Breast Cancer

16:02 EDT 24th August 2019 | BioPortfolio

Track and monitor developments in breast cancer research and commercial development.  Follow the tabs above to read the latest global news, research, clinical trials on breast cancer and follow companies active in the development of breast cancer treatments.  BioPortfolio also markets and sells market research reports on breast cancer research and developments.

Breast cancer symptoms

Signs of breast cancer vary widely — from lumps to swelling to skin changes — and many breast cancers have no obvious symptoms at all. Symptoms that are similar to those of breast cancer may be the result of non-cancerous conditions like infection or a cyst.

Breast self-exam should be part of your monthly health care routine, and you should visit your doctor if you experience breast changes. If you're over 40 or at a high risk for the disease, you should also have an annual mammogram and physical exam by a doctor. The earlier breast cancer is found and diagnosed, the better your chances of beating it.

Breast cancer awareness - signs of breast cancer - see your medical practitioner if you notice any of the following:

  • a lump or area of thickened tissue in either breast
  • a change in the size or shape of one or both breasts
  • discharge from either of your nipples (which may be streaked with blood)
  • a lump or swelling in either of your armpits
  • dimpling on the skin of your breasts
  • a rash on or around your nipple
  • a change in the appearance of your nipple, such as becoming sunken into your breast
  • breast pain in either of your breasts or armpits not related to your period

Inflammatory breast cancer

Inflammatory breast cancer (IBC) is a rare and very aggressive disease in which cancer cells block lymph vessels in the skin of the breast. This type of breast cancer is called “inflammatory” because the breast often looks swollen and red, or “inflamed.”

Inflammatory breast cancer accounts for 1 to 5 percent of all breast cancers diagnosed in the United States. Most inflammatory breast cancers are invasive ductal carcinomas, which means they developed from cells that line the milk ducts of the breast and then spread beyond the ducts.

Inflammatory breast cancer progresses rapidly, often in a matter of weeks or months. Inflammatory breast cancer is either stage III or IV at diagnosis, depending on whether cancer cells have spread only to nearby lymph nodes or to other tissues as well.

Review the latest research on inflammatory breast cancer.

Triple negative breast cancer

If yout pathology report indicates that the breast cancer cells tested negative for estrogen receptors (ER-), progesterone receptors (PR-), and HER2 (HER2-) the cancer is triple-negative.

These negative results mean that the growth of the cancer is not supported by the hormones estrogen and progesterone, nor by the presence of too many HER2 receptors. Therefore, triple-negative breast cancer does not respond to hormonal therapy (such as tamoxifen or aromatase inhibitors) or therapies that target HER2 receptors, such as Herceptin (chemical name: trastuzumab). However, other medicines can be used to treat triple-negative breast cancer.

Review the latest research on triple-negative breast cancer.

Breast cancer stages

Extensive information can be found at:

Research and Developmet

BioPortfolio provides extensive access to the latest strides against breast cancer, clinical trials, news, companies and research - please refer to the tabs above.

Breast cancer facts - UK

Breast cancer in the UK is diagnosed in nearly  46,000 people  each year, with just over 12,000 dying from breast cancer each year in he UK. There are several risk factors for developing breast cancer including age and a family history of the disease (BRAC2 gene mutation).

The type of cancer determines the treatment options, which have improved over the last decade or so;

Chemotherapy uses cytotoxic drugs to destroy breast cancer cells. It is known as a systemic treatment because the whole body is exposed to the drugs. This may be used in addition to surgery and/or radiotherapy, and it is usually given after surgery and before radiotherapy (adjuvant chemotherapy) or before surgery (neo-adjuvant chemotherapy or primary chemotherapy).

Hormone therapy may be used if your breast cancer is hormone receptor positive. Oestrogen receptor positive cancers make up around 75 per cent of breast cancers in post-menopausal women and around 50 to 60 per cent in pre-menopausal women. A hormone receptor test is now routinely carried out on tissue taken during a biopsy or after the operation to remove the breast cancer.

Radiotherapy uses high energy x-rays to destroy cancer cells, either before or after surgery. Surgery is usually the first treatment for breast cancer; either breast conserving surgery (lumpectomy or wide local excision) or a total mastectomy. Lymph nodes in the axilla be also be removed. Targeted therapies such as Herceptin (trastuzumab) are becoming more widely used, as they target the cancer cells directly, and there are clinical trials for many at the moment.

Breast Cancer Facts - USA

Definition of breast cancer: Cancer that forms in tissues of the breast. The most common type of breast cancer is ductal carcinoma, which begins in the lining of the milk ducts (thin tubes that carry milk from the lobules of the breast to the nipple). Another type of breast cancer is lobular carcinoma, which begins in the lobules (milk glands) of the breast. Invasive breast cancer is breast cancer that has spread from where it began in the breast ducts or lobules to surrounding normal tissue. Breast cancer occurs in both men and women, although male breast cancer is rare.

Estimated new cases and deaths from breast cancer in the United States in 2013:

New cases: 232,340 (female); 2,240 (male)
Deaths: 39,620 (female); 410 (male)

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