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Diseasemodifying drugs - Biotech, Pharma and Life Science Channel

14:25 EST 21st February 2018 | BioPortfolio

PubMed Articles [4316 Associated PubMed Articles listed on BioPortfolio]

Green-modified micellar liquid chromatography for isocratic isolation of some cardiovascular drugs with different polarities through experimental design approach.

Bilayer pseudo-stationary phase micellar liquid chromatography (MLC) was developed for simultaneous isocratic isolation of hydrochlorothiazide, as a basic-polar (hydrophilic) cardiovascular drug, as w...

Semi-automated set-up for exhaustive micro-electromembrane extractions of basic drugs from biological fluids.

Manual handling of microliter volumes of samples and reagents is usually prone to errors and may have direct consequence on the overall performance of microextraction process. Direct connection of a s...

Chinese quince seed gum and poly (N,N-diethylacryl amide-co-methacrylic acid) based pH-sensitive hydrogel for use in drug delivery.

In this investigation, a variety of innovative pH-sensitive polymers consisting of Chinese quince seed gum (CQSG) and poly (N,N-diethylacryl amide-co-methacrylic acid) were synthesized via free radica...

Translational new approaches for investigating mood disorders in rodents and what they may reveal about the underlying neurobiology of major depressive disorder.

Mood disorders represent one of society's most costly and challenging health burdens. The drug treatments used today were initially discovered serendipitously in the 1950s. Animal models were then dev...

HPMCAS as an effective precipitation inhibitor in amorphous solid dispersions of the poorly soluble drug candesartan cilexetil.

Among the strategies to improve the biopharmaceutic properties of poorly soluble drugs, Supersaturating Drug Delivery Systems like polymer-based amorphous solid dispersions (SD) have been successfully...

Structural characterization, antioxidant and hepatoprotective activities of polysaccharides from Sophorae tonkinensis Radix.

In current study we present two polysaccharides, STRP1 and STRP2, purified from Sophorae tonkinensis Radix via column chromatography. Structural analyses indicated that STRP1 and STRP2 were consisted ...

A novel approach for fabricating nanocomposite materials by embedding stabilized core-shell micelles into polysaccharide cryogel matrix.

We report a novel approach for fabricating nanocomposite polysaccharide-based carriers for sustained delivery of poorly-water-soluble drugs by embedding stabilized core-shell micelles (SPM) possessing...

Aldehyde-functionalized chitosan-montmorillonite films as dynamically-assembled, switchable-chemical release bioplastics.

Temporal release of synergistic and/or complementary chemicals (e.g.: drugs) is recognized as extremely challenging because of their frequently intertwined kinetic delivery and presently, straightforw...

Sequencing the oligosaccharide pool in the low molecular weight heparin dalteparin with offline HPLC and ESI-MS/MS.

Low molecular weight heparins (LMWHs) are widely used anticoagulant drugs. The composition and sequence of LMWH oligosaccharides determine their safety and efficacy. The short oligosaccharide pool in ...

Gastrointestinal Nematodes, Diagnosis and Control.

Disease caused by nematodes in the gastrointestinal tract of cattle is primarily economic and the effect of treatment is cattle grow larger faster because of increased feed intake. The disease, contro...

News Articles [3718 Associated News Articles listed on BioPortfolio]

STAT Plus: Lawmakers urge HHS to sidestep patents on hepatitis C drugs

To address the high cost of prescription drugs, congressional Democrats are urging federal officials to tap a little-known 1910 law to sidestep patents on hepatitis C medicines.

Monoclonal Antibodies Cost $100G More Per Year When Used for Cancer, Study in The American Journal of Managed Care® Finds

The “magic bullets” that bind to targets in the body have been used to treat severe skin conditions, high cholesterol, and many kinds of cancer. A new study finds that FDA-app...

Triplet Therapy May Be on the Horizon for BRAF-Mutant Melanoma

The past decade of drug discovery has brought a dramatic expansion in the number of new therapies to treat patients with advanced or metastatic melanoma in 2 modalities: checkpoint blockade immunother...

Merck To Buy Australia's Viralytics For $394 Mln In Cash

KENILWORTH (NJ) (dpa-AFX) - Drugs major Merck (MRK) announced Wednesday a definitive agreement to acquire Viralytics Limited (VLA.AX, VRACY), an Australian company focused on oncolytic immunothera...

Structure of Enzyme Discovered that Converts Ribonucleotides into Deoxyribonucleotides

Researchers have uncovered the structure of an enzyme that is crucial for maintaining an adequate supply of deoxyribonucleotides in human cells. Their new structure also reveals the likely mechan...

Taiwan Liposome Plans to Stage $50 Million IPO in the US

Taiwan Liposome, a company developing extended-release delivery of known drugs, has filed for a $50 million IPO on the NASDAQ exchange. The company is already listed in Taiwan, where it has a market c...

Recruiting the immune system to prevent relapse

(American Chemical Society) Substance abuse, particularly opioid abuse, is an ongoing issue in the US. While treatments such as drug counseling and a handful of medications to combat withdrawal sympto...

'Local environment' plays key role in breast cancer progression

(Biophysical Society) Many of the drugs and therapies available today for treating breast cancer target the cancer cells but tend to neglect the surrounding 'local environment,' which includes surroun...

AZ signs kidney drug deal with Ionis for up to $330m

AstraZeneca has licensed in an antisense drug from Ionis Pharmaceuticals to treat kidney disease in a deal worth up to $330 million. Antisense drugs contain non-coding strands of mRNA that block the ...

AZ buys kidney disease drug from Ionis for up to $330m

AstraZeneca has licensed in an antisense drug from Ionis Pharmaceuticals to treat kidney disease in a deal worth up to $330 million. Antisense drugs contain non-coding strands of mRNA that block the ...

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Companies [289 Associated Companies listed on BioPortfolio]

Applied Therapeutics Inc.

Applied Therapeutics is a privately held biotechnology company, focused on developing transformative drugs in areas of high unmet medical need – fatal or debilitating disease...

Synedgen Inc.

Synedgen Inc. is developing a new class of drugs with the ability to suppress inflammation, reduce infection and improve healing in the gastrointestinal tract and pulmonary tree a...

Celltrion Inc.

Headquartered in Incheon, Korea, Celltrion is a leading biopharmaceutical company, specializing in research, development and manufacture of biosimilar and innovative drugs. Celltr...

Drugwatch

Drugwatch is a consumer education and advocacy website based in Orlando. A trusted resource since 2009, Drugwatch provides information to patients on prescription drugs they take,...

ImmunoMolecular Therapeutics

IM Therapeutics is developing personalized immuno-therapeutic drugs for autoimmune diseases based on the genetic risk attributed by human leukocyte antigen genes. The lead candida...

Kubota Pharmaceutical Holdings Co., Ltd.

Kubota Pharmaceutical Holdings Co., Ltd. (Tokyo 4596) is committed to translating innovation into a diverse portfolio of drugs and devices to preserve and restore vision for milli...

Italfarmaco

Italfarmaco is a specialty pharmaceutical company engaged in the discovery, development, manufacturing and marketing of branded prescription and nonprescription products in more t...

Neuronax SAS

NEURONAX is a privately-held biopharmaceutical company focusing on the development and discovery of therapeutic approaches to treat central nervous system disorders. Combining an expertise in the dev...

DisperSol Technologies LLC

DisperSol is an innovator in the formulation development and manufacture of pharmaceutical drugs. DisperSol’s KinetiSol® technology has dramatically improved the effective...

Lin BioScience, Inc.

Lin BioScience, Inc. is a drug development company specializing in innovative therapies for diseases with unmet medical needs. Lin BioScience's diverse pipeline consists of first-...

Clinical Trials [1271 Associated Clinical Trials listed on BioPortfolio]

Effects of Nonsteroidal Anti-Inflammatory Drugs in Recurrence of Spondyloarthritis Patients After Remission

The multicenter, randomized controlled trial is to investigate and evaluate the effect of NSAIDs therapy on recurrence in patients with axial spondyloarthritis;

Enteral Nutrition and Vasoactive Drugs

Enteral nutrition in critically ill patients undergoing vasoactive support due to hemodynamic instability is controversial. Hypothesis: enteral nutrition delivered in such patients can be ...

Efficacy of Fixed-doses of Antihypertensive and Statin Drugs

The purpose of this study is to evaluate the efficacy of different fixed-dose combination of Viena II in treatment of hypertension and dyslipidemia.

Edoxaban for Prevention of Blood Vessels Being Blocked by Clots (Thrombolytic Events) in Children at Risk Because of Cardiac Disease

A committee will judge the safety and effectiveness of edoxaban and the regular treatment (standard of care). All children in the study will receive free treatment. They will have a 2 in ...

Metabolic Imprints of Alcoholic Beverages

Metabolic imprints of five different types of alcohol will be investigated in two study groups. The study will be an assessor-blinded, parallel dietary trial (crossover design). Th...

Removal of Beta Blocker Drugs by Hemodialysis

Eight maintenance hemodialysis patients are given one of four beta blocker drugs (atenolol, bisoprolol, carvedilol, metoprolol) three hours prior to a hemodialysis session. Blood samples a...

Evaluating Treatment as Prevention Among People Who Inject Drugs in Dundee for HCV

The aim of this study is to conduct an evaluation of hepatitis C treatments in NHS Tayside in order to empirically test the "treatment as prevention" models. This will be done by analysing...

Tazemetostat in Treating Patients With Recurrent Ovarian, Primary Peritoneal, or Endometrial Cancer

This phase II trial studies how well tazemetostat works in treating patients with ovarian, primary peritoneal, or endometrial cancer that has come back. Drugs used in chemotherapy, such as...

A Study to Evaluate the Effect of 2 Drugs on the Pharmacokinetics of BMS-986205 in Healthy Subjects

Assess the effects of itraconazole and rifampin on the pharmacokinetics, safety, and tolerability of BMS-986205.

Evaluation of Adherence to Clinical Treatment of Glaucoma

Evaluation of adherence to clinical treatment of glaucoma in patients of a Reference Ophthalmological Hospital in Goiânia using Morisky Adhesion scale as a validated questionary.

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Medical and Biotech [MESH] Definitions

Drugs used by veterinarians in the treatment of animal diseases. The veterinarian's pharmacological armamentarium is the counterpart of drugs treating human diseases, with dosage and administration adjusted to the size, weight, disease, and idiosyncrasies of the species. In the United States most drugs are subject to federal regulations with special reference to the safety of drugs and residues in edible animal products.

Drugs which have received FDA approval for human testing but have yet to be approved for commercial marketing. This includes drugs used for treatment while they still are undergoing clinical trials (Treatment IND). The main heading includes drugs under investigation in foreign countries.

The use of multiple drugs administered to the same patient, most commonly seen in elderly patients. It includes also the administration of excessive medication. Since in the United States most drugs are dispensed as single-agent formulations, polypharmacy, though using many drugs administered to the same patient, must be differentiated from DRUG COMBINATIONS, single preparations containing two or more drugs as a fixed dose, and from DRUG THERAPY, COMBINATION, two or more drugs administered separately for a combined effect. (From Segen, Dictionary of Modern Medicine, 1992)

Drugs that mimic the effects of parasympathetic nervous system activity. Included here are drugs that directly stimulate muscarinic receptors and drugs that potentiate cholinergic activity, usually by slowing the breakdown of acetylcholine (CHOLINESTERASE INHIBITORS). Drugs that stimulate both sympathetic and parasympathetic postganglionic neurons (GANGLIONIC STIMULANTS) are not included here.

Drugs used to specifically facilitate learning or memory, particularly to prevent the cognitive deficits associated with dementias. These drugs act by a variety of mechanisms. While no potent nootropic drugs have yet been accepted for general use, several are being actively investigated.

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