Cardiovascular disease (CVD) Research

01:24 EDT 17th October 2018 | BioPortfolio

Respiratory- and cardiac motion-corrected simultaneous whole-heart PET and dual phase coronary MR angiography.

To develop a framework for efficient and simultaneous acquisition of motion-compensated whole-heart coronary MR angiography (CMRA) and left ventricular function by MR and myocardial integrity by PET on a 3T PET-MR system.

Role of T cells in CD47/DST-induced immune tolerance in skin-heart transplantation mice.

To explore the role of T cells in the establishment of immune tolerance induced by donor specific transfusion (DST) in mice with skin-heart transplantation.

Cross-Sectional Inverse Association of Regular Soy Intake with Insulin Resistance in Japanese Elderly.

Levels of isoflavones, biomarkers of soy intake, in 24-hour urine (24U) were inversely related to coronary heart disease (CHD) mortality in the World Health Organization's Cardiovascular Disease and Alimentary Comparison Study. Considering 24 U isoflavone levels were highest and CHD mortality was lowest in the Japanese, who maintained the world's longest life expectancy, the association of regul...

'SI VIS VITAM, PARA MORTEM' terror management theory and psychosocial healthcare practice.

Terror management theory (TMT) contends that the need to manage the anxiety evoked by the awareness of one's own mortality, through proximal and distal defenses, lies at the heart of any human motivation. Proximal defenses aim at dismissing death awareness. Distal defenses aim at keeping them out of frame. The terror management health model (TMHM) applies TMT to issues of health and illness. TMT a...

Antithrombotic therapy in patients with peripheral artery diseases.

Complications of cardiovascular diseases whose substrate is atherothrombosis continue to occupy leading positions in the structure of mortality worldwide. Peripheral artery diseases (PAD), in particular, are characterized by an especially unfavourable life prognosis for patients with cardiovascular diseases. In order to decrease the risks of ischaemic complications in patients with PAD, various ap...

Lifespan of patients after endured embolism of the aorta and major arteries of the limbs.

The authors analysed the remote results of treatment of patients having endured embologenic arterial obstruction. Over the last 47 years, specialists of the Department of Cardiovascular Surgery No1 of the North-Western State Medical University named after I.I. Mechnikov have rendered emergency medical care to a total of 3,455 patients presenting with embolisms of the aorta and arteries of the limb...

Carotid endarterectomy: three-year results of follow up within the framework of a single-centre register.

The purpose of the study was to determine the incidence rate and structure of cardiovascular complications in patients presenting with lesions of the carotid arteries and multifocal atherosclerosis, having endured carotid endarterectomy (CEA), during a three-year period within the framework of a single-centre register. The study included a total of 1,035 patients subjected to CEA over the period f...

Surgical treatment of chronic thromboembolic pulmonary hypertension.

Analysed herein are the results of pulmonary endarterectomy (PEA) performed in a total of 169 patients presenting with chronic thromboembolic pulmonary hypertension (CTEPH) at the National Medical Research Centre named after Academician E.N. Meshalkin over the period from 2004 to 2014. Pulmonary endarterectomy was carried out according to the standard technique in the conditions of assisted circul...

Individual variability of vascularization of the anterior papillary muscle within the right ventricle of human heart.

To date there is scarce published evidence reporting the dual blood supply reaching anterior papillary muscle (APM), which descends from both major coronary arteries. Such a vascular configuration can prevent the dysfunction of right ventricular entire valvular system in case of the occlusion of proximal part of either right coronary artery (RCA) or left coronary artery (LCA). The aim of our study...

Inhibition of GSK-3 to induce cardiomyocyte proliferation-a recipe for in situ cardiac regeneration.

With an estimated 38 million current patients, heart failure (HF) is a leading cause of morbidity and mortality worldwide. Although the etiology differs, HF is largely a disease of cardiomyocyte (CM) death or dysfunction. Due to the famously limited amount of regenerative capacity of the myocardium, the only viable option for advanced HF patients is cardiac transplantation; however, donor's hearts...

Cardiovascular risk profile among patients with inflammatory bowel disease: a population-based study of >100,000 individuals.

Patients with inflammatory bowel disease have increased risks of cardiovascular diseases but the role of traditional and non-traditional cardiovascular risk factors remains unclear. We investigated if the cardiovascular risk profile differs between patients with inflammatory bowel disease and individuals in the general population.

Valvular heart disease: tricuspid regurgitation is the new frontier.

ESC Congress Munich 2018.

A £30m international research award.

Back to the Future with Munich 2018.

Effect of rapamycin on the level of autophagy in rats with early heart failure.

Heart failure (HF) progression can be prevented by an inhibitor of the mammalian target of rapamycin and an autophagy enhancer rapamycin. This current study aimed to investigate the effect of rapamycin on HF progression and myocardial cells apoptosis.

Comparison of echocardiography and 64-slice spiral computed tomography in the diagnosis of congenital heart disease in children.

The diagnosis of congenital heart disease in children has been an issue in the medical community. Timely diagnosis and treatment can provide a greater guarantee for children's healthy growth. In recent years, there have been more and more studies on the diagnosis of congenital heart disease in children. This paper compares the advantages and disadvantages of echocardiography and 64-slice spiral co...

Cardiac CaMKII activation promotes rapid translocation to its extra-dyadic targets.

Calcium-calmodulin dependent protein kinase IIδ (CaMKIIδ) is an important regulator of cardiac electrophysiology, calcium (Ca) balance, contraction, transcription, arrhythmias and progression to heart failure. CaMKII is readily activated at mouths of dyadic cleft Ca channels, but because of its low Ca-calmodulin affinity and presumed immobility it is less clear how CaMKII gets activated near oth...

Cardiovascular disease in Greece; the latest evidence on risk factors.

Cardiovascular disease (CVD) is a significant and ever-growing problem in Europe, accounting for nearly 45% of all deaths and leading to significant morbidity. Greece is one of the European Union member states that top the list of deaths due to ischemic heart disease and stroke, a fact that is mainly attributed to unfavorable changes in modifiable risk factors. The aim of this review is to examine...

The correlation of TGFβ1 gene polymorphisms with congenital heart disease susceptibility.

The aim of this study was to investigate the relationship between single nucleotide polymorphisms (SNPs) in transforming growth factor beta 1 (TGFβ1) gene (rs1982073 and rs1800471) and congenital heart disease (CHD) susceptibility.

Global Disparities in Cardiac Pacemaker Therapy: Problem Statement, Potential Solution, and Call to Action.

PRMT1 Deficiency in Mouse Juvenile Heart Induces Dilated Cardiomyopathy and Reveals Cryptic Alternative Splicing Products.

Protein arginine methyltransferase 1 (PRMT1) catalyzes the asymmetric dimethylation of arginine residues in proteins and methylation of various RNA-binding proteins and is associated with alternative splicing in vitro. Although PRMT1 has essential in vivo roles in embryonic development, CNS development, and skeletal muscle regeneration, the functional importance of PRMT1 in the heart remains to ...

Arsenic, one carbon metabolism and diabetes-related outcomes in the Strong Heart Family Study.

Inorganic arsenic exposure and inter-individual differences in its metabolism have been associated with cardiometabolic risk. A more efficient arsenic metabolism profile (lower MMA%, higher DMA%) has been associated with reduced risk for arsenic-related health outcomes; however, this profile has also been associated with increased risk for diabetes-related outcomes. The mechanism behind these cont...

Lipoprotein(a) and secondary prevention of atherothrombotic events: A critical appraisal.

Elevated plasma concentrations of lipoprotein(a) [Lp(a)] are an independent, and possibly causal, risk factor for atherothrombotic diseases including coronary heart disease. The principal evidence base for this comes from large population studies focusing on first atherothrombotic events. However, inconsistent findings have been reported from studies investigating the impact of elevated Lp(a) on a...

Characterization of bilirubin interference in three commonly used digoxin assays.

Due to the narrow therapeutic range of digoxin, determining serum/plasma digoxin concentrations is critical for assessing patients with congestive heart failure, atrial fibrillation, and certain types of arrhythmias. However, digoxin quantification by competitive immunoassays is susceptible to interferences that may alter the accuracy of its measurement in patient plasma. This study aimed to chara...

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