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Paroxysmal supraventricular tachycardia (PSVT) - Biotech, Pharma and Life Science Channel

02:03 EDT 21st September 2018 | BioPortfolio

Paroxysmal supraventricular tachycardia (PSVT) is episodes of rapid heart rate that start in a part of the heart above the ventricles. "Paroxysmal" means from time to time.

The heart will suddenly start racing, then stop or slow down abruptly.  Episodes can last for seconds, minutes, hours or (in rare cases) days. They may occur regularly, several times a day, or very infrequently, once or twice a year.  The heart rate may be as high as 250 beats per minute, but is usually between 140 and 180 (a normal heartbeat should be 60-100 beats per minute at rest).

SVT is caused by abnormal electrical impulses that start suddenly in the upper chambers of your heart (the atria). These impulses override your heart's natural rhythm.  It is often a short circuit in the electrical system of your heart that causes these spontaneous impulses. The short circuit causes an electrical signal to travel continuously around in a circle. Each time the signal completes the circuit, the impulse spreads out to the rest of your heart, forcing it to beat rapidly.  SVT attacks often happen for no obvious reason. However, they may be triggered by a change in posture, exertion, emotional upset, coffee or alcohol.

Source: http://www.nhs.uk/conditions/Supraventricular-tachycardia/Pages/Introduction.aspx

View research papers on diagnosiscauses and treatment.

PubMed Articles [281 Associated PubMed Articles listed on BioPortfolio]

Coinfection by astrovirus and Neisseria B meningitidis in a girl.

Meningococcal infection associates high morbidity and mortality. Viral coinfection has been described mainly with herpes and respiratory virus. We describe a child who suffered a tonic-clonic seizure ...

High density characterization of a localized reentry circuit occurred after AF ablation.

We present the case of a localized reentry circuit which developed 24h after RF ablation of atrial fibrillation. The circuit was of interest because it overlapped with sites of previous defragmentatio...

Benign Paroxysmal Positional Vertigo in Children.

To describe the clinical features of benign paroxysmal positional vertigo (BPPV) in children.

Paediatric electroencephalograph: The benefits of guidelines.

The electroencephalogram (EEG) is an important but often over-relied upon investigation in evaluating paroxysmal events of childhood. The UK National Institute for Health and Care Excellence (NICE) gu...

Hospitalization rate of paroxysmal supraventricular tachycardia in Sweden.

The hospitalization rate of paroxysmal supraventricular tachycardia (PSVT) in a nationwide study is not established. We determined age- and sex-specific hospitalization rates and time trends for hospi...

The Role of Whole-Body Magnetic Resonance Imaging (WB-MRI) in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH).

In PNH thromboembolic events (TEs) represent the leading cause of morbidity and mortality. Between Dec 2013 and Jan 2016 37 PNH patients (pts) (23 PNH, 14 AA/PNH; 51% (19/37) females; median age 44 y...

Changes in f-wave characteristics during cryoballoon catheter ablation.

Changes in ECG-derived parameters are studied in atrial fibrillation (AF) patients undergoing cryoballoon catheter ablation. Approach: Parameters characterizing f-wave frequency, morphology by p...

Mechanical tachycardia of the slow pathway induced by a percutaneous tricuspid valve device.

Diagnosis and management of PNH: review and recommendations from a Belgian expert panel.

Despite its considerable morbidity and mortality, paroxysmal nocturnal haemoglobinuria (PNH) is still underdiagnosed. Patients with PNH can suffer from cardiovascular, gastro-intestinal, neurological ...

Lactic Acidosis in a Critically Ill Patient: Not Always Sepsis.

Lactic acidosis in the emergency department and other hospital settings is typically due to tissue hypoxia with sepsis being the most common cause. However, in patients with persistently elevated lact...

News Articles [71 Associated News Articles listed on BioPortfolio]

Ranolazine Doesn't Cut VT, VF, Death in High-Risk ICD Patients

TUESDAY, Sept. 18, 2018 -- For high-risk patients with implantable cardioverter-defibrillators (ICDs), ranolazine does not significantly reduce the risk of ventricular tachycardia (VT) or ventricular ...

Positive data reported on PNH candidate study

All four patients with paroxysmal nocturnal hemoglobinuria who were treated with Apellis Pharmaceuticals' APL-2 and Alexion P -More- 

Ra Pharma Announces Completion of End-of-Phase 2 Interactions with FDA and Design of Phase 3 PNH Program

Plans to initiate a global, pivotal, single-arm Phase 3 trial in treatment-naïve PNH patients Ra Pharmaceuticals, Inc. (Nasdaq:RARX) today announced the completion of ...

Apellis Pharmaceuticals Announces that All Four Severely Anemic Soliris™-Treated Patients with Paroxysmal Nocturnal Hemoglobinuria in Ongoing Phase 1b Trial Have Been Transitioned to APL-2 Monotherapy

PHAROAH Trial Results to-Date Show APL-2 Monotherapy Eliminated Transfusion Dependency and Improved Markers of Anemia in PNH Patients on Soliris™ CRESTWOOD, Ky. and WALTHAM, Mass., Sept. 04, 201...

Radiological Case: Spontaneous Ureteral Injury

What was the cause of this woman's worsening abdominal pain, tachycardia, and mild hypotension following a reportedly uncomplicated vaginal delivery? Applied Radiology

Chest pain drug falls short in preventing first episode of ventricular arrhythmia or death

(University of Rochester Medical Center) A trial of more than 1,000 patients with implantable cardioverter defibrillators found that the drug ranolazine (used to treat chest pain; brand name Ranexa®)...

Guideline Adherence Still Not Optimal for Benign Paroxysmal Positional Vertigo

Adherence to guidelines for the diagnosis and treatment of benign paroxysmal positional vertigo (BPPV) is improving but remains suboptimal among ambulatory-care physicians, according to a new survey. ...

Milestone Pharmaceuticals Inc Pharmaceuticals Healthcare Deals and Alliances Profile [Report Updated: 23042018] Prices from USD $250

SummaryMilestone Pharmaceuticals Inc Milestone Pharmaceuticals is a cardiovascular drug development company that develops novel small molecule therapeutics. The company undertakes the development of s...

FDA Accepts Priority Review of ALXN1210 for Treatment of Rare Blood Disorder

NewsIf approved, ALXN1210 would be the first and only long-acting complement inhibitor for patients with Paroxysmal Nocturnal Hemoglobinuria.

FDA Accepts Priority Review of Alexion’s ALXN1210 as a Treatment for Paroxysmal Nocturnal Hemoglobinuria

BOSTON–(BUSINESS WIRE)–Alexion Pharmaceuticals, Inc. (NASDAQ:ALXN) announced today that the U.S. Food and Drug Administration (FDA) has accepted for review the Company’s Biologics Licens...

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Companies [5 Associated Companies listed on BioPortfolio]

Alexion Pharmaceuticals Inc.

Alexion is a global biopharmaceutical company focused on developing and delivering life-transforming therapies for patients with devastating and rare disorders. Alexion developed ...

Alexion Pharmaceuticals Incorporated

Alexion is a global biopharmaceutical company that combines groundbreaking science with a steadfast commitment to meeting the needs of patients living with severe, life-threatening and often ultra-rar...

Topera, Inc.

Topera Medical (Topera, Inc.) is developing the proprietary FIRMap® System to assist electrophysiologists in the identification of the electrical source of cardiac arrhythmias....

Acutus Medical and Index Ventures

Acutus Medical is a medical technology company committed to developing an innovative breakthrough platform technology of safe, cost effective and clinically advanced tools for the...

Topera Medical

Topera Medical (Topera, Inc.) is developing the proprietary FIRMap® System to assist electrophysiologists in the identification of the electrical source of cardiac arrhythmias....

Clinical Trials [444 Associated Clinical Trials listed on BioPortfolio]

Propafenone in the Treatment of Atrial Fibrillation

This is a open label randomized, multi-center study conducted in Taiwan. The study aims to evaluate the effectiveness and safety of oral Rhynorm (A drug) and Rytmonorm (B drug) for the con...

Atrial Function and Supraventricular Arrhythmia of the Veteran Athlete.

Supraventricular arrhythmias (including atrial fibrillation) are the most common arrhythmias of the veteran athlete and have a major impact in terms of morbidity and mortality. Although mo...

Development of a Novel Convolution Neural Network for Arrhythmia Classification

Identifying the correct arrhythmia at the time of a clinic event including cardiac arrest is of high priority to patients, healthcare organizations, and to public health. Recent developmen...

Rapid Response VA-ECMO in Refractory Out-of-hospital Cardiac Arrest

A selected group of patients with refractory cardiac arrest may benefit from inhospital treatment and this may warrant transfer to the hospital with ongoing CPR. In patients with VF or ven...

"Ventricular Tachycardia Ablation Registry".

Catheter ablation of Ventricular Tachycardias is a well-established approach in clinical practice in patients with Implantable Cardioverter Defibrillator (ICD) implanted. Previous studies ...

Detraining on Atrial Fibrillation

This study will examine the effect of detraining as a clinical tool to prevent recurrence of lone paroxysmal atrial fibrillation (AF) and improve quality of life. Persons who engage in end...

Evaluation of the Prevalence of BPPV and Longterm Effects of Its Therapy Using the Rotundum Device in Retirement Homes

Benign paroxysmal positional vertigo (BPPV) is one of the most common types of vertigo, especially in elderly. Therefore the investigators have set the goal to evaluate the prevalence of B...

Clinical Investigation of the VytronUS Ablation System for Treatment of Paroxysmal Atrial Fibrillation

The study is a single center, open-label, single arm, prospective pre-market study designed to assess the safety and efficacy of the VytronUS Ablation System (VAS) for the treatment of atr...

Safety Study of Intranasal Etripamil for the Termination of Spontaneous Episodes of PVST. NODE-302

The primary objective of this study is to evaluate the safety of etripamil nasal spray (NS) 70 mg when self-administered by patients with an episode of Paroxysmal Supraventricular Tachycar...

Ivabradine in Stage D Heart Failure Patients on Chronic Inotropes

Ivabradine, a selective inhibitor of the If current in the sinoatrial node, provides heart rate reduction and leads to a reduction in heart failure hospitalizations. For this reason, the A...

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Medical and Biotech [MESH] Definitions

A generic expression for any tachycardia that originates above the BUNDLE OF HIS.

A rare form of supraventricular tachycardia caused by automatic, not reentrant, conduction initiated from sites at the atrioventricular junction, but not the ATRIOVENTRICULAR NODE. It usually occurs during myocardial infarction, after heart surgery, or in digitalis intoxication with a HEART RATE ranging from 140 to 250 beats per minute.

Abnormally rapid heartbeats with sudden onset and cessation.

An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the BUNDLE OF HIS, either as autonomic impulse formation or reentrant impulse conduction. Depending on the etiology, onset of ventricular tachycardia can be paroxysmal (sudden) or nonparoxysmal, its wide QRS complexes can be uniform or polymorphic, and the ventricular beating may be independent of the atrial beating (AV dissociation).

A condition characterized by the recurrence of HEMOGLOBINURIA caused by intravascular HEMOLYSIS. In cases occurring upon cold exposure (paroxysmal cold hemoglobinuria), usually after infections, there is a circulating antibody which is also a cold hemolysin. In cases occurring during or after sleep (paroxysmal nocturnal hemoglobinuria), the clonal hematopoietic stem cells exhibit a global deficiency of cell membrane proteins.

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