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Vantictumab - Biotech, Pharma and Life Science Channel

00:31 EDT 23rd October 2017 | BioPortfolio

Anti-Fzd7 (vantictumab, OMP-18R5)

Vantictumab is OncoMed’s lead program in the Wnt pathway. Screened against the Frizzled 7 receptor, the antibody binds a conserved epitope on five of the Frizzled receptors. It has been shown in preclinical studies to induce tumor cell differentiation. Vantictumab entered Phase 1 clinical testing in 2011.

Vantictumab is a monoclonal antibody optimized to block a key signaling pathway in cancer. Specifically, vantictumab selectively targets Frizzled receptors, activators of Wnt signaling. Vantictumab exhibits broad anti-tumor activity in nonclinical models. Vantictumab is currently in Phase 1 and will be evaluated in chemotherapy combinations in Phase 1b trials. Vantictumab is part of OncoMed’s collaboration with Bayer Pharma AG.

PubMed Articles [5375 Associated PubMed Articles listed on BioPortfolio]

Diagnostics for Lassa Fever: Detecting Host Antibody Responses.

There are two types of viral diagnostics: (1) those that detect components of the pathogen (like viral RNA or proteins) and (2) those that detect host molecules that rise or fall as a consequence of p...

FRET on lateral flow test strip to enhance sensitivity for detecting cancer biomarker.

Fluorescence resonance energy transfer (FRET) between fluorescein isothiocyanate (FITC) and gold nanoparticles (Au NPs) is introduced in the lateral flow strip to detect cancer biomarker CEA with the ...

Gold nanoparticle labeling with tyramide signal amplification for highly sensitive detection of alpha fetoprotein in human serum by ICP-MS.

In this work, we developed an immunoassay based on tyramide signal amplification (TSA) and gold nanoparticles (Au NPs) labeling for highly sensitive detection of alpha fetoprotein (AFP) by inductively...

Trace analysis of nitrite ions in environmental samples by using in-situ synthesized Zein biopolymeric nanoparticles as the novel green solid phase extractor.

For the first time, a novel green method using Zein biopolymeric nanoparticles as a green dispersive solid-phase extractor is reported for the separation and preconcentration of trace amount of nitrit...

Chain-length dependent interfacial immunoreaction kinetics on self-assembled monolayers revealed by surface-enhanced infrared absorption spectroscopy.

Self-assembled monolayer (SAM) has been extensively applied as ideal interface layer for construction of biosensors. Its chain length and end functional groups determine the physical and chemical prop...

Effects and mechanisms of actions of phytochemicals on Alzheimer's disease neuropathology.

Alzheimer's disease affects millions of people, yet, there are only a limited number approaches for it pharmacological treatment. Thus, identifying factors that decrease the risk of developing Alzheim...

Asiatic acid nullified aluminium toxicity in in vitro model of Alzheimer's disease.

Aluminium (Al) is a ubiquitously distributed environmental toxicant that lacks biological functions; however, its accumulation in the brain has been demonstrated to be linked to several neuropathologi...

Anti-tick vaccines in the omics era.

Tick vaccines have been available for more than 20 years. They are useful and effective control agents when used properly. However, no new products have emerged since the Bm86-based Gavac vaccine was ...

Centchroman: A safe reversible postcoital contraceptive with curative and prophylactic activity in many disorders.

Centchroman (INN: Ormeloxifene), a reversible post-coital/weekly oral contraceptive (half-life of about 168 hours), designed and developed at CDRI, Lucknow is the only non-steroidal oral contraceptive...

Enzymatically modified LDL, atherosclerosis and beyond: paving the way to acceptance.

The eLDL (enzymatically modified LDL) hypothesis proposes that modification of LDL during atherogenesis occurs through the action of ubiquitous hydrolytic enzymes. eLDL is recognized by multiple macro...

News Articles [1808 Associated News Articles listed on BioPortfolio]

The flu vaccine doesn’t cause the flu. Period.

Flu vaccines are available, and so that means that the anti-vaccine brigade is out in force. The Daily Mail published an anti-vaccine op-ed by a former reality TV contestant named Katie Hopkins. It...

Novel CV Risk Marker in RA Identified (CME/CE)

(MedPage Today) -- Measurement of anti-citrullinated fibrinogens may improve risk stratification

Billionaire Babis scores big Czech election win, seeks partners to rule

By Robert Muller and Petra Vodstrcilova PRAGUE (Reuters) - Czech billionaire Andrej Babis won a thumping victory in Saturday's election as voters shunned traditional parties and gave a mandate to the...

Populist billionaire Andrej Babis wins Czech vote

He may be facing charges over alleged EU subsidy fraud, but billionaire businessman Andrej Babis has won the support of voters in the Czech general election by pushing his trademark anti-corruption an...

'Czech Trump' clinches election victory, eurosceptics boosted

With voters upset over traditional parties and orders from Brussels, billionaire populist Andrej Babis, dubbed the "Czech Trump", clinched victory in the Czech Republic's election on Saturday, while e...

Steve Bannon Attacks Bush for Anti-Trump Speech

Steve Bannon ripped into former President George W. Bush Friday night, calling Bush’s presidency "destructive" and saying he had "embarrassed himself" with an anti-bigotry speech...

Supporters of white supremacist Richard Spencer arrested for attempted murder hours after his speech

Supporters of white surpemacist Richard Spencer were arrested for attempted murder just hours after he made a controversial speech at the University of Florida. Shouting "hail hitler", the three men ...

Bannon: Bush Presidency Most 'Destructive' in U.S. History

Steve Bannon lashed out at the George W. Bush, saying the 43rd president had "embarrassed himself" with an anti-bigotry speech earlier this week that was widely perceived as a broadside agai...

Philippines' Duterte says he will shoot criminals

Philippine President Rodrigo Duterte has offered to shoot criminals himself, while warning he may bring police back to the frontlines of his deadly war on drugs. Duterte made the comments late Friday...

Suzhou's CStone Pharma Starts Phase I Trial of PD-L1 Candidate

CStone Pharma of Suzhou has dosed the first patient in a Phase I trial of its anti-PD-L1 monoclonal antibody. The company claims CS1001 is China's first fully human and full-length PD-L1 candidate. Fo...

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Companies [143 Associated Companies listed on BioPortfolio]

Adtalem Global Education

The purpose of Adtalem Global Education is to empower students to achieve their goals, find success, and make inspiring contributions to our global community. Adtalem Global Educa...

Promethera Biosciences SA

Promethera Biosciences is a global innovator in liver cell-based medicines whose mission is to help patients overcome acute and chronic liver diseases. Our lead clinical program, ...

Synergys Biotherapeutics

Synergys is an early stage company developing multifunctional anti-vascularization antibody drugs targeting VEGF-alternative pathways. The Company’s most advanced product can...

Aus Bio Ltd.

Aus Bio Ltd. is a public but unlisted, Melbourne based biotechnology research and development company. It develops innovative research program to create new therapeutic products f...

FLX Bio, Inc.

FLX475 is a best-in-class oral, small molecule antagonist of CCR4. CCR4 ligands are elevated in multiple tumor types when compared to normal tissue. In preclinical studies, FLX475...

Applied DNA Sciences, Inc.

Applied DNA Sciences makes life real and safe by providing innovative, molecular-based technology solutions and services that can help protect products, brands, entire supply chai...

Turnstone Biologics

Turnstone Biologics is a clinical-stage, immuno-oncology company focused on the development of next-generation oncolytic viral immunotherapies for patients with a broad range of s...

Helix BioMedix, Inc

Helix BioMedix, Inc. was founded in 1988 with the mission of developing and commercializing small proteins known as bioactive-peptides. We are headquartered in Bothell, Washington and shares of our co...

TeamViewer GmbH

TeamViewer is a leading global software provider for digital networking and collaboration. Founded in 2005 in Göppingen, Germany, the company employs around 700 people from mor...

Blade Therapeutics

Blade Therapeutics is a private biopharmaceutical company advancing novel anti-fibrotic therapies to meet important patient needs. Blade has assembled a critical mass of fibrosis ...

Clinical Trials [2330 Associated Clinical Trials listed on BioPortfolio]

Sym021 (Anti-PD-1) in Patients With Advanced Solid Tumor Malignancies or Lymphomas

This is the first study to test Sym021 in humans. The primary purpose of this study is to see if Sym021 is safe and tolerable for patients with locally advanced/unresectable or metastatic ...

Treatment and Outcomes of Atrial Fibrillation and Acute Coronary Syndrome in Sweden

Many people who suffer from irregular heartbeats (atrial fibrillation) which might cause stroke, need to take blood thinners to prevent it. However, people with atrial fibrillation are als...

Anti—PD-L1 and SAbR for Ovarian Cancer

Programmed death-1 receptor ligand (PD-L1) the ligand for PD-1 is a key therapeutic target in the reactivation of the immune response against multiple cancers. Pharmacologic inhibitors of ...

Anti-Xa Levels in Critically Ill Patients Receiving Low-molecular-weight Heparin for Thromboprophylaxis in China

Critically ill Patients are at high risk to develop deep venous thrombosis. However, despite receiving of a standard dose of Low-molecular-weight Heparin(LMWH), many patients still dev...

Anti-EGFR Therapy Rechallenge in Combination With Chemotherapy in Patients With Advanced Colorectal Cancer

A-REPEAT (Anti-Epidermal Growth Factor Receptor -EGFR- rechallenge and plasma genotyping of patients with advanced colorectal tumors) is a Greek, investigator-initiated, single arm open-la...

Adverse Drug Reactions to Anti-TB Drugs in the Treatment of Latent Tuberculosis Infection

The investigators aim to study the prevalence of adverse reactions of anti-tuberculosis (TB) drugs in latent tuberculosis infection (LTBI), and determine the risk factors of anti-TB drug-r...

A Phase Ia/Ib Study of CS1001 in Advanced Solid Tumors

This is a phase Ia/Ib, open-label, multiple-dose, dose-escalation and expansion study to evaluate the safety, tolerability, pharmacokinetics and anti-tumor activity of CS1001 in subjects w...

Neoadjuvant Treatment Associated With Maintenance Therapy by Anti-PD1 Immunotherapy in Patients With Resectable Head and Neck Mucosal Melanoma

The main objective will be to estimate the disease free survival (DFS) of patients with resectable head and neck mucosal melanomas treated by neo-adjuvant anti-PD1 followed by surgery, rad...

Evolution of the Heart Function When Monitoring Immunotherapies Anti-cancerous Inhibiting PD-1

Prospective, monocentric clinical study. Patients selected for nivolumab therapy in AP-HM for melanoma and non-small cell lung cancer will be eligible. Do not include patients with conditi...

Carnosine and Cardiovascular Disease

Carnosine is a naturally occurring peptide found in high levels in skeletal muscle and the brain and is also available commercially as a dietary supplement. Since carnosine has anti-oxidan...

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Medical and Biotech [MESH] Definitions

A non-steroidal anti-fertility agent with anti-hormonal properties.

One of the ADRENERGIC BETA-ANTAGONISTS used as an antihypertensive, anti-anginal, and anti-arrhythmic agent.

An IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It inhibits prostaglandin synthesis and has been proposed as an anti-arthritic.

An anti-inflammatory, anti-allergic glucocorticoid that can be administered orally, by inhalation, locally, and parenterally. It may cause water and salt retention.

An anti-inflammatory, synthetic glucocorticoid. It is used topically as an anti-inflammatory agent and in aerosol form for the treatment of ASTHMA.

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