Advertisement

Topics

Eligard - Biotech, Pharma and Life Science Channel

14:58 EST 13th November 2018 | BioPortfolio

Eligard® is a hormone compound for the treatment of advanced, hormone-dependent prostate cancer. The active ingredient (leuprolide acetate) significantly reduces the level of the male sex hormone testosterone, thus suppressing testosterone-dependent tumor growth. The established active ingredient is combined with a novel drug delivery system known as Atrigel® depot technology. The liquid drug is injected subcutaneously and Eligard® forms a gel-like implant which slowly disintegrates, steadily releasing the drug over a period of one, three or six months, depending on the dosage administered.

Medigene acquired the European marketing rights to Eligard® from Atrix Laboratories, Inc. (now Tolmar Therapeutics, Inc.) and successfully brought the drug through the market approval procedure in Germany. The European market launch of Eligard® by Medigene’s partner Astellas Pharma Europe, Ltd. started as early as 2004. Eligard® in its one-month, three-month and six-month dosage forms is now available in most European countries.

In mid-2010, Medigene sold the exclusive European marketing and distribution rights for Eligard® to Astellas Pharma Europe Ltd. against payment of €25 million and royalties of 2% on product sales. With the sale of the Eligard® rights, Medigene no longer bears any obligations or risks associated with the supply of Eligard® to Astellas. In addition, Medigene will no longer be liable for any procurement costs and license payments to Tolmar.

In June 2012, Medigene transferred its two percent royalty share of Eligard® European net sales to US-based investor, Cowen Healthcare Royalty Partners II, L.P., for a cash payment of appr. €14.1 million. Medigene plans to invest these proceeds in further strengthening the company’s pipeline.

Source: http://www.medigene.com/products-pipeline/products/eligard

News Articles [66 Associated News Articles listed on BioPortfolio]

Sanyal Biotechnology and Innovate Biopharmaceuticals Present Data at AASLD Validating a Proprietary “Leaky Gut” Assay Demonstrating Reduced Intestinal Permeability with Larazotide Acetate Treatment in a NASH Preclinical Study

Significant effect on gut epithelial integrity, a mechanism thought to be key for bacterial translocation leading to NAFLD and NASH. Innovate plans to launch a clinical development program for NASH i...

NOCDURNA® (desmopressin acetate) Sublingual Tablets Now Available by Prescription in US for Treatment of Nocturia Due to Nocturnal Polyuria

NOCDURNA is the first and only sublingual tablet for the treatment of nocturia due to nocturnal polyuria in adults who awaken at least two times per night to void.1 ...

Chongqing Lummy Pharmaceutical Co Ltd 300006 Pharmaceuticals Healthcare Deals and Alliances Profile [Report Updated: 23102018] Prices from USD $250

SummaryChongqing Lummy Pharmaceutical Co Ltd Lummy is a pharmaceutical company that provides pharmaceutical ingredients and drugs and related products. The company's products include antibacterial dru...

Global Dexamethasone Acetate Market Status and Outlook 20182025 [Report Updated: 16082018] Prices from USD $4000

Report SnapshotKey Content of Chapters Including and can be customized, report is a semifinished version, and it takes 4872 hours to upgradePart 1:Terminology Definition, Industry Chain,Industry Dynam...

FDA takes action to stop the use of lead acetate in hair dyes

FDA takes action to stop the use of lead acetate in hair dyes. FDA will no longer allow lead acetate to be used in certain hair coloring products based on data that demonstrate that there is no longer...

Chongqing Lummy Pharmaceutical Co Ltd 300006 Pharmaceuticals Healthcare Deals and Alliances Profile [Report Updated: 13082018] Prices from USD $250

SummaryChongqing Lummy Pharmaceutical Co Ltd Lummy is a pharmaceutical company that provides pharmaceutical ingredients and drugs and related products. The company's products include antibacterial dru...

Innovate Biopharmaceuticals Announces Positive Effect of Larazotide Acetate on reducing Intestinal Permeability in a NASH Preclinical Study

Top line results showed larazotide having a significant effect on intestinal permeability, a mechanism thought to be key for bacterial translocation leading to NAFLD/NASH Further preclinical data i...

Cellulose Esters Market by Type Cellulose Acetate, Cellulose Acetate Butyrate, Cellulose Acetate Propionate, Cellulose Nitrate, by Application Coatings, Plasticizers, Cigarette Filters, Films tapes, Inks, and Region Global Forecast to 2023 [Report Updat

The increasing demand for cellulose esters from the Asia Pacific region and technological advancements in various applications is fueling the growth of the cellulose esters market across the globe.The...

Astellas Pharma Inc 4503 Pharmaceuticals Healthcare Deals and Alliances Profile [Report Updated: 24092018] Prices from USD $250

SummaryAstellas Pharma Inc Astellas is one of the leading global pharmaceutical companies, which focuses on the research, development, manufacture and commercialization of a wide range of pharmaceutic...

Tianjin Tianyao Pharmaceutical Co Ltd 600488 Pharmaceuticals Healthcare Deals and Alliances Profile [Report Updated: 27092018] Prices from USD $250

SummaryTianjin Tianyao Pharmaceutical Co Ltd TTPC is a provider of active pharmaceutical ingredients and GMP products. The company offers bulk drug products such as dexamethasone, dexamethasone sodium...

Events [0 Results]

None

Companies [4 Associated Companies listed on BioPortfolio]

Sunovion Pharmaceuticals, Inc.

Sunovion is a leading pharmaceutical company dedicated to discovering, developing and commercializing therapeutic products that advance the science of medicine in the Psychiatry &...

Celanese Corporation

We are an integrated global producer of value-added industrial chemicals and have the first or second market positions worldwide in products comprising the majority of our sales. We are the world’s ...

Graceway Pharmaceuticals, LLC

Graceway Pharmaceuticals, LLC ("Graceway"), headquartered in Bristol, TN, is a pharmaceutical company focused on acquiring, in-licensing, and developing branded prescription pharm...

Proof Eyewear

Proof was established in 2010 by three brothers in Boise, Idaho. They were inspired by their entrepreneur grandfather who started a wood sawmill and also by the outdoors around th...

Clinical Trials [694 Associated Clinical Trials listed on BioPortfolio]

Study on Olaparib Plus Abiraterone as First-line Therapy in Men With Metastatic Castration-resistant Prostate Cancer

The purpose of this study is to evaluate the efficacy and safety (including evaluating side effects) of combination of olaparib and abiraterone versus placebo and abiraterone in patients w...

The Results of Multiple Aspirations and Injections of Unicameral Bone Cyst by Methyl Prednisolone Acetate

Evaluation of the efficacy of methyl prednisolone injection in treatment o f simple bone cyst to prevent all possible complications as pathological fractures and to avoid prolonged restric...

PentoxIfylline and Tocopherol for the Treatment of Post-radiotherapy Fibrosis in Head and Neck Cancer Patients

Objectives: This is a feasibility study in preparation for the main multicentre randomised trial, which is anticipated to have two arms: - Arm A: the current best standard of ca...

G56W1 in Women With Postmenopausal Osteoporosis

This study will assess the pharmacokinetics and safety and explore therapeutic effects with once-weekly recombinant human parathyroid hormone for injection ( 1-34 ) ( G56W1 ) in women with...

Beta Glucan and Acetate Production

Based on our hypothesis that orally administered resistant starch and beta glucan will be fermented into a SCFA pattern high in acetate and that this will lead to beneficial effects on hum...

Inulin and Acetate Production and Human Substrate Metabolism

Based on our hypothesis that orally administered resistant starch and inulin/beta glucan will be fermented into a SCFA pattern high in acetate and that this will lead to beneficial effects...

Treatment of FUS-Related ALS With Betamethasone - The TRANSLATE Study

By doing this study the investigator hopes to learn more about a potential cause of amyotrophic lateral sclerosis (ALS) called "oxidative stress". Oxidative stress is essentially an imbala...

A Study of Abiraterone Acetate Plus Prednisone With or Without Abemaciclib (LY2835219) in Participants With Prostate Cancer

This study is being done to see how safe and effective abemaciclib is when given together with abiraterone acetate plus prednisone in participants with metastatic castration resistant pros...

A Study to Evaluate Injection Pain and Local Tolerability Following Subcutaneous Administration of TV46046

The purpose of this study is to evaluate the local tolerability associated with the subcutaneous administration of TV-46046, and inform next steps of the TV-46046 development program.

Knee Injection RCT

Hypothesis: Ketorolac injection is a cost-effective adjunct in the nonoperative treatment of knee osteoarthritis (OA) compared to steroids and viscosupplementation. Aims/objectives: The o...

PubMed Articles [751 Associated PubMed Articles listed on BioPortfolio]

Novel resources of Taxol from endophytic and entomopathogenic fungi: Isolation, characterization and LC-Triple mass spectrometric quantification.

This work presents a second-to-none method for Taxol isolation from the Endophytic fungus Cladosporium sphaerospermum (AUMC 6896) and the Entomopathogenic fungus Metarizium anisopliae (AUMC 5130). The...

Polymeric ionically conductive composite matrices and electrical stimulation strategies for nerve regeneration: In vitro characterization.

Stem cell strategies and the use of electrical stimulation (ES) represent promising new frontiers for peripheral nerve regeneration. Composite matrices were fabricated by coating electrospun polycapro...

Cardioprotective and anti-apoptotic effects of Potentilla reptans L. root via Nrf2 pathway in an isolated rat heart ischemia/reperfusion model.

Previous studies have shown that proanthocyanidins have cardioprotective effects which are mediated via the release of nitric oxide (NO) ultimately resulting in increasing the antioxidant activity. We...

Design and 22-step synthesis of highly potent D-ring modified and linker-equipped analogs of spongistatin 1.

Spongistatin 1 is among the most potent anti-proliferative agents ever discovered rendering it an attractive candidate for development as a payload for antibody-drug conjugates and other targeted deli...

Divergent short-chain fatty acid production and succession of colonic microbiota arise in fermentation of variously-sized wheat bran fractions.

Though the physical structuring of insoluble dietary fiber sources may strongly impact their processing by microbiota in the colon, relatively little mechanistic information exists to explain how thes...

Enhancing the Potential Exploitation of Food Waste: Extraction, Purification, and Characterization of Renewable Specialty Chemicals from Blackcurrants ( Ribes nigrum L.).

Natural colorants were extracted from renewable botanical sources, specifically waste epicarp from the blackcurrant fruit pressing industry. A process was developed which used acidified water extracti...

Novel Symmetrical Benzazolyl Derivatives Endowed with Potent anti-Heparanase Activity.

Heparanase is the only mammalian endo-β-D-glucuronidase involved in a variety of major diseases. Up-regulation of heparanase expression increases tumor size, angiogenesis and metastasis, representing...

Bioanalytical technique for determination of Tasimelteon in human plasma by LC-MS/MS and its application to pharmacokinetic study in humans.

A highly sensitive, specific and rapid Liquid Chromatography-Tandem Mass Spectrometry technique for the quantification of tasimelteon in human plasma has been developed and validated using tasimelteon...

Hyphae fragments from A. fumigatus sensitize lung cells to silica particles (Min-U-Sil): Increased release of IL-1β.

Exposure to particulate matter (PM), such as mineral particles and biological particles/components may be linked to aggravation of respiratory diseases, including asthma. Here we report that exposure ...

RIFM fragrance ingredient safety assessment, guaiyl acetate, CAS Registry Number 134-28-1.

Videos

None available.

Medical and Biotech [MESH] Definitions

An enzyme that catalyzes the conversion of acetate esters and water to alcohols and acetate. EC 3.1.1.6.

Megestrol acetate is a progestogen with actions and uses similar to those of the progestogens in general. It also has anti-androgenic properties. It is given by mouth in the palliative treatment or as an adjunct to other therapy in endometrial carcinoma and in breast cancer. Megestrol acetate has been approved to treat anorexia and cachexia. (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)

A 6-methyl PROGESTERONE acetate with reported glucocorticoid activity and effect on ESTRUS.

An enzyme that catalyzes the formation of CoA derivatives from ATP, acetate, and CoA to form AMP, pyrophosphate, and acetyl CoA. It acts also on propionates and acrylates. EC 6.2.1.1.

An enzyme that catalyzes reversibly the phosphorylation of acetate in the presence of a divalent cation and ATP with the formation of acetylphosphate and ADP. It is important in the glycolysis process. EC 2.7.2.1.

Advertisement
Quick Search
Advertisement
Advertisement

 

Relevant Topics

Endocrinology
Diabetes Diabetes Endocrine Obesity Oxycontin Renal Disease Thyroid Disorders Endocrinology is the study of the endocrine glands and the hormones that they secrete (Oxford Medical Dictionary). There are several groups of h...

Endocrine Disorders
Endocrine disorders are grouped into two categories: hormone imbalance - when a gland produces too much or too little of an endocrine hormone development of lesions (such as nodules or tumors) in the endocrine system, which may or may not affect...

Cancer
  Bladder Cancer Brain Cancer Breast Cancer Cancer Cervical Cancer Colorectal Head & Neck Cancers Hodgkin Lymphoma Leukemia Lung Cancer Melanoma Myeloma Ovarian Cancer Pancreatic Cancer ...

review and buy Eligard market research data and corporate reports here

Channels Quicklinks