Advertisement

Topics

Adenosine Deaminase - Biotech, Pharma and Life Science Channel

21:43 EDT 19th October 2017 | BioPortfolio

PubMed Articles [486 Associated PubMed Articles listed on BioPortfolio]

ATP mediated rolling circle amplification and opening DNA-gate for drug delivery to cell.

Here, we have developed a facile fluorometric system for the detection of adenosine triphosphate (ATP) by a rolling circle amplification (RCA) based on proximity ligation mediated amplification, and s...

Regulation of poly(ADP-Ribose) polymerase 1 functions by post-translational modifications.

The poly(ADP-ribose) polymerases (PARPs) catalyze poly(ADP-ribosyl)ation, a post-translational modification of proteins. This  consists of the attachment of mono- or poly-adenosine diphosphate (ADP)-...

PARP-1 and PARP-2 activity in cancer-induced cachexia: potential therapeutic implications.

Skeletal muscle dysfunction and mass loss is a characteristic feature in patients with chronic diseases including cancer and acute conditions such as critical illness. Maintenance of an adequate muscl...

The Product of Yersinia pseudotuberculosis mcc Operon Is a Peptide-cytidine Antibiotic Activated Inside Producing Cells by the TldD/E Protease.

Microcin C is a heptapeptide-adenylate antibiotic produced by some strains of Escherichia coli. Its peptide part is responsible for facilitated transport inside sensitive cells where it is proteolysed...

Adenosine versus intravenous calcium channel antagonists for supraventricular tachycardia.

People with supraventricular tachycardia (SVT) frequently are symptomatic and present to the emergency department for treatment. Although vagal manoeuvres may terminate SVT, they often fail, and subse...

Resting Pd/Pa and haemodynamic relevance of coronary stenosis as evaluated by fractional flow reserve.

Fractional flow reserve (FFR) currently represents the gold standard in the evaluation of the haemodynamic relevance of coronary stenoses. However, both intracoronary and intravenous adenosine may be ...

Effects of Extremely Low Frequency Electromagnetic Fields on Melanogenesis through p-ERK and p-SAPK/JNK Pathways in Human Melanocytes.

This study evaluated frequency-dependent effects of extremely low frequency electromagnetic fields (ELF-EMFs) on melanogenesis by melanocytes in vitro. Melanocytes were exposed to 2 mT EMFs at 30-75 H...

Chemical composition of the essential oils isolated from peel of three citrus species and their mosquitocidal activity against Culex pipiens.

Three essential oils (EOs) were isolated from the peel of citrus fruits Citrus reticulata L., Citrus reticulata chinase Blanco and Citrus sinensis (L.) Osbeck (Family: Rutaceae) and evaluated against ...

Cervical cancer cells (HeLa) response to photodynamic therapy using a zinc phthalocyanine photosensitizer.

Cervical cancer is the most common gynecological malignancy worldwide, and the leading cause of cancer related deaths among females. Conventional treatment for early cervical cancer is radical hystere...

Limonene protects osteoblasts against methylglyoxal-derived adduct formation by regulating glyoxalase, oxidative stress, and mitochondrial function.

Methylglyoxal (MG) is a potent protein glycating agent and an important precursor of advanced glycation end products, which are involved in the pathogenesis of diabetic osteopathy. In this study, we i...

News Articles [51 Associated News Articles listed on BioPortfolio]

Can-Fite Issued Patent in Korea for Piclidenoson in the Treatment of Psoriasis

Can-Fite has distribution agreements in Korea for Piclidenoson and Namodenoson Piclidenoson slated to enter Phase III study in treatment of psor...

Dynamic landscape and regulation of RNA editing in mammals

Adenosine-to-inosine (A-to-I) RNA editing is a conserved post-transcriptional mechanism mediated by ADAR enzymes that diversifies the transcriptome by altering selected nucleotides in RNA molecules. A...

Inotek Pharmaceuticals Corp ITEK Pharmaceuticals Healthcare Deals and Alliances Profile [Report Updated: 17082017] Prices from USD $250

SummaryInotek Pharmaceuticals Corp IPC is a pharmaceutical company that discovers, develops and commercializes therapeutics for the treatment of glaucoma and serious diseases of the eye. The company's...

Cayman Chemical Cyclic AMP TR-FRET Kit

Cyclic adenosine monophosphate (cAMP) is an intracellular signalling molecule that is a key mediator in a variety of pathways, including glycogen metabolism, gene regulation and olfactory sensory tran...

Adenosine A2B Receptor Antagonist Pipeline Insights, 2017 [Report Updated: 01092017] Prices from USD $1250

DelveInsight's, Adenosine A2B Receptor AntagonistMechanism of action Insights, 2017, report provides comprehensive insights of the ongoing therapeutic research and development across Adenosine A2B Rec...

Adenosine A2A Receptor Agonist Pipeline Insights, 2017 [Report Updated: 01092017] Prices from USD $1250

DelveInsight's, Adenosine A2A Receptor AgonistMechanism of action Insights, 2017, report provides comprehensive insights of the ongoing therapeutic research and development across Adenosine A2A Recept...

Adenosine A1 Receptor Antagonist Pipeline Insights, 2017 [Report Updated: 01092017] Prices from USD $1250

DelveInsight's, Adenosine A1 Receptor AntagonistMechanism of action Insights, 2017, report provides comprehensive insights of the ongoing therapeutic research and development across Adenosine A1 Recep...

Poxel Announces PXL770 Advances into a Phase 1b Multiple Ascending Dose Trial

PXL770 is a direct AMPK activator; a central regulator of multiple metabolic pathways that provides the opportunity to treat a wide range of metabolic diseases ...

Adenosine A2 Receptor Antagonist Pipeline Insights, 2017 [Report Updated: 01092017] Prices from USD $1250

DelveInsight's, Adenosine A2 Receptor AntagonistMechanism of action Insights, 2017, report provides comprehensive insights of the ongoing therapeutic research and development across Adenosine A2 Recep...

Adenosine A1 Receptor Agonist Pipeline Insights, 2017 [Report Updated: 01092017] Prices from USD $1250

DelveInsight's, Adenosine A1 Receptor AgonistMechanism of action Insights, 2017, report provides comprehensive insights of the ongoing therapeutic research and development across Adenosine A1 Receptor...

Events [0 Results]

None

Companies [3 Associated Companies listed on BioPortfolio]

Arcus Biosciences

Arcus Biosciences (“Arcus”) is a biotechnology company focused on the discovery and development of innovative cancer immunotherapies. Arcus was founded in 2015 by Ter...

Inotek Pharmaceuticals Corp.

Inotek Pharmaceuticals is a clinical-stage biopharmaceutical company focused on the discovery, development and commercialization of therapies for glaucoma and other eye diseases. ...

ArQule, Inc.

ArQule is a biotechnology company engaged in the research and development of next-generation, small-molecule cancer therapeutics. The Company’s targeted, broad-spectrum produ...

Clinical Trials [154 Associated Clinical Trials listed on BioPortfolio]

A Double-Blind, Placebo-Controlled Trial of Anti-Aging, Pro-Autophagy Effects of Metformin in Adults With Prediabetes

The goal of this pilot and feasibility study is to investigate the effects of a short course of metformin therapy on a surrogate marker of cellular senescence and autophagy among adult pat...

Retroviral Insertion Site Methodology Study

Adenosine deaminase (ADA) is an enzyme involved in the development and functioning of the immune system. Deficiency of ADA results in severe combined immunodeficiency (SCID), a fatal inher...

Trial of PBF-1129 in Patients With Advanced Non-Small Cell Lung Cancer (NSCLC)

Phase I clinical trial in Eastern Cooperative Oncology Group (ECOG) 0-1 patients with locally advanced or metastatic NSCLC to evaluate safety and tolerability of the compound PBF-1129, an ...

Performance of a New REsting Pressure Index During Invasive Angiography Compared To Adenosine Hyperemic FFR

To test the feasibility and diagnostic accuracy of a new automated pressure derived resting index (Pd/Pamin), using FFR as gold standard, in de novo coronary lesions in which invasive phys...

A Dose Titration Study to Assess the Effects of SAR407899 in Patients With Microvascular Angina and/or Persistent Stable Angina Despite Angiographically Successful Elective PCI

The Primary Objective of this study: -To assess the effects of SAR407899 on coronary vasomotor function using the coronary flow reserve (CFR) in patients with microvascular angina and/or ...

Hyperemic Efficacy of IV Adenosine in HFrEF

Little is known about the hyperemic efficacy of IV adenosine as well as safety in patients with heart failure with reduced ejection fraction (HFrEF) because they were excluded from the maj...

Evaluating the Effectiveness of STRIMVELIS Risk Minimization Measures (RMMs)

STRIMVELIS is a medicinal product developed by GSK that restores adenosine deaminase (ADA) function in hematopoietic cell lineages, thereby preventing impaired immune function. STRIMVELIS ...

Coronary Artery Vasculopathy in Pediatric Heart Transplant Patients

Heart transplantation is a life-sustaining therapy that allows patients with either congenital or acquired heart disease and severe cardiac dysfunction to survive. Over time, however, the ...

Varlitinib Plus Capecitabine in Chinese Patients With Advanced or Metastatic Biliary Tract Cancer

This protocol for Varlitinib is developed for the treatment of Biliary Tract Cancer. Varlitinib (also known as ASLAN001) is a small-molecule, adenosine triphosphate competitive inhibitor o...

Effect of Light-Emitting Diode on the Strenght and Resistence Capacities of Cycling Athletes

Phototherapy is a therapeutic resource of increasing use in the last decade. The photobiomodulatory effects are commonly produced by means of low intensity lasers or LED emitting diodes, a...

Videos

None available.

Medical and Biotech [MESH] Definitions

Drugs that inhibit ADENOSINE DEAMINASE activity.

An enzyme that catalyzes the hydrolysis of adenosine to inosine with the elimination of ammonia. Since there are wide tissue and species variations in the enzyme, it has been used as a tool in the study of human and animal genetics and in medical diagnosis. EC 3.5.4.4.

A nucleoside that is composed of adenine and d-ribose. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.

A ribonucleoside antibiotic synergist and adenosine deaminase inhibitor isolated from Nocardia interforma and Streptomyces kaniharaensis. It is proposed as an antineoplastic synergist and immunosuppressant.

A potent inhibitor of ADENOSINE DEAMINASE. The drug induces APOPTOSIS of LYMPHOCYTES, and is used in the treatment of many lymphoproliferative malignancies, particularly HAIRY CELL LEUKEMIA. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.

Quick Search
Advertisement
 
review and buy Adenosine Deaminase market research data and corporate reports here

Channels Quicklinks