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Diseasemodifying drugs - Biotech, Pharma and Life Science Channel

10:20 EDT 26th September 2018 | BioPortfolio

PubMed Articles [4470 Associated PubMed Articles listed on BioPortfolio]

Antileishmanial activity of sulphonamide nanoemulsions targeting the β-carbonic anhydrase from Leishmania species.

The β-carbonic anhydrase (CA, EC 4.2.1.1) from Leishmania spp. (LdcCA) is effectively inhibited by aromatic/heterocyclic sulphonamides, in the low nanomolar range, but no in vitro antileishmanial act...

A novel biosensor based on Au@Ag core-shell nanoparticles for sensitive detection of methylamphetamine with surface enhanced Raman scattering.

We describe a novel biosensing strategy for sensitive detection of methylamphetamine (MAMP) based on surface enhanced Raman scattering (SERS) by the mediation of spacing between 4-mercaptobenzoic acid...

Hyperbranched mixed-mode anion-exchange polymeric sorbent for highly selective extraction of nine acidic non-steroidal anti-inflammatory drugs from human urine.

This paper describes the poly(divinylbenzene) (PDVB) supported synthesis of quaternized hyperbranched macromolecules (QHMs) and its use as a highly selective, high-capacity mixed-mode anion-exchange (...

Bioresponsive albumin-conjugated paclitaxel prodrugs for cancer therapy.

The efficacy of traditional chemotherapy often suffers from rapid clearance and off-target toxicity. Drug delivery systems and controlled release are applied to improve the therapeutic efficiencies of...

Recruitment and Engagement in Preventive Clinical Trials: Interdependencies and Mediation.

This article takes a standpoint based in the human and social sciences to examine a decisive time in any research related to HIV-AIDS, ie, when healthy, seronegative individuals agree to take part in ...

Exceptional Risk: Healthy Volunteers' Perceptions of HIV/AIDS Clinical Trials.

As with all early-stage testing of investigational drugs, clinical trials targeting HIV/AIDS can pose unknown risks to research subjects. Unlike sick participants seeking a therapeutic benefit, the mo...

The Management of Nausea at the End of Life.

The evaluation and management of nausea in patients near the end of life can be more challenging than that of nausea in patients undergoing antineoplastic therapies. Unlike in the oncology setting in ...

Chronic recurrent multifocal osteomyelitis: pediatric clinical case.

Chronic recurrent multifocal osteomyelitis has recently been classified as an autoinflammatory disorder characterized by episodes of systemic inflammation including serological signs of inflammation o...

Analgesics and Sedatives in Critically Ill Newborns and Infants: The Impact on Long-Term Neurodevelopment.

Inadequate pain and/or stress management in preterm- and term-born infants has been associated with increased morbidity and even mortality. However, exposure to analgosedatives during early infancy ma...

Opioids in Breast Milk: Pharmacokinetic Principles and Clinical Implications.

Safety of maternal drug therapy during breastfeeding may be assessed from estimated levels of drug exposure of the infant through milk. Pharmacokinetic (PK) principles predict that the lower the clear...

News Articles [4931 Associated News Articles listed on BioPortfolio]

Premier Biotech secures FDA 510(k) clearance for two additional oral fluid assays

In total, OralTox has 510(k) clearance for in vitro diagnostic use including point-of-care sites for the following 8 drugs: Amphetamine, Cocaine, Marijuana, Methadone, Methamphetamine, Opiates, Oxycod...

Gilead to launch generic versions of hepatitis C drugs in US

Gilead’s treatments for chronic hepatitis C virus (HCV) will be launched in the US, through a newly created subsidiary, Asegua Therapeutics. The authorized generics will launch at a The post Gilead...

Premier Biotech gets FDA approval for OralTox device to detect Oxycodone in oral fluid

In total, OralTox has 510(k) clearance for in vitro diagnostic use including point-of-care sites for the following 8 drugs: Amphetamine, Cocaine, Marijuana, Methadone, Methamphetamine, Opiates, Oxycod...

TFF Pharmaceuticals Receives Notice of Intention to Grant European Patent for Its Thin Film Freezing Process, Providing IP Protection in Europe until 2028

The patent, “Formation of Stable Submicron Peptide or Protein by Thin Film Freezing,” will strengthen the company’s intellectual property portfolio of more than 30 patents a...

STELLAR PERFORMANCE ON ANDA

Once again, the Indian R&D─based pharmaceutical companies and their subsidiaries have shown their prowess in getting a large chunk of final abbreviated new drug application approvals from the US FDA...

Do provisions to ASU drugs need amendment?

Ayush pharmaceuticals and drugs have faced several challenges in the past and in present times also, it is facing some undefined challenges.

Arix Biosciences investee company eyeing NASDAQ float

LogicBio is a specialist in genome editing that is developing drugs for rare diseases

Ganovo Enrolled in the Basic Medical Insurance of Tianjin--Capped Reimbursement-Per-Patient Pilot Program

HANGZHOU and SHAOXING, China, Sept. 26, 2018 /PRNewswire/ -- Ascletis Pharma Inc. (1672.HK) announced today that Ganovo® (Danoprevir) has been enrolled in the Basic Medical Insurance of Tianj...

STAT Plus: Gilead sparked outrage when it introduced its first hepatitis C treatment for $84,000 in 2013. Now in a surprise move, it will begin selling generic versions of its hep C drugs for less than one-third that price. https://buff.ly/2IeE3J9 

STAT Plus: Gilead sparked outrage when it introduced its first hepatitis C treatment for $84,000 in 2013. Now in a surprise move, it will begin selling generic versions of its hep C drugs for less tha...

STAT Plus: A new study "contradicts the idea" that rigorous FDA rules make clinical trials so expensive. "We’re choking off the emergence of dramatic new drugs,” a co-author said. https://buff.ly/2Q6QHfZ 

STAT Plus: A new study "contradicts the idea" that rigorous FDA rules make clinical trials so expensive. "We’re choking off the emergence of dramatic new drugs,” a co-author said. https:/...

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Companies [313 Associated Companies listed on BioPortfolio]

TFF Pharmaceuticals, Inc.

TFF Pharmaceuticals, Inc. is an early-stage biopharmaceutical company focused on the development and commercialization of new inhalation products for the treatment of chronic resp...

SCOUT

SCOUT is a leading healthcare marketing firm with special expertise in rare diseases, orphan drugs and specialty pharmaceuticals. With offices in Atlanta, Chicago, San Diego and N...

Travecta Therapeutics

Travecta Therapeutics is an emerging biotech company developing a platform that leverages our proprietary knowledge of the MFSD2a transport for the targeted delivery of the...

System1 Biosciences, Inc.

System1 Biosciences, Inc., is a San Francisco-based neurotherapeutics company that employs phenotypic screening to discover novel drugs for complex neurological and psychiatric di...

Gibson Oncology, LLC

Gibson is a private oncology drug development company dedicated to bringing its novel, cost-effective, and very well-tolerated Indeno anti-cancer treatments to market. Gibson inte...

Antidote Therapeutics, Inc.

Antidote Therapeutics, Inc. is a biotechnology company with a portfolio of first-in-class nicotine-blocking drugs to treat diseases caused or worsened by nicotine. In addition to...

ApoGen Biotechnologies, Inc.

ApoGen Biotechnologies, Inc. is a biotechnology company focused on the development of a new class of therapeutics targeting drivers of cancer genomic mutations. ApoGen is building...

DNAlite Therapeutics, Inc.

DNAlite Therapeutics, Inc. is an early-stage preclinical biotechnology company committed to bringing the next-generation of drugs to organs protected by mucosal barriers. DNAlite ...

AcuraStem

AcuraStem is a biotechnology company formed in 2016 to create an innovative precision medicine platform, iNeuroRX™, which leverages patient stem cells and advanced machine le...

Vitality Health Plan of California, Inc.

Vitality Health Plan of California, Inc., a wholly-owned subsidiary of Vitality Health Plans, Inc., offers Medicare Advantage with Prescription Drugs products to Medicare recipien...

Clinical Trials [1591 Associated Clinical Trials listed on BioPortfolio]

Effects of Hyperprolactinemia Induced by Antipsychotic Drugs on Bone Metabolism

The study is aimed to assess the severities of hyperprolactinemia caused by antipsychotic drugs and the effects of the duration of hyperprolactinemia on bone metabolism in schizophrenia pa...

Multi-center, Open-label, Phase 1b Clinical Trial to Evaluate the Safety, Tolerability, and Exploratory Efficacy of TEW-7197 in Combination With FOLFOX in Patients With Metastatic Pancreatic Ductal Adenocarcinoma Who Have Failed First-Line Gemcitabine and

- Inclusion 1. Subjects who are males or females ≥ 19 years of age 2. Subjects who have the following history of first-line gemcitabine and nab-paclitaxe...

BA Trial for Co-Occurring Depression and Substance Use

A large proportion of people seeking treatment for drug and alcohol issues also have clinically significant depression symptoms. This combination of problems tends to have a negative impac...

The Effect of ECMO on the Pharmacokinetics of the Drugs and Their Clinical Efficacy

This study will examine the pharmacokinetics of the various, routinely given antibiotics, sedatives, and opioids in patients undergoing venous-venous extra-corporal oxygenation (ECMO). Lit...

Rheumatoid Arthritis Memory B Cells and Abatacept (RAMBA)

Single-Open Label Study to Assess Changes in the Immune Profile in Response to Treatment with Intravenous Abatacept Adults with Rheumatoid Arthritis who are Naive to Biologic Disease-Modif...

Recurrent Ovarian CarcinoSarcoma Anti-pd-1 Niraparib

Carcinosarcomas (CS) (malignant mixed Müllerian tumors) are highly aggressive and rare tumors with a worldwide annual incidence between 0.5-3.3 cases/100.000 women. Gynecological CS, i.e. ...

Study to Determine if the Flu Vaccine Increases the Risk of Muscle Damage in Participants Taking Drugs That Block Certain Proteins Made by Some Types of Immune System Cells

A retrospective, observational study conducted on cancer patients receiving a drug that blocks certain proteins made by some types of immune system cells

Neoadjuvant Therapy Followed by Stereotactic Body Radiotherapy (SBRT) for Locally Advanced Pancreatic Cancer

The purpose of this study is to evaluate a new treatment routine for patients with borderline resectable and unresectable pancreas cancers.

Bioequivalence Study of Levothyroxine Sodium Tablets 150 mcg

The objective of this study is to establish the bioequivalence of two levothyroxine formulations through the estimation of T4 levels in serum samples after baseline correction, according t...

Population Pharmacokinetics of Anti-tuberculosis Drugs in Children With Tuberculosis

This study is based on the hypothesis that the pharmacokinetics of anti-tuberculosis drugs in TB children are different from adults. We aim to study the population pharmacokinetics of chil...

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Medical and Biotech [MESH] Definitions

Drugs used by veterinarians in the treatment of animal diseases. The veterinarian's pharmacological armamentarium is the counterpart of drugs treating human diseases, with dosage and administration adjusted to the size, weight, disease, and idiosyncrasies of the species. In the United States most drugs are subject to federal regulations with special reference to the safety of drugs and residues in edible animal products.

Drugs which have received FDA approval for human testing but have yet to be approved for commercial marketing. This includes drugs used for treatment while they still are undergoing clinical trials (Treatment IND). The main heading includes drugs under investigation in foreign countries.

The use of multiple drugs administered to the same patient, most commonly seen in elderly patients. It includes also the administration of excessive medication. Since in the United States most drugs are dispensed as single-agent formulations, polypharmacy, though using many drugs administered to the same patient, must be differentiated from DRUG COMBINATIONS, single preparations containing two or more drugs as a fixed dose, and from DRUG THERAPY, COMBINATION, two or more drugs administered separately for a combined effect. (From Segen, Dictionary of Modern Medicine, 1992)

Drugs that mimic the effects of parasympathetic nervous system activity. Included here are drugs that directly stimulate muscarinic receptors and drugs that potentiate cholinergic activity, usually by slowing the breakdown of acetylcholine (CHOLINESTERASE INHIBITORS). Drugs that stimulate both sympathetic and parasympathetic postganglionic neurons (GANGLIONIC STIMULANTS) are not included here.

Drugs used to specifically facilitate learning or memory, particularly to prevent the cognitive deficits associated with dementias. These drugs act by a variety of mechanisms. While no potent nootropic drugs have yet been accepted for general use, several are being actively investigated.

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