Advertisement

Topics

Xofigo (radium-223 dichloride) - Biotech, Pharma and Life Science Channel

01:33 EDT 17th October 2017 | BioPortfolio

New treatment for castration-resistant prostate cancer (CRPC) patients with bone metastases.

Xofigo shown in a pivotal phase III trial to significantly improve overall survival.

Xofigo® with the active ingredient radium 223 dichloride (radium 223) is an alpha particle-emitting radioactive therapeutic agent with an anti-tumor effect on bone metastases. Radium 223 mimics calcium and forms complexes with the bone mineral hydroxyapatite at areas of increased bone turnover, such as bone metastases. The high linear energy transfer of alpha emitters may cause double-strand DNA breaks in adjacent cells, resulting in an anti-tumor effect on bone metastases. The alpha particle range from radium 223 is less than 100 micrometers, which may limit the damage to the surrounding normal tissue.

The US Food and Drug Administration (FDA) has approved Xofigo® (radium-223 dichloride) injection for the treatment of patients with castration-resistant prostate cancer, symptomatic bone metastases and no known visceral metastatic disease. Xofigo is the first alpha particle-emitting radioactive therapeutic agent approved by the FDA, that has demonstrated improvement in overall survival (OS) and delay in time to first symptomatic skeletal event (SSE) compared to placebo, as shown in the pivotal phase III ALSYMPCA trial.

The commercial production of Xofigo is underway, and first doses are expected to be ready for patient treatment within a few weeks. Bayer has worldwide exclusive marketing rights for Xofigo. Algeta US, LLC and Bayer Healthcare will co-promote the product in the US.

Source: http://www.algeta.com/news/

Xofigo® is a registered trademark of Bayer.

News Articles [19 Associated News Articles listed on BioPortfolio]

Global Isophthaloyl Dichloride Market Research Report Forecast 20172022 [Report Updated: 18092017] Prices from USD $2800

Delivery of the Report will take 4872 hours once order is placed.The Global Isophthaloyl Dichloride Market Research Report Forecast 20172022 is a valuable source of insightful data for business stra...

The Norwegian Radium Hospital Research Foundation Pharmaceuticals Healthcare Deals and Alliances Profile [Report Updated: 14092017] Prices from USD $250

SummaryThe Norwegian Radium Hospital Research Foundation RF is a healthcare research hospital that offers clinical studies. The hospital conducts research programs and clinical studies. It provides se...

Bayer to Highlight New Research at ESMO 2017 Congress

WHIPPANY, N.J., Sept. 1, 2017 /PRNewswire/ -- Bayer will present the latest research from across its growing oncology portfolio at the European Society for Medical Oncology (ESMO) 2017 Congress, ...

Global Isophthaloyl Dichloride Market Research Report Forecast 20172022 [Report Updated: 01072017] Prices from USD $2800

Delivery of the Report will take 4872 hours once order is placed.The Global Isophthaloyl Dichloride Market Research Report Forecast 20172022 is a valuable source of insightful data for business stra...

Xofigo Drug Insights, 2017 [Report Updated: 10072017] Prices from USD $1000

DelveInsight's pharmaceuticals report, Xofigo Drug Insights, 2017 highlights the Drug marketed details and the Global API Manufacturers details across the globe along with the location. The report co...

Human medicines European public assessment report (EPAR): Xofigo, radium Ra223 dichloride, Revision: 7, Authorised

Amerigroup Georgia Launches Style Tour to Provide Back-to-School Clothing and Grooming to Prepare Kids for New School Season

Statewide Initiative to Provide Thousands of Georgia Families with Much Needed Resources Amerigroup Community Care of Georgia is launching new efforts to help families ...

Radium Medical Aesthetics Introduces LASEMD for Effective Skin Care Treatment

SINGAPORE, July 27, 2017 /PRNewswire/ -- Radium Medical Aesthetics, a leading medical aesthetic clinic in Singapore introduces LASEMD, designed to delay aging by effectively addressing several sk...

Global Paraquat Dichloride Market Research Report Forecast 2017 to 2022 [Report Updated: 05072017] Prices from USD $2800

Delivery of the Report will take 23 working days once order is placed.The Global Paraquat Dichloride Market Research Report Forecast 20172022 is a valuable source of insightful data for business strat...

Global and Chinese Tri Ethylene Glycol Dichloride Industry, 2017 Market Research Report [Report Updated: 01011970] Prices from USD $3000

The 'Global and Chinese Tri Ethylene Glycol Dichloride Industry, 20122022 Market Research Report' is a professional and indepth study on the current state of the global Tri Ethylene Glycol Dichloride ...

Events [0 Results]

None

Companies [4 Associated Companies listed on BioPortfolio]

Nextera Communications

Nextera is a privately owned Norwegian biotech company. Our approach is to manipulate the disease at the initiation of the escalating immune cascade by identifying and subsequentl...

Ultimovacs AS

Ultimovacs AS ('Ultimovacs') was established by Inven2 in 2011. The company's goal is to develop technology from the Norwegian Radium Hospital for use in cancer treatment and to m...

Targovax

Targovax was started in October 2010 to develop TG01, a vaccine targeting pancreatic cancer. TG01 is based on research from The Radium Hospital and Norsk Hydro in the end of the 9...

Axiall Corporation

Axiall Corporation is a leading integrated chemicals and building products company. It is an international manufacturer of chlor-alkali and derivatives, chlorovinyls and aromatics...

Clinical Trials [36 Associated Clinical Trials listed on BioPortfolio]

Radium-223 and Radiotherapy in Hormone-Naïve Men With Oligometastatic Prostate Cancer to Bone

This is a phase IIa, open label, single arm, and prospective study of hormone therapy-naïve men with oligometastatic prostate cancer to the bone. The study will test if treating the prima...

Bone Marrow Suppression and Recovery During Radionuclide Treatment

Radium-223-dichloride is approved therapy for patients with metastatic castration-resistant prostate cancer and bone metastases. Therapy is administered intravenously every 4 weeks for up ...

Sequencing of Radium-223 and Docetaxel in Symptomatic Bone-only Metastatic Castration-resistant Prostate Cancer

Randomized, multicentre phase II trial of the sequencing of Radium-223 and Docetaxel plus prednisone in symptomatic bone-only metastatic castration-resistant prostate cancer (mCRPC) Open-...

Radium-223 and Atezolizumab in Patients With Urothelial Carcinoma With Bone Metastases Who Have Had Disease Progression After Platinum-Based Chemotherapy

This is a single-arm, single-site pilot of Radium-223 (55 kBq/kg) IV q3 weeks for up to 6 doses in combination with Atezolizumab 1200mg IV once every 3 weeks until investigator determined ...

Study Evaluating the Addition of Pembrolizumab to Radium-223 in mCRPC

This research study is studying the safety and tolerability of an investigational combination of drugs, radium-223 plus pembrolizumab as a possible treatment for castration-resistant prost...

Radium Ra 223 Dichloride and Niraparib in Treating Patients With Hormone- Resistant Prostate Cancer Metastatic to the Bone

This phase Ib trial studies the side effects and best dose of niraparib when given together with radium Ra223 dichloride in treating patients with prostate cancer that keeps growing even w...

Metabolic Change in Prostate Cancer Bone Metastases on 68Ga-HBED-CC-PSMA (DKFZ-11) PET/CT Following Radium-223 Therapy

Broadly, the objective of this study is to evaluate the fractional decline of intensity of tracer uptake measured by SUVmax on 68Ga-PSMA PET/CT in bone metastases from prostate cancer foll...

Value of FLT PET/CT in Radium-223 Therapy of mCRPC Patients

The aim of the study is to investigate whether positron emission tomography (PET) using the tracer 18F-Fluorothymidine (FLT) can provide information on proliferative activity in bone marro...

A Phase II Clinical Trial of Radium-223 Activity in Patients With Metastatic Castration-resistant Prostate Cancer (mCRPC) With Asymptomatic Progression While on Abiraterone Acetate or Enzalutamide Besides AR-V7 Mutational Status (EXCAAPE)

Radium-223 is indicated for the treatment of patients with mCRPC with symptomatic bone metastases and no known visceral metastatic disease. However, very few data have been reported in pat...

Assess Gamma H2AX Positivity in Circulating Prostate Cancer Cells Before and After Radium 223

This is a prospective biomarker study on prostate cancer patients receiving Radium 223 as standard of care. Participants will take part in this research study because they have chosen Rad...

PubMed Articles [55 Associated PubMed Articles listed on BioPortfolio]

LINE-1 as a therapeutic target for castration-resistant prostate cancer.

Prostate cancer is the third leading cause of death by cancer in men. Surgery or hormone deprivation usually contains the progression of the local forms of the disease. In metastatic situations, chemo...

Phosgene-induced acute lung injury (ALI): differences from chlorine-induced ALI and attempts to translate toxicology to clinical medicine.

Phosgene (carbonyl dichloride) gas is an indispensable chemical inter-mediate used in numerous industrial processes. There is no clear consensus as to its time- and inhaled-dose-dependent etiopatholog...

Re-treatment with radium-223: first experience from an international, open-label, phase I/II study in patients with castration-resistant prostate cancer and bone metastases.

Six radium-223 injections at 4-week intervals is indicated for patients with castration-resistant prostate cancer and symptomatic bone metastases. However, patients usually develop disease progression...

Geological and hydrogeochemical controls on radium isotopes in groundwater of the Sinai Peninsula, Egypt.

Radium isotopes ((226)Ra and (228)Ra) were analyzed in 18 groundwater samples from the Nubian Sandstone Aquifer System (NSAS) and the shallow alluvial aquifers overlying the basement complex of the Si...

Influence of grain size on radionuclide activity concentrations and radiological hazard of building material samples.

The knowledge of radioactivity content in various radionuclides in building materials plays an important role in health physics; therefore, we measured the amount of naturally occurring radionuclides ...

Dutch Economic Value of Radium-223 in Metastatic Castration-Resistant Prostate Cancer.

The treatment of metastatic castration-resistant prostate cancer has changed with the introduction of radium-223, cabazitaxel, abiraterone and enzalutamide. To assess value for money, their cost effec...

Radium-223 therapy of advanced metastatic castration-resistant prostate cancer: quantitative assessment of skeletal tumor burden for prognostication of clinical outcome and hematological toxicity.

Aim: To investigate the prognostic value of quantitative assessment of skeletal tumor burden on bone scintigraphy (Bone Scan Index) in patients with advanced metastatic castration-resistant prostate c...

Soft Tissue Response on 18F-Fluorocholine PET/CT in Metastatic Castrate-Resistant Prostate Cancer Treated With 223Ra-Dichloride: A Possible Abscopal Effect?

Two patients with castrate-resistant prostate cancer and symptomatic skeletal metastases underwent F-fluorocholine PET/CT prior to treatment with Ra-dichloride to reveal additional active lesions in t...

Self-Assembly in Aqueous Oppositely Charged Gemini Surfactants: A Correlation between Morphology and Solubilization Efficacy.

Micellization behaviour of oppositely charged gemini surfactants (anionic surfactant; phosphoric acid, P, P'-1,4-butanedieyl, P,P' didodecylester, disodium salt (12-4-12A),and cationic surfactant; but...

Applications of radon and radium isotopes to determine submarine groundwater discharge and flushing times in Todos os Santos Bay, Brazil.

Todos os Santos Bay (BTS) is the 2nd largest bay in Brazil and an important resource for the people of the State of Bahia. We made measurements of radon and radium in selected areas of the bay to eval...

Videos

None available.

Medical and Biotech [MESH] Definitions

Radium. A radioactive element of the alkaline earth series of metals. It has the atomic symbol Ra, atomic number 88, and atomic weight 226. Radium is the product of the disintegration of uranium and is present in pitchblende and all ores containing uranium. It is used clinically as a source of beta and gamma-rays in radiotherapy, particularly BRACHYTHERAPY.

1,1'-Bis(phenylmethyl)4,4'-bipyridinium dichloride. Oxidation-reduction indicator.

Radon. A naturally radioactive element with atomic symbol Rn, atomic number 86, and atomic weight 222. It is a member of the noble gas family and released during the decay of radium and found in soil. There is a link between exposure to radon and lung cancer.

Therapeutic practices which are not currently considered an integral part of conventional allopathic medical practice. They may lack biomedical explanations but as they become better researched some (PHYSICAL THERAPY MODALITIES; DIET; ACUPUNCTURE) become widely accepted whereas others (humors, radium therapy) quietly fade away, yet are important historical footnotes. Therapies are termed as Complementary when used in addition to conventional treatments and as Alternative when used instead of conventional treatment.

Quick Search
Advertisement
 

Relevant Topics

Osteoporosis
Osteoporosis is a disease in which the bones become extremely porous, are subject to fracture, and heal slowly, occurring especially in women following menopause and often leading to curvature of the spine from vertebral collapse. Follow and track&n...

Clincial Trials
In a clinical trial or interventional study, participants receive specific interventions according to the research plan or protocol created by the investigators. These interventions may be medical products, such as drugs or devices; procedures; or change...

review and buy Xofigo (radium-223 dichloride) market research data and corporate reports here

Channels Quicklinks