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G-protein-coupled receptors (GPCRs) - Biotech, Pharma and Life Science Channel

13:02 EST 19th November 2017 | BioPortfolio

GPCRs are a large family of cell surface receptors that respond to a variety of external signals. Binding of a signaling molecule to a GPCR results in G protein activation, which in turn triggers the production of any number of second messengers. Through this sequence of events, GPCRs help regulate an incredible range of bodily functions, from sensation to growth to hormone responses.

Source: http://www.nature.com/scitable/topicpage/gpcr-14047471

PubMed Articles [136 Associated PubMed Articles listed on BioPortfolio]

The Role of the Mammalian Prion Protein in the Control of Sleep.

Sleep disruption is a prevalent clinical feature in many neurodegenerative disorders, including human prion diseases where it can be the defining dysfunction, as in the case of the "eponymous" fatal f...

A Functional Kinase Short Interfering Ribonucleic Acid Screen Using Protease-Activated Receptor 2-Dependent Opening of Transient Receptor Potential Vanilloid-4.

Protease-activated receptor 2 (PAR2) is a proinflammatory G-protein coupled receptor (GPCR) that is activated by inflammatory proteases, and its activation initiates signaling pathways that modulate t...

G-Protein Coupled Receptors Targeted by Analgesic Venom Peptides.

Chronic pain is a complex and debilitating condition associated with a large personal and socioeconomic burden. Current pharmacological approaches to treating chronic pain such as opioids, antidepress...

Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics.

Biased agonism has been proposed as a means to separate desirable and adverse drug responses downstream of G protein-coupled receptor (GPCR) targets. Herein, we describe structural features of a serie...

Tuning Biased GPCR Signaling for Physiological Gain.

Effective and safe doses of opiate painkillers, like morphine, can be limited by respiratory depression. Schmid et al. (2017) now present a quantitative method to design ligands and correlate GPCR si...

Genomic analysis of atypical fibroxanthoma.

Atypical fibroxanthoma (AFX), is a rare type of skin cancer affecting older individuals with sun damaged skin. Since there is limited genomic information about AFX, our study seeks to improve the unde...

GPCR Signaling From Intracellular Membranes - A Novel Concept.

Modifying expression modes of human neurotensin receptor type 1 alters sensing capabilities for agonists in yeast signaling biosensor.

Neurotensin receptor type 1 (NTSR1), a member of the G-protein-coupled receptor (GPCR) family, is naturally activated by binding of a neurotensin peptide, leading to a variety of physiological effects...

Improving virtual screening of G protein-coupled receptors via ligand-directed modeling.

G protein-coupled receptors (GPCRs) play crucial roles in cell physiology and pathophysiology. There is increasing interest in using structural information for virtual screening (VS) of libraries and ...

Gene expression profiling in colon of mice exposed to food additive titanium dioxide (E171).

Dietary factors that may influence the risks of colorectal cancer, including specific supplements, are under investigation. Previous studies showed the capacity of food additive titanium dioxide (E171...

News Articles [41 Associated News Articles listed on BioPortfolio]

Global GProtein Coupled Receptor GPCR Targeting Market Data Survey Report 2025 [Report Updated: 11112017] Prices from USD $1500

SummaryG proteincoupled receptors GPCRs which are also known as seventransmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G proteinlinked receptors GPLR, con...

Modifying expression modes of human neurotensin receptor type 1 alters sensing capabilities for agonists in yeast signaling biosensor

Neurotensin receptor type 1 (NTSR1), a member of the G‐protein‐coupled receptor (GPCR) family, is naturally activated by binding of a neurotensin peptide, leading to a variety of physiological eff...

Strategic Minority Investment Company MiNA Therapeutics Enters Into Collaboration and Licensing Agreement With Boehringer Ingelheim

Sosei Group Corporation (‘Sosei’; TSE Mothers Index 4565), is pleased to note that our strategic minority investment company MiNA Therapeutics ('MiNA') has announced a collabo...

Omeros Corporation to Announce Third Quarter 2017 Financial Results on November 9, 2017

Omeros Corporation (NASDAQ: OMER), today announced that the company will issue its third quarter 2017 financial results for the period ended September 30, 2017, on Thursday, Novem...

Visualizing GPCR Activation Using Cryo-Electron Microscopy

ArticleResearchers have recently used cryo-electron microscopy (cryo-EM) to determine the three-dimensional (3D) atomic structure of two class B G-protein coupled receptors (GPCRs) and revealed the st...

Researchers map drug development trends

G protein-coupled receptors (GPCR) are a target of around 40% drugs. A major mapping of these drugs by researchers has found that their pharmacological mechanisms are becoming more complex. From a dr...

Omeros Announces Upcoming Presentation of Clinical OMS721 Data at the American Society of Nephrology Annual Meeting

Omeros Corporation (NASDAQ: OMER) today announced that a subset of data will be presented from the company’s Phase 2 clinical trial of OMS721, Omeros’ lead human monoclonal an...

G protein-coupled receptors: Gut feeling on bacterial GPCR agonists

Trends in GPCR drug discovery: new agents, targets and indications

Omeros Announces Upcoming Presentation of Clinical OMS721 Data at European Society for Blood and Marrow Transplantation

Omeros Corporation (NASDAQ: OMER) today announced that data will be presented from the company’s Phase 2 clinical trial of OMS721, Omeros’ lead human monoclonal antibody targe...

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Companies [13 Associated Companies listed on BioPortfolio]

MEBIAS Discovery LLC

MEBIAS, an emerging leader in the field of biased agonism GPCR drug discovery, was founded by three highly experienced drug discovery scientists, formerly of Merck and Johnson & J...

Carmot Therapeutics, Inc.

Carmot Therapeutics, Inc. is pioneering a transformative lead-identification technology, Chemotype Evolution, to identify superior therapeutics for human diseases. The technology ...

Lanthio Pharma

Lanthio Pharma is a privately held drug discovery company that applies its proprietary lanthionine-peptide technology to the discovery of novel peptide therapeutics with longer ha...

Anchor Therapeutics, Inc.

Anchor Therapeutics, Inc. is a leader in the development of pepducin technology. The Company is engaged in the licensing of pepducin technology as research tools for drug developm...

Receptos, Inc.

Receptos is a biopharmaceutical company developing best- and first-in-class G protein-coupled receptor (GPCR) therapeutic candidates through information-driven drug discovery, inc...

Anchor Therapeutics

Anchor Therapeutics is developing first-in-class pepducin drug candidates, novel molecules that can selectively target G protein coupled receptors (GPCRs) to allosterically modula...

Tranzyme Pharma

Tranzyme Pharma is a clinical-stage drug development company that discovers and develops novel small molecule macrocyclic drugs for both acute care (hospital-based) and chronic in...

BioFocus

BioFocus is a collaborative drug discovery company providing an integrated platform of expertise and technologies in medicinal chemistry and biological screening to the global biopharmaceutical indust...

Dimerix Bioscience Pty Ltd

Dimerix is a Perth-based drug discovery company focused on developing pharmaceutical products targeting heteromers or complexes of GPCRs. Approximately 40% of all currently market...

DiscoveRx® Corporation

Founded in 2000, DiscoveRx is a privately held, venture-backed company headquartered in Fremont, California, with an additional office in Birmingham, England. The Company pioneere...

Clinical Trials [2 Associated Clinical Trials listed on BioPortfolio]

A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Efficacy of BC 007 in Healthy Subjects

Berlin Cures develops BC 007 to treat patients suffering from diseases (chronic heart failure, pulmonary hypertension, chronic fatigue syndrome etc.) which are associated with functional a...

Ghrelin Resistance in Adolescents With Idiopathic Scoliosis

Adolescent idiopathic Scoliosis (AIS) is the most common spine pathology. It is opposed to secondary scoliosis due to chronic diseases. Many hypotheses have been made to elucidate the orig...

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Medical and Biotech [MESH] Definitions

Non-visual system arrestins that negatively regulate G-PROTEIN-COUPLED RECEPTORS (GPCRs) and may also function independently of GPCR signaling. They bind and recruit many different signaling factors, including MITOGEN-ACTIVATED PROTEIN KINASES; SRC-FAMILY-KINASES; and FILAMIN to GPCRs and may recognize different phosphorylation states of the receptors to determine the specificity of the cellular response to signaling.

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Endocrine Disorders
Endocrine disorders are grouped into two categories: hormone imbalance - when a gland produces too much or too little of an endocrine hormone development of lesions (such as nodules or tumors) in the endocrine system, which may or may not affect...

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