Advertisement

Topics

Vantictumab - Biotech, Pharma and Life Science Channel

02:32 EST 24th January 2019 | BioPortfolio

Anti-Fzd7 (vantictumab, OMP-18R5)

Vantictumab is OncoMed’s lead program in the Wnt pathway. Screened against the Frizzled 7 receptor, the antibody binds a conserved epitope on five of the Frizzled receptors. It has been shown in preclinical studies to induce tumor cell differentiation. Vantictumab entered Phase 1 clinical testing in 2011.

Vantictumab is a monoclonal antibody optimized to block a key signaling pathway in cancer. Specifically, vantictumab selectively targets Frizzled receptors, activators of Wnt signaling. Vantictumab exhibits broad anti-tumor activity in nonclinical models. Vantictumab is currently in Phase 1 and will be evaluated in chemotherapy combinations in Phase 1b trials. Vantictumab is part of OncoMed’s collaboration with Bayer Pharma AG.

PubMed Articles [5640 Associated PubMed Articles listed on BioPortfolio]

Identification of hydroxytyrosyl oleate, a derivative of hydroxytyrosol with anti-inflammatory properties, in olive oil by-products.

Hydroxytyrosyl esters with short, medium and long acyl chains were evaluated for their ability to reduce nitric oxide (NO) production by lipopolysaccharide-stimulated RAW264.7 macrophages. Among the c...

Comparing the effects of thermal and non-thermal technologies on pomegranate juice quality: A review.

The consumption of pomegranate juice (PJ) has increased substantially since scientific literature reported its therapeutic benefits that are attributable to antioxidant, antimicrobial, anti-carcinogen...

Phenotypes of Severe Cutaneous Adverse Reactions Caused by Nonsteroidal Anti-inflammatory Drugs.

Nonsteroidal anti-inflammatory drugs (NSAIDs) are common cause of severe cutaneous adverse reactions (SCARs). The present study aimed to investigate the characteristics of SCARs induced by NSAIDs in t...

Eperisone-Induced Anaphylaxis: Pharmacovigilance Data and Results of Allergy Testing.

Eperisone is an oral muscle relaxant used in musculoskeletal disorders causing muscle spasm and pain. For more effective pain control, eperisone is usually prescribed together with nonsteroidal anti-i...

Oxidative grafting vs. monolayers self-assembling on gold surface for the preparation of electrochemical immunosensors. Application to the determination of peptide YY.

A comparison of the performance of two electrochemical immunosensors for the determination of the anorexigen biomarker peptide YY (PYY) is reported by using as scaffolds screen printed gold electrodes...

Anti-NGF treatment can reduce chronic neuropathic pain by changing peripheral mediators and brain activity in rats.

Neuropathic pain is driven by abnormal peripheral and central processing, and treatments are insufficiently effective. Antibodies against nerve growth factor (anti-NGF) have been investigated as a pot...

Four lines of anaplastic lymphoma kinase inhibitors and brain radiotherapy in a long-surviving non-small-cell lung cancer anaplastic lymphoma kinase-positive patient with leptomeningeal carcinomatosis.

Lung cancer is the most common tumor and the leading cause of cancer-related death worldwide. Approximately 6.7% of non-small-cell lung cancers (NSCLCs) show anaplastic lymphoma kinase (ALK) rearrange...

Trophoblast-derived hyaluronan promotes the regulatory phenotype of decidual macrophages.

There is delicate crosstalk between fetus-derived trophoblasts (Tros) and maternal cells during normal pregnancy. Dysfunctions in interaction are highly linked to some pregnancy complications, such as...

Uncoupling protein 2 reprograms the tumor microenvironment to support the anti-tumor immune cycle.

Immune checkpoint blockade therapy has shifted the paradigm for cancer treatment. However, the majority of patients lack effective responses due to insufficient T cell infiltration in tumors. Here we ...

Osthole alleviates MPTP-induced parkinson's disease mice by suppressing Notch signaling pathway.

Parkinson's disease (PD) is an age-related neurodegenerative disease characterized by motor dysfunctions. Dopaminergic neuron loss, inflammation and oxidative stress responses play key roles in the pa...

News Articles [1670 Associated News Articles listed on BioPortfolio]

Accelerated Approval: US FDA Labeling Guidance Calls Out Surrogate Endpoints Needing ‘Additional Context’

For Indications and Usage section of some drugs, such as anti-cancer agents, it may be enough merely to state that...   

Accelerated Appproval: US FDA Labeling Guidance Calls Out Surrogate Endpoints Needing ‘Additional Context’

For Indications and Usage section of some drugs, such as anti-cancer agents, it may be enough merely to state that...   

State Highlights: NYC Mayor Taps City’s Workers To Help Enroll Uninsured; Measles Outbreak In Oregon Anti-Vaccination ‘Hot Spot’ Escalates

Media outlets report on news from New York, Oregon, Montana, Wisconsin, Massachusetts, California, Maryland, Ohio, Georgia, Tennessee and New Hampshire.

State Judge Strikes Down Iowa’s ‘Fetal Heartbeat’ Law As Unconstitutional

The legislation that would have outlawed abortion as soon as a fetal heartbeat was detected -- which is usually at six weeks, often before a woman even realizes she's pregnant -- would have been the m...

CBD Luxe Launches New Portfolio of Full Spectrum Hemp Oil Inhalers

First of its kind in the market, CBD Luxe inhalers guarantee precise dosing and predictable efficacy from organic-certified whole plant extracts CBD Luxe, the hi...

Anti-VEGF Efficacy in DME: Early Response Is Not Destiny

New data from Protocol T shows that eyes with poor 12-week response often had good vision at 2 years without switching therapies. Medscape Ophthalmology

Medical News Today: Can Noxzema help with eczema?

Noxzema is an anti-acne cream designed to clear pimples. In this article, we look at whether Noxzema products can also help with eczema, and we discuss the research, risks, and alternatives.

Preempting the annual misrepresentation of NZ dental health data by anti-fluoride activists

The latest NZ school dental service data again confirms that community water fluoridation is effective. The data show benefits of up to about 30% improvement in oral health. But, anti-fluoride activis...

Medical News Today: How your flu medicine can affect your heart

Flu and colds are common this season, and we often treat them with anti-inflammatories and decongestants. However, these can affect cardiovascular risk.

How to Shift Anti-Transgender Attitudes

A new study shows that door-to-door “deep canvassing” conversations can change real voters’ attitudes to be more tolerant -- Read more on ScientificAmerican.com

Companies [169 Associated Companies listed on BioPortfolio]

Lupin Pharmaceuticals, Inc.

Headquartered in Mumbai, India, Lupin Limited is an innovation led transnational pharmaceutical company producing a wide range of quality, affordable generic and branded formulations and APIs for the ...

Lupin Limited

Lupin is an innovation led transnational pharmaceutical company developing and delivering a wide range of branded & generic formulations, biotechnology products and APIs globally....

Propanc Biopharma, Inc.

Propanc Biopharma, Inc. (the "Company") is a biopharmaceutical company developing new cancer treatments initially for patients suffering from pancreatic, ovarian and colorectal ca...

Cell Science Systems, Corp.

CSS is a CLIA licensed lab and an FDA registered Medical Device establishment, that has developed the Alcat test for food and chemical sensitivities, as well as GI function assays...

BryoLogyx

BryoLogyx is developing a new class of drugs to enhance the response rates and treatment durability of cancer immunotherapies and anti-HIV agents. The company’s initial focus...

Ocular Therapeutix™, Inc.

Ocular Therapeutix, Inc. is a biopharmaceutical company focused on the development, manufacturing and commercialization of innovative therapies for diseases and conditions of the ...

Brooklyn ImmunoTherapeutics LLC

Brooklyn ImmunoTherapeutics (formerly IRX Therapeutics) is focused on exploring the role that cytokine-based therapy can have in treating patients with cancer, both as a single ag...

Lyra Therapeutics, Inc.

Lyra Therapeutics is a clinical-stage biotechnology company developing medicines precisely designed to target ear, nose and throat (ENT) diseases, offering an alternative t...

Applied DNA Sciences Inc.

Applied DNA is a provider of molecular technologies that enable supply chain security, anti-counterfeiting and anti-theft technology, product genotyping and DNA mass production fo...

Lyra Therapeutics

Lyra Therapeutics is a clinical-stage biotechnology company developing medicines precisely designed to target ear, nose and throat (ENT) diseases, offering an alternative to conve...

Clinical Trials [2991 Associated Clinical Trials listed on BioPortfolio]

Study of Two Doses of ABX464 in Participants With Moderate to Severe Rheumatoid Arthritis

This Phase IIa study aims at investigating the safety and tolerability of 2 dose-levels of ABX464 administered daily in combination with methotrexate (MTX) in patients with moderate to sev...

Relationship Between Baseline Burden of Disease and TDM in Ulcerative Colitis

Ulcerative colitis (UC) is a chronic inflammatory bowel disease which often follows a relapsing/remitting course. Anti-TNF therapies are proven to be effective in UC and studies indicate t...

Cannabis Extract in Refractory Epilepsy Study

The purpose of this study is to examine whether a low dose of CBD+THC will decrease the frequency of convulsive seizures in adults with drug-resistant epilepsy, when used in addition to st...

A Safety and Pharmacokinetic Study of NBM-BMX Administered Orally to Asian Patients With Advanced Cancer

NBM-BMX is a new small molecule chemical entity being developed as a potential anti-cancer therapeutic by NatureWise. NBM-BMX is a histone deacetylase (HDAC) inhibitor and has been shown t...

A Phase I Study of CS1003 in Subjects With Advanced Solid Tumors or Lymphomas

This is a phase Ia/Ib, open-label, multiple-dose, dose-escalation and expansion study to evaluate the safety, tolerability, pharmacokinetics and anti-tumor activity of CS1003 in subjects w...

Toripalimab as Monotherapy for Patients With Small Cell Carcinoma of Esophagus Who Failed Chemotherapy

To evaluate the anti-tumor activity, safety and tolerance of toripalimab as monotherapy for patients with small cell esophageal cancer (SCCE), and to explore the potential biomarkers for t...

Study of Safety and Efficacy of Betalutin and Rituximab in Patients With FL

This study is a Phase 1b, open-label, single arm dose escalation study of Betalutin followed by rituximab in patients with previously treated follicular lymphoma. The purpose of this study...

Immune Damage and Vaccination in COPD Patients

Better understanding of the specificities of the vaccine response in patients with COPD

Personalized Medicine for Membranous Nephropathy

Randomized, open label, multicentre (20 sites), prospective trial comparing the efficacy of two therapeutic strategies to obtain clinical remission 1 year after diagnosis of Idiopathic Mem...

The Therapeutic Effect of Dau-Di-Wu-Gong in Patient With Ankle Fracture

Ankle fracture is one of most common bone fracture in Taiwan, although ankle fracture can be treated by surgical operation, local edema, pain and wound poor healing always is noted, accord...

Medical and Biotech [MESH] Definitions

A non-steroidal anti-fertility agent with anti-hormonal properties.

One of the ADRENERGIC BETA-ANTAGONISTS used as an antihypertensive, anti-anginal, and anti-arrhythmic agent.

An IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It inhibits prostaglandin synthesis and has been proposed as an anti-arthritic.

An anti-inflammatory, anti-allergic glucocorticoid that can be administered orally, by inhalation, locally, and parenterally. It may cause water and salt retention.

An anti-inflammatory, synthetic glucocorticoid. It is used topically as an anti-inflammatory agent and in aerosol form for the treatment of ASTHMA.

Advertisement
Quick Search
Advertisement
Advertisement

 

Relevant Topic

Cancer
  Bladder Cancer Brain Cancer Breast Cancer Cancer Cervical Cancer Colorectal Head & Neck Cancers Hodgkin Lymphoma Leukemia Lung Cancer Melanoma Myeloma Ovarian Cancer Pancreatic Cancer ...