Cancer Research

09:46 EDT 19th August 2018 | BioPortfolio

Photosensitiser-gold nanoparticle conjugates for photodynamic therapy of cancer.

Gold nanoparticles (AuNPs) have been extensively studied within biomedicine due to their biocompatibility and low toxicity. In particular, AuNPs have been widely used to deliver photosensitiser agents for photodynamic therapy (PDT) of cancer. Here we review the state-of-the-art for the functionalisation of the gold nanoparticle surface with both photosensitisers and targeting ligands for the activ...

Chemopreventive effects of some popular phytochemicals on human colon cancer: a review.

Colon cancer is one of the major causes of morbidity and mortality worldwide. Dietary phytochemicals have been drawing increasing attention for colon cancer prevention and treatment due to their chemical diversity, biological activity, easy availability, lack of toxic effects, and ability to modulate various signal transduction pathways and cell processes. The chemoprotective effects elicited by p...

Estimating Lung, Breast, and Effective Dose from Low-Dose Lung Cancer Screening CT Exams with Tube Current Modulation across a Range of Patient Sizes.

The purpose of this study was to estimate the radiation dose to the lung and breast as well as the effective dose from tube current modulated (TCM) lung cancer screening (LCS) scans across a range of patient sizes.

Multinational validation of the AJCC 8 edition pancreatic cancer staging system in a pancreas head cancer cohort.

The aim was to compare the 7 and 8 editions of the AJCC staging system for pancreas head cancer and to validate the 8 edition using three multinational tertiary center data.

Free radical damage can cause serious long-lasting effects.

Inhaled NO (iNO) is an approved therapy for pulmonary hypertension (PH) in term infants and its use is now increasing in preterm infants with hypoxemic respiratory failure (HRF) and, or, PH, despite the lack of sustained benefits. In the current issue of Acta Paediatrica, Dixon et al report that iNO use in the neonatal intensive care unit (NICU) may increase childhood cancer (1). In an earlier pu...

pH- and enzyme-sensitive IR820-paclitaxel conjugate self-assembled nanovehicles for near-infrared fluorescence imaging-guided chemo-photothermal therapy.

The short lifetime and easily quick elimination of near-infrared dye new indocyanine green (IR820) in body restrict its practical application as photothermal agent in cancer therapy. Meanwhile, the drawback of poor water solubility of chemotherapeutic drug paclitaxel (PTX) largely restricts its clinical applications. Herein we for the first time combined IR820 and PTX in an "all-in-one" fluorescen...

Rationally Developed Metallogelators Derived from Pyridyl Deriva-tives of NSAIDs Displaying Anti-inflammatory and Anti-cancer Activities.

Metal-ligand coordination involving hydrogen bond functionalized ligands was employed rationally to get an easy access to a series of metallogelators derived from 3-pyridyl derivatives of non-steroidal-anti-inflammatory drugs (NSAIDs) [e.g. ibuprofen, sulindac and flurbiprofen designated as 3-pyIBU, 3-pySUL and 3-pyFLR, respectively] and biogenic metal centers [Zn(II), Cu(II), Mn(II) and Ag(I)]. T...

Lysosome-Targeted Chemotherapeutics: Half-Sandwich Ruthenium(II) Complexes That Are Selectively Toxic to Cancer Cells.

Poor selectivity between cancer cells and normal cells is one of the major limitations of cancer chemotherapy. Lysosome-targeted ruthenium-based complexes target tumor cells selectively, only displaying rather weak cytotoxicity or inactivity toward normal cells. Confocal microscopy was employed for the first time to determine the cellular localization of the half-sandwich Ru complex.

Investigational therapies targeting the androgen signaling axis and the androgen receptor and in prostate cancer - recent developments and future directions.

Despite the heterogeneity of prostate cancer (PCa), androgen stimulation is fundamental to its development, growth and lethality. Therefore, the blockade of androgen receptor (AR) signaling is critical to controlling the disease, even after progression with castrate levels of androgens. Areas covered: We review the current understanding of new ways to block the AR, using novel antiandrogen inhibit...

Testing for AFP in combination with ultrasound improves early liver cancer detection.

Olaparib tablets for the treatment of germline BRCA-mutated metastatic breast cancer.

Introduction Germline BRCA mutations (gBRCAm) are diagnosed in approximately 5% of unselected breast cancer patients. Olaparib is a new treatment option for patients with a gBRCAm who have metastatic HER2-negative breast cancer. Areas Covered Olaparib is an oral poly (ADP-ribose) polymerase inhibitor that has been shown in phase I-III clinical trials to have single-agent efficacy in breast cancer ...

Association of Pregnancy History and Cervical Cancer Screening in a Community Sample of Sexual Minority Women.

Sexual minority women (SMW) face barriers to healthcare that may result in lower utilization of cervical cancer screening. Previous experiences with the healthcare system-specifically reproductive health-related encounters-have the potential to affect future use of screening services. This study aimed to examine the association between pregnancy history and cervical cancer screening in a diverse s...

Regulation of protective autophagy in anoikis-resistant glioma stem cells by SDCBP/MDA-9/Syntenin.

Glioblastoma multiforme (GBM) is a frequent and aggressive glial tumor, containing a small population of therapy-resistant cells, glioma stem cells (GSCs). Current dogma suggests that tumors regrow from GSCs, and these cells contribute to therapy resistance, poor prognosis, and recurrence; highlighting the importance of GSCs in glioma pathophysiology and therapeutic targeting. Macroautophagy/autop...

Endocrine Deficiency as a Function of Radiation Dose to the Hypothalamus and Pituitary in Pediatric and Young Adult Patients With Brain Tumors.

Purpose There are sparse data defining the dose response of radiation therapy (RT) to the hypothalamus and pituitary in pediatric and young adult patients with brain tumors. We examined the correlation between RT dose to these structures and development of endocrine dysfunction in this population. Materials and Methods Dosimetric and clinical data were collected from children and young adults (< 2...

Effects of placental growth factor deficiency on behavior, neuroanatomy and cerebrovasculature of mice.

Preeclampsia, a hypertensive syndrome occurring in 3-5% of human pregnancies, has lifelong health consequences for the fetus. Cognitive ability throughout life is altered and adult stroke risk is increased in these offspring. One potential etiological factor for altered brain development is low concentrations of pro-angiogenic placental growth factor (PGF). Impaired PGF production may promote an a...

Should Physicians New to a Case Counsel Patients and Their Families to Change Course at the End of Life?

Although new cancer therapies have changed the prognosis for some patients with advanced malignancies, the potential benefit for an individual patient remains difficult to predict. This uncertainty has impacted goals-of-care discussions for oncology patients during critical illness. Physicians need to have transparent discussions about end-of-life care options that explore different perspectives a...

Attachment Orientation and Relationships With Physicians and Nurses Among Israeli Patients With Advanced Cancer.

To examine the association between attachment orientation and relationships with physicians and nurses among Israeli patients with advanced cancer.

Well-Being of Child and Family Participants in Phase 1 Pediatric Oncology Clinical Trials.

Pediatric oncology phase 1 clinical trials (P1Ts) are essential to developing new anticancer therapies; however, they raise complex ethical concerns about balancing the need for this research with the well-being of participating children. The purpose of this integrative review was to synthesize and appraise the evidence of how P1T participation, which begins with consent and ends with the transiti...

Oncology Nurses' Knowledge of Pharmacogenomics Before and After Implementation of an Education Module.

To assess the efficacy of an interactive continuing education module in improving knowledge of pharmacogenomics in oncology nursing practice.

Food Safety Knowledge and Self-Reported Food-Handling Practices in Cancer Treatment.

To explore awareness of foodborne infection risk during chemotherapy treatment, to assess knowledge of risk-reducing food safety practices in patients with cancer and their family caregivers, and to determine self-reported food-handling practices.

Nurse-Delivered Symptom Assessment for Individuals With Advanced Lung Cancer.

To assess an intervention derived from self-regulation theory (SRT) to promote well-being for individuals with advanced lung cancer.

Feelings of Disenfranchisement and Support Needs Among Patients With Thyroid Cancer.

To offer a better understanding of the experiences, preferences, and needs of patients with thyroid cancer.

Response to "Taking Photos of Presentations: Dissemination or Distraction?"

I would like to thank Anne Katz, PhD, RN, FAAN, for her thoughtful editorial in the July 2018 issue of Oncology Nursing Forum. At least twice, that I am aware of, someone has used my slides without my permission. The first time happened about 10 years ago. I gave an educational program on the fundamentals of hereditary cancer syndromes at a regional conference for oncology nurses. I provided a det...

Feasibility of a Telemedicine-Delivered Cognitive Behavioral Therapy for Insomnia in Rural Breast Cancer Survivors.

To evaluate a nurse-led, telemedicine-delivered cognitive behavioral therapy for insomnia (CBTI) in rural breast cancer survivors (BCSs).

Support Needs of People With Head and Neck Cancer Regarding the Disease and Its Treatment.

To provide insight into people's experiences in dealing with the consequences of head and neck cancer (HNC) in daily life and their needs for self-management support.

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