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Fatal Insomnia - Biotech, Pharma and Life Science Channel

22:55 EST 21st November 2017 | BioPortfolio

PubMed Articles [869 Associated PubMed Articles listed on BioPortfolio]

Development of a quantitative approach in blood plasma for low-dosed hallucinogens and opioids using LC-high resolution mass spectrometry.

The WHO annually reports an increasing abuse of new psychoactive substances (NPS), which are a heterogeneous group of synthetic drugs and are consumed as substitute for controlled drugs of abuse. In t...

Evaluation of Low-Cost Hydrogen Sulfide Monitors for Use in Livestock Production.

Direct-reading gas monitors warn workers of the risk of potentially fatal hydrogen sulfide (H2S) exposures that may arise during manure handling. Low-cost, low-maintenance H2S monitors are available f...

Correction: Multiscale adaptive analysis of circadian rhythms and intradaily variability: Application to actigraphy time series in acute insomnia subjects.

[This corrects the article DOI: 10.1371/journal.pone.0181762.].

The Role of the Mammalian Prion Protein in the Control of Sleep.

Sleep disruption is a prevalent clinical feature in many neurodegenerative disorders, including human prion diseases where it can be the defining dysfunction, as in the case of the "eponymous" fatal f...

Calls due to suicidal behaviour made to the prehospital, emergency department in Málaga: characteristics and associated factors.

Suicidal behaviour (fatal and non-fatal) has become a serious public health problem in many countries. The aim of the study was to describe the differential characteristics of emergency calls due to s...

Long Term Outcomes in Patients with Type 2 Myocardial Infarction and Myocardial Injury.

Background -Type 2 myocardial infarction and myocardial injury are common in clinical practice, but long-term consequences are uncertain. We aimed to define long-term outcomes and explore risk stratif...

Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin.

Leishmania is a single-celled eukaryotic parasite afflicting millions of humans worldwide, with current therapies limited to a poor selection of drugs that mostly target elements in the parasite's cel...

Beyond Pathologizing Harm: Understanding PTSD in the Context of War Experience.

An alternative to objectifying approaches to understanding Post-traumatic Stress Disorder (PTSD) grounded in hermeneutic phenomenology is presented. Nurses who provided care for soldiers injured in th...

The Multidisciplinary Approach to Localized Pancreatic Adenocarcinoma.

Pancreatic adenocarcinoma 2030 (PCa) is predicted to be the second leading cause of cancer death in USA by 2030. To date, attempts at early detection have been unsuccessful. Therapies for resectable P...

Use of Postmortem Computed Tomography to Detect Bowel Obstruction and its Relationship to the Cause of Death.

Bowel distension frequently indicates bowel obstruction, which is a common diagnosis in clinical radiology. Typically, symptoms and complaints lead to radiological examinations and the detection of th...

News Articles [608 Associated News Articles listed on BioPortfolio]

Exelixis Announces Phase 3 CELESTIAL Trial Results of Cabozantinib in Previously Treated Advanced Hepatocellular Carcinoma to be Presented at 2018 Gastrointestinal Cancers Symposium

– Accepted as a late-breaking oral presentation at the 2018 American Society of Clinical Oncology’s Gastrointestinal Cancers Symposium (ASCO-GI), January 18-20, 2018 – ...

Cytokinetics sinks on abandoning ALS drug after failed trial

(Reuters) - Cytokinetics Inc shares plummeted nearly 28 percent on Tuesday after the drugmaker said it would stop developing one of its treatments for ALS, a fatal neuro-degenerative disorder, after t...

Cytokinetics abandons ALS drug after failed trial

(Reuters) - Cytokinetics Inc said on Tuesday it would discontinue developing its drug to treat ALS, a fatal neuro-degenerative disorder, after the treatment failed in a late-stage trial.

Global and Regional Earth Leakage Protection Market Research Report 2017 [Report Updated: 10112017] Prices from USD $3500

SummaryEarth Leakage Protection is used to protect the circuit from overload and short circuit. It is worked in the situation when it is in the event of a leakage fault and a fatal danger of personal ...

New study points the way to therapy for rare cancer that targets the young

(Rockefeller University) Scientists have engineered a mouse model to study a rare and often-fatal form of liver cancer. They've used it to clarify what drives these tumors at the molecular level, and ...

Scientists develop new method to study Creutzfeldt-Jakob disease in the lab

Scientists have developed a new system to study Creutzfeldt-Jakob disease in the laboratory, paving the way for research to find treatments for the fatal brain disorder.

Goya Voluntary Recall of Adobo Because of Possible Health Risk

Goya de Puerto Rico is recalling 28 ounces Adobo with Cumin Seasoning and 28 ounces Adobo with Pepper Seasoning because they have the potential to be contaminated with Salmonella, an organism which ca...

Ex-Tulsa officer gets prison in daughter's boyfriend's death

TULSA, Okla. (AP) — A white ex-Oklahoma police officer was sentenced Monday to 15 years in prison for the fatal off-duty shooting of his daughter's black boyfriend, after four trials spanning ne...

Brain cell advance brings fresh hope for Creutzfeldt-Jakob disease therapies

Scientists have developed a new system to study Creutzfeldt-Jakob disease in the laboratory, paving the way for research to find treatments for the fatal brain disorder.

U.S. marine accused of drunk driving after Japanese man dies in crash

A Japanese man was killed in a truck collision involving a 21-year-old U.S. marine who was well over the legal alcohol limit for driving, police said of a case that was likely to stoke resentment over...

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Companies [23 Associated Companies listed on BioPortfolio]

Pear Therapeutics

Pear Therapeutics is the leader in prescription digital therapeutics. The company’s approach is to integrate clinically-validated software applications with previously approv...

Happify Health

Happify Health (www.HappifyHealth.com) offers evidence-based emotional health behavioral change technology solutions for employers, health plans and enterprise organizations. ...

Agilis Biotherapeutics and GTRI

Agilis is advancing innovative gene therapies designed to provide long-term efficacy for patients with debilitating, often fatal, rare genetic diseases that affect the central ner...

Agilis Biotherapeutics, Inc.

Agilis is advancing innovative gene therapies designed to provide long-term efficacy for patients with debilitating, often fatal, rare genetic diseases that affect the central ner...

Rasna Therapeutics, Inc.

Rasna Therapeutics, Inc. is a development stage biotechnology company focused primarily on the high unmet need that exists for leukemias. Rasna’s primary indication is acute ...

Rasna Therapeutics , Inc.

Rasna Therapeutics, Inc. is a biotechnology company focused primarily on the high unmet need that exists for leukemias. Rasna’s primary indication is acute myeloid leukemia (...

CurePSP

CurePSP is the leading nonprofit advocacy organization focused on prime of life neurodegenerative diseases – a spectrum of fatal brain disorders that often strike during a pe...

Voyager Therapeutics

Voyager Therapeutics is a gene therapy company developing life-changing treatments for fatal and debilitating diseases of the central nervous system (CNS). Voyager is committed to...

Ario Pharma Ltd

ario pharma ltd focusses on the development of drugs for the treatment of respiratory indications. Ario is about to evaluate the anti-tussive properties of XEN-D0501, a potential best-in-class TRPV1...

Agilis Biotherapeutics, LLC

Agilis Biotherapeutics, LLC, is a biotechnology company focused on designing and engineering first-in-class DNA-based therapeutics to improve and save the lives of patients affect...

Clinical Trials [642 Associated Clinical Trials listed on BioPortfolio]

Pharmacogenetics of Clopidogrel in Acute Coronary Syndromes

The antiplatelet agent clopidogrel is an effective drug for the prevention of thrombotic events in patients with acute coronary syndromes, and is therefore one of the most frequently presc...

Cranial Electrical Stimulation (CES) as Treatment for Insomnia in Patients With Subacute Stroke

This will be a double blinded randomized clinical trial carried out at Zale-Lipshy and Parkland Hospital Inpatient Rehabilitation Facilities. Acute stroke patients with insomnia, identifie...

Spectroscopic and Diffusion Weighted Analysis of the Effects of Dexamethasone on High Altitude Cerebral Oedema (HACE)

When the brain detects a drop in oxygen levels in the blood (hypoxia) there is a compensatory increase in blood flow. Acute mountain sickness (AMS) is a cluster of symptoms which commonly ...

Project POINT: Effectiveness and Scalability of an Overdose Survivor Intervention

The investigators seek to assess the effectiveness of Project POINT (Planned Outreach, Intervention, Naloxone, and Treatment). Located in Indianapolis, Project POINT is a collaboration bet...

A Trial of Mindfulness Meditation for Chronic Insomnia

To evaluate the efficacy of mediation therapies on measures of sleep and arousal for people with chronic insomnia and with this the viability of smartphone delivered meditation based appro...

Restless Legs Syndrome in Hemodialysis Patients

Restless legs syndrome (RLS) is defined as the spontaneous movement of the limbs (mainly legs) associated with unpleasant - painful sensation which is relieved by moving the affected limb....

Safety and Efficacy of Medical Cannabis Oil in the Treatment of Patients With Chronic Pain

Seeking for effective therapeutic strategies, the investigators are proposing to test the effectiveness of different formulations of medical cannabis oil to alleviate chronic pain, which w...

An Investigational Study to Assess Efficacy and Pattern of Use of SM-1 in Subjects With a History of Transient Insomnia

The purpose of this study is to assess the efficacy and pattern of use of the combination drug product SM-1 in adults who sometimes have difficulty in falling asleep or staying asleep, but...

Effectiveness of BBT-I and Zopiclone for Chronic Insomnia

Background: Importance of chronic insomnia (CI) problem is determined by its high prevalence rate, comorbidity and resistance to the treatment. Although cognitive behavior treatment of ins...

An Investigational Study to Assess the Effectiveness and Safety of SM-1 Versus 2 Comparators and Placebo in Participants With a History of Transient Insomnia.

The purpose of this study is to investigate the effectiveness, safety and tolerability of a combination drug product (SM-1) containing diphenhydramine, zolpidem and lorazepam, in adult par...

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Medical and Biotech [MESH] Definitions

An autosomal dominant disorder characterized by degeneration of the THALAMUS and progressive insomnia. It is caused by a mutation in the prion protein (PRIONS).

An acute organic mental disorder induced by cessation or reduction in chronic alcohol consumption. Clinical characteristics include CONFUSION; DELUSIONS; vivid HALLUCINATIONS; TREMOR; agitation; insomnia; and signs of autonomic hyperactivity (e.g., elevated blood pressure and heart rate, dilated pupils, and diaphoresis). This condition may occasionally be fatal. It was formerly called delirium tremens. (From Adams et al., Principles of Neurology, 6th ed, p1175)

Membrane glycosylphosphatidylinositol-anchored glycoproteins that may aggregate into rod-like structures. The prion protein (PRNP) gene is characterized by five TANDEM REPEAT SEQUENCES that encode a highly unstable protein region of five octapeptide repeats. Mutations in the repeat region and elsewhere in this gene are associated with CREUTZFELDT-JAKOB DISEASE; FATAL FAMILIAL INSOMNIA; GERSTMANN-STRAUSSLER DISEASE; Huntington disease-like 1, and KURU.

Small proteinaceous infectious particles which resist inactivation by procedures that modify NUCLEIC ACIDS and contain an abnormal isoform of a cellular protein which is a major and necessary component. The abnormal (scrapie) isoform is PrPSc (PRPSC PROTEINS) and the cellular isoform PrPC (PRPC PROTEINS). The primary amino acid sequence of the two isoforms is identical. Human diseases caused by prions include CREUTZFELDT-JAKOB SYNDROME; GERSTMANN-STRAUSSLER SYNDROME; and INSOMNIA, FATAL FAMILIAL.

A hypnotic and sedative used in the treatment of INSOMNIA.

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