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Therapies targeting TNF have already demonstrated efficacy across a wide range of inflammatory diseases, including rheumatoid arthritis, juvenile idiopathic arthritis, ankylosing spondulitis, psoriasis and Crohn’s disease. The target market for Kinoids currently in development is estimated at over $24 billion, with potential to reach still broader markets (Source: LaMerie 2012).
Although powerful, current anti-TNFα therapies also have significant drawbacks, making new treatment approaches sorely needed. The most problematic aspect of monoclonal antibody (mAb) therapies is the frequent development of treatment resistance as they are used long-term to treat chronic diseases. For instance in Crohn’s disease, there is loss of response to monoclonal anti-TNF treatment in nearly 60% of patients (infliximab, adalimumab, certolizumab) during the first year of treament. Anti-TNFα treatments also have a cumbersome dosing regimen of frequent IV infusions or SC injections.
The TNF-Kinoid is a promising approach to address the shortcomings of the monoclonal antibodies.
SummaryNeovacs SA Neovacs is a biotechnology company that develops various therapeutic vaccines for autoimmune disorders, inflammatory diseases and cancers. The company offers TNF kinoid and IFNa kino...
This study is a Proof of Concept study aiming to evaluate the production of anti-IFNα antibodies (immune response) in adult subjects with dermatomyositis
The safety and immunogenicity of the IFN-Kinoid (IFN-K) have been evaluated in a phase I clinical study conducted in subjects with SLE. Preliminary results were promising. The principal a...
The objective of this trial is to demonstrate that active immunization with anti-TNFα kinoid (TNF-K) is able to induce polyclonal anti-TNFα antibodies in RA patients who were previously ...
Interferon alpha (IFNa) is involved in the pathogenesis of systemic lupus erythematosus (SLE)and IFNa levels are associated with the severity of the disease. Blocking IFNa could be an attr...
Evaluation of the safety and the immune response induced by active immunization through a TNFa kinoid in patients with Crohn's disease.
Cytokine Tumour Necrosis Factor (TNF)
TNF is a compound that is classified as a cytokine which plays a central role in the cellular mechanisms of apoptosis or cell death. However, there are a number of different kinds of TNF, just under twenty, but the family of molecules have very similar a...
Arthroplasty Joint Disorders Orthopedics Spinal Cord Disorders Orthopedics is the science or practice of correcting deformities caused by disease or damage to the bones and joints of the skeleton. This specialized branch of surgery may ...
Arthritis Fibromyalgia Gout Lupus Rheumatic Rheumatology is the medical specialty concerned with the diagnosis and management of disease involving joints, tendons, muscles, ligaments and associated structures (Oxford Medical Diction...