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Host Defense Mechanisms - Biotech, Pharma and Life Science Channel

17:41 EDT 21st October 2017 | BioPortfolio

PubMed Articles [9290 Associated PubMed Articles listed on BioPortfolio]

Desiccation: An environmental and food industry stress that bacteria commonly face.

Water is essential for all living organisms, for animals as well as for plants and micro-organisms. For these latter, the presence of water or a humid environment with a high air relative humidity (RH...

Diagnostics for Lassa Fever: Detecting Host Antibody Responses.

There are two types of viral diagnostics: (1) those that detect components of the pathogen (like viral RNA or proteins) and (2) those that detect host molecules that rise or fall as a consequence of p...

Entry Studies of New World Arenaviruses.

Identification of cell moieties involved in viral binding and internalization is essential since their expression would render a cell susceptible. Further steps that allow the uncoating of the viral p...

Studies of Lassa Virus Cell Entry.

Host cell entry is the first and most fundamental step of every virus infection and represents a major barrier for zoonotic transmission and viral emergence. Targeting viral entry appears further as a...

Assays to Demonstrate the Roles of Arenaviral Nucleoproteins (NPs) in Viral RNA Synthesis and in Suppressing Type I Interferon.

Arenaviruses, such as Lassa virus (LASV) and Pichindé virus (PICV), are enveloped viruses with a bi-segmented ambisense RNA genome. The large (L) genomic segment encodes the Z matrix protein and the ...

Hemorrhagic Fever Virus Budding Studies.

Independent expression of the VP40 or Z matrix proteins of filoviruses (marburgviruses and ebolaviruses) and arenaviruses (Lassa fever and Junín), respectively, gives rise to the production and relea...

Identifying Restriction Factors for Hemorrhagic Fever Viruses: Dengue and Junín.

Host restriction factors are cellular components that interfere with viral multiplication. They are up-regulated and expressed upon viral infection and in consequence their activity is specific. So fa...

A Brief History of Promoter Development for Use in Transgenic Maize Applications.

Promoters regulate gene expression, and are essential biotechnology tools. Since its introduction in the mid-1990s, biotechnology has greatly enhanced maize productivity primarily through the developm...

Use of a Virus Gene Silencing Vector for Maize Functional Genomics Research.

Virus-induced gene silencing (VIGS) is a genetic technology that exploits the RNA-mediated defense against virus. The method has great potential for plant reverse genetics as it could knock down gene ...

Defining the Pathways of Urogenital Schistosomiasis-Associated Urothelial Carcinogenesis through Transgenic and Bladder Wall Egg Injection Models.

Urogenital schistosomiasis (infection with Schistosoma haematobium) is a major cause of bladder carcinogenesis. However, the exact mechanisms of the sequelae leading up to the development of bladder c...

News Articles [2350 Associated News Articles listed on BioPortfolio]

Global Titanium Sponge Market Research Report 20112023 [Report Updated: 28092017] Prices from USD $3020

SummaryTitanium Sponge is porous, loose metallic titanium with sponge shape. It is the main raw material and intermediate product of making titanium ingot, titanium powder and other titanium products....

Global Melatonin Market Data Survey Report 2025 [Report Updated: 09102017] Prices from USD $1500

SummaryMelatonin, also known as Nacetyl5methoxy tryptamine, is a hormone that is produced by the pineal gland in animals and regulates sleep and wakefulness. Melatonin is also produced in plants where...

Pressure grows on Trump to reveal details of soldiers' deaths in Niger

The defense secretary, James Mattis, would not say if Donald Trump had authorized the US mission in Niger. Donald Trump’s administration is facing mounting pressure to release more details about th...

Pharmacist's 'deadly' choices sparked U.S. meningitis outbreak: prosecutors

BOSTON (Reuters) - A federal prosecutor told jurors on Friday that a Massachusetts pharmacist gambled with patients' lives by making drugs in unsafe ways that led to a deadly 2012 fungal meningitis ou...

Aircraft Fuel Systems Global Market Outlook 20172023 [Report Updated: 01062017] Prices from USD $4150

According to Stratistics MRC, the Global Aircraft Fuel Systems Market is accounted for $6.98 billion in 2016 and expected to grow at a CAGR of 8.2% to reach $12.15 billion by 2023. Factors such as dem...

The Medicines Company to Announce Third-Quarter 2017 Financial Results on October 25

The Medicines Company (NASDAQ:MDCO) will host a conference call on Wednesday, October 25, 2017, at 8:30 a.m., Eastern Time, to discuss its third-quarter 2017 financial re...

How the smallest bacterial pathogens outwit host immune defenses by stealth mechanisms

Despite their relatively small genome, mycoplasmas can cause persistent and difficult-to-treat infections in humans and animals. A study has shown how mycoplasmas escape the immune response. Mycoplasm...

Dr. Oz says losing weight is the most 'patriotic' thing you can do

As Congress and President Donald Trump continue to battle it out in Washington over health care reform, talk show host and cardiothoracic surgeon, Dr. Mehmet Oz, says the fight should be directed at r...

What's next for biopharma Q3 earnings

Bristol-Myers, AbbVie, Merck, Gilead and several other notable names will all host third quarter earnings calls next week.

NewLink Genetics to Host Its Third Quarter 2017 Financial Results Conference Call on November ...

AMES, Iowa, Oct. 20, 2017 (GLOBE NEWSWIRE) Read more...

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Companies [241 Associated Companies listed on BioPortfolio]

Little Hercules Foundation and Team Joseph

Little Hercules Foundation is a registered, non-profit 501(c)(3) organization based in Dublin, Ohio. Little Hercules Foundation got its start in January 2013 when three moms, two ...

365mc Networks Inc.

365mc is a liposuction specialty hospital in Korea. It is also a network of 17 branch clinics in addition to its main hospital, boasting the cutting-edge infrastructure for...

Engility Holdings, Inc.

Engility (NYSE: EGL) is engineered to make a difference. Built on six decades of heritage, Engility is a leading provider of integrated solutions and services, supporting U.S. gov...

Express Logic, Inc.

Headquartered in San Diego, CA, with field offices in Redditch, UK, and Hanover and Munich, Germany, Express Logic offers the most advanced run-time solutions and development tool...

Gelesis, Inc.

Gelesis100 is a new approach to weight loss that is designed to employ multiple mechanisms of action along the GI tract to promote satiety and induce weight loss. Gelesis100 is no...

Notable Labs

Notable Labs’ mission is to change the way cancer is treated, which starts with putting patients first. The company is developing a personalized treatment service for people ...

Verity Health System

Verity Health System is a nonprofit healthcare system employing more than 6,000 staff statewide. The hospitals include 1,650 inpatient beds, six active emergency rooms, a traum...

Intellicheck

Intellicheck is the industry leader in technology solutions that are the antivirus to the epidemic of counterfeit IDs providing real-time threat identification and identification ...

Health Net Federal Services, LLC,

Health Net Federal Services has a long history of providing cost-effective, quality managed health care programs for government agencies, including the U.S. Departments of Defense...

Futurpreneur Canada

Futurpreneur Canada has been fueling the entrepreneurial passions of enterprising young Canadians since 1996. We’re the only national, non-profit organization that provides f...

Clinical Trials [1967 Associated Clinical Trials listed on BioPortfolio]

Aortic Stenosis in Subjects With Heterozygous Familial Hypercholesterolemia on Prolonged Treatment With Statins

Aortic stenosis (AE) is a disease that has been increasing steadily in recent years in most countries, including Spain.Risk factors for the development of AE include age, hypercholesterole...

A Study of Pembrolizumab in Combination With Epacadostat in Women With Recurrent/Metastatic Endometrial Carcinoma

Expression of IDO and PD-1/L1 has been found to be increased in endometrial cancer. Expression of these markers on the tumor cells leads to immunosuppression in the micro-environment of tu...

Transcriptomic and Next Generation Sequencing Approaches to Infection With Treponema Pallidum

Syphilis is an important sexually transmitted infection. There has been an epidemic of syphilis amongst men who have sex with men in the United Kingdom in the last decade. Early infection ...

Anti—PD-L1 and SAbR for Ovarian Cancer

Programmed death-1 receptor ligand (PD-L1) the ligand for PD-1 is a key therapeutic target in the reactivation of the immune response against multiple cancers. Pharmacologic inhibitors of ...

The Alcohol-Pain Connection: Mechanisms and Genetic/Psychological Correlates

The societal impact of heavy alcohol consumption and chronic pain is substantial and warrants the existing research investment into their etiology and treatment. Moreover, evidence of sign...

Effects of Combined Aerobic Exercise and Cognitive Training (The ACT Trial)

This clinical trial tests the efficacy and additive/synergistic effects of an ACT intervention on cognition and relevant mechanisms (aerobic fitness, Alzheimer's disease [AD] signature cor...

Duality of Lipids: the Athlete's Paradox

Accumulation of intramyocellular lipids (IMCLs) due to increased supply of fatty acids can induce defects in the insulin signaling cascade, causing skeletal muscle insulin resistance. Howe...

Myeloablative Allo HSCT With Related or Unrelated Donor for Heme Disorders

This is a Phase II study of allogeneic hematopoietic stem cell transplant (HCT) using a myeloablative preparative regimen (of either total body irradiation (TBI); or, fludarabine/busulfan ...

Cognitive Training for PTSD

Posttraumatic stress disorder (PTSD) is a chronic, disabling condition that occurs in a subgroup of individuals after experiencing traumatic stress, and is common in Veterans seeking menta...

Interventions for Parent Caregivers of Injured Military/Veteran Personnel

This randomized clinical trial will test a behavioral caregiving intervention that has been used successfully for dementia and spinal cord injury caregivers to provide services to stressed...

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Medical and Biotech [MESH] Definitions

The mechanisms by which a cell becomes internalized in another. The host cell may engulf another as do PHAGOCYTIC CELLS, or the host cell may be invaded by another cell (ENTOSIS), or internalization processes may involve the cooperation of both the host cell and the cell being internalized. Viable cells may remain in non-phagocytic cells (EMPERIPOLESIS), undergo cell division, pass through and then out of the host cell (TRANSCELLULAR CELL MIGRATION), or trigger APOPTOSIS of the invaded cell.

Unconscious process used by an individual or a group of individuals in order to cope with impulses, feelings or ideas which are not acceptable at their conscious level; various types include reaction formation, projection and self reversal.

Processes that translocate macromolecules across the cell envelope of gram negative bacteria, often directly into the host. These effectors modulate the defense response and thereby facilitate survival of the pathogen.

A chemokine that is a chemoattractant for MONOCYTES and may also cause cellular activation of specific functions related to host defense. It is produced by LEUKOCYTES of both monocyte and lymphocyte lineage and by FIBROBLASTS during tissue injury. It has specificity for CCR2 RECEPTORS.

Defense mechanisms involving approach and avoidance responses to threatening stimuli. The sensitizing process involves intellectualization in approaching or controlling the stimulus whereas repression involves unconscious denial in avoiding the stimulus.

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