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Biotechnology Research

01:24 EST 21st November 2017 | BioPortfolio

Sulfolobus acidocaldarius uptakes pentoses via a cut2-type ABC transporter and metabolizes them through the aldolase-independent Weimberg pathway.

Sulfolobus spp. possess a great metabolic versatility and grow heterotrophically on various carbon sources such as different sugars and peptides. Known sugar transporters in Archaea predominantly belong to ABC transport systems. Although several ABC transporters for sugar uptake have been characterized in the crenarchaeon Sulfolobus solfataricus, only one homologue of these transporters, the malto...

Balancing a genetic toggle switch by real-time feedback control and periodic forcing.

Cybergenetics is a novel field of research aiming at remotely pilot cellular processes in real-time with to leverage the biotechnological potential of synthetic biology. Yet, the control of only a small number of genetic circuits has been tested so far. Here we investigate the control of multistable gene regulatory networks, which are ubiquitously found in nature and play critical roles in cell di...

Re-Framing Biotechnology Regulation.

Biotechnology is about to spill the banks of federal regulation. New genetic engineering techniques like CRISPR-Cas9 promise revolutionary breakthroughs in medicine, agriculture, and public health—but those techniques would not be regulated under the terms of the Coordinated Framework for Regulation of Biotechnology. This revolutionary moment in biotechnology offers an opportunity to correct the...

Genome-wide identification of tolerance mechanisms towards p-coumaric acid in Pseudomonas putida.

The soil bacterium Pseudomonas putida KT2440 has gained increasing biotechnological interest due to its ability to tolerate different types of stress. Here, the tolerance of P. putida KT2440 towards eleven toxic chemical compounds was investigated. P. putida was found to be significantly more tolerant towards three of the eleven compounds when compared to Escherichia coli. Increased tolerance was ...

When do two-stage processes outperform one-stage processes?

Apart from product yield and titer, volumetric productivity is a key performance indicator for many biotechnological processes. Due to the inherent trade-off between the production of biomass as catalyst and of the actual target product, yield and volumetric productivity cannot be optimized simultaneously. Therefore, in combination with genetic techniques for dynamic regulation of metabolic fluxes...

Biotechnology: A highly efficient tool for the current environmental challenges.

AFOB Special Issue on Industrial Biotechnology.

Overcoming the energetic limitations of syngas fermentation.

The fermentation of synthesis gas (including carbon monoxide, carbon dioxide, and hydrogen) with anaerobic acetogens is an established biotechnological process that has recently been transferred to a commercial scale. The natural product spectrum of acetogens is natively restricted to acetate, ethanol, and 2,3-butanediol but is rapidly expanding to heterologous products. Syngas fermentation can ac...

Third-quarter biotech job picture.

Around the world in a month.

Allergan's Mohawk evergreening patent deal draws criticism, but ultimately may flop.

RET-oncogene-targeting drugs draw notice.

Recent patents related to germline modification.

First AAV gene therapy poised for landmark approval.

3Q17-Funding and partnership into overdrive.

Spanish group defeats Shkreli in Chagas voucher race.

Reproducing with DNA.

When replacement becomes reversion.

Duchenne drug clings on for FDA nod.

First rounders: Stelios Papadopoulos.

Revisiting the Warnock rule.

Public views on gene editing and its uses.

Corrections.

This corrects the article DOI: 10.1038/nbt0617-493.

Ethical principles for the use of human cellular biotechnologies.

Query the merits of embryo editing for reproductive research now.

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