Cervical Cancer Research

09:36 EST 15th November 2018 | BioPortfolio

Decitabine attenuates nociceptive behavior in a murine model of bone cancer pain.

Bone cancer metastasis is extremely painful and decreases the quality of life of the affected patients. Available pharmacological treatments are not able to sufficiently ameliorate the pain and as cancer patients are living longer new treatments for pain management are needed. Decitabine (5-aza-2'-deoxycytidine), a DNA methyltransferases inhibitor, has analgesic properties in pre-clinical models o...

A colorectal cancer diet quality index is inversely associated with colorectal cancer in the Malmö diet and cancer study.

The World Cancer Research Fund International has concluded strong evidence for that high intake of dairy products and foods containing dietary fiber and low intake of processed meat are associated with decreased risk of colorectal cancer (CRC). As food items are consumed together, it is important to study dietary patterns. The aim of the present study was to examine the association between an a pr...

Strategies for caring for the well cancer survivor.

Surveillance of existing cancer, management of treatment-related adverse effects, and screening for second cancers are key to the care you'll provide.

Role of INSL4 Signaling in Sustaining the Growth and Viability of LKB1-Inactivated Lung Cancer.

The LKB1 tumor suppressor gene is commonly inactivated in non-small cell lung carcinomas (NSCLC), a major form of lung cancer. Targeted therapies for LKB1-inactivated lung cancer are currently unavailable. Identification of critical signaling components downstream of LKB1 inactivation has the potential to uncover rational therapeutic targets. Here we investigated the role of INSL4, a member of the...

Molecular-targeted therapies and precision medicine for endometrial cancer.

The overall survival rate of patients with early-stage endometrial cancer is relatively high; however, there are few treatment options for patients with advanced or recurrent endometrial cancer, and the prognosis of such patients remains poor. Recent progress in molecular-targeted therapies demonstrated that they have the potential to improve the long-term survival of cancer patients with appropri...

Acute Kidney Injury in Patients Receiving Systemic Treatment for Cancer: A Population-Based Cohort Study.

Patients undergoing treatment for cancer are at increased risk of acute kidney injury (AKI). There are few data on AKI incidence and risk factors in the current era of cancer treatment.

The antitumor effects of entinostat in ovarian cancer require adaptive immunity.

Ovarian cancer is poorly immunogenic; however, increased major histocompatibility complex class II (MHCII) expression correlates with improved immune response and prolonged survival in patients with ovarian cancer. The authors previously demonstrated that the histone deacetylase inhibitor entinostat increases MHCII expression on ovarian cancer cells. In the current study, they evaluated whether en...

Outcomes of very high-risk prostate cancer after radical prostatectomy: Validation study from 3 centers.

Among men with localized high-risk prostate cancer (PCa), patients who meet very high-risk (VHR) criteria have been shown to experience worse outcomes after radical prostatectomy (RP) in a previous study. Variations of VHR criteria have been suggested to be prognostic in other single-center cohorts, but multicenter outcomes validating VHR criteria have not been described. This study was designed t...

Ten-year change in neighborhood socioeconomic status and colorectal cancer.

A growing body of research has demonstrated that individuals who live in neighborhoods with more severe socioeconomic deprivation may have higher risks for colorectal cancer (CRC). However, previous studies have examined neighborhood socioeconomic status (SES) at only 1 point in time, and it is unclear whether changes in neighborhood SES also can influence the risks of CRC.

Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells.

In this study we interrogated the metabolome of human acute myeloid leukemia (AML) stem cells to elucidate properties relevant to therapeutic intervention. We demonstrate that amino acid uptake, steady-state levels, and catabolism are all elevated in the leukemia stem cell (LSC) population. Furthermore, LSCs isolated from de novo AML patients are uniquely reliant on amino acid metabolism for oxida...

RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer.

Pancreatic ductal adenocarcinoma (PDA) is characterized by immune tolerance and immunotherapeutic resistance. We discovered upregulation of receptor-interacting serine/threonine protein kinase 1 (RIP1) in tumor-associated macrophages (TAMs) in PDA. To study its role in oncogenic progression, we developed a selective small-molecule RIP1 inhibitor with high in vivo exposure. Targeting RIP1 reprogra...

β2 Adrenergic-Neurotrophin Feedforward Loop Promotes Pancreatic Cancer.

Long noncoding RNA IGF2AS is acting as an epigenetic tumor suppressor in human prostate cancer.

To assess the expression profile and functional mechanism of long non-coding RNA (lncRNA) insulin growth factor 2 antisense, IGF2AS in human prostate cancer (PCa).

Human papillomavirus infection is not involved in esophageal verrucous carcinoma.

Verrucous carcinoma of the esophagus (VCE) is a rare variant of squamous cell cancer, with a puzzling clinical, etiological, and molecular profile. The etiological involvement of human papillomavirus (HPV) in the cancer's natural history is controversial. This study considers nine cases of VCE, focusing on patients' clinical history before surgery, histological phenotype, immunophenotype (EGFR, E-...

Are WHO recommendations to perform two consecutive semen analyses for reliable diagnosis of male infertility still valid?

To evaluate whether a second semen analysis as suggested by the World Health Organization (WHO) Laboratory Manual for the Examination of Human Semen and Sperm-Cervical Mucus Interaction improves diagnostic reliability in the evaluation of male infertility.

Lactic acid induced microRNA-744 enhances motility of SiHa cervical cancer cells through targeting ARHGAP5.

High-risk (hr) human papillomaviruses (HPV) infection and integration has caused the majority of cervical cancer, of which E6 and E7 oncogenes are invariably retained and expressed to immortalize cells probably via affecting cell migration and invasion, and tumor metastasis. However, the underlying mechanism that mediates the procedure such as motility of cervical cancer cells within the tumor mic...

Mechanisms underlying acquired platinum resistance in high grade serous ovarian cancer - a mini review.

Advanced epithelial ovarian cancer is one of the hardest human malignancies to treat. Standard treatment involves cytoreductive surgery and platinum-based chemotherapy, however, median progression-free survival for patients diagnosed with advanced stage disease (FIGO stages III and IV) is approximately 18 months. There has been little improvement in overall survival over the past decade and less...

L-arginine/5-fluorouracil combination treatment approaches cells selectively: Rescuing endothelial cells while killing MDA-MB-468 breast cancer cells.

Reducing the adverse effects of chemotherapy on normal cells such as endothelial cells is a determinant factor of treatment success especially in pregnant women. In this regard, modulatory effect of L-arginine on various cancers is still a controversial topic in cancer therapy. So, this study aimed to compare the effect of L-arginine treatment alone and in combination with 5-fluorouracil (5-FU) on...

Human or not human? Performance monitoring ERPs during human agent and machine supervision.

Performance monitoring is a critical process which allows us to both learn from our own errors, and also interact with other human beings. However, our increasingly automated world requires us to interact more and more with automated systems, especially in risky environments. The present EEG study aimed at investigating and comparing the neuro-functional correlates associated with performance moni...

Etiological Role of Human Papillomavirus Infection in the Development of Penile Cancer.

To examine an association between human papillomavirus (HPV) infection and penile cancer among Japanese patients.

Peperomin E Induces Promoter Hypomethylation of Metastatic-Suppressor Genes and Attenuates Metastasis in Poorly Differentiated Gastric Cancer.

Peperomin E (PepE), a natural secolignan isolated from the whole plant of Peperomia dindygulensis, has been reported by ourselves and others to display potent anti-cancer effects in many types cancer cells, especially gastric cancer. However, the effects of PepE on the metastasis of poorly-differentiated gastric cancer cells and the underlying molecular mechanisms have not been well elucidated.

Synchronous mucinous metaplasia and neoplasia of the female genital tract.

To describe the clinicopathological features of synchronous mucinous metaplasia and neoplasia of the female genital tract (SMMN-FGT). The sample consisted of 7 cases of SMMN-FGT recorded from November 2014 to September 2017 at Obstetrics and Gynecology Hospital, Fudan University.PAP method was used in immunohistochemistry.Clinical histories were retrieved and pathological slides were reviewed. T...

Commentary: Surgical Resection of Cervical Meningioma: 3-Dimensional Operative Video.

Simultaneous four-channel recording of bilateral cervical and ocular vestibular-evoked myogenic potentials in response to stimulation by forehead bone-conducted vibration: Our experience in 20 healthy adults.

Various vestibular stimuli, including air-conducted sound (ACS), bone-conducted vibration (BCV), and galvanic vestibular stimulation (GVS), can be used to elicit vestibular-evoked myogenic potential (VEMP). VEMP obtained from the sternocleidomastoid (SCM) muscle is called cervical VEMP (cVEMP), while that recorded at extraocular muscles is termed ocular VEMP (oVEMP). cVEMP was first recognized as ...

Effect of heat treatment on the anti-tumor activity of lactoferrin in human colon tumor (HT29) model.

To investigate the effect of heat treatment on the anti-tumor activity of lactoferrin in colon cancer cells and colon tumors, the HT-29 (human intestinal epithelial tumor cell) cell line was exposed to lactoferrin and various heat treatments. The impacts on cell proliferation, invasion as well as migration was observed in vitro, and nude mice bearing HT29 tumors were administered lactoferrin and u...

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