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An antibody is a protein produced by the body's immune system when it detects harmful substances, called antigens. Examples of antigens include microorganisms (such as bacteria, fungi, parasites, and viruses) and chemicals.
Antibodies may be produced when the immune system mistakenly considers healthy tissue a harmful substance. This is called an autoimmune disorder.
Each type of antibody is unique and defends the body against one specific type of antigen. Antibodies are large Y-shaped proteins. They are recruited by the immune system to identify and neutralize foreign objects like bacteria and viruses.
The antibody drugs featured in the top 10 drugs are:
#8 = Roche's Avastin (bevacizumab), with 2012 sales of US$6.260 billion
#7 = Johnson & Johnson's Remicade (infliximab), with 2012 sales of US$6.139 billion
#5 = Roche's Hereceptin (trastuzumab), with 2012 sales of US$6.397 billion
#3 = Roche's Rituxan (rituximab), with 2012 sales of US$7.285 billion
#1 = AbbVie's Humira (adalimumab), with 2012 sales of US$9.265 billion.
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