduates were pseudo-randomly assigned to one of three groups: a) a s...

A study of the impact of excipient shielding on initial drug release using UV imaging.

Knowledge on the dissolution behaviour of a drug is critical for efficient and effective product development. As the drug has almost always to be formulated with excipients in the design of a dosage form, it is important to examine the implications of the choice of excipients on the dissolution of the drug, among others, especially in the case of an immediate release dosage form. The objective of ...

Optimization of sample preparation for transporter protein quantification in tissues by LC-MS/MS.

Reproducible quantification of drug transporter protein expression in tissues is important for predicting transporter mediated drug disposition. Many mass-spectrometry based transporter protein quantification methods result in high variability of the estimated transporter quantities. Therefore, we aimed to evaluate and optimize mass spectrometry-based quantification method for drug transporter pro...

Pain among non-verbal critically Ill mechanically ventilated patients: Prevalence, correlates and predictors.

To investigate pain levels and factors that are predictive of pain for mechanically ventilated patients during rest and during routine nursing procedures.

Debora: Acceptance and Feasibility of Pain Competence and Depression Prevention Training in Multidisciplinary Inpatient Rehabilitation.

There is an increasing need for patient education in chronic low back pain with mental comorbidity. The present study was carried out in the setting of multidisciplinary inpatient rehabilitation and investigated the acceptance and feasibility of the Debora pain competence and depression prevention training comparing an intervention group with a control group. While patients of the intervention gro...

Minocycline inhibits formalin-induced inflammatory pain and the underlying mechanism.

To unravel the underlying mechanism of minocycline in formalin-induced inflammatory pain, and to investigate the effects of minocycline on synaptic transmission in substantia gela-tinosa (SG) neurons of rat spinal dorsal horn.

Perioperative parameters and prognosis analysis of patients aged 80 years or older treated with radical prostatectomy for prostate cancer.

To assess the perioperative outcome, continence recovery and oncologic outcome of Chinese patients aged 80 years or older treated with radical prostatectomy for prostate cancer.

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