Biotechnology Business Research

05:28 EST 23rd January 2019 | BioPortfolio

Tumor mutational burden (TMB) standardization initiatives: Recommendations for consistent TMB assessment in clinical samples to guide immunotherapy treatment decisions.

Characterization of tumors utilizing next-generation sequencing methods, including assessment of the number of somatic mutations (tumor mutational burden [TMB]), is currently at the forefront of the field of personalized medicine. Recent clinical studies have associated high TMB with improved patient response rates and survival benefit from immune checkpoint inhibitors; hence, TMB is emerging as a...

Challenges in developing collaborative interdisciplinary research between gastroenterologists and engineers.

The role of technology in healthcare is rapidly evolving. However, it can be argued that gastroenterology has not kept pace with other medical fields due to the multifaceted needs of this speciality and other issues. Innovation in healthcare technology increasingly requires interdisciplinary collaboration between engineers and clinicians. Nevertheless, working in such an interdisciplinary environm...

Protecting User Privacy and Rights in Academic Data-Sharing Partnerships: Principles From a Pilot Program at Crisis Text Line.

Data sharing between technology companies and academic health researchers has multiple health care, scientific, social, and business benefits. Many companies remain wary about such sharing because of unaddressed concerns about ethics, data security, logistics, and public relations. Without guidance on these issues, few companies are willing to take on the potential work and risks involved in nonco...

Public Views on Using Mobile Phone Call Detail Records in Health Research: Qualitative Study.

Mobile phone call detail records (CDRs) are increasingly being used in health research. The location element in CDRs is used in various health geographic studies, for example, to track population movement and infectious disease transmission. Vast volumes of CDRs are held by multinational organizations, which may make them available for research under various data governance regimes. However, there...

Clinical pharmacist perspectives for optimizing pharmacotherapy within Enhanced Recovery After Surgery (ERAS) Programs.

One of the most durable approaches to perioperative enhanced recovery programming has culminated in the formation of perioperative organizations devoted to improvements in the quality of the surgical patient experience, such as the Enhanced Recovery After Surgery (ERAS) Society. Members of the American College of Clinical Pharmacy (ACCP) Perioperative Care Practice and Research Network (PRN) and o...

Assessing research impact: Australian Research Council criteria and the case of Family Wellbeing research.

Researchers worldwide are increasingly reporting the societal impact of their research as part of national research productivity assessments. However, the challenges they encounter in developing their impact case studies against specified government assessment criteria and how pitfalls can be mitigated are not reported. This paper examines the key steps taken to develop an Aboriginal Family Wellbe...

Hormone and Metabolic Research: 50 Years of Research.

Modified Research Utilization Questionnaire (M-RUQ): development and validation study amongst Italian nurses.

The purpose of this study was to develop the modified research utilization questionnaire (M-RUQ), and to establish its content and face validity, construct validity and reliability.

Formative research experiences in pediatric surgeons: a mixed methods study of Pediatric Trauma Society members.

A career in pediatric surgery has historically required extensive research experience, but the optimal research training is not well defined. The purpose of this study was to explore the formative research experiences among pediatric surgeons.

Measurement of attitudes toward interprofessional collaboration in an operating theatre - a cross-sectional study.

Measurement of attitudes toward interprofessional collaboration in an operating theatre - a cross-sectional study Abstract.

Association of Physician Group Participation in Accountable Care Organizations With Patient Social and Clinical Characteristics.

Accountable care organizations (ACOs) may increase health care disparities by excluding physician groups that care for socially and clinically vulnerable patients.

The role of data custodians in establishing and maintaining social licence for health research.

In this article we explore the role of data custodians in establishing and maintaining social licence for the use of personal information in health research. Personal information from population-level data collections can be used to make significant contributions to health and medical research, but this use is dependent on community acceptance or a social licence. We conducted semi-structured inte...

The European Cancer Patient Coalition and its central role in connecting stakeholders to advance patient-centric solutions in the mission on cancer.

There is an urgent need for solutions to the economic and social inequalities in cancer care that still exist in many European countries. Patient preferences, "big data", mobile digital technology, and molecular and genomic profiling are among the innovative research topics that connect cancer patients to comprehensive cancer centres, and link translational research to cancer diagnosis, treatment,...

Cancer Core Europe: A translational research infrastructure for a European mission on cancer.

Cancer Core Europe is a European legal alliance consisting of seven leading cancer centres - most of them Comprehensive Cancer Centres (CCCs) - with a single portal system to engage in various research projects with partners. Cancer Core Europe was established to create a sustainable, high-level, shared research infrastructure platform hosting research collaborations and taskforces (data sharing, ...

Towards a Mission-oriented Approach to Cancer in Europe: An Unmet Need in Cancer Research Policy.

Today, cancer is a significant challenge for society, healthcare systems, and the growing number of affected patients and their families. This article argues that new paradigms and conditions for responsible science and innovation policy across the EU require the collective action of Research & Development institutions, a system approach to health systems, higher education, and patient organizatio...

Best practices in nutrition science to earn and keep the public's trust.

Public trust in nutrition science is the foundation on which nutrition and health progress is based, including sound public health. An ASN-commissioned, independent Advisory Committee comprehensively reviewed the literature and available public surveys about the public's trust in nutrition science and the factors that influence it and conducted stakeholder outreach regarding publicly available inf...

Orphan drugs: major development challenges at the clinical stage.

Biotechnology has provided powerful tools to assist in research and development (R&D) for rare diseases. However, orphan drug development presents several major challenges and obstacles, such as low disease prevalence, disease severity, small and heterogeneous patient populations, difficulties in patient recruitment, and limited knowledge of the natural history of disease, among others. Several st...

Cardiovascular Research by Leonardo da Vinci (1452-1519).

Response to the Commentary: Measurement Challenges in Research With Individuals With Cognitive Impairment: What Should We Measure and Why?

Civic Engagement Among California High School Teens.

This policy brief describes civic engagement among California adolescents in high school. Using data from the California Health Interview Survey (CHIS), the study found that the most common civic engagement activity among California high school teens is volunteering. Latino teens and those from low-income families have lower rates of civic engagement. Higher rates of civic engagement are associate...

Is it Time to Revise the Definition of Research Misconduct?

US federal policy defines research misconduct as fabrication of data, falsification of data, or plagiarism (FFP). In recent years, some have argued or suggested that the definition of research misconduct should also include sexual harassment, sabotage, deceptive use of statistics, and failure to disclose a significant conflict of interest. While the arguments for revising the definition of miscond...

High-Load Soft Grippers Based on Bionic Winding Effect.

The improvement of the load capacity of soft grippers has always been a challenge. To tackle this load capacity challenge, this work presents four novel types of high-load (HL) soft grippers that are bioinspired by bionic winding models. The winding models are found commonly in many animals and plants, where different winding patterns are used to grip different objects. Inspired by the winding mod...

Human Papillomavirus Infection and Transmission Among Couples Through Heterosexual Activity (HITCH) Cohort Study: Protocol Describing Design, Methods, and Research Goals.

Human papillomavirus (HPV) epidemiological research has generally been individual based, typically focusing on women, with couple-based research mostly consisting of cross-sectional assessment of prevalent HPV infection in both partners.

Association Between the Growth of Accountable Care Organizations and Physician Work Hours and Self-employment.

The share of the population covered by accountable care organizations (ACOs) is growing, but the association between this increase and physician employment is unknown.

Publication of Randomized Clinical Trials in Pediatric Research: A Follow-up Study.

Nonpublication of research results in considerable research waste and compromises medical evidence and the safety of interventions in child health.

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