Advertisement

Topics

Fibroblast Growth Factors FGFs - Biotech, Pharma and Life Science Channel

00:49 EST 22nd November 2017 | BioPortfolio

The family of fibroblast growth factors (FGFs) regulates a plethora of developmental processes, including brain patterning, branching morphogenesis and limb development.

Quite a number of FGF-R agonists are in development or even marketed in a range of different indications of tissue repair:

Cancer: FGF/FGFR signalling is important in tumour angiogenesis but studies in the last few years have uncovered increasing evidence that FGFRs are driving oncogenes in certain cancers and act in a cell autonomous fashion to maintain the malignant properties of tumour cells. These observations make FGFRs increasingly attractive as targets for therapeutic intervention in cancer. There is a range of therapeutic strategies currently employed or in development to antagonise de-regulated FGFRs including antibodies and small molecule tyrosine kinase inhibitors.

Cardiovascular Diseases: Fibroblast growth factor-2 (FGF-2 has been shown over the years to exert acute and direct pro-survival effects, irrespectively of whether it is administered before, during or after an ischemic insult to the heart. FGF-2 is also a potent angiogenic protein and a crucial agent for the proliferation, expansion, and survival of several cell types including those with stem cell properties. Human clinical trials have pointed to a good safety record for this protein.

Wound Healing:  Currently, patients are treated by three growth factors: PDGF-BB, bFGF, and GM-CSF, but FGF is shown to have a role in tissue repair, so may lead to novel treatments.

Dental and Bone Tissue Repair: The role of growth factors (GF) in bone repair is widely recognised, particularly for bone morphogenetic proteins (BMPs) and fibroblast growth factor (FGF). GF are usually stored in the extracellular matrix (ECM), but after injury are actively released by ECM, cells and platelets.

Source; Pharmacol Ther. 2010 Jan;125(1):105-17. (De-regulated FGF receptors as therapeutic targets in cancer)

Add the Fibroblast GF News Channel to your RSS reader;

News Articles [9642 Associated News Articles listed on BioPortfolio]

Global Medical Tunable Laser Market Research Report Forecast 2017 to 2021 [Report Updated: 13112017] Prices from USD $2800

The Global Medical Tunable Laser Market Research Report Forecast 20172021 is a valuable source of insightful data for business strategists. It provides the Medical Tunable Laser industry overview with...

Global Introducer Sheaths Market Research Report Forecast 2017 to 2021 [Report Updated: 30102017] Prices from USD $2800

The Global Introducer Sheaths Market Research Report Forecast 20172021 is a valuable source of insightful data for business strategists. It provides the Introducer Sheaths industry overview with gro...

Daehan New Pharm Co Ltd 054670 Financial and Strategic SWOT Analysis Review [Report Updated: 13112017] Prices from USD $300

SummaryDaehan New Pharm Co Ltd Daehan New Pharm is a pharmaceutical company that manufactures nutritional supplements and drugs. The company develops and distributes generic and ethical pharmaceutical...

Global Trimethylboron Market Research Report Forecast 2017 to 2021 [Report Updated: 30102017] Prices from USD $2800

The Global Trimethylboron Market Research Report Forecast 20172021 is a valuable source of insightful data for business strategists. It provides the Trimethylboron industry overview with growth anal...

Global Beryllium Hydroxide Market Research Report Forecast 2017 to 2022 [Report Updated: 30102017] Prices from USD $2800

Delivery of the Report will take 23 working days once order is placed.The Global Beryllium Hydroxide Market Research Report Forecast 20172022 is a valuable source of insightful data for business strat...

Cognitive Analytics Market by Application Fraud and Risk Management, Customer Analysis and Personalization, and Sales and Marketing Management, Component, Deployment Model, Organization Size, Industry, and Region Global Forecast to 2022 [Report Updated:

Proliferation of data and the rise in adoption of cognitive computing are the major factors driving the growth of the cognitive analytics market.MarketsandMarkets forecasts the global cognitive analyt...

Global Digital Lenses Market Research Report Forecast 2017 to 2021 [Report Updated: 18092017] Prices from USD $2800

The Global Digital Lenses Market Research Report Forecast 20172021 is a valuable source of insightful data for business strategists. It provides the Digital Lenses industry overview with growth analys...

Repligen Corp RGEN Financial and Strategic SWOT Analysis Review [Report Updated: 13112017] Prices from USD $300

SummaryRepligen Corp Repligen is a life science company that develops and commercializes consumable products for manufacturing biological drugs. The company's products include rProtein A affinity resi...

Global Cellulose Triacetate Fiber Market Research Report Forecast 2017 to 2021 [Report Updated: 13112017] Prices from USD $2800

The Global Cellulose Triacetate Fiber Market Research Report Forecast 20172021 is a valuable source of insightful data for business strategists. It provides the Cellulose Triacetate Fiber industry ove...

Global Thermoformed Plastic Market Research Report Forecast 2017 to 2022 [Report Updated: 30102017] Prices from USD $2800

Delivery of the Report will take 23 working days once order is placed.The Global Thermoformed Plastic Market Research Report Forecast 20172022 is a valuable source of insightful data for business stra...

Events [0 Results]

None

Companies [345 Associated Companies listed on BioPortfolio]

Heritage Group and Relode

Heritage Group has more than 30 years of experience financing and operating healthcare companies at all stages. With $400 million under management, Heritage provides capital and u...

CBT Pharmaceuticals

CBT Pharmaceuticals is a life sciences company developing innovative oncology therapeutics targeting the growth and proliferation of cancer cells. The company is advancing a pipel...

M3 Biotechnology, Inc.

M3 Biotechnology is a clinical stage company with a novel platform of disease-modifying regenerative therapies particularly relevant to neurodegenerative diseases, with a focus on...

Vennli

Vennli is a voice of the marketplace solution, delivering customer insights through the company’s cloud-based platform. Vennli’s approach to business intelligence uses a...

Love’s Travel Stops & Country Stores

Founded in 1964 by Tom Love, Love’s Travel Stops & Country Stores is headquartered in Oklahoma City, Okla., and remains entirely family-owned and operated. With more than 275...

Catalyst Advisors, L.P.

Catalyst Advisors helps high-growth life sciences companies identify and attract the transformative board members, CEOs and other senior leaders needed to successfully navigate cr...

Mitochon Pharmaceuticals, Inc.

Mitochon was founded in 2014 with the mission to develop treatments for insidious diseases through the modulation of mitochondrial physiology, with applications to neurodegenerati...

Phoenix Biotechnology, Inc.

Phoenix Biotechnology, Inc., a San Antonio, Texas based biotechnology company, was incorporated in Texas in 2003 to develop promising agents with minimal or no side effects for ta...

PatientPop

PatientPop is the first all-in-one practice growth platform uniquely designed for healthcare. Its software empowers healthcare providers to thrive in the digital age by combining ...

Medicxi

Medicxi is based in London, Geneva and Jersey. The Company's mission is to invest across the full healthcare continuum. Medicxi was established by the former Index Ventur...

Clinical Trials [4816 Associated Clinical Trials listed on BioPortfolio]

Transcapillary Plasma Refill in Advanced Chronic Kidney Disease

Background: Haemodynamic instability during haemodialysis has long been linked to poor cardiovascular outcomes. It does not always reflect overall hydration but rather plasma volume deplet...

Effect of Exercise Programme on Gut Microbiota, CVD Risk Factors and Appetite Regulation in Overweight Women

Evidence suggests that gut microbiota contributes to the development of atherosclerosis and therefore CVDs. Exercise has been extensively reported to be protective against CVDs due to modi...

Factors Associated With Post-Traumatic Stress Disorder in Patients With After Preterm Delivery

Each year in France, between 50,000 and 60,000 children are born prematurely (< 37 weeks of amenorrhea). Literature has shown that preterm deliveries can be associated with the development...

A Long-Term Trial Investigating Safety and Efficacy of TransCon hGH in Children With Growth Hormone Deficiency Who Have Completed a Prior TransCon hGH Clinical Trial

A multicenter, phase 3, long-term extension trial of TransCon hGH administered once-weekly in children with growth hormone deficiency (GHD) who previously participated in a phase 3 TransCo...

Imatinib for Cytomegalovirus Prophylaxis and Treatment After Allogeneic Hematopoietic Stem Cell Transplantation

This study aim at examining whether blocking platelet-derived growth factor receptor-α by imatinib lowers the risk of post-allogeneic hematopoietic stem cell transplantation CMV infection...

WEE1 Inhibitor AZD1775, External Beam Radiation Therapy, and Cisplatin in Treating Patients With Cervical, Vaginal, or Uterine Cancer

This phase I trial studies the side effects and best dose of WEE1 inhibitor AZD1775 when given together with external beam radiation therapy and cisplatin in treating patients with cervica...

Brain Metastases in Norway

The overall aim and primary outcome of this study will be a descriptive analysis of the current treatment practice of BM in Norway. Specifically, it may give answers to the following resea...

dbGaP Protocol: The Pediatric Cardiac Genetics Consortium (PCGC)

Background: Researchers do not know much about the causes of congenital heart disease (CHD). They do know that many factors play a role. Some factors are environmental. Some are genetic. ...

Early Adiposity Rebound Amongst 4-y.o. Children and Overweight Risk Amongst 11-y.o Children : Third Phase of a Cohort Study in Franche-Comté

This study aims to assess different methods for early adiposity rebound determination at the age of 4/5 years old according to current medical screening criteria in schools, and to assess ...

Identification of Host Factors of Norovirus Infections in Mini-Gut Model

The primary objective in this study is to establish a list of host cellular proteins that mediate norovirus infection. Norovirus is one of the most common pathogens attributed to diarrhea...

PubMed Articles [15556 Associated PubMed Articles listed on BioPortfolio]

Preparation and prebiotic potential of pectin oligosaccharides obtained from citrus peel pectin.

Pectin oligosaccharide (POS) fractions were obtained by controlled chemical degradation of citrus peel pectin. By adjusting trifluoroacetic acid (TFA) concentration, three oligosaccharides were obtain...

9,10-Anthraquinone deposit in tea plantation might be one of the reasons for contamination in tea.

9,10-Anthraquinone (AQ) was a new contaminant, with unknown sources, occurred globally in tea. European Union (EU) fixed the maximum residue limit (MRL) of 0.02mg/kg. The pollution source of AQ in tea...

Abscisic acid stimulates anthocyanin accumulation in 'Jersey' highbush blueberry fruits during ripening.

Non-climacteric blueberry (Vaccinium spp.) fruits accumulate high levels of anthocyanins during ripening, which are a good source of dietary antioxidants. This study examined the effects of exogenous ...

Corrigendum to "Formulation and processing factors affecting trichothecene mycotoxins within industrial biscuit-making" Food Chem. (2017) 597-603.

Nonalcoholic Fatty Liver Disease and Metabolic Syndrome.

Nonalcoholic fatty liver disease (NAFLD) and metabolic syndrome (MS) are highly prevalent, affecting approximately one-third of the US population. The relationship between NAFLD and MS is complex and ...

Risk Factors for the Development of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis, Including Genetics.

Nonalcoholic fatty liver disease is emerging as the most common cause of chronic liver disease worldwide. This trend is, in part, secondary, to the growing incidence of obesity, type 2 diabetes, and m...

Desiccation: An environmental and food industry stress that bacteria commonly face.

Water is essential for all living organisms, for animals as well as for plants and micro-organisms. For these latter, the presence of water or a humid environment with a high air relative humidity (RH...

Internalization and dissemination of human norovirus and Tulane virus in fresh produce is plant dependent.

Human norovirus (NoV) is a leading cause of fresh produce associated outbreaks. Previous research indicates that the roots of growing leafy greens and berries internalize human NoV. However the effect...

Impact of growth temperature on exopolysaccharide production and probiotic properties of Lactobacillus paracasei strains isolated from kefir grains.

EPS-producing LAB are widely used in the dairy industry since these polymers improve the viscosity and texture of the products. Besides, EPS might be responsible for several health benefits attributed...

Antimicrobial efficacy of phytochemicals against Bacillus cereus in reconstituted infant rice cereal.

The objective of this study was to determine the potential use of Trans-cinnamaldehyde (TC), (-)-Epigallocatechin gallate (EGCG) and [10]-Gingerol (GI) to inhibit the growth of B. cereus in infant ri...

Videos

None available.

Medical and Biotech [MESH] Definitions

A fibroblast growth factor receptor with specificity for FIBROBLAST GROWTH FACTORS; HEPARAN SULFATE PROTEOGLYCAN; and NEURONAL CELL ADHESION MOLECULES. Several variants of the receptor exist due to multiple ALTERNATIVE SPLICING of its mRNA. Fibroblast growth factor receptor 1 is a tyrosine kinase that transmits signals through the MAP KINASE SIGNALING SYSTEM.

A family of small polypeptide growth factors that share several common features including a strong affinity for HEPARIN, and a central barrel-shaped core region of 140 amino acids that is highly homologous between family members. Although originally studied as proteins that stimulate the growth of fibroblasts this distinction is no longer a requirement for membership in the fibroblast growth factor family.

A fibroblast growth factor receptor that is found in two isoforms. One receptor isoform is found in the MESENCHYME and is activated by FIBROBLAST GROWTH FACTOR 2. A second isoform of fibroblast growth factor receptor 2 is found mainly in EPITHELIAL CELLS and is activated by FIBROBLAST GROWTH FACTOR 7 and FIBROBLAST GROWTH FACTOR 10. Mutation of the gene for fibroblast growth factor receptor 2 can result in APERT SYNDROME.

The most divergent of the known fibroblast growth factor receptors. It does not contain an intracellular TYROSINE KINASE domain and has been shown to interact with FIBROBLAST GROWTH FACTOR 2. Fibroblast growth factor receptor 5 is found primarily in skeletal tissue.

These growth factors are soluble mitogens secreted by a variety of organs. The factors are a mixture of two single chain polypeptides which have affinity to heparin. Their molecular weight are organ and species dependent. They have mitogenic and chemotactic effects and can stimulate endothelial cells to grow and synthesize DNA. The factors are related to both the basic and acidic FIBROBLAST GROWTH FACTORS but have different amino acid sequences.

Quick Search
Advertisement
 

Relevant Topics

Alzheimer's Disease
Of all the types of Dementia, Alzheimer's disease is the most common, affecting around 465,000 people in the UK. Neurons in the brain die, becuase  'plaques' and 'tangles' (mis-folded proteins) form in the brain. People with Al...

Cancer Disease
Cancer is not just one disease but many diseases. There are more than 100 different types of cancer. Most cancers are named for the organ or type of cell in which they start - for example, cancer that begins in the colon is called colon cancer; cancer th...

review and buy Fibroblast Growth Factors FGFs market research data and corporate reports here

Channels Quicklinks