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Diseasemodifying drugs - Biotech, Pharma and Life Science Channel

22:06 EST 20th January 2019 | BioPortfolio

PubMed Articles [4463 Associated PubMed Articles listed on BioPortfolio]

First characterizations by capillary electrophoresis of human Chorionic Gonadotropin at the intact level.

In the present work, the first characterizations by Capillary Electrophoresis of the human Chorionic Gonadotropin (hCG) hormone at the intact level were carried out. hCG is a hetero-dimeric glycoprote...

Four lines of anaplastic lymphoma kinase inhibitors and brain radiotherapy in a long-surviving non-small-cell lung cancer anaplastic lymphoma kinase-positive patient with leptomeningeal carcinomatosis.

Lung cancer is the most common tumor and the leading cause of cancer-related death worldwide. Approximately 6.7% of non-small-cell lung cancers (NSCLCs) show anaplastic lymphoma kinase (ALK) rearrange...

Prescriber Implementation of STOPP/START Recommendations for Hospitalised Older Adults: A Comparison of a Pharmacist Approach and a Physician Approach.

Two randomised controlled trials (RCTs) conducted simultaneously in the same Irish university teaching hospital have shown that provision of Screening Tool of Older Persons' Prescriptions (STOPP)/Scre...

Modern Computational Strategies for Designing Drugs to Curb Human Diseases: A Prospect.

Drug discovery is an exhaustive and time consuming process involving numerous stages like target identification, validation, lead optimization, preclinical trials, clinical trials and finally post mar...

Drug Repurposing for Retinoblastoma: Recent Advances.

Retinoblastoma is the intraocular malignancy that occurs during early childhood. The current standard of care includes chemotherapy followed by focal consolidative therapies, and enucleation. Unfortun...

Comparative analysis of thymic subpopulations during different modes of atrophy identifies the ROS scavenger, N-acetyl cysteine, to increase the survival of thymocytes during infection- and lipopolysaccharide-induced thymic atrophy.

The development of immunocompetent T cells entails a complex pathway of differentiation in the thymus. Thymic atrophy occurs with ageing and during conditions such as malnutrition, infections, cancer ...

Intramolecular hydrogen bonding: An opportunity for improved design in medicinal chemistry.

Recent literature shows that intramolecular hydrogen bond (IMHB) formation can positively impact upon the triad of permeability, solubility, and potency of drugs and candidates. IMHB modulation can be...

Human Disease/Clinical Medical Sciences for Dentistry in Early-years Dental Graduates: Transition from Undergraduate Study to Clinical Practice.

Dental bodies across Europe have published curricula aiming to guide the development of a graduating dentist who is safe and competent, and which also contain direction on what knowledge and understan...

Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma.

Drugs that modify the epigenome are powerful tools for treating cancer, but these drugs often have pleiotropic effects, and identifying patients who will benefit from them remains a major clinical cha...

E47 modulates hepatic glucocorticoid action.

Glucocorticoids (GCs) are effective drugs, but their clinical use is compromised by severe side effects including hyperglycemia, hyperlipidemia and obesity. They bind to the Glucocorticoid Receptor (G...

News Articles [4513 Associated News Articles listed on BioPortfolio]

STAT Plus: The government shutdown could soon jeopardize highly anticipated new drugs for depression, diabetes and multiple sclerosis, as well as a host of other potential new therapies. https://buff.ly/2FCdvDn 

STAT Plus: The government shutdown could soon jeopardize highly anticipated new drugs for depression, diabetes and multiple sclerosis, as well as a host of other potential new therapies. https://buff...

LISTEN: The latest episode of "The Readout LOUD" #podcast is here. The team asks the important questions this week. Like, is the FDA going broke? Can video games be drugs? And when did “Flashdance” come out? Find out the answers here: https://buff.ly/

LISTEN: The latest episode of "The Readout LOUD" #podcast is here. The team asks the important questions this week. Like, is the FDA going broke? Can video games be drugs? And when did “Flashda...

Able-Handed Drugs Could Push GPCR Buttons, Say Conformation Mappers: http://ow.ly/MKp630nj5Ez pic.twitter.com/WBH6S38zb8

Able-Handed Drugs Could Push GPCR Buttons, Say Conformation Mappers: http://ow.ly/MKp630nj5Ez  pic.twitter.com/WBH6S38zb8

Publisher Correction: Radioactive drugs emerge from the shadows to storm the market

Medical News Today: What role does the immune system play in hypertension?

Researchers have found that a type of immune cell can help regulate blood pressure. They explain the mechanism and identify drugs that may affect it.

Weekly Policy Update: Importing Drugs and the Governor's Budget

Last week CBSA took an opposition position to Senate Bill 005 – Import Prescription Drugs from Canada. As a reminder this bill would create the "Colorado Wholesale Importation of Prescrip...

What is the FDA?

The Food and Drug Administration is the federal government agency that oversees the safety of drugs, medical devices and most food.

Hepatitis C-infected patients with a history of liver cancer can be treated with antivirals

A large, multi-center study refutes earlier suggestions that antiviral drugs for treating hepatitis C may lead to a higher recurrence of liver cancer.

CMS Seeks to Prod Insurers to Negotiate Lower Drug Prices

CMS' Seema Verma proposed a voluntary test to address what she calls "perverse incentives" in Part D. The model will ask insurers to accept more financial risk for customers who need expensi...

STAT Plus: After its own megamerger, Celgene signs deals with two biotechs for their cancer drugs

Two Massachusetts biotech startups working on potential cancer treatments said they have made deals to collaborate with Celgene.

Companies [328 Associated Companies listed on BioPortfolio]

ImmunSYS, Inc.

ImmunSYS, Inc. is a clinical stage biopharmaceutical company focused on the development of innovative cancer immunotherapy products to improve the lives of patients with late-sta...

Paramount Rx Inc.

Paramount Rx is a full-service prescription benefits manager (PBM) focused on consumer-driven health care to help clients provide services for consumers to save money on prescript...

Vetex Medical

Vetex Medical is a privately-held company focused on making venous clot removal predictable, quick and cost-effective. The company’s first innovation – the Vetex Thrombe...

Incyte

Incyte's vision is to become a leading drug discovery and development company by building a proprietary product pipeline of novel small molecule drugs. We have an experienced management and discovery ...

Aro Biotherapeutics

Aro is a biotechnology company focused on the research and development of a new generation of protein biologics called Centyrins. The company is developing a wholly-owned pipeline...

LEO Pharma A/S

LEO Pharma is a globally, leading pharmaceutical company within Dermatology and Critical Care. We maintain a strong focus on developing, manufacturing and marketing safe and efficacious drugs for tre...

Turning Point Therapeutics, Inc.

Turning Point Therapeutics is a clinical-stage precision oncology company forging a new path for targeted cancer care. Founded in October 2013 by Dr. J. Jean Cui, the lead invento...

Inflazome

Utilizing the scientific expertise of our founders and advisors, Inflazome is leading the way in developing orally available drugs to address clinical unmet needs in inflammatory ...

Nexus Pharmaceuticals

Nexus Pharmaceuticals, a US-based healthcare company, specializes in innovative processes to make difficult-to-manufacture specialty and generic drugs that are easier to use, less...

Lyndra Therapeutics

Lyndra Therapeutics’ orally administered dosage form is designed to deliver sustained, steady-state release of one or more drugs for up to a week or longer while temporarily ...

Clinical Trials [1750 Associated Clinical Trials listed on BioPortfolio]

Personality, as a Predictive Factor of Therapeutic Response on Quality of Life After Continuous Perfusion of Dopaminergic Drugs, in Parkinson's Disease

The aim of the study is to evaluate if patients' personality could be considerate as predictive factor of quality of life after the establishment of continuous infusion of dopaminergic tre...

Effect of Stimulant Drugs on Social Perception

The study will improve our understanding of the "prosocial" effects of ± 3,4-Methylenedioxymethamphetamine (MDMA), relative to a prototypical stimulant, methamphetamine (MA). The investig...

A Study to Compare MP-513 20mg & Metformin XR 1000mg FDC With Coadministration of the Two Separate Drugs

The purpose of this study is to compare the safety and pharmacokinetic characteristics of fixed-dose combination of MP-513 20mg and Metformin XR 1000mg with coadministration of the two sep...

SOR-C13 in Treating Patients With Advanced Refractory Solid Tumors

This phase I trial studies the side effects and best dose of SOR-C13 in treating patients with solid tumors that have spread to other places in the body and does not respond to treatment. ...

Pevonedistat and Belinostat in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome

This phase I trial studies side effects and best dose of pevonedistat and belinostat in treating patients with acute myeloid leukemia or myelodysplastic syndrome that has come back or does...

Effect of Some Drugs on Liver Fibrosis

Effect of Some Drugs on Liver Fibrosis

Effect of Some Drugs on Rheumatoid Arithritis Activity

Effect of Some Drugs on Rheumatoid Arithritis Activity.

Examination of Efficacy and Safety of Other Anti-Resorption Drugs After 2-year-Denosumab Therapy in Japanese Osteoporosis Patients

The aim of this study is to examine the efficacy and adverse events in the following 3 groups in Japanese osteoporosis patients after 2-year-denosumab therapy: SERM and eldecalcitol treat...

Effect of an Electronic Reminder System on Direct Oral Anticoagulant and Oral Diabetes Medication Adherence

In this study, the effect of an electronic device attached to a push through pill package and a smart phone application on chronic disease medication adherence is studied.

An Observational Study of Maviret (Glecaprevir/Pibrentasvir) for Korean Chronic Hepatitis C Genotypes 1 to 6 Patients According to the Standard for Re-examination of New Drugs

Post-marketing surveillance study to evaluate the real world safety and effectiveness of Maviret (Glecaprevir/Pibrentasvir) administered under a normal, routine treatment practice by Korea...

Medical and Biotech [MESH] Definitions

Drugs used by veterinarians in the treatment of animal diseases. The veterinarian's pharmacological armamentarium is the counterpart of drugs treating human diseases, with dosage and administration adjusted to the size, weight, disease, and idiosyncrasies of the species. In the United States most drugs are subject to federal regulations with special reference to the safety of drugs and residues in edible animal products.

Drugs which have received FDA approval for human testing but have yet to be approved for commercial marketing. This includes drugs used for treatment while they still are undergoing clinical trials (Treatment IND). The main heading includes drugs under investigation in foreign countries.

The use of multiple drugs administered to the same patient, most commonly seen in elderly patients. It includes also the administration of excessive medication. Since in the United States most drugs are dispensed as single-agent formulations, polypharmacy, though using many drugs administered to the same patient, must be differentiated from DRUG COMBINATIONS, single preparations containing two or more drugs as a fixed dose, and from DRUG THERAPY, COMBINATION, two or more drugs administered separately for a combined effect. (From Segen, Dictionary of Modern Medicine, 1992)

Drugs that mimic the effects of parasympathetic nervous system activity. Included here are drugs that directly stimulate muscarinic receptors and drugs that potentiate cholinergic activity, usually by slowing the breakdown of acetylcholine (CHOLINESTERASE INHIBITORS). Drugs that stimulate both sympathetic and parasympathetic postganglionic neurons (GANGLIONIC STIMULANTS) are not included here.

Drugs used to specifically facilitate learning or memory, particularly to prevent the cognitive deficits associated with dementias. These drugs act by a variety of mechanisms. While no potent nootropic drugs have yet been accepted for general use, several are being actively investigated.

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