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APC (adenomatous polyposis coli)

17:20 EST 22nd November 2017 | BioPortfolio

APC stands for adenomatous polyposis coli, a form of colorectal cancer and is a tumour suppressor. When APC it mutated, it can cause this particular type of colorectal cancer. When not present in its correct form, APC is correlated with increased risk of chromosomal disjunction because APC is located on kinetochores. This can cause patients to become susceptible to multiple polyps in the colon.

The disease caused by APC mutations is due to the fact that APC regulates myc via B-cat,a beta-catenin protein.

But the actions of APC are not just limited to the gut. Research suggests that APC is involved in the assembly of receptors in the nervous system that respond to nicotinic acetylcholine neurotransmitter. http://www.bioportfolio.com/resources/pmarticle/141793/Evidence-For-The-Involvement-Of-Adenomatous-Polyposis-Coli-apc-Protein-In-Maintaining.html

However, the focus of APC research is on colorectal cancers. Strong genetic familial links (http://www.bioportfolio.com/resources/pmarticle/307050/Going-Against-The-Tide-Increasing-Incidence-Of-Colorectal-Cancer-Among-Koreans-Filipinos.html) have helped researchers to target APC mutations. Drugs and genetic modulations (http://www.bioportfolio.com/resources/pmarticle/341948/Restoration-Of-Full-length-Apc-Protein-In-Sw480-Colon-Cancer-Cells-Induces.html) to mimic the apoptotic downstream effects of APC which are lost in mutated genotypes and disease phenotypes (http://www.bioportfolio.com/resources/pmarticle/199928/Genotype-phenotype-Correlation-In-Colorectal-Polyposis.html) are a good therapeutic option.

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