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BIOD‑531 Research

07:35 EST 23rd February 2019 | BioPortfolio

Diabetes Technology and the Human Factor.

Technologies in Diabetes-the Tenth ATTD Yearbook.

Ginseng Extract Modified by Pectin Lyase Inhibits Retinal Vascular Injury and Blood-Retinal Barrier Breakage in a Rat Model of Diabetes.

GS-E3D is an enzymatically modified ginseng extract by pectin lyase. In this study, we evaluated the preventive effects of GS-E3D on blood-retinal barrier (BRB) leakage in a rat model of diabetes. To produce diabetes, rats were injected with streptozotocin. GS-E3D was orally gavaged at 25, 50, and 100 mg/kg body weight for 6 weeks. We then compared the effect of GS-E3D with that of an unmodified...

A review of dupilumab in the treatment of atopic diseases.

Dupilumab is a fully human monoclonal IgG4 antibody directed against the alpha subunit of the IL-4 receptor and prevents the signaling of IL-4 and IL-13, two type 2 cytokines known to be important drivers of atopic diseases. In March of 2017, the United States Food and Drug Administration (FDA) approved dupilumab for the treatment of moderate-to-severe atopic dermatitis in adults that is uncontrol...

Is patient insurance type related to physician recommendation, administration and referral for adult vaccination? A survey of US physicians.

This study evaluated physician practices and perceived barriers for influenza, tetanus, diphtheria, pertussis (Tdap), and zoster vaccination of adults in the United States (US), with emphasis on patients with Medicare versus commercial insurance. A cross-sectional internet-based survey of board-certified general/family practitioners and internists (N = 1,000) recruited from a national US physici...

Things We Do For No Reason: Sliding-Scale Insulin as Monotherapy for Glycemic Control in Hospitalized Patients.

Thyroid disorders in Brazil: the contribution of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

Thyroid disorders are common diseases, both in Brazil and worldwide. The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) is a prospective cohort study that investigates cardiovascular diseases, diabetes, and associated factors, including non-classical cardiovascular risk factors such as thyroid function. Thyroid function was classified according to thyrotropin stimulating hormone (TSH),...

Ramipril can alleviate the accumulation of renal mesangial matrix in rats with diabetic nephropathy by inhibiting insulin-like growth factor-11.

To investigate the impact of Ramipril (RAM) on the expressions of insulin-like growth factor-1 (IGF-1) and renal mesangial matrix (RMM) in rats with diabetic nephropathy (DN).

Clinical Features and Comorbidities of Patients With Necrobiosis Lipoidica With or Without Diabetes.

Necrobiosis lipoidica (NL) is a rare granulomatous condition. Current knowledge of its key features is based on a limited number of studies and case reports, leading to wide variability in the characterization of its defining features, with limited comparison of patients with or without diabetes.

Systematic review of randomized controlled trials on antibiotic treatment for osteomyelitis in diabetes.

To evaluate the efficacy of antibiotic therapy in osteomyelitis treatment among people with diabetes.

Dietary intakes of women with Type 1 diabetes before and during pregnancy: a pre-specified secondary subgroup analysis among CONCEPTT participants.

To describe the dietary intakes of women with Type 1 diabetes before and during pregnancy.

Comment on the consensus report on the management of hyperglycaemia in Type 2 diabetes by the American Diabetes Association and the European Association for the Study of Diabetes.

We read with interest the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) joint consensus report on the management of hyperglycaemia in Type 2 diabetes. Following publication of the report, discussions of the content among networks of behavioural and educational researchers prompted us to write this letter. This consensus report is to be commended ...

Fixed-ratio combination of insulin degludec and liraglutide (IDegLira) improves cardiovascular risk markers in patients with type 2 diabetes uncontrolled on basal insulin.

This post hoc analysis investigated effects of insulin degludec/liraglutide fixed-ratio combination (IDegLira) versus comparators on cardiovascular (CV) risk markers from DUAL II (versus insulin degludec), DUAL V (versus insulin glargine 100 units/mL) and DUAL VII (versus basal-bolus therapy) in patients grouped by sex, age (

Basal insulin glargine and omega-3 on lower limb arterial disease outcome in patients with dysglycemia. An analysis of the Outcome Reduction with an Initial Glargine INtervention (ORIGIN) Trial.

The impact of insulin or omega-3 supplements on the incidence and progression of peripheral artery disease (PAD) in patients with dysglycemia has not been well studied. The ORIGIN trial randomized participants with dysglycemia and cardiovascular risk factors to titrated insulin glargine versus standard care, and to either 1 g of omega-3 per day or placebo. We assessed incident PAD, defined as the ...

Allosteric Interactions in Human Cytochrome P450 CYP3A4: The Role of Phenylalanine 213.

The role of Phe213 in the allosteric mechanism of human cyto-chrome P450 CYP3A4 was studied using a combination of progesterone (PGS) and carbamazepine (CBZ) as probe sub-strates. We expressed, purified and incorporated in POPC Nanodiscs three mutants, F213A, F213S, and F213Y, and compared them with the wild-type CYP3A4 monitoring spec-tral titration, the rate of NADPH oxidation and steady-state p...

Short Telomere Subtelomeric Hypomethylation is associated with Telomere Attrition in Elderly Diabetic Patients.

Telomere shortening is well known to be associated with the aging process and aging-associated diseases, including diabetes. The telomere length and subtelomeric methylation status in peripheral leucocytes (LTL) were compared in elderly type 2 diabetes patients (T2D) and diabetes free controls (C). The methylation status was analyzed the between of MspI-TRF lengths and HpaII-TRF lengths by using m...

Continuous Glucose Monitoring in Children with Type 1 Diabetes Improves Well-Being, Alleviates Worry and Fear of Hypoglycemia.

There is limited published evidence regarding the psychological effect of use of continuous glucose monitoring (CGM) in the pediatric population with type 1 diabetes mellitus on metabolic control, fear of hypoglycemia, and patient or carer well-being. The aim of this study was to evaluate the effects of CGM on patient and carer well-being, worry, fear of hypoglycemia, and glycemic control.

Contributions of Rho-kinase and AMP-related kinase (AMPK) Signaling Pathways to Endothelium-Derived Contracting Factors (EDCF)-mediated Responses in Diabetic Rat Aorta.

Diabetes-induced endothelium damage leads to vascular dysfunction. The current study was designed to determine the effects of short-term (4-week) streptozotocin (STZ)-induced diabetes on endothelium-derived contracting factors (EDCF)-mediated responses with possible contributions of Rho-kinase and AMP-activated kinase (AMPK) signaling pathways. The effects of STZ-diabetes on vascular functions wer...

A Multilevel Intervention With African American Churches to Enhance Adoption of Point-of-Care HIV and Diabetes Testing, 2014-2018.

We describe a multilevel intervention to enhance adoption of point-of-care HIV and diabetes testing at church health fairs in Atlanta, Georgia. Church leaders viewed a leadership video and subsequently conducted social activities that support testing. After the multilevel intervention, a third of churches hosted HIV and diabetes health fairs, and church leaders engaged in more social activities. O...

The risk factors for diabetic peripheral neuropathy: A meta-analysis.

Diabetic peripheral neuropathy (DPN), the most common chronic complication of diabetes, has become an important public health crisis worldwide. Given that DPN is extremely difficult to treat, determining its risk factors and controlling it at an early stage is critical to preventing its serious consequences and the burden of social disease. Current studies suggest that the risk factors for diabeti...

Association of cardiovascular autonomic dysfunction with peripheral arterial stiffness in patients with type 1 diabetes.

Cardiovascular autonomic (CAN) neuropathy appears to contribute to peripheral arterial stiffness (AS) in type 1 diabetes. If CAN in patients with AS is associated to concomitant asymptomatic atherosclerotic disease (aPAD) remains unclear.

Association of vaspin rs2236242 gene variants with type 2 diabetes and obesity in a Chinese population: A prospective, single-center study.

Vaspin is an adipokine separated from visceral fat tissues of obese diabetic rats. This study was to investigate the association between vaspin rs2236242 gene polymorphism and type 2 diabetes mellitus (T2DM) or obesity in a Chinese population.

Birth weight and risk of type 2 diabetes mellitus: a dose-response meta-analysis of cohort studies.

The association between birth weight and type 2 diabetes mellitus has been debated for several decades, and the dose-response relationship has not been reported. The objective of this systematic review and meta-analysis was to quantitatively clarify the association between birth weight and risk of type 2 diabetes mellitus based on cohort studies.

Diabetes Alters pH Control in Rat Retina.

The purpose of this study was to determine whether the ability of the rat retina to control its pH is affected by diabetes.

Varicella Zoster Virus Induces Differential Cell-Type Specific Responses in Human Corneal Epithelial Cells and Keratocytes.

While VZV DNA and antigen have been detected in acute and chronic VZV keratitis, it is unclear whether productive infection of corneal cells is ongoing or whether residual, noninfectious VZV antigens elicit inflammation. Herein, we examined VZV-infected primary human corneal epithelial cells (HCECs) and keratocytes (HKs) to elucidate the pathogenesis of VZV keratitis.

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