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Cytotoxic drugs - Biotech, Pharma and Life Science Channel

16:58 EDT 23rd October 2017 | BioPortfolio

PubMed Articles [5346 Associated PubMed Articles listed on BioPortfolio]

Trends in Financial Access to Prescription Drugs Among Cancer Survivors.

Little is known about the competing effects of increasing prescription drug costs and expansions in insurance coverage on prescription drug access and whether trends vary for adults with and without a...

The N-butyl-N-4-hydroxybutyl Nitrosamine Mouse Urinary Bladder Cancer Model.

Urinary bladder cancer (UBC) is a common and complex malignancy, with a multifactorial etiology, like environmental factors, such as cigarette smoking, occupational exposure, and genetic factors.UBC e...

Visualization and Quantitative Measurement of Drug-Induced Platinum Adducts in the Nuclear DNA of Individual Cells by an Immuno-Cytological Assay.

Immunocytological staining with adduct-specific antibodies allows the visualization and measurement of structurally defined types of DNA damage in the nuclei of individual cells. Here we describe an i...

Development of a quantitative approach in blood plasma for low-dosed hallucinogens and opioids using LC-high resolution mass spectrometry.

The WHO annually reports an increasing abuse of new psychoactive substances (NPS), which are a heterogeneous group of synthetic drugs and are consumed as substitute for controlled drugs of abuse. In t...

Full validation of a method for the determination of drugs of abuse in non-mineralized dental biofilm using liquid chromatography-tandem mass spectrometry and application to postmortem samples.

Alternative matrices play a major role in postmortem forensic toxicology, especially if common matrices (like body fluids or hair) are not available. Incorporation of illicit and medicinal drugs into ...

Review on investigations of antisense oligonucleotides with the use of mass spectrometry.

Antisense oligonucleotides have been investigated as potential drugs for years. They inhibit target gene or protein expression. The present review summarizes their modifications, modes of action, and ...

Structural characterization of electrochemically and in vivo generated potential metabolites of selected cardiovascular drugs by EC-UHPLC/ESI-MS using an experimental design approach.

In the last few years, a number of studies were conducted which aimed at understanding the mechanisms of cardiovascular drug, metabolism, and there is still the need to determine the metabolites of ca...

Development of a semi-automated image-based high-throughput drug screening system.

We previously reported that the innate sensing of the endosymbiont Leishmania RNA virus 1 (LRV1) within Leishmania (Viannia) guyanensis through Toll-like receptor 3, worsens the pathogenesis of parasi...

Microfluidics technology for drug delivery: A review.

Microfluidics is undoubtedly an influential technology that is currently revolutionizing the chemical and biological studies by replicating laboratory bench-top technology on a miniature chip-scale de...

LINE-1 as a therapeutic target for castration-resistant prostate cancer.

Prostate cancer is the third leading cause of death by cancer in men. Surgery or hormone deprivation usually contains the progression of the local forms of the disease. In metastatic situations, chemo...

News Articles [5335 Associated News Articles listed on BioPortfolio]

Health Mart and APCI engage lawmakers for Florida Independent Pharmacy Day

Michael JohnsenState Rep. Jay Trumbull, representing Florida’s 6th District, is just one of the legislators supporting his local independent pharmacy, Coopers Drugs in Panama City. read more

STAT Plus: U.K. government is urged to widen access for drugs developed with taxpayer funds

The U.K. groups argue the government ought to require drug makers to disclose R&D costs and licensing terms for medicines discovered with taxpayer money.

Global Prostate Cancer Drugs Market Research Report Forecast 2017 to 2021 [Report Updated: 16102017] Prices from USD $2800

The Global Prostate Cancer Drugs Market Research Report Forecast 20172021 is a valuable source of insightful data for business strategists. It provides the Prostate Cancer Drugs industry overview wi...

Enanta’s Announces Positive Early-Stage Results for its Lead FXR Agonist

WATERTOWN, Mass.–(BUSINESS WIRE)–Enanta Pharmaceuticals, Inc. (NASDAQ:ENTA), a chemistry-driven biotechnology company dedicated to creating small molecule drugs for viral infections and li...

Rutgers researchers to explore ways for tackling emerging fungal infections

In recent years, hospitals nationwide have been reporting an increase in life-threatening illnesses resulting from a deadly fungal infection caused by the yeast Candida auris that can enter the bloods...

Teva allegedly paid Canadian pharmacies to buy its drugs

The "Toronto Star" gave its findings to the Ontario provincial government, which has begun an investigation.

So my brain amyloid level is elevated: What does that mean?

Testing drugs to prevent or delay the onset of Alzheimer's dementia and using them in the clinic will mean identifying and informing adults who have a higher risk of Alzheimer's but are still cognitiv...

Growing cancer drugs in chicken eggs could lower costs by 90%

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Psychedelic drugs may reduce criminal behavior

Newly published research suggests that common psychedelic drugs -- such as 'magic mushrooms', LSD and mescaline (a substance derived from the peyote cactus) -- may reduce criminal offenses. The new st...

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Companies [286 Associated Companies listed on BioPortfolio]

Vidac Pharma

Vidac Pharma is an innovative clinical-stage oncology- and dermatology-focused pharmaceutical company, developing novel drugs to help people suffering from a range of diseases. Vi...

LEO Pharma

Founded more than 100 years ago, LEO Pharma is an independent, research-based specialty pharmaceutical company committed to the discovery and development of novel drugs for patien...

NanOlogy LLC

NanOlogy, LLC (www.nanology.us) is a company formed by DFB Pharmaceuticals, LLC of Fort Worth, TX, CritiTech, Inc. of Lawrence, KS, and US Biotest, Inc. of San Luis Obispo,...

Phoenix Biotechnology, Inc.

Phoenix Biotechnology, Inc., a San Antonio, Texas based biotechnology company, was incorporated in Texas in 2003 to develop promising agents with minimal or no side effects for ta...

teckro

Teckro partners with leading pharmaceutical and biotech companies and research institutions to simplify the clinical development process — a recognized bottleneck in the effo...

Aspect Biosystems Ltd.

Aspect Biosystems is operating at the leading edge of 3D bioprinting and tissue engineering. The company’s proprietary Lab-on-a-Printer™ platform technology is enabling ...

Boehringer Ingelheim GmbH

Boehringer Ingelheim is a research-driven group of companies dedicated to researching, developing, manufacturing and marketing pharmaceuticals that improve health and quality of life.Our business cons...

Rare Disease Communications®

Rare Disease Communications® is a health care communications and media company focused on the rare disease community and dedicated to raising awareness of rare diseases and orp...

NanOlogy, LLC

NanOlogy, LLC (www.nanology.us) is a company formed by DFB Pharmaceuticals, LLC of Fort Worth, TX, CritiTech, Inc. of Lawrence, KS, and US Biotest, Inc. of San Luis Obispo,...

Context Therapeutics

Context Therapeutics is a private, Philadelphia, PA-based biotechnology company dedicated to creating new medicines to treat Sigma1-associated diseases. The company leverages brea...

Clinical Trials [1395 Associated Clinical Trials listed on BioPortfolio]

Adverse Drug Reactions to Anti-TB Drugs in the Treatment of Latent Tuberculosis Infection

The investigators aim to study the prevalence of adverse reactions of anti-tuberculosis (TB) drugs in latent tuberculosis infection (LTBI), and determine the risk factors of anti-TB drug-r...

A Research Study of a New Investigational Medicinal Product for the Treatment of Patients With Advanced or Metastatic Solid Tumors

W0101 combines a cytotoxic compound to a monoclonal antibody targeting a receptor commonly overexpressed in many cancers. The development of antibody-drug conjugates takes advantage of th...

Bendamustine + Obinutuzumab Induction With Obinutuzumab Maintenance in Untreated Mantle Cell Lymphoma

This is a phase II single-arm, open-label, multicenter study evaluating the efficacy and safety of the combination of induction chemoimmunotherapy with bendamustine and obinutuzumab (BO) f...

Effect of Anti-epileptic Drugs on Etonogestrel-releasing Implant Pharmacokinetics in Women With Epilepsy

Data on the interaction between the etonogestrel (ENG) implant and antiepileptic drug (AED) regimen are scarce. We will evaluated the effect of 2 AED regimens (1 including carbamazepine an...

Depletion of Myeloid Derived Suppressor Cells to Enhance Anti PD-1 Therapy

Metastatic non small cell lung cancer can be treated with cytotoxic chemotherapy or using recently approved immunotherapy with antibody, Nivolumab. Both the therapies have limitation due t...

Talimogene Laherparepvec, Capecitabine, and Chemoradiation Before Surgery in Treating Patients With Locally Advanced or Metastatic Rectal Cancer

This phase I trial studies the best dose and side effects of talimogene laherparepvec in combination with capecitabine and chemoradiation before surgery in treating patients with rectal ca...

Oligometastases of the Liver Treated With Chemotherapy With or Without Radiotherapy in Patients With Colorectal Cancer

Colorectal cancer is a major cause of morbidity and mortality throughout the world and accounts for more than 9% of all cancer outcomes. Global mortality from colorectal cancer is approxim...

Safety and Efficacy of the ONCOlytic VIRus Armed for Local Chemotherapy, TG6002/5-FC, in Recurrent Glioblastoma Patients

Glioblastoma is the most common and the most aggressive primary brain cancer in adults. Indeed, despite very intensive treatments (i.e. maximal safe surgery, radiotherapy and several lines...

Functional Plasticity of Human IL-17-producing CD8+ T Cells

Human Tc17 cells (IL-17-producing CD8+ T cells) have been found to contribute to different kinds of human inflammatory and malignant diseases. Previous studies indicate that Tc17 cells can...

Novel Blood-based Colorectal Cancer Screening Method Using Natural Killer Cell Activity and Gene Panel Expression

Natural killer cells (NK cells) are cytotoxic lymphocytes that play an important role in the innate immune system. In particular, it plays a very important defense function against host ce...

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Medical and Biotech [MESH] Definitions

A cytokine which resembles IL-1 structurally and IL-12 functionally. It enhances the cytotoxic activity of NK CELLS and CYTOTOXIC T-LYMPHOCYTES, and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity.

A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.

Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and cytostatic dye exclusion tests as well as in vivo measurement of tumor growth parameters in laboratory animals.

A critical subpopulation of regulatory T-lymphocytes involved in MHC Class I-restricted interactions. They include both cytotoxic T-lymphocytes (T-LYMPHOCYTES, CYTOTOXIC) and CD8+ suppressor T-lymphocytes.

The phenomenon of target cell destruction by immunologically active effector cells. It may be brought about directly by sensitized T-lymphocytes or by lymphoid or myeloid "killer" cells, or it may be mediated by cytotoxic antibody, cytotoxic factor released by lymphoid cells, or complement.

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