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G-protein-coupled receptors (GPCRs) - Biotech, Pharma and Life Science Channel

02:09 EST 24th January 2019 | BioPortfolio

GPCRs are a large family of cell surface receptors that respond to a variety of external signals. Binding of a signaling molecule to a GPCR results in G protein activation, which in turn triggers the production of any number of second messengers. Through this sequence of events, GPCRs help regulate an incredible range of bodily functions, from sensation to growth to hormone responses.

Source: http://www.nature.com/scitable/topicpage/gpcr-14047471

PubMed Articles [120 Associated PubMed Articles listed on BioPortfolio]

An online resource for GPCR structure determination and analysis.

G-protein-coupled receptors (GPCRs) transduce physiological and sensory stimuli into appropriate cellular responses and mediate the actions of one-third of drugs. GPCR structural studies have revealed...

Shaky ground - The nature of metastable GPCR signalling complexes.

How G protein-coupled receptors (GPCR) interact with one another remains an area of active investigation. Obligate dimers of class C GPCRs such as metabotropic GABA and glutamate receptors are well ac...

Molecular characterization of ecdysis triggering hormone and its receptor in citrus red mite (Panonychus citri).

Neuropeptide ecdysis triggering hormone (ETH) plays crucial roles in invertebrates by activating a G protein-coupled receptor (GPCR), the ecdysis triggering hormone receptor (ETHR), which has been int...

The role of Cox-2 and prostaglandin E receptor EP3 in pancreatic β-cell death.

Elevated levels of lipids, in particular saturated fatty acids, are known to be associated with type 2 diabetes (T2D) and to have a negative effect on β-cell function and survival. We bring new evide...

Expression and Preparation of a G-Protein-Coupled Cannabinoid Receptor CB for NMR Structural Studies.

Cannabinoid receptor type II, or CB , is an integral membrane protein that belongs to a large class of G-protein-coupled receptors (GPCR)s. CB is a part of the endocannabinoid system, which plays an i...

In vivo assembly and large-scale purification of a GPCR - Gα fusion with Gβγ, and characterization of the active complex.

G protein coupled receptors (GPCRs) are central players in recognizing a variety of stimuli to mediate diverse cellular responses. This myriad of functions is accomplished by their modular interaction...

ANTI-HYPERTENSIVE MECHANISMS OF CYCLIC DEPSIPEPTIDE INHIBITOR LIGANDS FOR G CLASS G PROTEINS.

Augmented vasoconstriction is a hallmark of hypertension and is mediated partly by hyper-stimulation of G protein couple receptors (GPCRs) and downstream signaling components. Although GPCR blockade i...

Expression patterns of C1ql4 and its cell-adhesion GPCR Bai3 in the murine testis and functional roles in steroidogenesis.

C1q-like 4 (C1QL4), a novel member of the C1q- and TNF-related protein family, was found to be highly expressed in rodent and human testis. However, the localization, developmental, and hormonally reg...

Receptor selectivity between the G proteins Gα and Gα is defined by a single leucine-to-isoleucine variation.

Despite recent advances in structural definition of GPCR-G protein complexes, the basis of receptor selectivity between G proteins remains unclear. The Gα and Gα subtypes together form the least stu...

PI3Kβ - a versatile transducer for GPCR, RTK and small GTPase signaling.

The phosphoinositide 3-kinase (PI3K) family includes 8 distinct catalytic subunits and seven regulatory subunits. Only two PI3Ks are directly regulated downstream from G Protein-Coupled Receptors (GPC...

News Articles [41 Associated News Articles listed on BioPortfolio]

An online resource for GPCR structure determination and analysis

Able-Handed Drugs Could Push GPCR Buttons, Say Conformation Mappers: http://ow.ly/MKp630nj5Ez pic.twitter.com/WBH6S38zb8

Able-Handed Drugs Could Push GPCR Buttons, Say Conformation Mappers: http://ow.ly/MKp630nj5Ez  pic.twitter.com/WBH6S38zb8

Able-Handed Drugs Could Push GPCR Buttons, Say Conformation Mappers: http://ow.ly/MKp630nj5Ez pic.twitter.com/73Sv1mAFpe

Able-Handed Drugs Could Push GPCR Buttons, Say Conformation Mappers: http://ow.ly/MKp630nj5Ez  pic.twitter.com/73Sv1mAFpe

Able-Handed Drugs Could Push GPCR Buttons, Say Conformation Mappers

One does not bang on the drug target known as the G-protein-coupled receptor (GPCR) as though it were a drum. Neither does one play the GPCR like a violin. The GPCR is something in between, an instrum...

Omeros Corporation Announces Record High Quarterly Revenue Results for the Fourth Quarter 2018

– Broadening OMIDRIA Coverage from Payers and Increasing Funding for OMS721 Commercial Preparations – Omeros Corporation (Nasdaq: OMER), today announced unaudited prelimin...

GPCR Products

Cell Sciences Presenting a new, advanced line of G protein-coupled receptor (GPCRs) products. The superfamily of G protein-coupled receptors includes over 800 receptors in the human body that particip...

Confo Therapeutics Announces Exclusive, Worldwide License Agreement with VIB for Powerful Novel Structure Determination Technology

Licence provides Confo Therapeutics with exclusive access to ‘Megabody’ Technology for High Resolution Cryo-Electron Microscopy evaluation of G-Protein Coupled Receptors, stre...

Domain Therapeutics SA Pharmaceuticals Healthcare Deals and Alliances Profile [Report Updated: 13112018] Prices from USD $250

SummaryDomain Therapeutics SA Domain Therapeutics, formerly Faust Pharmaceuticals SA is a biopharmaceutical company that discovers and develops innovative therapeutics for the treatment of central ner...

#news #biotech Boehringer inks pact with Domain for GPCR neurology drugs

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Boehringer inks pact with Domain for GPCR neurology drugs .French-Canadian bi...

Confo Therapeutics Appoints Frank Landolt as its Chief Counsel Legal & Intellectual Property

Confo Therapeutics, an emerging drug discovery company, today announces the appointment of Frank Landolt as its Chief Counsel Legal & IP, effective from 1 January 2019. Frank ...

Companies [15 Associated Companies listed on BioPortfolio]

Escient Pharmaceuticals, Inc.

Escient Pharmaceuticals is a privately held biotechnology company that is advancing first-in-class G Protein-Coupled Receptor (GPCR)-targeted drugs to address serious, unserved me...

MEBIAS Discovery LLC

MEBIAS, an emerging leader in the field of biased agonism GPCR drug discovery, was founded by three highly experienced drug discovery scientists, formerly of Merck and Johnson & J...

Escient Pharmaceuticals

Escient Pharmaceuticals is a privately held biotechnology company that is advancing first-in-class G Protein-Coupled Receptor (GPCR)-targeted drugs to address serious, unserved me...

Carmot Therapeutics, Inc.

Carmot Therapeutics, Inc. is pioneering a transformative lead-identification technology, Chemotype Evolution, to identify superior therapeutics for human diseases. The technology ...

Lanthio Pharma

Lanthio Pharma is a privately held drug discovery company that applies its proprietary lanthionine-peptide technology to the discovery of novel peptide therapeutics with longer ha...

Anchor Therapeutics, Inc.

Anchor Therapeutics, Inc. is a leader in the development of pepducin technology. The Company is engaged in the licensing of pepducin technology as research tools for drug developm...

Receptos, Inc.

Receptos is a biopharmaceutical company developing best- and first-in-class G protein-coupled receptor (GPCR) therapeutic candidates through information-driven drug discovery, inc...

Anchor Therapeutics

Anchor Therapeutics is developing first-in-class pepducin drug candidates, novel molecules that can selectively target G protein coupled receptors (GPCRs) to allosterically modula...

Tranzyme Pharma

Tranzyme Pharma is a clinical-stage drug development company that discovers and develops novel small molecule macrocyclic drugs for both acute care (hospital-based) and chronic in...

BioFocus

BioFocus is a collaborative drug discovery company providing an integrated platform of expertise and technologies in medicinal chemistry and biological screening to the global biopharmaceutical indust...

Clinical Trials [3 Associated Clinical Trials listed on BioPortfolio]

Effect of Dietary Oils as G-protein-coupled Receptor Agonists on Glucose Tolerance

Agonistic activation of fat metabolite responsive G-protein-coupled receptors (GPCR) has been linked to improved glucose metabolism through increased glucose-stimulated-insulin-secreting (...

A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Efficacy of BC 007 in Healthy Subjects

Berlin Cures develops BC 007 to treat patients suffering from diseases (chronic heart failure, pulmonary hypertension, chronic fatigue syndrome etc.) which are associated with functional a...

Ghrelin Resistance in Adolescents With Idiopathic Scoliosis

Adolescent idiopathic Scoliosis (AIS) is the most common spine pathology. It is opposed to secondary scoliosis due to chronic diseases. Many hypotheses have been made to elucidate the orig...

Medical and Biotech [MESH] Definitions

Non-visual system arrestins that negatively regulate G-PROTEIN-COUPLED RECEPTORS (GPCRs) and may also function independently of GPCR signaling. They bind and recruit many different signaling factors, including MITOGEN-ACTIVATED PROTEIN KINASES; SRC-FAMILY-KINASES; and FILAMIN to GPCRs and may recognize different phosphorylation states of the receptors to determine the specificity of the cellular response to signaling.

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